Sodium Chloride 7% Neb Sol 30x4ml
It is used to thin mucus so it can be taken from the body by coughing.It is used to mix with other drugs for use in a special machine (nebulizer).It may be given to you for other reasons. Talk with the doctor.
Drug Class
Mucolytic, Osmotic agent
Pharmacologic Class
Electrolyte solution, Osmotic agent
Pregnancy Category
Category B
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Sodium Chloride 7% Nebulizer Solution is a salty water solution that you breathe in through a nebulizer. It helps to thin the thick mucus in your lungs, making it easier to cough up and clear your airways. This can help you breathe more easily.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications by throwing them away. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of medications, consult your pharmacist. You may also have access to drug take-back programs in your area.
Missing a Dose
If you take this medication regularly, take a missed dose as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications by throwing them away. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of medications, consult your pharmacist. You may also have access to drug take-back programs in your area.
Missing a Dose
If you take this medication regularly, take a missed dose as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
Lifestyle & Tips
- Maintain good hydration by drinking plenty of fluids, as this also helps to thin mucus.
- Practice good airway clearance techniques as advised by your healthcare provider (e.g., chest physiotherapy, vest therapy).
- Clean your nebulizer equipment regularly as instructed to prevent infections.
Available Forms & Alternatives
Available Strengths:
- Sod Chloride 0.9% Inj, 1000ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sodium Chloride 1gm Tablets
- Sodium Chloride 0.9% Inj, 10ml
- Sodium Chloride 0.9% Inj, 50ml
- Sodium Chloride 0.9% Inj, 20ml
- Sod Chloride 0.45%/20meqkcl
- Sod Chloride 0.9% Inj, 500ml
- Sod Chloride 0.9% W/ 20meq Kcl
- Sodium Chloride 4meq/ml (23.4%) Inj
- Sod Chloride 0.9% Excel Inj 250ml
- Sodium Chloride 0.9% Neb Sol 30x3ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sod Chloride 23.4% Inj, 100ml
- Sod Chloride 0.45% Inj, 500ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 500ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sodium Chloride 3% Neb Sol 15ml
- Sod Chloride 0.9% Neb Sol 100 X 5ml
- Sodium Chloride 10% Neb Soln, 15ml
- Sod Chloride 0.9% Inj, 5ml
- Sodium Chloride 5% Ophth Oint 3.5gm
- Sod Chloride 0.9% Inj, 10ml
- Sodium Chloride 7% Neb Sol 60x4ml
- Sodium Chloride 3% Inj, 500ml
- Sod Chloride 23.4% Inj, 200ml
- Sod Chloride 0.9% Neb Sol 25 X 5ml
- Sod Chloride 0.9% Neb Sol 100 X 3ml
- Sod Chloride 0.9% Neb Sol 50 X 15ml
- Sodium Chloride 10% Neb Sol 60x4ml
- Sodium Chloride 0.9% Inj, 2ml
- Sodium Chloride 2.5meq/ml Inj, 20ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sod Chloride 4meq/ml Inj, 25x30ml
- Sod Chloride 5% Ophth Soln 15ml
- Sod Chloride 0.9% Inj, 1000ml
- Sodium Chloride 3% Neb Sol 30x4ml
- Sodium Chloride 7% Neb Sol 30x4ml
- Sodium Chloride 3% Neb Sol 60x4ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.9% Inj, 150ml
- Sodium Chloride 0.9% Inj,100ml
- Sod Chloride 0.9% Inj, 25ml
- Sod Chloride 0.9% Inj, 125ml
- Sod Chloride 0.45% Inj, 250ml
- Sod Chloride 0.45% Inj, 50ml
- Sod Chloride 0.45% Inj, 100ml
- Sod Chloride 5% Inj, 500ml
- Sod Chloride 0.45%/20meq Kcl
Dosing & Administration
Adult Dosing
Standard Dose:
4 mL of 7% solution via nebulizer 2 to 4 times daily
Dose Range:
2 - 4 mg
Condition-Specific Dosing:
cysticFibrosis:
Often used as part of a daily regimen to improve mucociliary clearance.
Pediatric Dosing
Neonatal:
Not established (use with caution, risk of bronchospasm)
Infant:
4 mL of 7% solution via nebulizer 2 to 4 times daily (monitor closely for bronchospasm)
Child:
4 mL of 7% solution via nebulizer 2 to 4 times daily
Adolescent:
4 mL of 7% solution via nebulizer 2 to 4 times daily
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Dialysis:
No specific considerations as systemic absorption is minimal
Hepatic Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Pharmacology
Mechanism of Action
Sodium chloride 7% (hypertonic saline) is an osmotic agent that draws water into the airway lumen by creating an osmotic gradient across the airway surface. This rehydrates the airway surface liquid, thins the mucus, and improves mucociliary clearance, facilitating the expectoration of sputum.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption
Tmax:
Not applicable (local action)
FoodEffect:
Not applicable
Distribution:
Vd:
Not applicable (local action)
ProteinBinding:
Not applicable (local action)
CnssPenetration:
No
Elimination:
HalfLife:
Not applicable (local action)
Clearance:
Cleared from airways by mucociliary action and expectoration
ExcretionRoute:
Expectorated or swallowed
Unchanged:
Not applicable
Pharmacodynamics
OnsetOfAction:
Rapid (within minutes of inhalation)
PeakEffect:
Within 15-30 minutes
DurationOfAction:
Variable, typically 1-2 hours, depending on individual mucociliary clearance and mucus burden
Safety & Warnings
Side Effects
Serious Side Effects: Seek Medical Attention Immediately
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:
* Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:
* Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Worsening shortness of breath or difficulty breathing immediately after using the nebulizer.
