Sodium Chloride 3% Neb Sol 30x4ml
It is used to thin mucus so it can be taken from the body by coughing.It is used to mix with other drugs for use in a special machine (nebulizer).It may be given to you for other reasons. Talk with the doctor.
Drug Class
Mucolytic, Respiratory agent, Osmotic agent
Pharmacologic Class
Electrolyte, Osmotic agent
Pregnancy Category
Category B
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Sodium Chloride 3% Nebulizer Solution is a sterile, concentrated salt water solution used with a nebulizer machine. It helps to thin and loosen thick mucus in your lungs, making it easier to cough up and clear your airways. This can help you breathe more easily, especially if you have conditions like cystic fibrosis or bronchiolitis.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. When disposing of unused or expired medication, do not flush it down the toilet or pour it down the drain unless instructed to do so. Instead, ask your pharmacist about the best way to dispose of it, or check if there are any drug take-back programs in your area.
What to Do If You Miss a Dose
If you take this medication regularly, take the missed dose as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
To use this medication properly, follow your doctor's instructions and read all the information provided. You will inhale this medication through your mouth using a special machine called a nebulizer. Your doctor will show you how to use it correctly.
Storing and Disposing of Your Medication
Store this medication at room temperature in a dry place, away from bathrooms and heat sources. Keep all medications in a safe location, out of the reach of children and pets. When disposing of unused or expired medication, do not flush it down the toilet or pour it down the drain unless instructed to do so. Instead, ask your pharmacist about the best way to dispose of it, or check if there are any drug take-back programs in your area.
What to Do If You Miss a Dose
If you take this medication regularly, take the missed dose as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not use it more frequently than directed by your doctor.
Lifestyle & Tips
- Maintain good hydration by drinking plenty of fluids.
- Practice good airway clearance techniques as advised by your healthcare provider.
- Avoid respiratory irritants like smoke, dust, and allergens.
- Ensure proper nebulizer hygiene by cleaning the device regularly.
Available Forms & Alternatives
Available Strengths:
- Sod Chloride 0.9% Inj, 1000ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sodium Chloride 1gm Tablets
- Sodium Chloride 0.9% Inj, 10ml
- Sodium Chloride 0.9% Inj, 50ml
- Sodium Chloride 0.9% Inj, 20ml
- Sod Chloride 0.45%/20meqkcl
- Sod Chloride 0.9% Inj, 500ml
- Sod Chloride 0.9% W/ 20meq Kcl
- Sodium Chloride 4meq/ml (23.4%) Inj
- Sod Chloride 0.9% Excel Inj 250ml
- Sodium Chloride 0.9% Neb Sol 30x3ml
- Sod Chloride 0.9% Inj, 100ml
- Sod Chloride 0.9% Inj, 50ml
- Sod Chloride 23.4% Inj, 100ml
- Sod Chloride 0.45% Inj, 500ml
- Sod Chloride 0.45% Inj, 1000ml
- Sod Chloride 0.9% Inj, 500ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sodium Chloride 3% Neb Sol 15ml
- Sod Chloride 0.9% Neb Sol 100 X 5ml
- Sodium Chloride 10% Neb Soln, 15ml
- Sod Chloride 0.9% Inj, 5ml
- Sodium Chloride 5% Ophth Oint 3.5gm
- Sod Chloride 0.9% Inj, 10ml
- Sodium Chloride 7% Neb Sol 60x4ml
- Sodium Chloride 3% Inj, 500ml
- Sod Chloride 23.4% Inj, 200ml
- Sod Chloride 0.9% Neb Sol 25 X 5ml
- Sod Chloride 0.9% Neb Sol 100 X 3ml
- Sod Chloride 0.9% Neb Sol 50 X 15ml
- Sodium Chloride 10% Neb Sol 60x4ml
- Sodium Chloride 0.9% Inj, 2ml
- Sodium Chloride 2.5meq/ml Inj, 20ml
- Sodium Chloride 2.5meq/ml Inj, 40ml
- Sod Chloride 4meq/ml Inj, 25x30ml
- Sod Chloride 5% Ophth Soln 15ml
- Sod Chloride 0.9% Inj, 1000ml
- Sodium Chloride 3% Neb Sol 30x4ml
- Sodium Chloride 7% Neb Sol 30x4ml
- Sodium Chloride 3% Neb Sol 60x4ml
- Sod Chloride 0.9% Inj, 250ml
- Sod Chloride 0.9% Inj, 150ml
- Sodium Chloride 0.9% Inj,100ml
- Sod Chloride 0.9% Inj, 25ml
- Sod Chloride 0.9% Inj, 125ml
- Sod Chloride 0.45% Inj, 250ml
