Humalog 100 U/ml Kwik Pen Inj 3ml

Insulin lispro is a rapid-acting insulin analog that lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following signs or symptoms, contact your doctor or seek medical attention immediately:

Allergic reaction symptoms, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Note: In rare cases, allergic reactions can be fatal.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ Abnormal heartbeat
Signs of infection, such as:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or changed sputum production
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Injection site reactions, including:
+ Thick skin
+ Pits or lumps
Swelling in the arms or legs
Low blood sugar symptoms, which may include:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Rapid heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures
If you experience any of these low blood sugar symptoms, contact your doctor right away and follow their instructions for managing the condition, which may include taking glucose tablets, liquid glucose, or consuming certain fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild ones. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical attention if they bother you or persist:

Weight gain
Flu-like symptoms
Nose or throat irritation
Common cold symptoms
Headache
Cough
Upset stomach
Stomach pain or diarrhea
Feeling tired or weak
* Irritation at the injection site

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have low blood sugar (hypoglycemia), as this may affect your treatment plan.

This is not an exhaustive list of potential interactions. To ensure your safety, it is crucial to discuss all of your:

Prescription and over-the-counter (OTC) medications
Natural products
Vitamins
Health problems

with your doctor and pharmacist. They will help you determine whether it is safe to take this medication in combination with your other medications and health conditions. Never start, stop, or adjust the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

This drug may cause low blood sugar, which can lead to seizures, loss of consciousness, permanent brain damage, and even death if not treated promptly. Consult your doctor to discuss the risks and prevention strategies. Additionally, this medication may cause low blood potassium levels, which can result in abnormal heart rhythms, severe breathing difficulties, and potentially death if left untreated. It is crucial to discuss this risk with your doctor.

Until you understand how this medication affects you, avoid driving and other activities that require your full attention. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure or worsen existing heart failure, especially when combined with insulin. If you are taking one of these medications, consult your doctor to discuss the potential risks.

Ensure you have the correct insulin product and understand how to measure and prepare your dose, as insulin products are available in various containers, including vials, cartridges, and pens. If you have any questions or concerns, contact your doctor or pharmacist.

Stressful situations, such as fever, infection, injury, or surgery, may make it more challenging to control your blood sugar levels. Changes in physical activity, exercise, or diet can also impact your blood sugar levels.

Wear a medical alert identification to ensure prompt treatment in case of an emergency. Avoid driving if you have experienced low blood sugar, as it increases the risk of accidents. Monitor your blood sugar levels as instructed by your doctor and undergo regular blood tests as recommended.

Consult your doctor before consuming alcohol or using products containing alcohol. Do not share your insulin product, including pens, cartridge devices, needles, or syringes, with others, even if the needle has been changed, as this can transmit infections.

If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the benefits and risks of this medication for both you and your baby.

• Beta-blockers (may mask symptoms of hypoglycemia)
• Thiazolidinediones (TZDs) - e.g., pioglitazone, rosiglitazone (increased risk of fluid retention and heart failure when used with insulin)
• Corticosteroids (may increase blood glucose, requiring higher insulin doses)
• Diuretics (e.g., thiazides, loop diuretics) (may increase blood glucose, requiring higher insulin doses)
• Sympathomimetics (e.g., epinephrine, albuterol) (may increase blood glucose)
• Danazol (may increase blood glucose)
• Growth hormone (may increase blood glucose)
• Protease inhibitors (may increase blood glucose)

• Alcohol (may potentiate or reduce hypoglycemic effect)
• Salicylates (e.g., aspirin) (may enhance hypoglycemic effect)
• Sulfonamide antibiotics (may enhance hypoglycemic effect)
• MAO inhibitors (may enhance hypoglycemic effect)
• ACE inhibitors (may enhance hypoglycemic effect)
• Angiotensin II receptor blockers (ARBs) (may enhance hypoglycemic effect)
• Octreotide/Lanreotide (may increase or decrease insulin requirements)
• Lithium (may increase or decrease insulin requirements)

• Symptoms of hypoglycemia (e.g., sweating, tremor, dizziness, confusion, hunger, irritability, blurred vision, palpitations)
• Symptoms of hyperglycemia (e.g., polyuria, polydipsia, polyphagia, fatigue, blurred vision)
• Signs of allergic reaction (e.g., rash, itching, swelling, difficulty breathing)
• Signs of injection site reactions (e.g., redness, swelling, itching, pain, lipodystrophy)

Insulin is the preferred treatment for glycemic control in pregnant women with pre-existing diabetes or gestational diabetes. Insulin lispro is generally considered safe and effective during pregnancy. Close monitoring of blood glucose is essential.

Insulin lispro is considered compatible with breastfeeding. Insulin is a normal component of breast milk and is not expected to harm the breastfed infant. Maternal insulin requirements may change during lactation.

Insulin lispro is approved for use in pediatric patients with diabetes. Dosing must be carefully individualized based on age, weight, and metabolic needs. Close monitoring for hypoglycemia is crucial.

Elderly patients may be at increased risk of hypoglycemia due to impaired renal/hepatic function, reduced counter-regulatory responses, and polypharmacy. Start with lower doses and titrate carefully. Monitor glucose frequently.

• Humalog is a rapid-acting insulin; ensure patients eat a meal or snack within 5-15 minutes of injection to prevent hypoglycemia.
• Always verify the correct insulin type (rapid, short, intermediate, long-acting) and concentration (U-100, U-200, U-500) before administration.
• Educate patients on proper injection technique, site rotation, and storage (refrigerated for unopened, room temperature for opened/in-use).
• Stress the importance of carrying a fast-acting carbohydrate source for hypoglycemia.
• Patients should be aware that insulin requirements can change with illness, stress, changes in diet, or exercise.
• Humalog KwikPens are for single-patient use only and should never be shared, even if the needle is changed.

• Other rapid-acting insulins (e.g., insulin aspart, insulin glulisine, ultra-rapid insulin lispro [Lyumjev], ultra-rapid insulin aspart [Fiasp])
• Short-acting insulins (e.g., Regular insulin)
• Intermediate-acting insulins (e.g., NPH insulin)
• Long-acting insulins (e.g., insulin glargine, insulin detemir, insulin degludec)
• Oral antidiabetic agents (e.g., metformin, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists) for Type 2 Diabetes.

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.