- New or increased wheezing or whistling sounds when breathing.
- Severe or uncontrollable coughing spells.
- Chest pain or tightness that does not resolve.
- Signs of an allergic reaction (rare): rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as they may affect the safety and efficacy of this medication.
To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to determine the best course of treatment for you.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as they may affect the safety and efficacy of this medication.
To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to determine the best course of treatment for you.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are pregnant, planning to become pregnant, or are breast-feeding, you must discuss this with your doctor. This conversation will help you understand the benefits and risks of taking this drug, both for you and your baby, allowing you to make an informed decision.
Overdose Information
Overdose Symptoms:
- Severe bronchospasm (worsening wheezing, shortness of breath, chest tightness)
- Persistent cough
- Throat irritation
What to Do:
Discontinue use immediately. If symptoms are severe or persistent, seek immediate medical attention or call 911. For general advice, call a poison control center at 1-800-222-1222.
Drug Interactions
Moderate Interactions
- Other inhaled medications (administer sequentially with adequate spacing to avoid dilution or altered deposition)
Monitoring
Baseline Monitoring
Baseline respiratory assessment (lung sounds, cough, sputum characteristics)
Rationale: To establish a baseline for evaluating treatment efficacy and adverse effects.
Timing: Prior to initiation of therapy
Routine Monitoring
Respiratory status (e.g., lung sounds, work of breathing, cough, sputum production)
Frequency: Before and after each dose, or as clinically indicated
Target: Improvement in symptoms, ease of breathing
Action Threshold: Worsening cough, increased wheezing, shortness of breath, or chest tightness may indicate bronchospasm and require intervention.
Spirometry (e.g., FEV1)
Frequency: Periodically, as per clinical protocol (especially in CF patients)
Target: Maintenance or improvement in lung function
Action Threshold: Significant decline may indicate disease progression or inadequate therapy.
Symptom Monitoring
- Increased cough (especially if persistent or worsening)
- Wheezing
- Shortness of breath
- Chest tightness
- Throat irritation
- Sore throat
Special Patient Groups
Pregnancy
Sodium chloride 7% nebulizer solution is generally considered safe for use during pregnancy due to minimal systemic absorption. Consult with a healthcare provider.
Trimester-Specific Risks:
First Trimester:
Low risk, minimal systemic absorption.
Second Trimester:
Low risk, minimal systemic absorption.
Third Trimester:
Low risk, minimal systemic absorption.
Lactation
Sodium chloride 7% nebulizer solution is considered safe for use during lactation. Systemic absorption is minimal, and it is not expected to be excreted in breast milk in clinically significant amounts.
Infant Risk:
Low risk
Pediatric Use
Can be used in pediatric patients, especially those with cystic fibrosis. Close monitoring for bronchospasm is recommended, particularly in younger children or those with reactive airways. Pre-treatment with a bronchodilator may be considered.
Geriatric Use
Generally safe for use in geriatric patients. No specific dose adjustments are typically required due to minimal systemic absorption. Monitor for tolerance and potential for bronchospasm.
Clinical Information
Clinical Pearls
- Always pre-treat with a short-acting bronchodilator (e.g., albuterol) 10-15 minutes before administering hypertonic saline, especially in patients with reactive airways, to minimize the risk of bronchospasm.
- Instruct patients on proper nebulizer technique to ensure optimal drug delivery to the lungs.
- Monitor patients, especially during the first few doses, for signs of bronchospasm (e.g., increased cough, wheezing, shortness of breath).
- Hypertonic saline is often used as part of a comprehensive airway clearance regimen in conditions like cystic fibrosis, bronchiectasis, and COPD.
- Ensure the solution is at room temperature before nebulization for patient comfort.
Alternative Therapies
- Dornase alfa (Pulmozyme) - another mucolytic for cystic fibrosis
- N-acetylcysteine (Mucomyst) - mucolytic, less commonly used via nebulizer for chronic conditions
- Normal saline (0.9% NaCl) - for general airway hydration, but less effective as a mucolytic than hypertonic saline
- Mannitol dry powder for inhalation (Bronchitol, Aridol) - osmotic agent for airway clearance
Cost & Coverage
Average Cost:
$10 - $30 per 30x4ml box
Generic Available:
Yes
Insurance Coverage:
Tier 1 or 2 (often covered by most insurance plans)
General Drug Facts
If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When reporting the incident, be prepared to provide details about the medication taken, the amount, and the time it occurred.