- Sod Chloride 0.45% Inj, 50ml
- Sod Chloride 0.45% Inj, 100ml
- Sod Chloride 5% Inj, 500ml
- Sod Chloride 0.45%/20meq Kcl
Dosing & Administration
Adult Dosing
Standard Dose:
4 mL of 3% solution, 2 to 4 times daily via nebulizer
Dose Range:
2 - 4 mg
Condition-Specific Dosing:
Cystic Fibrosis:
4 mL of 3% solution, 2 to 4 times daily
Bronchiolitis:
4 mL of 3% solution, 2 to 4 times daily
Pediatric Dosing
Neonatal:
Not established (use with caution, often 2-4 mL, 2-4 times daily if clinically indicated)
Infant:
2-4 mL of 3% solution, 2 to 4 times daily (commonly used for bronchiolitis)
Child:
4 mL of 3% solution, 2 to 4 times daily
Adolescent:
4 mL of 3% solution, 2 to 4 times daily
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Dialysis:
No specific considerations (minimal systemic absorption)
Hepatic Impairment:
Mild:
No adjustment needed (not metabolized by liver)
Moderate:
No adjustment needed (not metabolized by liver)
Severe:
No adjustment needed (not metabolized by liver)
Pharmacology
Mechanism of Action
Hypertonic saline (3% NaCl) creates an osmotic gradient across the airway mucosa, drawing water from the submucosa into the airway lumen. This rehydrates airway surface liquid, thins tenacious mucus, and improves mucociliary clearance, facilitating easier expectoration of secretions. It may also induce cough and stimulate chloride secretion.
Pharmacokinetics
Absorption:
Bioavailability:
Not applicable (minimal systemic absorption; primarily local effect)
Tmax:
Not applicable (minimal systemic absorption)
FoodEffect:
Not applicable
Distribution:
Vd:
Not clinically relevant (primarily localized to respiratory tract)
ProteinBinding:
Not clinically relevant (ions)
CnssPenetration:
No (minimal systemic absorption)
Elimination:
HalfLife:
Not clinically relevant (minimal systemic absorption)
Clearance:
Not clinically relevant (minimal systemic absorption)
ExcretionRoute:
Primarily cleared from respiratory tract via mucociliary clearance and expectoration; any systemically absorbed ions are renally excreted.
Unchanged:
100% (as ions)
Pharmacodynamics
OnsetOfAction:
Rapid, within minutes of inhalation
PeakEffect:
Within 10-30 minutes post-inhalation
DurationOfAction:
Varies, effects can last for several hours depending on individual and condition
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Attention Immediately
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:
- Signs of an allergic reaction, such as:
- Rash
- Hives
- Itching
- Red, swollen, blistered, or peeling skin (with or without fever)
- Wheezing
- Tightness in the chest or throat
- Trouble breathing, swallowing, or talking
- Unusual hoarseness
- Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
All medications can cause side effects, but many people experience no side effects or only mild ones. If you have side effects that bother you or do not go away, contact your doctor or seek medical help.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, contact your doctor for medical advice. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:
- Signs of an allergic reaction, such as:
- Rash
- Hives
- Itching
- Red, swollen, blistered, or peeling skin (with or without fever)
- Wheezing
- Tightness in the chest or throat
- Trouble breathing, swallowing, or talking
- Unusual hoarseness
- Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
All medications can cause side effects, but many people experience no side effects or only mild ones. If you have side effects that bother you or do not go away, contact your doctor or seek medical help.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, contact your doctor for medical advice. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Increased shortness of breath or difficulty breathing immediately after use
- Severe or persistent coughing
- New or worsening wheezing
- Chest tightness or pain
- Signs of an allergic reaction (rare): rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is not an exhaustive list, and it is crucial to disclose all your medications to avoid potential interactions.
