Dextrose 5%/nacl 0.3% Inj, 250ml

Dextrose provides a source of calories and free water. It is metabolized via glycolysis and the Krebs cycle, producing carbon dioxide and water. Sodium chloride provides essential electrolytes (sodium and chloride) which are crucial for maintaining fluid and electrolyte balance, osmotic pressure, and normal cellular function. The solution helps to expand extracellular fluid volume and provides a small amount of calories.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek emergency medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of fluid and electrolyte problems, such as:
+ Mood changes
+ Confusion
+ Muscle pain or weakness
+ Fast or abnormal heartbeat
+ Severe dizziness or passing out
+ Increased thirst
+ Seizures
+ Feeling very tired or weak
+ Decreased appetite
+ Unable to pass urine or change in the amount of urine produced
+ Dry mouth
+ Dry eyes
+ Severe upset stomach or vomiting
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Swelling, warmth, numbness, change of color, or pain in a leg or arm
Chest pain or pressure
Fever
Shortness of breath
Sudden weight gain
Swelling in the arms or legs

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild ones. If you notice any of the following side effects or any other unusual symptoms, contact your doctor for advice:

Irritation or swelling at the injection site
* Pain at the injection site

This is not a comprehensive list of all possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about any allergies you have, including:
- An allergy to this medication or any of its components
- An allergy to other medications, foods, or substances
When discussing your allergies, be sure to describe the symptoms you experienced.

This medication may interact with other medications or health conditions. To ensure safe use, it is crucial to:
- Inform your doctor and pharmacist about all the medications you are taking, including prescription and over-the-counter drugs, natural products, and vitamins
- Share information about any health problems you have
You must verify that it is safe to take this medication with all your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

If your medication contains potassium, consult your doctor before using any salt substitutes or products that also contain potassium.

If your medication contains dextrose and you have diabetes (high blood sugar), discuss this with your doctor to ensure safe management of your condition.

Regular blood tests will be necessary as directed by your doctor. Be sure to follow their instructions and discuss any concerns or questions you may have.

When administering this medication to newborns, exercise caution, as they may have a higher risk of experiencing side effects.

If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor. They will help you weigh the benefits and risks of this medication to both you and your baby, ensuring you make an informed decision about your care.

• Patients with known hypersensitivity to corn or corn products (for dextrose)
• Patients with clinically significant hypernatremia or hyperchloremia
• Patients with severe hyperglycemia or uncontrolled diabetes mellitus
• Patients with anuria or severe oliguria (unless dialysis is initiated)

• Corticosteroids (may increase sodium and fluid retention)
• Drugs that cause sodium retention (e.g., NSAIDs, some antihypertensives)
• Drugs that affect glucose metabolism (e.g., insulin, oral hypoglycemics - may require dose adjustment)

• Diuretics (especially loop diuretics - may alter electrolyte balance, requiring careful monitoring)
• Drugs that increase ADH secretion (e.g., carbamazepine, oxcarbazepine, SSRIs, tricyclic antidepressants - may increase risk of hyponatremia)

• Signs of fluid overload (e.g., peripheral edema, pulmonary crackles, dyspnea, elevated jugular venous pressure)
• Signs of dehydration (e.g., dry mucous membranes, decreased skin turgor, decreased urine output, thirst)
• Symptoms of electrolyte imbalance (e.g., muscle weakness, cramps, confusion, lethargy, seizures, cardiac arrhythmias)
• Symptoms of hyperglycemia (e.g., polyuria, polydipsia, fatigue, blurred vision)
• Symptoms of hypoglycemia (e.g., sweating, tremors, dizziness, confusion, hunger)

Generally considered safe and often used for hydration and electrolyte balance during pregnancy. Close monitoring of fluid and electrolyte status is recommended.

Compatible with breastfeeding. The components (water, glucose, sodium, chloride) are natural constituents of breast milk and are not expected to cause adverse effects in the infant.

Dosing must be carefully calculated based on weight, age, and clinical condition to avoid fluid overload, electrolyte imbalances (especially hyponatremia), and hyperglycemia. Close monitoring of fluid balance, electrolytes, and glucose is critical.

Increased susceptibility to fluid overload, electrolyte imbalances (e.g., hyponatremia, hypernatremia), and renal impairment. Requires careful monitoring of fluid balance, electrolytes, and renal function. Lower infusion rates may be necessary.

• This solution is hypotonic relative to plasma after dextrose metabolism, providing free water. It is useful for maintenance fluid therapy and to replace insensible fluid losses.
• Always monitor serum electrolytes (especially sodium) and blood glucose levels closely, particularly in patients at risk for hyponatremia (e.g., SIADH, post-operative patients) or hyperglycemia (e.g., diabetics, stressed patients).
• Not suitable for rapid volume expansion alone due to its hypotonicity after dextrose metabolism.
• Not a significant source of calories for prolonged nutritional support; other solutions or methods are needed for full nutritional requirements.
• Administer slowly to avoid rapid fluid shifts and potential complications like cerebral edema (in susceptible patients) or osmotic diuresis.

• Oral Rehydration Solutions (for mild to moderate dehydration)
• Other intravenous crystalloid solutions (e.g., Plasma-Lyte, Normosol-R)
• Colloid solutions (e.g., albumin, for specific volume expansion needs)
• Parenteral nutrition (for comprehensive nutritional support)

If your symptoms or health problems persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others or take someone else's medication. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly; do not flush them down the toilet or pour them down the drain unless instructed to do so by a healthcare professional. If you are unsure about the correct disposal method, consult your pharmacist, who can also inform you about potential drug take-back programs in your area. Additionally, some medications may come with a separate patient information leaflet, which your pharmacist can provide. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide information about the medication taken, the amount, and the time it occurred.