Humalog 100u/ml Vial 3ml

Insulin Lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.

Urgent Side Effects: Seek Medical Attention Immediately

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Note: In rare cases, allergic reactions can be fatal.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Signs of infection, such as:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or discolored sputum
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Local injection site reactions, including:
+ Thick skin
+ Pits or lumps
Swelling in the arms or legs
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Fast heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures
If you experience any of these symptoms, contact your doctor immediately. If you have low blood sugar, follow your doctor's instructions, which may include taking glucose tablets, liquid glucose, or some fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical help:

Weight gain
Flu-like symptoms
Nose or throat irritation
Common cold symptoms
Headache
Cough
Upset stomach
Stomach pain or diarrhea
Feeling tired or weak
* Irritation at the injection site

This is not an exhaustive list of possible side effects. If you have questions or concerns, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have low blood sugar (hypoglycemia), as this may affect your treatment plan.

This list is not exhaustive, and it is crucial to discuss all your medications, health conditions, and concerns with your doctor. Please disclose all the following to your doctor and pharmacist:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or supplements you are using
Vitamins you are taking
Any health problems you have

To ensure your safety, it is vital to verify that this medication is compatible with all your other medications and health conditions. Never start, stop, or adjust the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

This drug may cause low blood sugar, which can lead to seizures, loss of consciousness, permanent brain damage, and even death if not properly managed. Consult your doctor to discuss the risks and prevention strategies. Additionally, this medication may cause low blood potassium levels, which can result in abnormal heart rhythms, severe breathing difficulties, and potentially death if left untreated. It is crucial to discuss this risk with your doctor.

Until you understand how this medication affects you, avoid driving and other activities that require your full attention. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure, especially when used in combination with insulin. If you are taking one of these medications, consult your doctor to discuss the potential risks.

Ensure you have the correct insulin product and understand how to properly measure and prepare your dose. Insulin products are available in various containers, including vials, cartridges, and pens. If you have any questions or concerns, contact your doctor or pharmacist.

During periods of stress, such as illness, infection, injury, or surgery, it may be more challenging to control your blood sugar levels. Changes in physical activity, exercise, or diet can also impact your blood sugar levels.

Wear a medical alert identification to ensure prompt care in case of an emergency. Avoid driving if you have experienced low blood sugar, as it can increase your risk of being involved in an accident.

Monitor your blood sugar levels as directed by your doctor and undergo regular blood tests as scheduled. Consult your doctor before consuming alcohol or using products that contain alcohol.

Do not share your insulin product or any related devices, including pens, cartridge devices, needles, or syringes, with others. Sharing can lead to the transmission of infections, including those you may not be aware of having.

If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the potential benefits and risks to you and your baby.

• Pramlintide (increased risk of severe hypoglycemia)
• Certain atypical antipsychotics (may cause hyperglycemia, requiring increased insulin dose)
• Corticosteroids (may cause hyperglycemia, requiring increased insulin dose)
• Diuretics (thiazides, loop diuretics - may cause hyperglycemia, requiring increased insulin dose)
• Sympathomimetics (e.g., albuterol, epinephrine - may cause hyperglycemia, requiring increased insulin dose)

• Beta-blockers (may mask symptoms of hypoglycemia, prolong recovery from hypoglycemia)
• ACE inhibitors (may enhance insulin's glucose-lowering effect)
• Angiotensin Receptor Blockers (ARBs) (may enhance insulin's glucose-lowering effect)
• Salicylates (e.g., aspirin - may enhance insulin's glucose-lowering effect)
• Sulfonamide antibiotics (may enhance insulin's glucose-lowering effect)
• Alcohol (may potentiate hypoglycemic effect, especially with fasting)
• Oral Contraceptives (may cause hyperglycemia, requiring increased insulin dose)
• Thyroid hormones (may cause hyperglycemia, requiring increased insulin dose)

• Hypoglycemia: sweating, tremor, dizziness, confusion, hunger, irritability, headache, blurred vision, rapid heartbeat, anxiety, slurred speech, seizures, unconsciousness.
• Hyperglycemia: increased thirst, increased urination, fatigue, blurred vision, dry skin, fruity breath odor, nausea, vomiting, abdominal pain (signs of DKA).

Insulin Lispro is considered a Category B drug in pregnancy. It is the preferred treatment for glycemic control in pregnant women with diabetes (pre-existing or gestational) as it does not cross the placenta in significant amounts. Strict glycemic control is crucial to prevent adverse maternal and fetal outcomes.

Insulin Lispro is considered safe for use during lactation (L1). Insulin is a normal component of breast milk and is not expected to cause adverse effects in a breastfed infant. Insulin requirements may change during lactation, requiring dose adjustments.

Insulin Lispro is approved for use in pediatric patients with diabetes mellitus. Dosing must be highly individualized based on age, weight, metabolic needs, and blood glucose monitoring. Close supervision and education for parents/caregivers are essential.

Geriatric patients may be at increased risk of hypoglycemia due to age-related decline in renal function, cognitive impairment, and polypharmacy. Dosing should be initiated cautiously with careful titration and frequent blood glucose monitoring. Lower glycemic targets may be appropriate for some elderly patients to minimize hypoglycemia risk.

• Insulin Lispro should be administered within 15 minutes before a meal or immediately after a meal to optimize postprandial glucose control.
• Always check the insulin label carefully before each injection to ensure the correct type of insulin is being used.
• Rotate injection sites within the same region (e.g., abdomen) to reduce the risk of lipodystrophy.
• Patients should be educated on the signs and symptoms of hypoglycemia and how to treat it promptly.
• Never mix Humalog U-100 with other insulins in the same syringe, except for NPH insulin. If mixing, draw Humalog first.
• Vials should be stored in a refrigerator (2°C to 8°C) until first use. After first use, vials can be stored at room temperature (up to 30°C) for up to 28 days.

• Other rapid-acting insulins: Insulin Aspart (Novolog, Fiasp), Insulin Glulisine (Apidra)
• Short-acting insulins: Regular Human Insulin (Humulin R, Novolin R)
• Intermediate-acting insulins: NPH Human Insulin (Humulin N, Novolin N)
• Long-acting insulins: Insulin Glargine (Lantus, Toujeo, Basaglar), Insulin Detemir (Levemir), Insulin Degludec (Tresiba)
• Oral antidiabetic agents (e.g., Metformin, Sulfonylureas, SGLT2 inhibitors, GLP-1 receptor agonists - often used in Type 2 diabetes, sometimes in combination with insulin)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the medication taken, the amount, and the time it occurred.