Humalog Jr 100u/ml Kwikpnhalf Unit

Insulin lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you experience any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Note: In rare cases, allergic reactions can be fatal.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Signs of infection, such as:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or discolored sputum
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Thick skin, pits, or lumps at the injection site
Swelling in the arms or legs
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Fatigue or weakness
+ Shaking
+ Rapid heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures
If you experience any of these symptoms, contact your doctor right away. If you have low blood sugar, follow your doctor's instructions, which may include taking glucose tablets, liquid glucose, or certain fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical attention if you experience any of the following side effects or if they bother you or persist:

Weight gain
Flu-like symptoms
Nose or throat irritation
Common cold symptoms
Headache
Cough
Upset stomach
Stomach pain or diarrhea
Fatigue or weakness
* Irritation at the injection site

This is not an exhaustive list of possible side effects. If you have questions or concerns, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have low blood sugar (hypoglycemia), as this may affect your treatment plan.

This is not an exhaustive list of potential interactions. To ensure your safety, it is crucial to disclose all of the following to your doctor and pharmacist:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your complete medical history, including any health problems you have

Before starting, stopping, or changing the dose of any medication, including this one, you must consult with your doctor to confirm that it is safe to do so. This will help prevent any potential interactions or adverse effects.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

This drug may cause low blood sugar, which can lead to seizures, loss of consciousness, permanent brain damage, and even death if not properly managed. Consult your doctor to discuss the risks and prevention strategies. Additionally, this medication may cause low blood potassium levels, which can result in abnormal heart rhythms, severe breathing problems, and potentially death if left untreated. It is crucial to discuss this risk with your doctor.

Until you understand how this medication affects you, avoid driving and other activities that require your full attention. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure or worsen existing heart failure, especially when combined with insulin. If you are taking one of these medications, consult your doctor to discuss the potential risks.

Ensure you have the correct insulin product and understand how to measure and prepare your dose, as insulin products are available in various containers, including vials, cartridges, and pens. If you have any questions or concerns, contact your doctor or pharmacist.

Your blood sugar levels may be more challenging to control during stressful events, such as fever, infection, injury, or surgery. Changes in physical activity, exercise, or diet can also impact your blood sugar levels.

Wear a medical alert identification to ensure prompt care in case of an emergency. Avoid driving if you have experienced low blood sugar, as it increases the risk of accidents. Monitor your blood sugar levels as directed by your doctor and undergo regular blood tests as recommended.

Consult your doctor before consuming alcohol or using products containing alcohol. Do not share your insulin product, including pens, cartridge devices, needles, or syringes, with others, even if the needle has been changed, as this can transmit infections.

If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the benefits and risks of this medication for both you and your baby.

• Beta-blockers (may mask symptoms of hypoglycemia and delay recovery)
• Corticosteroids (may increase blood glucose, requiring higher insulin doses)
• Thiazide diuretics (may increase blood glucose, requiring higher insulin doses)
• Sympathomimetics (may increase blood glucose)
• Atypical antipsychotics (may cause hyperglycemia)
• Protease inhibitors (may cause hyperglycemia)
• Somatostatin analogs (e.g., octreotide, lanreotide - may decrease insulin requirements)
• Alcohol (may potentiate hypoglycemic effect)

• Sulfonylureas (increased risk of hypoglycemia)
• GLP-1 receptor agonists (increased risk of hypoglycemia when co-administered with insulin, may require insulin dose reduction)
• SGLT2 inhibitors (increased risk of hypoglycemia when co-administered with insulin, may require insulin dose reduction)
• Salicylates (e.g., aspirin - may enhance insulin's glucose-lowering effect)
• MAO inhibitors (may enhance insulin's glucose-lowering effect)
• ACE inhibitors (may enhance insulin's glucose-lowering effect)
• Angiotensin receptor blockers (ARBs) (may enhance insulin's glucose-lowering effect)

• Symptoms of hypoglycemia: sweating, tremor, dizziness, confusion, hunger, irritability, headache, blurred vision, slurred speech, anxiety, palpitations, weakness.
• Symptoms of hyperglycemia: increased thirst (polydipsia), increased urination (polyuria), increased hunger (polyphagia), fatigue, blurred vision, weight loss.

Insulin lispro is considered a preferred insulin for managing diabetes in pregnancy. It does not readily cross the placental barrier. Close monitoring of blood glucose is essential to achieve optimal glycemic control and reduce risks to both mother and fetus.

Insulin lispro is considered safe for use during lactation. Insulin is a normal component of breast milk, but the amount transferred is negligible and not expected to harm the breastfed infant. Maternal insulin requirements may change during lactation.

Insulin lispro is approved for use in pediatric patients with diabetes. The Humalog Jr. KwikPen Half Unit is particularly beneficial for pediatric patients due to its ability to deliver doses in 0.5-unit increments, allowing for more precise titration and better glycemic control, especially in very young children or those with low insulin requirements.

No overall differences in safety or effectiveness have been observed between elderly and younger patients, but greater sensitivity to insulin's effects may occur in some older individuals. Renal and hepatic impairment, which are more common in the elderly, may reduce insulin requirements. Close glucose monitoring and careful dose titration are recommended.

• Humalog Jr. KwikPen Half Unit is ideal for patients, especially children, who require very small or precise insulin doses, as it allows for 0.5-unit increments.
• Always administer insulin lispro 5-15 minutes before a meal or immediately after a meal to optimize postprandial glucose control.
• Ensure patients understand the difference between rapid-acting (lispro) and other types of insulin to prevent dosing errors.
• Emphasize the importance of rotating injection sites to prevent lipodystrophy, which can affect insulin absorption.
• Educate patients on the symptoms and management of hypoglycemia, including having a rapid-acting carbohydrate source readily available.
• Never mix insulin lispro with other insulins in the Humalog Jr. KwikPen Half Unit. Only Humalog U-100 KwikPen is designed for this specific formulation.

• Other rapid-acting insulin analogs (e.g., insulin aspart (Novolog), insulin glulisine (Apidra), faster-acting insulin aspart (Fiasp), insulin lispro-aabc (Lyumjev))
• Short-acting human insulin (e.g., Humulin R, Novolin R)
• Intermediate-acting insulin (e.g., NPH insulin)
• Long-acting insulin analogs (e.g., insulin glargine (Lantus, Toujeo, Basaglar), insulin detemir (Levemir), insulin degludec (Tresiba))
• Oral antidiabetic agents (e.g., metformin, sulfonylureas, SGLT2 inhibitors, GLP-1 receptor agonists - for Type 2 Diabetes)

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.