Sod Chloride 0.9% Neb Sol 100 X 5ml
It is used to thin mucus so it can be taken from the body by coughing.It is used to mix with other drugs for use in a special machine (nebulizer).It may be given to you for other reasons. Talk with the doctor.
Drug Class
Mucolytic, Respiratory Hydrant, Diluent
Pharmacologic Class
Electrolyte Solution, Osmotic Agent (Isotonic)
Pregnancy Category
Category A
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Sodium Chloride 0.9% Nebulizer Solution is a sterile, salt-water solution. When used with a nebulizer, it creates a fine mist that you breathe in. This helps to moisten your airways, thin out thick mucus in your lungs, and make it easier to cough up phlegm, helping you breathe more comfortably.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications by throwing them away. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of medications, consult your pharmacist. You may also have access to drug take-back programs in your area.
Missing a Dose
If you take this medication regularly, take a missed dose as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications by throwing them away. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of medications, consult your pharmacist. You may also have access to drug take-back programs in your area.
Missing a Dose
If you take this medication regularly, take a missed dose as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
Lifestyle & Tips
- Maintain good hydration by drinking plenty of fluids unless otherwise advised by your doctor.
- Practice good hand hygiene to prevent respiratory infections.
- Avoid irritants like smoke, dust, and strong fumes that can worsen respiratory symptoms.
Available Forms & Alternatives
Available Strengths:
- Sod Chloride 0.9% Inj, 1000ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sodium Chloride 1gm Tablets
- Sodium Chloride 0.9% Inj, 10ml
- Sodium Chloride 0.9% Inj, 50ml
- Sodium Chloride 0.9% Inj, 20ml
- Sod Chloride 0.45%/20meqkcl
- Sod Chloride 0.9% Inj, 500ml
- Sod Chloride 0.9% W/ 20meq Kcl
- Sodium Chloride 4meq/ml (23.4%) Inj
- Sod Chloride 0.9% Excel Inj 250ml
- Sodium Chloride 0.9% Neb Sol 30x3ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sod Chloride 23.4% Inj, 100ml
- Sod Chloride 0.45% Inj, 500ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 500ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sodium Chloride 3% Neb Sol 15ml
- Sod Chloride 0.9% Neb Sol 100 X 5ml
- Sodium Chloride 10% Neb Soln, 15ml
- Sod Chloride 0.9% Inj, 5ml
- Sodium Chloride 5% Ophth Oint 3.5gm
- Sod Chloride 0.9% Inj, 10ml
- Sodium Chloride 7% Neb Sol 60x4ml
- Sodium Chloride 3% Inj, 500ml
- Sod Chloride 23.4% Inj, 200ml
- Sod Chloride 0.9% Neb Sol 25 X 5ml
- Sod Chloride 0.9% Neb Sol 100 X 3ml
- Sod Chloride 0.9% Neb Sol 50 X 15ml
- Sodium Chloride 10% Neb Sol 60x4ml
- Sodium Chloride 0.9% Inj, 2ml
- Sodium Chloride 2.5meq/ml Inj, 20ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sod Chloride 4meq/ml Inj, 25x30ml
- Sod Chloride 5% Ophth Soln 15ml
- Sod Chloride 0.9% Inj, 1000ml
- Sodium Chloride 3% Neb Sol 30x4ml
- Sodium Chloride 7% Neb Sol 30x4ml
- Sodium Chloride 3% Neb Sol 60x4ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.9% Inj, 150ml
- Sodium Chloride 0.9% Inj,100ml
- Sod Chloride 0.9% Inj, 25ml
- Sod Chloride 0.9% Inj, 125ml
- Sod Chloride 0.45% Inj, 250ml
- Sod Chloride 0.45% Inj, 50ml
- Sod Chloride 0.45% Inj, 100ml
- Sod Chloride 5% Inj, 500ml
- Sod Chloride 0.45%/20meq Kcl
Dosing & Administration
Adult Dosing
Standard Dose:
2.5 mL to 5 mL via nebulizer, 3 to 4 times daily or as needed
Dose Range:
2.5 - 5 mg
Condition-Specific Dosing:
airwayhydration:
2.5 mL to 5 mL via nebulizer, 3 to 4 times daily or as needed to aid in mucociliary clearance and hydration of respiratory secretions.