* Any health problems you have, as they may affect the safety of taking this medication.
To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is your responsibility to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to help you make informed decisions about your treatment.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is not an exhaustive list, and it is crucial to disclose all your medications to avoid potential interactions.
* Any health problems you have, as they may affect the safety of taking this medication.
To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is your responsibility to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to help you make informed decisions about your treatment.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are pregnant, planning to become pregnant, or are breast-feeding, notify your doctor promptly. You and your doctor will need to discuss the potential benefits and risks of this medication to both you and your baby to make an informed decision.
Overdose Information
Overdose Symptoms:
- Unlikely with nebulized administration due to minimal systemic absorption.
- Excessive use might lead to increased airway irritation, coughing, or bronchospasm.
What to Do:
Discontinue use and seek medical attention if severe symptoms occur. For general overdose concerns, call 1-800-222-1222 (Poison Control).
Drug Interactions
Monitoring
Routine Monitoring
Respiratory symptoms (e.g., cough, sputum production, dyspnea)
Frequency: During and after each treatment, or as clinically indicated
Target: Improvement in symptoms
Action Threshold: Worsening symptoms, increased wheezing, or significant bronchospasm
Pulmonary function tests (e.g., FEV1)
Frequency: Periodically, as part of disease management (e.g., in cystic fibrosis)
Target: Maintenance or improvement of lung function
Action Threshold: Significant decline in lung function
Symptom Monitoring
- Cough (frequency and productivity)
- Sputum characteristics (volume, viscosity, color)
- Shortness of breath
- Wheezing
- Chest tightness
- Bronchospasm
Special Patient Groups
Pregnancy
Generally considered safe for use during pregnancy due to minimal systemic absorption. Consult with a healthcare provider.
Trimester-Specific Risks:
First Trimester:
No known specific risks.
Second Trimester:
No known specific risks.
Third Trimester:
No known specific risks.
Lactation
Compatible with breastfeeding. Sodium chloride is an endogenous substance, and systemic absorption from nebulized administration is minimal, posing no significant risk to the nursing infant.
Infant Risk:
No known risk.
Pediatric Use
Commonly used and generally safe in pediatric populations, including infants (e.g., for bronchiolitis) and children with cystic fibrosis. Dosing may be adjusted based on age and clinical response.
Geriatric Use
No specific dose adjustments are typically needed for geriatric patients. Use with caution in patients with pre-existing severe respiratory conditions, as transient bronchospasm may occur.
Clinical Information
Clinical Pearls
- Hypertonic saline can cause transient cough or bronchospasm, especially in sensitive individuals. Pre-treatment with a short-acting bronchodilator (e.g., albuterol) may be considered, particularly for patients with reactive airways or a history of bronchospasm.
- It is a cornerstone therapy for airway clearance in patients with cystic fibrosis and is increasingly used in infants with bronchiolitis.
- Ensure patients are instructed on proper nebulizer technique for optimal delivery and efficacy.
- Not to be confused with normal saline (0.9% NaCl), which has different therapeutic uses and mechanisms.
Alternative Therapies
- Dornase alfa (Pulmozyme) - for cystic fibrosis
- N-acetylcysteine (NAC) - mucolytic agent
- Mannitol inhalation powder (Bronchitol) - for cystic fibrosis
- Bronchodilators (e.g., albuterol, ipratropium) - to manage bronchospasm
- Airway clearance techniques (e.g., chest physiotherapy, high-frequency chest wall oscillation)
Cost & Coverage
Average Cost:
$15 - $40 per 30x4ml box
Generic Available:
Yes
Insurance Coverage:
Tier 1 (Preferred Generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the medication taken, the amount, and the time it occurred.