Dextrose 5%/nacl 0.45% Inj, 1000ml

Dextrose 5% provides a source of calories (170 kcal/L) and free water, which is metabolized to carbon dioxide and water, helping to prevent ketosis and reduce protein catabolism. Sodium Chloride 0.45% (half-normal saline) provides sodium and chloride ions, essential electrolytes for maintaining fluid and electrolyte balance, and contributes to the tonicity of the solution, helping to expand the extracellular fluid compartment.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of fluid and electrolyte problems, including:
+ Mood changes
+ Confusion
+ Muscle pain or weakness
+ Fast or abnormal heartbeat
+ Severe dizziness or fainting
+ Increased thirst
+ Seizures
+ Feeling extremely tired or weak
+ Decreased appetite
+ Difficulty urinating or changes in urine output
+ Dry mouth
+ Dry eyes
+ Severe stomach upset or vomiting
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Swelling, warmth, numbness, color changes, or pain in a leg or arm
Chest pain or pressure
Fever
Shortness of breath
Sudden weight gain
Swelling in the arms or legs

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms, contact your doctor for advice:

Irritation or swelling at the injection site
* Pain at the injection site

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects. If you have questions or concerns, don't hesitate to contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor identify potential interactions between this medication and other substances.
* Any existing health problems, as this medication may interact with certain conditions.

To ensure your safety, it is crucial to verify that it is safe to take this medication with all your current medications and health conditions. Always consult your doctor before starting, stopping, or changing the dose of any medication.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

If your medication contains potassium, consult your doctor before using a salt substitute or any product that also contains potassium.

If your medication contains dextrose and you have diabetes (high blood sugar), discuss this with your doctor to ensure safe use.

Regular blood tests will be necessary, as directed by your doctor, to monitor your condition. Be sure to follow your doctor's instructions and discuss any concerns with them.

When administering this medication to newborns, exercise caution, as the risk of side effects may be increased in this age group.

If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor. It is crucial to discuss the potential benefits and risks of this medication to both you and your baby to make an informed decision.

• Corticosteroids (may cause sodium and fluid retention)
• Drugs causing sodium retention (e.g., NSAIDs, some antihypertensives)
• Insulin (may require adjustment due to dextrose content)

• Diuretics (may alter fluid and electrolyte balance, requiring careful monitoring)
• Drugs affecting glucose metabolism (e.g., oral hypoglycemics)

• Signs of fluid overload (e.g., peripheral edema, pulmonary crackles, dyspnea, jugular venous distension)
• Signs of dehydration (e.g., dry mucous membranes, decreased skin turgor, decreased urine output, orthostatic hypotension)
• Signs of electrolyte imbalance (e.g., muscle weakness, cramps, confusion, seizures, cardiac arrhythmias)
• Signs of hyperglycemia (e.g., polyuria, polydipsia, fatigue, blurred vision)
• Signs of phlebitis or extravasation at infusion site (pain, redness, swelling)

Generally considered safe for use during pregnancy when clinically indicated for fluid and electrolyte replacement. Careful monitoring of fluid balance and electrolytes is important.

Considered safe for use during lactation. The components (water, glucose, sodium, chloride) are natural constituents of breast milk and are not expected to cause adverse effects in the infant.

Use with extreme caution in neonates and infants due to immature renal function and increased risk of fluid and electrolyte imbalances (e.g., hyponatremia, hyperglycemia). Close monitoring of fluid intake/output, electrolytes, and blood glucose is essential. Dosing is weight-based and highly individualized.

Use with caution in elderly patients due to increased risk of fluid overload, electrolyte imbalances, and impaired renal or cardiac function. Start with lower infusion rates and monitor fluid status, electrolytes, and renal function closely.

• Always assess patient's fluid status, electrolyte levels, and renal function before initiating and throughout therapy.
• Infusion rate must be carefully controlled to avoid fluid overload, especially in patients with cardiac, renal, or hepatic impairment.
• Monitor blood glucose levels regularly, particularly in diabetic patients or those receiving prolonged infusions, to prevent hyperglycemia.
• This solution is hypotonic relative to plasma (after dextrose metabolism) and can cause hyponatremia if administered rapidly or in large volumes, especially in pediatric patients or those with conditions predisposing to hyponatremia (e.g., SIADH).
• Not suitable for rapid volume expansion alone; for significant hypovolemia, isotonic solutions (e.g., 0.9% NaCl) are generally preferred.
• Check for particulate matter and discoloration before administration. Do not use if solution is not clear or seal is broken.

• Oral rehydration solutions (for mild dehydration)
• Other intravenous crystalloids or colloids depending on specific fluid and electrolyte needs
• Parenteral nutrition (for comprehensive nutritional support)

If your symptoms or health problems persist or worsen, it is essential to contact your doctor for further guidance. To ensure safe use, never share your medication with others, and do not take medication prescribed for someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly. Unless instructed to do so by a healthcare professional, do not flush medications down the toilet or pour them down the drain. If you are unsure about the proper disposal method, consult your pharmacist for guidance. Many communities have drug take-back programs, which your pharmacist can help you locate. Some medications may come with an additional patient information leaflet; check with your pharmacist to see if this applies to your prescription. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide information about the medication taken, the amount, and the time it was taken to ensure prompt and effective treatment.