Insulin Lispro Prt Mix 75/25kwikpen

Insulin lispro protamine and insulin lispro are human insulin analogs that lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis. The protamine component prolongs the action of insulin lispro, providing an intermediate-acting effect, while the unbound insulin lispro provides a rapid-acting effect.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Some allergic reactions can be life-threatening, so prompt medical attention is crucial.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Thick skin, pits, or lumps at the injection site
Swelling in the arms or legs
Shortness of breath
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Fast heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures

If you experience any of these symptoms, call your doctor right away. If you have low blood sugar, follow the instructions you have been given, which may include taking glucose tablets, liquid glucose, or some fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you notice any of the following side effects or any other symptoms that concern you or do not go away, contact your doctor:

Irritation at the injection site
* Weight gain

This is not a comprehensive list of all possible side effects. If you have questions or concerns about side effects, talk to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have low blood sugar (hypoglycemia), as this may affect your treatment plan.

This list is not exhaustive, and it is crucial to discuss all your medications, health conditions, and concerns with your doctor. Please provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or supplements you use
Vitamins you take
Existing health problems or conditions

Before starting, stopping, or changing the dose of any medication, including this one, consult with your doctor to ensure your safety and the effectiveness of your treatment plan.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before engaging in activities that require alertness, such as driving, wait until you understand how this drug affects you.

Be aware that this medication can cause low blood sugar (hypoglycemia), which may lead to seizures, loss of consciousness, permanent brain damage, and even death if not properly managed. Consult your doctor to discuss the risks and prevention strategies.

Additionally, this medication can cause low blood potassium (hypokalemia), which, if left untreated, may result in abnormal heart rhythms, severe breathing difficulties, and potentially death. Discuss this risk with your doctor.

If you are taking other diabetes medications like pioglitazone or rosiglitazone, be aware that they may increase the risk of heart failure or worsen existing heart failure. Using insulin with these medications may further increase this risk. If you are taking one of these medications, consult your doctor to discuss the potential risks.

Ensure you have the correct insulin product and understand how to properly measure and prepare your dose. Insulin products are available in various containers, including vials, cartridges, and pens. If you have any questions or concerns, contact your doctor or pharmacist.

During times of stress, such as fever, infection, injury, or surgery, it may be more challenging to control your blood sugar levels. Changes in physical activity, exercise, or diet can also impact your blood sugar control.

Wear a medical alert identification (ID) to inform others of your condition in case of an emergency.

Do not drive if you have experienced low blood sugar, as this can increase your risk of being involved in an accident. Monitor your blood sugar levels as directed by your doctor.

Regularly undergo blood tests as recommended by your doctor to ensure your blood sugar levels are within a healthy range. Discuss any concerns or questions with your doctor.

Before consuming alcohol or using products containing alcohol, consult your doctor to discuss the potential risks and interactions.

Do not share your insulin product, including pens, cartridge devices, needles, or syringes, with anyone else, even if the needle has been changed. Sharing can transmit infections, including those you may not be aware of having.

If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the benefits and risks to both you and your baby.

• Non-selective beta-blockers (may mask symptoms of hypoglycemia and prolong hypoglycemic episodes)
• Thiazolidinediones (TZDs) - e.g., pioglitazone, rosiglitazone (increased risk of fluid retention and heart failure when used with insulin)
• Alcohol (can potentiate or diminish the hypoglycemic effect of insulin)

• Corticosteroids (may increase blood glucose, requiring higher insulin doses)
• Thiazide diuretics (may increase blood glucose, requiring higher insulin doses)
• Sympathomimetics (e.g., albuterol, epinephrine) (may increase blood glucose)
• Oral contraceptives (may increase blood glucose)
• Growth hormone (may increase blood glucose)
• Danazol (may increase blood glucose)
• Sulfonylureas, Meglitinides, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT2 inhibitors (increased risk of hypoglycemia when co-administered with insulin)
• Salicylates (e.g., aspirin in high doses) (may enhance hypoglycemic effect)
• ACE inhibitors, Angiotensin Receptor Blockers (ARBs) (may enhance hypoglycemic effect)
• Octreotide, Lanreotide (may increase or decrease insulin requirements)
• Certain antipsychotics (e.g., olanzapine, clozapine) (may increase blood glucose)
• Protease inhibitors (may affect glucose metabolism)

• Not available

• Symptoms of hypoglycemia (e.g., sweating, tremor, dizziness, confusion, hunger, irritability, blurred vision, headache, rapid heartbeat, anxiety, weakness, slurred speech, seizures, unconsciousness)
• Symptoms of hyperglycemia (e.g., increased thirst, increased urination, fatigue, blurred vision, unexplained weight loss)
• Signs of injection site reactions (e.g., redness, swelling, itching, pain, lipodystrophy)
• Signs of allergic reactions (e.g., rash, itching, shortness of breath, swelling of face/tongue/throat)

Insulin is the preferred treatment for diabetes in pregnancy (pre-existing or gestational diabetes) due to its efficacy and safety profile. Insulin lispro is generally considered safe for use during pregnancy. Close monitoring of blood glucose is essential to achieve optimal glycemic control and reduce risks to both mother and fetus.

Insulin is compatible with breastfeeding. Insulin is a large protein molecule and is not excreted into breast milk in clinically significant amounts. It is not expected to cause adverse effects in breastfed infants.

Dosing must be carefully individualized and titrated based on age, weight, pubertal status, activity level, and glycemic targets. Children and adolescents may have varying insulin sensitivities and are at higher risk for hypoglycemia, especially during growth spurts or changes in activity. Close monitoring and education for patients and caregivers are essential.

Older adults may be more susceptible to hypoglycemia due to impaired renal/hepatic function, polypharmacy, and reduced counter-regulatory responses. Dosing should be initiated cautiously with careful titration. Glycemic targets may be less stringent to avoid hypoglycemia. Assess for cognitive impairment and ability to self-administer.

• Always ensure the patient understands the difference between rapid-acting, intermediate-acting, and combination insulins to prevent dosing errors.
• Instruct patients to always check the insulin label carefully before each injection to ensure they are using the correct type of insulin.
• Remind patients to rotate injection sites within the same general area (e.g., abdomen) to minimize lipodystrophy and improve absorption.
• Humalog Mix 75/25 should be gently rolled between the palms 10 times and inverted 10 times immediately before each injection to ensure the suspension is uniformly mixed.
• Patients should be educated on the symptoms and management of hypoglycemia, including carrying a fast-acting carbohydrate source.
• This insulin is typically given 15 minutes before a meal or immediately after a meal. Consistency in timing relative to meals is important.

• Basal insulins (e.g., insulin glargine, insulin detemir, insulin degludec)
• Bolus/prandial insulins (e.g., insulin lispro, insulin aspart, insulin glulisine, regular human insulin)
• Oral antidiabetic agents (e.g., metformin, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists)
• Other injectable non-insulin antidiabetic agents (e.g., GLP-1 receptor agonists, amylin analogs)

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.