Sod Chloride 0.9% Neb Sol 25 X 5ml
It is used to thin mucus so it can be taken from the body by coughing.It is used to mix with other drugs for use in a special machine (nebulizer).It may be given to you for other reasons. Talk with the doctor.
Drug Class
Respiratory Hydrating Agent, Mucolytic, Diluent
Pharmacologic Class
Electrolyte Solution, Isotonic Solution
Pregnancy Category
Category A
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
This is a sterile salt water solution used with a nebulizer machine. It helps to moisten your airways, making it easier to breathe and clear mucus from your lungs. It can also be used to mix with other medicines for your nebulizer.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications responsibly. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of your medication, consult your pharmacist. You may also want to check if there are drug take-back programs in your area.
What to Do If You Miss a Dose
If you take this medication regularly, use the missed dose as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications responsibly. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of your medication, consult your pharmacist. You may also want to check if there are drug take-back programs in your area.
What to Do If You Miss a Dose
If you take this medication regularly, use the missed dose as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
Lifestyle & Tips
- Maintain good nebulizer hygiene by cleaning the nebulizer cup and mouthpiece after each use as directed by the manufacturer.
- Store vials at room temperature, away from direct light and heat.
- Use each vial only once and discard any unused solution.
Available Forms & Alternatives
Available Strengths:
- Sod Chloride 0.9% Inj, 1000ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sodium Chloride 1gm Tablets
- Sodium Chloride 0.9% Inj, 10ml
- Sodium Chloride 0.9% Inj, 50ml
- Sodium Chloride 0.9% Inj, 20ml
- Sod Chloride 0.45%/20meqkcl
- Sod Chloride 0.9% Inj, 500ml
- Sod Chloride 0.9% W/ 20meq Kcl
- Sodium Chloride 4meq/ml (23.4%) Inj
- Sod Chloride 0.9% Excel Inj 250ml
- Sodium Chloride 0.9% Neb Sol 30x3ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sod Chloride 23.4% Inj, 100ml
- Sod Chloride 0.45% Inj, 500ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 500ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sodium Chloride 3% Neb Sol 15ml
- Sod Chloride 0.9% Neb Sol 100 X 5ml
- Sodium Chloride 10% Neb Soln, 15ml
- Sod Chloride 0.9% Inj, 5ml
- Sodium Chloride 5% Ophth Oint 3.5gm
- Sod Chloride 0.9% Inj, 10ml
- Sodium Chloride 7% Neb Sol 60x4ml
- Sodium Chloride 3% Inj, 500ml
- Sod Chloride 23.4% Inj, 200ml
- Sod Chloride 0.9% Neb Sol 25 X 5ml
- Sod Chloride 0.9% Neb Sol 100 X 3ml
- Sod Chloride 0.9% Neb Sol 50 X 15ml
- Sodium Chloride 10% Neb Sol 60x4ml
- Sodium Chloride 0.9% Inj, 2ml
- Sodium Chloride 2.5meq/ml Inj, 20ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sod Chloride 4meq/ml Inj, 25x30ml
- Sod Chloride 5% Ophth Soln 15ml
- Sod Chloride 0.9% Inj, 1000ml
- Sodium Chloride 3% Neb Sol 30x4ml
- Sodium Chloride 7% Neb Sol 30x4ml
- Sodium Chloride 3% Neb Sol 60x4ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.9% Inj, 150ml
- Sodium Chloride 0.9% Inj,100ml
- Sod Chloride 0.9% Inj, 25ml
- Sod Chloride 0.9% Inj, 125ml
- Sod Chloride 0.45% Inj, 250ml
- Sod Chloride 0.45% Inj, 50ml
- Sod Chloride 0.45% Inj, 100ml
- Sod Chloride 5% Inj, 500ml
- Sod Chloride 0.45%/20meq Kcl
Dosing & Administration
Adult Dosing
Standard Dose:
2.5 mL to 5 mL per nebulization session, 1 to 4 times daily or as needed.
Dose Range:
2.5 - 5 mg
Condition-Specific Dosing:
diluent:
As needed to dilute other nebulized medications to a total volume of 2.5 mL to 5 mL.
Pediatric Dosing
Neonatal:
2.5 mL per nebulization session, as needed or as diluent.
Infant:
2.5 mL per nebulization session, as needed or as diluent.
Child:
2.5 mL to 5 mL per nebulization session, as needed or as diluent.
Adolescent:
2.5 mL to 5 mL per nebulization session, as needed or as diluent.
Dose Adjustments
Renal Impairment:
Mild:
No specific dose adjustment required as systemic absorption is minimal.
Moderate:
No specific dose adjustment required as systemic absorption is minimal.
Severe:
No specific dose adjustment required as systemic absorption is minimal.
Dialysis:
No specific considerations for nebulized use.
Hepatic Impairment:
Mild:
No specific dose adjustment required.
Moderate:
No specific dose adjustment required.
Severe:
No specific dose adjustment required.
Pharmacology
Mechanism of Action
Sodium chloride 0.9% (isotonic saline) delivered via nebulization helps to moisten the respiratory tract, loosen and thin tenacious secretions, and facilitate their removal. It can also be used as a diluent for other nebulized medications, ensuring proper delivery and patient comfort.