Pediatric Dosing
Neonatal:
2.5 mL via nebulizer, 3 to 4 times daily or as needed
Infant:
2.5 mL to 5 mL via nebulizer, 3 to 4 times daily or as needed
Child:
2.5 mL to 5 mL via nebulizer, 3 to 4 times daily or as needed
Adolescent:
2.5 mL to 5 mL via nebulizer, 3 to 4 times daily or as needed
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Dialysis:
No specific considerations for nebulized use due to minimal systemic absorption.
Hepatic Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Pharmacology
Mechanism of Action
Sodium chloride 0.9% (isotonic saline) nebulizer solution works by hydrating the respiratory tract. When inhaled, it helps to moisten and thin tenacious mucus and secretions in the airways, making them less viscous and easier to clear through coughing or mucociliary action. It also helps to maintain the osmotic balance of the airway lining.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption
Tmax:
Not applicable (primarily local action)
FoodEffect:
Not applicable
Distribution:
Vd:
Not applicable (primarily local action)
ProteinBinding:
Not applicable
CnssPenetration:
No
Elimination:
HalfLife:
Not applicable (primarily local action)
Clearance:
Not applicable
ExcretionRoute:
Primarily cleared from the respiratory tract via mucociliary clearance and coughing; some may be swallowed and excreted renally.
Unchanged:
Not applicable
Pharmacodynamics
OnsetOfAction:
Rapid (local effect, within minutes of inhalation)
PeakEffect:
Within minutes of inhalation
DurationOfAction:
Variable, typically lasts for the duration of the nebulization and shortly thereafter, depending on the patient's condition and frequency of use.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor immediately or seek emergency medical attention:
- Signs of an allergic reaction, such as:
- Rash
- Hives
- Itching
- Red, swollen, blistered, or peeling skin (with or without fever)
- Wheezing
- Tightness in the chest or throat
- Difficulty breathing, swallowing, or talking
- Unusual hoarseness
- Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch. Your doctor is available to provide medical advice about side effects.
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor immediately or seek emergency medical attention:
- Signs of an allergic reaction, such as:
- Rash
- Hives
- Itching
- Red, swollen, blistered, or peeling skin (with or without fever)
- Wheezing
- Tightness in the chest or throat
- Difficulty breathing, swallowing, or talking
- Unusual hoarseness
- Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch. Your doctor is available to provide medical advice about side effects.
Seek Immediate Medical Attention If You Experience:
- Worsening shortness of breath or difficulty breathing
- Increased wheezing or chest tightness
- Development of new chest pain
- Signs of infection (e.g., fever, chills, increased purulent sputum)
- Any unexpected or severe reaction after using the solution
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have to this medication, its components, or other substances, including foods and drugs. Be sure to describe the allergic reaction you experienced, including the symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is not an exhaustive list, and it is crucial to disclose all your medications and health issues to your doctor and pharmacist.
Any health problems you have, as they may interact with this medication. Your doctor and pharmacist need to be aware of your complete medical profile to ensure safe treatment.
Do not initiate, discontinue, or modify the dosage of any medication without first consulting your doctor to confirm it is safe to do so. This precaution is vital to prevent potential interactions and ensure the effectiveness of your treatment.
It is essential to inform your doctor about the following:
Any allergies you have to this medication, its components, or other substances, including foods and drugs. Be sure to describe the allergic reaction you experienced, including the symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is not an exhaustive list, and it is crucial to disclose all your medications and health issues to your doctor and pharmacist.
Any health problems you have, as they may interact with this medication. Your doctor and pharmacist need to be aware of your complete medical profile to ensure safe treatment.
