Sod Chloride 0.9% Inj, 125ml
It is used to flush IV sets and access devices.It may be given to you for other reasons. Talk with the doctor.
Drug Class
Electrolyte, Fluid Replacement, Solvent
Pharmacologic Class
Isotonic Solution, Electrolyte
Pregnancy Category
Not formally categorized, generally considered safe for physiological replacement.
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Sodium Chloride 0.9% Injection is a sterile salt water solution. It's commonly used in hospitals to give you fluids, to dilute other medicines before they are given through an IV, or to flush your IV line to keep it clear and working properly.
How to Use This Medicine
To use this medication correctly, follow your doctor's instructions and carefully read all accompanying information. Adhere to the dosage instructions and guidelines provided to ensure safe and effective use.
For proper storage and disposal of this medication, consult with your doctor, nurse, or pharmacist to determine the best approach for your specific situation.
If you miss a dose, contact your doctor promptly to receive guidance on the appropriate course of action to take.
For proper storage and disposal of this medication, consult with your doctor, nurse, or pharmacist to determine the best approach for your specific situation.
If you miss a dose, contact your doctor promptly to receive guidance on the appropriate course of action to take.
Lifestyle & Tips
- No specific lifestyle modifications are required for the use of Sodium Chloride 0.9% Injection itself, as it is typically administered in a clinical setting.
Available Forms & Alternatives
Available Strengths:
- Sod Chloride 0.9% Inj, 1000ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sodium Chloride 1gm Tablets
- Sodium Chloride 0.9% Inj, 10ml
- Sodium Chloride 0.9% Inj, 50ml
- Sodium Chloride 0.9% Inj, 20ml
- Sod Chloride 0.45%/20meqkcl
- Sod Chloride 0.9% Inj, 500ml
- Sod Chloride 0.9% W/ 20meq Kcl
- Sodium Chloride 4meq/ml (23.4%) Inj
- Sod Chloride 0.9% Excel Inj 250ml
- Sodium Chloride 0.9% Neb Sol 30x3ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sod Chloride 23.4% Inj, 100ml
- Sod Chloride 0.45% Inj, 500ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 500ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sodium Chloride 3% Neb Sol 15ml
- Sod Chloride 0.9% Neb Sol 100 X 5ml
- Sodium Chloride 10% Neb Soln, 15ml
- Sod Chloride 0.9% Inj, 5ml
- Sodium Chloride 5% Ophth Oint 3.5gm
- Sod Chloride 0.9% Inj, 10ml
- Sodium Chloride 7% Neb Sol 60x4ml
- Sodium Chloride 3% Inj, 500ml
- Sod Chloride 23.4% Inj, 200ml
- Sod Chloride 0.9% Neb Sol 25 X 5ml
- Sod Chloride 0.9% Neb Sol 100 X 3ml
- Sod Chloride 0.9% Neb Sol 50 X 15ml
- Sodium Chloride 10% Neb Sol 60x4ml
- Sodium Chloride 0.9% Inj, 2ml
- Sodium Chloride 2.5meq/ml Inj, 20ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sod Chloride 4meq/ml Inj, 25x30ml
- Sod Chloride 5% Ophth Soln 15ml
- Sod Chloride 0.9% Inj, 1000ml
- Sodium Chloride 3% Neb Sol 30x4ml
- Sodium Chloride 7% Neb Sol 30x4ml
- Sodium Chloride 3% Neb Sol 60x4ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.9% Inj, 150ml
- Sodium Chloride 0.9% Inj,100ml
- Sod Chloride 0.9% Inj, 25ml
- Sod Chloride 0.9% Inj, 125ml
- Sod Chloride 0.45% Inj, 250ml
- Sod Chloride 0.45% Inj, 50ml
- Sod Chloride 0.45% Inj, 100ml
- Sod Chloride 5% Inj, 500ml
- Sod Chloride 0.45%/20meq Kcl
Dosing & Administration
Adult Dosing
Standard Dose:
Variable, depends on clinical need (e.g., IV line flush, medication dilution, maintenance fluid). For flushing, typically 3-10 mL per flush. For dilution, as per medication instructions.
Condition-Specific Dosing:
IV Line Flush:
3-10 mL per flush, as needed to maintain patency or before/after medication administration.
Medication Dilution:
Volume determined by the specific medication's reconstitution or dilution requirements.
Pediatric Dosing
Neonatal:
Dosing is highly individualized based on weight, fluid status, and specific clinical need (e.g., 1-3 mL per flush for IV lines).