Pharmacokinetics
Absorption:
Bioavailability:
Not applicable for local action
Tmax:
Immediate local effect
FoodEffect:
Not applicable
Distribution:
Vd:
Not applicable for local action
ProteinBinding:
Not applicable
CnssPenetration:
No
Elimination:
HalfLife:
Not applicable for local action
Clearance:
Not applicable for local action
ExcretionRoute:
Primarily cleared from airways via mucociliary clearance and expectoration; minimal systemic absorption handled by renal excretion.
Unchanged:
Not applicable for local action
Pharmacodynamics
OnsetOfAction:
Immediate upon inhalation
PeakEffect:
Immediate
DurationOfAction:
Variable, depending on individual patient's respiratory condition and frequency of use, typically lasts for the duration of the nebulization and shortly thereafter.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Attention Immediately
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:
- Signs of an allergic reaction, such as rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch. Your doctor is available to provide medical advice about side effects.
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:
- Signs of an allergic reaction, such as rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch. Your doctor is available to provide medical advice about side effects.
Seek Immediate Medical Attention If You Experience:
- Increased shortness of breath
- Wheezing
- Chest tightness
- Unusual cough
- Any signs of allergic reaction (e.g., rash, itching, swelling, severe dizziness, trouble breathing)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or other drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is not an exhaustive list, and it is crucial to disclose all your medications and health issues to your doctor and pharmacist.
* Any health problems you have, as this information will help your doctor determine if it is safe for you to take this medication.
Remember, you must verify that it is safe to take this medication with all your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or other drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is not an exhaustive list, and it is crucial to disclose all your medications and health issues to your doctor and pharmacist.
* Any health problems you have, as this information will help your doctor determine if it is safe for you to take this medication.
Remember, you must verify that it is safe to take this medication with all your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all of your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are pregnant, planning to become pregnant, or are currently breast-feeding, be sure to discuss this with your doctor. Your doctor will need to weigh the benefits and risks of this medication for both you and your baby to determine the best course of action.
Overdose Information
Overdose Symptoms:
- Overdose is highly unlikely with nebulized 0.9% sodium chloride due to minimal systemic absorption. Symptoms would be related to excessive fluid or electrolyte imbalance if large quantities were somehow absorbed, but this is not a risk with nebulization.
What to Do:
If accidental ingestion of a large quantity occurs, or if any unusual symptoms are observed, contact a poison control center or seek immediate medical attention. Call 1-800-222-1222.
Drug Interactions
Monitoring
Baseline Monitoring
Respiratory assessment
Rationale: To establish baseline respiratory status and assess need for therapy.
Timing: Prior to initiation of therapy
Routine Monitoring
Respiratory comfort and ease of breathing
Frequency: During and after each nebulization session
Target: Improved comfort, reduced work of breathing
Action Threshold: If no improvement or worsening of symptoms, reassess treatment plan.
Mucus viscosity and clearance
Frequency: Daily, or as needed
Target: Thinner, easier to clear secretions
Action Threshold: If secretions remain thick or difficult to clear, consider alternative or adjunctive therapies.
Symptom Monitoring
- Improved breathing
- Reduced cough
- Easier expectoration of mucus
- Absence of irritation or bronchospasm (rare with isotonic saline)
Special Patient Groups
Pregnancy
Considered safe for use during pregnancy. Sodium chloride is a natural component of the body and is not expected to cause harm to the fetus.
Trimester-Specific Risks:
First Trimester:
No known risks.
Second Trimester:
No known risks.
Third Trimester:
No known risks.
Lactation
Compatible with breastfeeding. Sodium chloride is naturally present in breast milk and is not expected to cause adverse effects in a breastfed infant.
Infant Risk:
Low risk (L1).
Pediatric Use
Generally safe and well-tolerated across all pediatric age groups, including neonates. Dosing is typically by volume (e.g., 2.5 mL or 5 mL) rather than weight-based for nebulization. Ensure proper nebulizer mask fit for infants and young children.
Geriatric Use
Generally safe and well-tolerated in geriatric patients. No specific dose adjustments are typically required. Monitor for comfort and effectiveness.
Clinical Information
Clinical Pearls
- 0.9% Sodium Chloride Nebulizer Solution is isotonic and generally well-tolerated, making it suitable for routine airway hydration and as a diluent for other nebulized medications.
- Unlike hypertonic saline (e.g., 3% or 7% NaCl), 0.9% saline is less likely to induce bronchospasm, making it a safer choice for patients prone to airway reactivity.
- Emphasize proper nebulizer cleaning and maintenance to prevent bacterial contamination and ensure effective drug delivery.
- Always check the compatibility of other medications when using 0.9% sodium chloride as a diluent.
Alternative Therapies
- Humidifiers (for general airway hydration)
- Hypertonic saline (e.g., 3% or 7% NaCl) for specific conditions like cystic fibrosis or bronchiolitis, which has a different osmotic mechanism and may induce bronchospasm.
- Dornase alfa (Pulmozyme) for mucolysis in cystic fibrosis.
Cost & Coverage
Average Cost:
Inexpensive per 25 x 5ml vials
Generic Available:
Yes
Insurance Coverage:
Tier 1 (Generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the overdose, including the medication taken, the amount, and the time it occurred.