Dextrose 5%/nacl 0.3% Inj, 1000ml
It is used to give fluids to the body when more fluids and electrolytes are needed.It is used as a way to give other drugs as a shot.It may be given to you for other reasons. Talk with the doctor.
Drug Class
Fluid and Electrolyte Replenishers; Nutritional Supplement
Pharmacologic Class
Crystalloid Solutions; Carbohydrate and Electrolyte Solutions
Pregnancy Category
Not formally assigned, generally considered safe when clinically indicated.
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
This is an intravenous fluid, commonly called an 'IV drip,' given directly into your vein. It contains a small amount of sugar (dextrose) for energy and a small amount of salt (sodium chloride) to help keep your body's fluids balanced. It's used when you can't drink enough fluids, need extra hydration, or when other medications need to be given through an IV.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. This medication is administered as an infusion into a vein over a period of time. Your doctor may instruct you on how to self-administer this medication.
Before and after handling the medication, wash your hands thoroughly. Do not use the solution if it appears cloudy, is leaking, or contains particles. Additionally, do not use the solution if it has changed color.
To dispose of used needles and other sharp objects, use a designated needle/sharp disposal box. Never reuse needles or other items. When the disposal box is full, follow local regulations for proper disposal. If you have any questions or concerns, consult your doctor or pharmacist.
Storage and Disposal
Typically, this medication is administered in a hospital or doctor's office. If you need to store it at home, follow the storage instructions provided by your doctor.
Missed Dose
If you miss a dose, contact your doctor to determine the best course of action.
To use this medication correctly, follow your doctor's instructions and read all the information provided. This medication is administered as an infusion into a vein over a period of time. Your doctor may instruct you on how to self-administer this medication.
Before and after handling the medication, wash your hands thoroughly. Do not use the solution if it appears cloudy, is leaking, or contains particles. Additionally, do not use the solution if it has changed color.
To dispose of used needles and other sharp objects, use a designated needle/sharp disposal box. Never reuse needles or other items. When the disposal box is full, follow local regulations for proper disposal. If you have any questions or concerns, consult your doctor or pharmacist.
Storage and Disposal
Typically, this medication is administered in a hospital or doctor's office. If you need to store it at home, follow the storage instructions provided by your doctor.
Missed Dose
If you miss a dose, contact your doctor to determine the best course of action.
Lifestyle & Tips
- Not applicable, administered in a clinical setting. Follow healthcare provider's instructions regarding oral fluid intake and diet while receiving IV fluids.
Available Forms & Alternatives
Available Strengths:
- Dextrose 5% Inj, 1000ml
- Dextrose 5% Inj, 250ml
- Dextrose 5% Inj, 100ml
- Dextrose 5% Inj, 50ml
- Dextrose 5%/nacl 0.2% Inj, 1000ml
- Dextrose 5%/nacl 0.45% Inj, 1000ml
- D5w/nacl 0.9% Inj, 1000ml
- Dextrose 50% Injection Ftv 25x50ml
- Dextrose 5% Inj, 500ml
- Dextrose 70% Inj, 2000ml
- Dextrose 5%/nacl 0.45% Inj, 500ml
- Dextrose 50% Inj, 50ml
- Dextrose 10% Inj, 500ml
- Dextrose 10% Inj, 250ml
- Dextrose 5% Inj, 25ml
- Dextrose 5% Pgbk Inj, 100ml
- Dextrose 5%/nacl 0.3% Inj, 1000ml
- Dextrose 5% Inj, 150ml
- Dextrose 5%/nacl 0.45% Inj, 250ml
- Dextrose 5%/nacl 0.3% Inj, 500ml
- Dextrose 30% Inj, 500ml
- Dextrose 20% Inj, 500ml
- Dextrose 70% Inj, 500ml
- Dextrose 10% Inj, 1000ml
- Dextrose 5%/nacl 0.3% Inj, 250ml
Dosing & Administration
Adult Dosing
Standard Dose:
Highly individualized based on patient's fluid, electrolyte, and caloric needs. Typically 500-3000 mL/24 hours, administered via intravenous infusion at a rate determined by clinical status and purpose (e.g., maintenance, rehydration, vehicle for medication).
Pediatric Dosing
Neonatal:
Highly individualized based on weight, age, clinical condition, and fluid/electrolyte balance. Requires careful calculation to avoid fluid overload or electrolyte disturbances (e.g., hyponatremia, hyperglycemia).
Infant:
Highly individualized based on weight, age, clinical condition, and fluid/electrolyte balance. Requires careful calculation to avoid fluid overload or electrolyte disturbances (e.g., hyponatremia, hyperglycemia).