Infant:
Dosing is highly individualized based on weight, fluid status, and specific clinical need (e.g., 1-5 mL per flush for IV lines).
Child:
Dosing is highly individualized based on weight, fluid status, and specific clinical need (e.g., 3-10 mL per flush for IV lines).
Adolescent:
Similar to adult dosing, individualized based on clinical need.
Dose Adjustments
Renal Impairment:
Mild:
No specific adjustment for the solution itself, but monitor fluid and electrolyte balance carefully.
Moderate:
No specific adjustment for the solution itself, but monitor fluid and electrolyte balance carefully; risk of fluid overload or hypernatremia may be increased.
Severe:
Use with extreme caution; monitor fluid and electrolyte balance closely. Risk of fluid overload, hypernatremia, and pulmonary edema is significantly increased.
Dialysis:
Use with extreme caution; monitor fluid and electrolyte balance closely. Volume and electrolyte status must be carefully assessed before and after administration.
Hepatic Impairment:
Mild:
No specific adjustment.
Moderate:
No specific adjustment.
Severe:
No specific adjustment, but monitor for fluid retention if ascites or edema are present.
Pharmacology
Mechanism of Action
Sodium Chloride 0.9% Injection is an isotonic solution that provides water and electrolytes (sodium and chloride) to maintain osmotic pressure and expand the extracellular fluid volume. It is used to restore fluid and electrolyte balance, as a vehicle for drug administration, and for flushing intravenous catheters.
Pharmacokinetics
Absorption:
Bioavailability:
100% (intravenous administration)
Tmax:
Immediate
FoodEffect:
Not applicable
Distribution:
Vd:
Approximately 0.2 L/kg (distributes primarily into the extracellular fluid space)
ProteinBinding:
Not applicable (ions)
CnssPenetration:
Limited for large molecules, but water and ions can cross the blood-brain barrier to maintain osmotic equilibrium.
Elimination:
HalfLife:
Not applicable in the traditional pharmacokinetic sense; depends on fluid balance, renal function, and physiological needs.
Clearance:
Primarily renal excretion; regulated by kidneys to maintain fluid and electrolyte homeostasis.
ExcretionRoute:
Renal (urine)
Unchanged:
100%
Pharmacodynamics
OnsetOfAction:
Immediate
PeakEffect:
Immediate
DurationOfAction:
Depends on the patient's fluid and electrolyte balance, renal function, and ongoing fluid losses/intake.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Attention Immediately
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:
- Signs of an allergic reaction, such as rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch. Your doctor is available to provide medical advice about side effects.
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:
- Signs of an allergic reaction, such as rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch. Your doctor is available to provide medical advice about side effects.
Seek Immediate Medical Attention If You Experience:
- Swelling in your hands, feet, or ankles (edema)
- Difficulty breathing or shortness of breath
- Sudden weight gain
- Unusual thirst or dry mouth
- Confusion or dizziness
- Muscle weakness or cramps
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as these may affect the safety and efficacy of this medication.
To ensure your safety, it is crucial to verify that this medication can be taken with all your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as these may affect the safety and efficacy of this medication.
To ensure your safety, it is crucial to verify that this medication can be taken with all your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are pregnant, planning to become pregnant, or are breast-feeding, be sure to discuss this with your doctor. You and your doctor will need to carefully weigh the benefits and risks of using this medication to ensure the best possible outcome for both you and your baby.
Overdose Information
Overdose Symptoms:
- Fluid overload (e.g., pulmonary edema, peripheral edema, hypertension, tachycardia)
- Hypernatremia (e.g., thirst, lethargy, confusion, seizures, coma)
- Metabolic acidosis (due to high chloride load with large volumes)
What to Do:
Discontinue infusion immediately. Management is supportive and depends on the severity of symptoms and specific electrolyte imbalances. May involve diuretics for fluid overload, or other interventions to correct electrolyte abnormalities. Call 1-800-222-1222 (Poison Control) for specific guidance if accidental overdose occurs outside of a clinical setting.
Drug Interactions
Moderate Interactions
- Corticosteroids (may increase sodium and fluid retention)
- Lithium (increased sodium intake may increase lithium excretion, potentially reducing lithium levels)
- Diuretics (may alter fluid and electrolyte balance, requiring careful monitoring)
Monitoring
Baseline Monitoring
Fluid status (e.g., vital signs, urine output, edema)
Rationale: To assess baseline hydration and identify risk of fluid overload or dehydration.