Do not initiate, discontinue, or modify the dosage of any medication without first consulting your doctor to confirm it is safe to do so. This precaution is vital to prevent potential interactions and ensure the effectiveness of your treatment.
Precautions & Cautions
It is essential to inform all of your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are pregnant, planning to become pregnant, or are breast-feeding, you must discuss this with your doctor. This conversation will help you understand the benefits and risks of taking this drug, both for you and your baby, allowing you to make an informed decision.
Overdose Information
Overdose Symptoms:
- Overdose with nebulized 0.9% sodium chloride is highly unlikely due to minimal systemic absorption. Excessive use might theoretically lead to temporary airway irritation or coughing.
What to Do:
Discontinue use and seek medical attention if any concerning symptoms occur. For general overdose concerns, call 1-800-222-1222 (Poison Control).
Drug Interactions
Monitoring
Baseline Monitoring
Respiratory assessment
Rationale: To establish baseline lung sounds, breathing pattern, and presence/character of secretions.
Timing: Prior to initiation of therapy
Routine Monitoring
Respiratory status (e.g., lung sounds, work of breathing)
Frequency: Before and after each treatment, or as clinically indicated
Target: Improved or stable respiratory effort and breath sounds
Action Threshold: Worsening shortness of breath, increased wheezing, or signs of bronchospasm may require discontinuation or medical evaluation.
Sputum characteristics (e.g., quantity, viscosity, color)
Frequency: Daily or as clinically indicated
Target: Thinner, less viscous, and easier to expectorate sputum
Action Threshold: Increased sputum viscosity or difficulty clearing secretions may indicate inadequate hydration or need for alternative therapies.
Symptom Monitoring
- Cough effectiveness
- Ease of breathing
- Chest congestion
- Sputum production and characteristics
Special Patient Groups
Pregnancy
Sodium chloride 0.9% nebulizer solution is considered safe for use during pregnancy. It is an isotonic solution, naturally occurring in the body, and systemic absorption from nebulized administration is minimal.
Trimester-Specific Risks:
First Trimester:
No known risks.
Second Trimester:
No known risks.
Third Trimester:
No known risks.
Lactation
Sodium chloride 0.9% nebulizer solution is considered safe for use during lactation. It is an isotonic solution, naturally occurring in the body, and systemic absorption from nebulized administration is minimal, posing no risk to the nursing infant.
Infant Risk:
None (L1 - Safest)
Pediatric Use
Sodium chloride 0.9% nebulizer solution is commonly used and considered safe in pediatric patients, including neonates, infants, children, and adolescents, for airway hydration and mucus thinning. Dosing is generally similar to adults (2.5-5 mL per treatment) or adjusted based on clinical need.
Geriatric Use
No specific dose adjustments or precautions are generally required for geriatric patients. It is considered safe and well-tolerated in this population for airway hydration and mucus thinning.
Clinical Information
Clinical Pearls
- Sodium chloride 0.9% nebulizer solution is often used as a diluent for other nebulized medications (e.g., bronchodilators, corticosteroids) to achieve the desired volume for nebulization.
- It is a non-pharmacological intervention that can provide symptomatic relief for patients with thick, tenacious secretions.
- Ensure proper nebulizer technique and maintenance for optimal delivery and hygiene.
- While generally safe, some patients, particularly those with highly reactive airways, might experience transient coughing or mild bronchospasm, though this is more common with hypertonic saline.
Alternative Therapies
- Hypertonic saline nebulizer solutions (e.g., 3%, 7%) for more significant mucolytic effect (requires careful monitoring for bronchospasm).
- Dornase alfa (Pulmozyme) for cystic fibrosis patients.
- N-acetylcysteine (NAC) as an oral or nebulized mucolytic (less common for routine use).
- Adequate systemic hydration (oral or intravenous fluids).
Cost & Coverage
Average Cost:
Very low (e.g., $0.10 - $0.50 per 5mL vial) per 5mL vial
Generic Available:
Yes
Insurance Coverage:
Tier 1 (Preferred Generic) or OTC
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.