Child:
Highly individualized based on weight, age, clinical condition, and fluid/electrolyte balance. Requires careful calculation to avoid fluid overload or electrolyte disturbances (e.g., hyponatremia, hyperglycemia).
Adolescent:
Highly individualized based on weight, age, clinical condition, and fluid/electrolyte balance. Requires careful calculation to avoid fluid overload or electrolyte disturbances (e.g., hyponatremia, hyperglycemia).
Dose Adjustments
Renal Impairment:
Mild:
Use with caution; monitor fluid balance, electrolytes (especially sodium), and renal function closely. Adjust rate and volume as needed to prevent fluid overload or electrolyte imbalance.
Moderate:
Use with caution; monitor fluid balance, electrolytes (especially sodium), and renal function closely. Adjust rate and volume as needed to prevent fluid overload or electrolyte imbalance.
Severe:
Use with caution; monitor fluid balance, electrolytes (especially sodium), and renal function closely. Adjust rate and volume as needed to prevent fluid overload or electrolyte imbalance.
Dialysis:
Administer with extreme caution; fluid and electrolyte needs are highly specific and often managed by dialysis prescription. Avoid fluid overload and hypernatremia.
Hepatic Impairment:
Mild:
No specific adjustment typically required.
Moderate:
Use with caution, especially if ascites or significant fluid retention is present. Monitor fluid balance and electrolytes.
Severe:
Use with caution, especially if ascites or significant fluid retention is present. Monitor fluid balance and electrolytes.
Pharmacology
Mechanism of Action
Dextrose (glucose) provides a source of calories and is readily metabolized via glycolysis and the Krebs cycle, producing carbon dioxide and water. Sodium chloride provides essential electrolytes (sodium and chloride) necessary for maintaining fluid and electrolyte balance, osmotic pressure, and normal cellular function. The solution provides free water for renal excretion of solutes and helps maintain hydration.
Pharmacokinetics
Absorption:
Bioavailability:
100% (intravenous administration)
Tmax:
Not applicable (continuous infusion)
FoodEffect:
Not applicable
Distribution:
Vd:
Dextrose distributes throughout total body water. Sodium distributes primarily in the extracellular fluid space.
ProteinBinding:
Not applicable (dextrose, sodium, chloride are not protein-bound)
CnssPenetration:
Yes (water, glucose, and sodium ions can cross the blood-brain barrier, but not in a drug-like manner)
Elimination:
HalfLife:
Not applicable (components are continuously utilized or excreted)
Clearance:
Dextrose is cleared metabolically. Sodium and water are cleared renally.
ExcretionRoute:
Renal (water, sodium, chloride); Metabolic (dextrose)
Unchanged:
Sodium and chloride are excreted largely unchanged; dextrose is metabolized.
Pharmacodynamics
OnsetOfAction:
Immediate
PeakEffect:
Continuous as infused, effects are sustained with ongoing administration.
DurationOfAction:
Effects persist as long as infusion continues and components are present in the body; rapidly utilized/excreted once infusion stops.
Safety & Warnings
Side Effects
Serious Side Effects: Seek Medical Help Right Away
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of fluid and electrolyte problems, including:
+ Mood changes
+ Confusion
+ Muscle pain or weakness
+ Fast or abnormal heartbeat
+ Severe dizziness or fainting
+ Increased thirst
+ Seizures
+ Feeling very tired or weak
+ Decreased appetite
+ Unable to pass urine or changes in urine production
+ Dry mouth
+ Dry eyes
+ Severe stomach upset or vomiting
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Swelling, warmth, numbness, color changes, or pain in a leg or arm
Chest pain or pressure
Fever
Shortness of breath
Sudden weight gain
Swelling in the arms or legs
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms, contact your doctor for advice:
Irritation or swelling at the injection site
* Pain at the injection site
This is not an exhaustive list of possible side effects. If you have questions or concerns, don't hesitate to reach out to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of fluid and electrolyte problems, including:
+ Mood changes
+ Confusion
+ Muscle pain or weakness
+ Fast or abnormal heartbeat
+ Severe dizziness or fainting
+ Increased thirst
+ Seizures
+ Feeling very tired or weak
+ Decreased appetite
+ Unable to pass urine or changes in urine production
+ Dry mouth
+ Dry eyes
+ Severe stomach upset or vomiting
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Swelling, warmth, numbness, color changes, or pain in a leg or arm
Chest pain or pressure
Fever
Shortness of breath
Sudden weight gain
Swelling in the arms or legs
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms, contact your doctor for advice:
Irritation or swelling at the injection site
* Pain at the injection site
This is not an exhaustive list of possible side effects. If you have questions or concerns, don't hesitate to reach out to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Any swelling in your hands, feet, or ankles
- Difficulty breathing or shortness of breath
- Rapid heart rate or palpitations
- Unusual thirst or excessive urination
- Confusion, dizziness, or unusual drowsiness
- Headache or nausea
- Pain, redness, or swelling at the IV site
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor and pharmacist assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as this medication may interact with certain conditions.
