Humalog Mix 50/50 Kwikpen Inj 3ml

Insulin lispro protamine and insulin lispro are human insulin analogs that lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis. Insulin lispro has a rapid onset and short duration of action due to its rapid absorption, while insulin lispro protamine is an intermediate-acting insulin due to its slower absorption from the injection site.

Serious Side Effects: Seek Medical Attention Immediately

Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Note: In rare cases, allergic reactions can be life-threatening.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Thick skin, pits, or lumps at the injection site
Swelling in the arms or legs
Shortness of breath
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Fast heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures

If you experience low blood sugar, follow your doctor's instructions, which may include taking glucose tablets, liquid glucose, or consuming some fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience:

Irritation at the injection site
* Weight gain

This is not an exhaustive list of possible side effects. If you have questions or concerns, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have low blood sugar (hypoglycemia), as this may affect your treatment plan.

This medication can interact with other drugs and health conditions. To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your health problems, including any medical conditions or diseases

Before starting, stopping, or changing the dose of any medication, including this one, you must consult with your doctor to confirm that it is safe to do so. This will help prevent any potential interactions or adverse effects.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before engaging in activities that require alertness, such as driving, wait until you understand how this drug affects you.

Be aware that this medication can cause low blood sugar, which may lead to seizures, loss of consciousness, permanent brain damage, and even death if not properly managed. Discuss this risk with your doctor.

Additionally, this medication can cause low blood potassium levels, which, if left untreated, can result in abnormal heart rhythms, severe breathing difficulties, and potentially death. Consult your doctor if you have concerns.

If you are taking diabetes medications like pioglitazone or rosiglitazone, be aware that they may increase the risk of heart failure or worsen existing heart failure. Using insulin with these medications may further increase this risk. If you are taking one of these medications, discuss this with your doctor.

Ensure you have the correct insulin product and understand how to measure and prepare your dose. Insulin products are available in various containers, including vials, cartridges, and pens. If you have questions, contact your doctor or pharmacist.

Stressful situations, such as fever, infection, injury, or surgery, can make it more challenging to control blood sugar levels. Changes in physical activity, exercise, or diet can also impact blood sugar control.

Wear a medical alert identification to indicate your condition. Avoid driving if you have experienced low blood sugar, as it increases the risk of accidents.

Monitor your blood sugar levels as directed by your doctor. Regular blood tests, as recommended by your doctor, are also crucial to ensure safe treatment.

Before consuming alcohol or using products containing alcohol, consult your doctor. Do not share your insulin product, including pens, cartridge devices, needles, or syringes, with others, even if the needle has been changed, as this can transmit infections.

If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the benefits and risks of this medication for both you and your baby.

• Beta-blockers (may mask hypoglycemia symptoms, prolong hypoglycemia)
• Corticosteroids (increase blood glucose, may require increased insulin dose)
• Thiazide diuretics (increase blood glucose, may require increased insulin dose)
• Sympathomimetics (increase blood glucose, may require increased insulin dose)
• Growth hormone (increase blood glucose, may require increased insulin dose)
• Danazol (increase blood glucose, may require increased insulin dose)
• Alcohol (potentiates hypoglycemic effect)
• Salicylates (e.g., aspirin, may enhance hypoglycemic effect)
• MAO inhibitors (may enhance hypoglycemic effect)
• ACE inhibitors (may enhance hypoglycemic effect)
• Angiotensin Receptor Blockers (ARBs) (may enhance hypoglycemic effect)
• Sulfonylureas (increased risk of hypoglycemia)
• Thiazolidinediones (TZDs) (increased risk of fluid retention and heart failure when used with insulin)

• Certain atypical antipsychotics (may cause hyperglycemia)
• Protease inhibitors (variable effects on glucose metabolism)
• Somatostatin analogs (e.g., octreotide, may decrease insulin requirements)

• Symptoms of hypoglycemia (e.g., sweating, tremor, dizziness, confusion, hunger, irritability, blurred vision, palpitations)
• Symptoms of hyperglycemia (e.g., increased thirst, increased urination, fatigue, blurred vision, unexplained weight loss)
• Signs of injection site reactions (e.g., redness, swelling, itching, pain, lipodystrophy)

Insulin is the preferred treatment for diabetes in pregnancy. Humalog Mix 50/50 can be used, but careful monitoring of blood glucose is essential to minimize risks to both mother and fetus. Dose requirements may change throughout pregnancy.

Insulin is compatible with breastfeeding. Insulin is a normal component of breast milk and is not harmful to the infant. Dose adjustments may be needed for the mother.

Dosing must be individualized and carefully monitored in pediatric patients due to varying insulin sensitivity and growth patterns. Risk of hypoglycemia is a concern.

Elderly patients may be more susceptible to the hypoglycemic effects of insulin and may have impaired renal or hepatic function, requiring lower doses and more careful monitoring. Cognitive impairment may affect self-management.

• Humalog Mix 50/50 should be administered subcutaneously 15 minutes before a meal or immediately after a meal.
• Always rotate injection sites within the same region (e.g., abdomen, thigh, upper arm) to reduce the risk of lipodystrophy.
• Do not mix Humalog Mix 50/50 with other insulins or solutions.
• Visually inspect the suspension before use; it should appear uniformly cloudy. If it looks clear or has particles, do not use it.
• Patients should be educated on the symptoms and management of hypoglycemia.
• Ensure patients understand the difference between the rapid-acting and intermediate-acting components and how they contribute to overall glucose control.

• Basal-bolus insulin regimens (e.g., long-acting insulin + rapid-acting insulin with meals)
• Basal insulin only (e.g., insulin glargine, insulin detemir, insulin degludec)
• Oral antidiabetic medications (e.g., metformin, sulfonylureas, SGLT2 inhibitors, GLP-1 receptor agonists - often used in combination with insulin or as monotherapy for Type 2 Diabetes)

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it occurred.