Temovate 0.05% Cream 45gm

Clobetasol propionate is a super-high potency topical corticosteroid. It induces phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. It exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood sugar, including:
+ Confusion
+ Feeling sleepy
+ Unusual thirst or hunger
+ Passing urine more often
+ Flushing
+ Fast breathing
+ Breath that smells like fruit
Signs of Cushing's syndrome, such as:
+ Weight gain in the upper back or belly
+ Moon face
+ Severe headache
+ Slow healing
Signs of a weak adrenal gland, including:
+ Severe upset stomach or vomiting
+ Severe dizziness or passing out
+ Muscle weakness
+ Feeling very tired
+ Mood changes
+ Decreased appetite
+ Weight loss
Skin changes, such as:
+ Pimples
+ Stretch marks
+ Slow healing
+ Hair growth
Irritation where the medication was applied
Thinning of the skin
Changes in eyesight, eye pain, or severe eye irritation

Other Possible Side Effects

Most people do not experience significant side effects, but some may occur. If you notice any of the following side effects or any other unusual symptoms, contact your doctor for advice:

Burning or stinging
Dry skin
* Redness

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have thinning skin at the site where you will be applying this medication.
* If there is an active infection at the site where this medication will be used.

This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. Additionally, inform them about any existing health problems. This will help ensure that it is safe for you to take this medication in conjunction with your other medications and health conditions.

Remember, do not start, stop, or modify the dosage of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

This medication is not intended to treat diaper rash, acne, rosacea, or rashes around the mouth. When applying it to a large area of skin or near open wounds, exercise caution and consult your doctor.

Before using any other skin products or medications, including soaps, discuss them with your doctor to ensure safe use. Avoid applying this medication to cuts, scrapes, or damaged skin. Do not use this medication for an extended period beyond the duration prescribed by your doctor.

If this medication is accidentally swallowed, seek immediate medical attention by calling a doctor or poison control center. Prolonged use of this medication may increase the risk of developing cataracts or glaucoma; therefore, consult your doctor about this potential risk.

This medication may not be suitable for children of all ages, so it is crucial to consult your doctor before administering it to a child. When used in children, this medication requires careful monitoring due to a higher risk of certain side effects. In some cases, it may affect growth in children and teenagers, necessitating regular growth checks; discuss this with your doctor.

If you are breastfeeding, avoid applying this medication directly to the nipple or the surrounding area. If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor to discuss the potential benefits and risks to both you and your baby.

• Drugs that inhibit CYP3A4 (e.g., ritonavir, itraconazole): May increase systemic exposure to clobetasol, potentially leading to increased systemic corticosteroid effects. Use with caution.

• Burning, itching, irritation, dryness at application site
• Folliculitis, hypertrichosis, acneiform eruptions
• Hypopigmentation, perioral dermatitis, allergic contact dermatitis
• Maceration of the skin, secondary infection, skin atrophy, striae, miliaria
• Signs of systemic absorption: weight gain, moon face, central obesity, muscle weakness, fatigue, easy bruising, delayed wound healing, mood changes, blurred vision (cataracts/glaucoma)

Category C. Use only if the potential benefit justifies the potential risk to the fetus. Animal studies have shown teratogenic effects with corticosteroids. Systemic absorption can occur.

L3 (Moderate risk). It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Use with caution. Avoid applying to the breast area to prevent infant ingestion.

Children are more susceptible to systemic toxicity from topical corticosteroids due to a larger skin surface area to body weight ratio and immature skin barrier. HPA axis suppression, Cushing's syndrome, and intracranial hypertension have been reported. Use is generally not recommended for children under 12 years of age. If used, limit to the smallest effective amount for the shortest duration possible, and avoid occlusive dressings.

No specific dosage adjustments are required. However, elderly patients may have thinner skin and be more prone to local adverse effects like skin atrophy and purpura. Monitor closely for both local and systemic adverse effects.

• Clobetasol is a super-high potency topical corticosteroid; use it sparingly and for short durations (typically no more than 2 weeks consecutively).
• Educate patients on the 'less is more' principle: a very thin layer is sufficient. Overuse increases the risk of local and systemic side effects.
• Avoid use on the face, groin, or axillae unless specifically directed by a dermatologist, as these areas are more susceptible to skin thinning and other adverse effects.
• Warn patients about the risk of HPA axis suppression, especially with prolonged use, large surface areas, or occlusive dressings. Symptoms can be subtle.
• Consider tapering off if used for longer periods to prevent rebound flares of the skin condition.
• Not for use in rosacea or perioral dermatitis, as it can exacerbate these conditions.

• Other topical corticosteroids (e.g., betamethasone, fluocinonide, triamcinolone, hydrocortisone - varying potencies)
• Topical calcineurin inhibitors (e.g., tacrolimus, pimecrolimus) for eczema
• Vitamin D analogs (e.g., calcipotriene) for psoriasis
• Topical retinoids (e.g., tazarotene) for psoriasis
• Systemic therapies (e.g., biologics, methotrexate, cyclosporine) for severe, widespread conditions

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide information about what was taken, the amount, and the time it occurred.