To ensure your safety, it is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Do not initiate, discontinue, or modify the dose of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor and pharmacist assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as this medication may interact with certain conditions.
To ensure your safety, it is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Do not initiate, discontinue, or modify the dose of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.
If your medication contains potassium, consult your doctor before using any salt substitutes or products that also contain potassium.
If your medication contains dextrose and you have diabetes (high blood sugar), discuss this with your doctor to ensure safe use.
Regular blood tests will be necessary, as directed by your doctor. Be sure to follow their instructions and discuss any concerns with them.
When administering this medication to newborns, exercise caution, as they may have a higher risk of experiencing side effects.
If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor. They will help you weigh the benefits and risks of using this medication to ensure the best outcome for both you and your baby.
If your medication contains potassium, consult your doctor before using any salt substitutes or products that also contain potassium.
If your medication contains dextrose and you have diabetes (high blood sugar), discuss this with your doctor to ensure safe use.
Regular blood tests will be necessary, as directed by your doctor. Be sure to follow their instructions and discuss any concerns with them.
When administering this medication to newborns, exercise caution, as they may have a higher risk of experiencing side effects.
If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor. They will help you weigh the benefits and risks of using this medication to ensure the best outcome for both you and your baby.
Overdose Information
Overdose Symptoms:
- Fluid overload (e.g., severe swelling, pulmonary edema, high blood pressure, heart failure)
- Hyperglycemia (e.g., excessive urination, extreme thirst, confusion, fatigue, blurred vision)
- Hypernatremia (e.g., extreme thirst, confusion, lethargy, seizures, coma)
- Electrolyte imbalances (e.g., hypokalemia, hyperchloremia)
What to Do:
Immediate cessation of infusion. Management is supportive and may include administration of diuretics for fluid overload, insulin for hyperglycemia, and correction of specific electrolyte imbalances. Seek immediate medical attention. Call 911 or poison control (1-800-222-1222).
Drug Interactions
Moderate Interactions
- Corticosteroids (may increase blood glucose and sodium retention)
- Diuretics (especially loop diuretics, may alter fluid and electrolyte balance, requiring careful monitoring)
- Insulin and oral hypoglycemics (may require dose adjustment due to dextrose content)
Monitoring
Baseline Monitoring
Serum Electrolytes (Sodium, Potassium, Chloride)
Rationale: To establish baseline fluid and electrolyte status and identify pre-existing imbalances.
Timing: Prior to initiation of therapy
Blood Glucose
Rationale: To establish baseline glucose levels and assess for pre-existing hyperglycemia or hypoglycemia.
Timing: Prior to initiation of therapy
Renal Function (BUN, Creatinine)
Rationale: To assess kidney's ability to handle fluid and electrolytes.
Timing: Prior to initiation of therapy
Fluid Status (Intake & Output, Daily Weight, Vital Signs)
Rationale: To assess hydration status and identify signs of fluid overload or dehydration.
Timing: Prior to initiation of therapy
Routine Monitoring
Fluid Balance (Intake & Output, Daily Weight)
Frequency: Daily or more frequently as clinically indicated
Target: Balanced I&O, stable weight (unless specific fluid goals)
Action Threshold: Significant positive or negative fluid balance, rapid weight changes (e.g., >1 kg/day)
Serum Electrolytes (Sodium, Potassium, Chloride)
Frequency: Daily or as clinically indicated (e.g., Q12-24h)
Target: Sodium: 135-145 mEq/L; Potassium: 3.5-5.0 mEq/L; Chloride: 98-107 mEq/L
Action Threshold: Sodium <130 or >150 mEq/L; Potassium <3.0 or >5.5 mEq/L; significant deviations from normal range
Blood Glucose
Frequency: Every 4-6 hours or as clinically indicated
Target: Typically 70-180 mg/dL (varies by patient condition)
Action Threshold: Glucose <70 mg/dL or >200 mg/dL (or target specific to patient)
Vital Signs (Heart Rate, Blood Pressure, Respiratory Rate)
Frequency: Regularly (e.g., Q4h or more frequently)
Target: Within normal limits for age and clinical condition
Action Threshold: Significant changes indicating fluid overload (e.g., hypertension, tachycardia, tachypnea) or dehydration
Symptom Monitoring
- Signs of fluid overload (e.g., peripheral edema, pulmonary crackles, dyspnea, jugular venous distention, sudden weight gain)
- Signs of electrolyte imbalance (e.g., muscle weakness, cramps, confusion, lethargy, arrhythmias, seizures)
- Signs of hyperglycemia (e.g., polyuria, polydipsia, fatigue, confusion)
- Signs of hyponatremia (e.g., headache, nausea, vomiting, lethargy, confusion, seizures)
Special Patient Groups
Pregnancy
Generally considered safe and often used during pregnancy when clinically indicated for hydration, electrolyte balance, or as a vehicle for medications. Close monitoring of fluid and electrolyte balance is crucial to prevent complications for both mother and fetus.