Timing: Prior to initiation of therapy.
Serum Electrolytes (Sodium, Chloride, Potassium)
Rationale: To assess baseline electrolyte balance and identify pre-existing imbalances.
Timing: Prior to initiation of therapy, especially if large volumes are anticipated or in patients with renal/cardiac compromise.
Renal Function (BUN, Creatinine)
Rationale: To assess kidney's ability to handle fluid and electrolyte load.
Timing: Prior to initiation of therapy in at-risk patients.
Routine Monitoring
Fluid balance (Intake/Output)
Frequency: Daily or more frequently as clinically indicated.
Target: Appropriate balance for patient's condition.
Action Threshold: Significant positive or negative balance; signs of fluid overload or dehydration.
Serum Electrolytes (Sodium, Chloride)
Frequency: As clinically indicated, especially with large volumes or in patients with impaired renal/cardiac function.
Target: Sodium: 135-145 mEq/L; Chloride: 98-107 mEq/L
Action Threshold: Values outside normal range, particularly hypernatremia or significant shifts.
Vital Signs (Blood Pressure, Heart Rate)
Frequency: Regularly, as per institutional protocol or clinical need.
Target: Within patient's normal limits.
Action Threshold: Significant changes indicating fluid overload (e.g., hypertension, tachycardia) or dehydration.
Symptom Monitoring
- Signs of fluid overload (e.g., peripheral edema, pulmonary crackles, dyspnea, weight gain, elevated blood pressure)
- Signs of hypernatremia (e.g., thirst, lethargy, confusion, seizures, coma)
- Signs of electrolyte imbalance (e.g., muscle weakness, arrhythmias, altered mental status)
Special Patient Groups
Pregnancy
Sodium Chloride 0.9% Injection is commonly used during pregnancy for fluid replacement, hydration, and as a vehicle for medication administration. It is generally considered safe for physiological replacement, but fluid and electrolyte balance should be carefully monitored.
Trimester-Specific Risks:
First Trimester:
No known specific risks.
Second Trimester:
No known specific risks.
Third Trimester:
No known specific risks, but careful monitoring of fluid balance is important, especially in pre-eclamptic patients or those at risk for fluid overload.
Lactation
Sodium Chloride 0.9% Injection is considered safe for use during lactation. Sodium and chloride are natural components of breast milk, and administration of this solution is not expected to harm the nursing infant.
Infant Risk:
Minimal to none.
Pediatric Use
Use with caution in neonates and infants due to immature renal function and higher susceptibility to fluid and electrolyte imbalances. Dosing must be carefully calculated based on weight and clinical need. Close monitoring of fluid balance and serum electrolytes is essential.
Geriatric Use
Use with caution in elderly patients due to potential for impaired renal or cardiac function, which may increase the risk of fluid overload or electrolyte imbalances. Close monitoring of fluid status, vital signs, and serum electrolytes is recommended.
Clinical Information
Clinical Pearls
- Sodium Chloride 0.9% is isotonic and is the most common IV fluid for general hydration, flushing, and medication dilution.
- While generally safe, excessive administration can lead to fluid overload, hypernatremia, and hyperchloremic metabolic acidosis.
- Always check for compatibility when using as a diluent for other medications.
- For IV line flushing, ensure proper technique to prevent catheter occlusion or infection.
- Not suitable for patients requiring free water (e.g., hypernatremia with dehydration) or significant electrolyte correction beyond sodium and chloride.
Alternative Therapies
- Other intravenous fluid solutions depending on the specific clinical need (e.g., hypotonic solutions for hypernatremia, hypertonic solutions for cerebral edema, specific electrolyte solutions for severe deficiencies).
- Oral rehydration solutions for mild to moderate dehydration.
Cost & Coverage
Average Cost:
$0.50 - $5.00 per 125 mL bag/vial
Generic Available:
Yes
Insurance Coverage:
Generally covered by most insurance plans as a medical supply or part of IV therapy.
General Drug Facts
If your symptoms or health problems persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others, and do not take medication prescribed for someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly. Unless instructed otherwise, do not flush medications down the toilet or pour them down the drain. If you are unsure about the correct disposal method, consult your pharmacist, who can also inform you about potential drug take-back programs in your area. Some medications may come with an additional patient information leaflet, which your pharmacist can provide. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide information about the medication taken, the amount, and the time of the incident.