Humalog Insulin (vl-7510) 10ml

Insulin lispro is a rapid-acting insulin analog that lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis. It also increases transport of amino acids into cells and accelerates protein synthesis.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Rarely, allergic reactions can be fatal.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ Abnormal heartbeat
Signs of infection, such as:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or changed sputum production
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Thick skin, pits, or lumps at the injection site
Swelling in the arms or legs
Low blood sugar (hypoglycemia), which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Fatigue or weakness
+ Shaking
+ Rapid heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures
If you experience any of these symptoms, contact your doctor immediately. Follow your doctor's instructions for managing low blood sugar, which may include taking glucose tablets, liquid glucose, or consuming certain fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild ones. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical attention if they bother you or persist:

Weight gain
Flu-like symptoms
Nose or throat irritation
Common cold symptoms
Headache
Cough
Upset stomach
Stomach pain or diarrhea
Fatigue or weakness
* Irritation at the injection site

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
If you have low blood sugar (hypoglycemia), as this may affect your treatment plan.

Additionally, this medication may interact with other health conditions or medications. To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter (OTC) medications you are currently taking
Any natural products or vitamins you are using
* Your complete medical history, including any health problems you have or have had in the past

Before starting, stopping, or changing the dose of any medication, including this one, consult with your doctor to confirm that it is safe for you to do so. This will help prevent potential interactions or adverse effects.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

You are at risk for low blood sugar (hypoglycemia) while taking this drug. Severe hypoglycemia can lead to seizures, loss of consciousness, permanent brain damage, and even death. Discuss this risk with your doctor to understand how to manage it.

Additionally, this medication may cause low blood potassium levels (hypokalemia). If left untreated, hypokalemia can result in abnormal heart rhythms, severe breathing difficulties, and potentially death. Consult your doctor if you have concerns about this potential side effect.

Until you understand how this medication affects you, avoid driving and engaging in activities that require your full attention. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure, especially when used in combination with insulin. If you are taking one of these medications, discuss the potential risks with your doctor.

Ensure you are using the correct insulin product, as they come in various containers, including vials, cartridges, and pens. Understand how to measure and prepare your dose correctly. If you have any questions or concerns, contact your doctor or pharmacist for guidance.

Be aware that stress, such as fever, infection, injury, or surgery, can make it more challenging to control your blood sugar levels. Changes in physical activity, exercise, or diet can also impact your blood sugar control.

Wear a medical alert identification (ID) to inform others of your condition in case of an emergency.

Do not drive if you have experienced low blood sugar, as it can increase your risk of being involved in an accident. Monitor your blood sugar levels as directed by your doctor.

Regular blood tests are necessary to ensure your safety while taking this medication. Follow your doctor's instructions for getting your blood work checked and discuss any concerns or questions you may have.

Before consuming alcohol or using products containing alcohol, consult your doctor to understand the potential risks and interactions.

Never share your insulin product, including pens, cartridge devices, needles, or syringes, with another person, even if the needle has been changed. Sharing can spread infections, including those you may not be aware of having.

If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the benefits and risks of this medication for both you and your baby.

• Beta-blockers (may mask symptoms of hypoglycemia)
• Thiazolidinediones (TZDs) - increased risk of fluid retention and heart failure when used with insulin
• Alcohol (can potentiate hypoglycemic effect)
• Certain atypical antipsychotics (may cause hyperglycemia, requiring increased insulin dose)

• Oral antidiabetic agents (additive hypoglycemic effect)
• ACE inhibitors (may enhance insulin sensitivity)
• Angiotensin receptor blockers (ARBs) (may enhance insulin sensitivity)
• Salicylates (e.g., aspirin) (may enhance insulin sensitivity)
• Sulfonamide antibiotics (may enhance insulin sensitivity)
• Monoamine oxidase inhibitors (MAOIs) (may enhance insulin sensitivity)
• Somatostatin analogs (e.g., octreotide) (may decrease insulin requirements)
• Corticosteroids (may increase blood glucose, requiring increased insulin dose)
• Diuretics (e.g., thiazides, loop diuretics) (may increase blood glucose, requiring increased insulin dose)
• Sympathomimetics (e.g., decongestants, beta-2 agonists) (may increase blood glucose, requiring increased insulin dose)
• Growth hormone (may increase blood glucose, requiring increased insulin dose)
• Danazol (may increase blood glucose, requiring increased insulin dose)
• Oral contraceptives (may increase blood glucose, requiring increased insulin dose)
• Thyroid hormones (may increase blood glucose, requiring increased insulin dose)

• Symptoms of hypoglycemia (e.g., sweating, tremor, dizziness, confusion, hunger, irritability, blurred vision, headache, rapid heartbeat)
• Symptoms of hyperglycemia (e.g., increased thirst, increased urination, fatigue, blurred vision, weight loss)
• Signs of allergic reaction (e.g., rash, itching, swelling, difficulty breathing)
• Injection site reactions (e.g., redness, swelling, itching, pain, lipodystrophy)

Insulin lispro is generally considered safe and is often the preferred insulin for managing gestational diabetes or pre-existing diabetes in pregnancy. Careful glycemic control is crucial during pregnancy to minimize risks to both mother and fetus.

Insulin lispro is considered compatible with breastfeeding. Insulin is a normal component of breast milk and is not expected to cause adverse effects in a breastfed infant. Maternal insulin requirements may change during lactation.

Insulin lispro is approved for use in pediatric patients with diabetes mellitus. Dosing must be carefully individualized based on age, weight, activity level, and glycemic control goals. Close monitoring for hypoglycemia is essential.

No overall differences in safety or effectiveness have been observed between elderly and younger patients, but greater sensitivity to insulin's effects and increased risk of hypoglycemia may occur in some older individuals. Renal and hepatic function should be monitored, and dose adjustments may be necessary.

• Insulin lispro is a rapid-acting insulin; instruct patients to administer it 5-15 minutes before a meal or immediately after a meal to optimize postprandial glucose control.
• Emphasize the importance of consistent carbohydrate intake and meal timing relative to insulin administration.
• Educate patients on recognizing and treating hypoglycemia promptly.
• Stress the importance of proper injection technique and site rotation to prevent lipodystrophy.
• Patients should always carry a source of fast-acting carbohydrate.
• Humalog U-100 vials are for subcutaneous injection only; do not administer intravenously unless under strict medical supervision in a hospital setting (e.g., for DKA management).
• Unopened vials should be stored in a refrigerator (2°C to 8°C [36°F to 46°F]). Once opened, vials can be stored at room temperature (below 30°C [86°F]) for up to 28 days.

• Other rapid-acting insulins: Insulin aspart (Novolog, Fiasp), Insulin glulisine (Apidra)
• Short-acting insulins: Regular human insulin (Humulin R, Novolin R)
• Long-acting insulins: Insulin glargine (Lantus, Toujeo, Basaglar), Insulin detemir (Levemir), Insulin degludec (Tresiba)
• Intermediate-acting insulins: NPH insulin (Humulin N, Novolin N)
• Oral antidiabetic agents (e.g., metformin, sulfonylureas, SGLT2 inhibitors, GLP-1 receptor agonists - often used in Type 2 diabetes, sometimes in combination with insulin)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.