Trimester-Specific Risks:
First Trimester:
No specific trimester-dependent risks identified beyond general fluid/electrolyte management.
Second Trimester:
No specific trimester-dependent risks identified beyond general fluid/electrolyte management.
Third Trimester:
No specific trimester-dependent risks identified beyond general fluid/electrolyte management.
Lactation
Compatible with breastfeeding. The components (water, dextrose, sodium, chloride) are natural constituents of the body and are not expected to pose a risk to the breastfed infant.
Infant Risk:
Low risk.
Pediatric Use
Use with extreme caution, especially in neonates and infants, due to their immature renal function and increased susceptibility to fluid and electrolyte imbalances (e.g., hyponatremia, hyperglycemia). Dosing must be precise and based on weight, age, and clinical status. Close monitoring of serum electrolytes and blood glucose is essential.
Geriatric Use
Use with caution due to increased risk of fluid overload, electrolyte imbalances, and underlying renal, cardiac, or hepatic comorbidities. Slower infusion rates and careful monitoring of fluid balance, electrolytes, and vital signs are often required to prevent complications.
Clinical Information
Clinical Pearls
- Always assess the patient's baseline fluid status, electrolyte levels, and glucose before initiating and throughout the infusion.
- This solution provides free water and a small amount of sodium; it is hypotonic relative to plasma after dextrose metabolism, carrying a risk of hyponatremia, especially in pediatric patients, those with SIADH, or those with compromised renal function.
- Not suitable for significant caloric replacement; primarily used for hydration, maintenance fluid, and as a vehicle for medication administration.
- Monitor closely for signs of fluid overload, particularly in patients with cardiac, renal, or hepatic dysfunction.
- Can be used as a diluent for various medications, but compatibility should always be checked.
- Ensure proper aseptic technique during administration to prevent infection.
Alternative Therapies
- Oral rehydration solutions (for patients who can tolerate oral intake and do not require IV access)
- Other crystalloid solutions based on specific fluid and electrolyte needs
Cost & Coverage
Average Cost:
$5 - $20 per 1000mL bag
Generic Available:
Yes
Insurance Coverage:
Tier 1 (Generic) - Generally covered by most insurance plans as a standard medical supply.
General Drug Facts
If your symptoms or health problems do not improve or worsen over time, it is essential to contact your doctor for further evaluation and guidance.
To ensure safe and effective use of your medication, never share your prescription with others, and do not take medication prescribed to someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion.
Proper disposal of unused or expired medications is crucial. Do not dispose of them by flushing down the toilet or pouring down the drain unless specifically instructed to do so by your pharmacist or healthcare provider. If you are unsure about the correct disposal method, consult your pharmacist for guidance. Many communities have drug take-back programs that provide a safe and environmentally friendly way to dispose of unwanted medications.
Some medications may come with an additional patient information leaflet. Check with your pharmacist to see if this applies to your prescription. If you have any questions or concerns about your medication, do not hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider for clarification and guidance.
In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide critical information, including the name of the medication, the amount taken, and the time it was ingested, to ensure prompt and effective treatment.
To ensure safe and effective use of your medication, never share your prescription with others, and do not take medication prescribed to someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion.
Proper disposal of unused or expired medications is crucial. Do not dispose of them by flushing down the toilet or pouring down the drain unless specifically instructed to do so by your pharmacist or healthcare provider. If you are unsure about the correct disposal method, consult your pharmacist for guidance. Many communities have drug take-back programs that provide a safe and environmentally friendly way to dispose of unwanted medications.
Some medications may come with an additional patient information leaflet. Check with your pharmacist to see if this applies to your prescription. If you have any questions or concerns about your medication, do not hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider for clarification and guidance.
In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide critical information, including the name of the medication, the amount taken, and the time it was ingested, to ensure prompt and effective treatment.