Insulin Lispro 100u/ml Kwikpen 3ml

Insulin Lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. It binds to insulin receptors on cells, facilitating the cellular uptake of glucose and inhibiting lipolysis and proteolysis.

Urgent Side Effects: Seek Medical Attention Immediately

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Note: In rare cases, allergic reactions can be fatal.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Signs of infection, such as:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or discolored sputum
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Local reactions at the injection site, including:
+ Thick skin
+ Pits or lumps
Swelling in the arms or legs
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Fatigue or weakness
+ Shaking
+ Rapid heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures
If you experience any of these symptoms, contact your doctor immediately. If you have low blood sugar, follow your doctor's instructions, which may include taking glucose tablets, liquid glucose, or consuming certain fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or persist, contact your doctor:

Weight gain
Flu-like symptoms
Nose or throat irritation
Common cold symptoms
Headache
Cough
Upset stomach
Stomach pain or diarrhea
Fatigue or weakness
* Irritation at the injection site

This is not an exhaustive list of possible side effects. If you have questions or concerns, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
If you have low blood sugar (hypoglycemia).

This medication may interact with other medications or health conditions. To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your existing health problems

Before starting, stopping, or changing the dose of any medication, including this one, consult with your doctor to confirm it is safe to do so. This will help prevent potential interactions and ensure the safe use of this medication.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

When taking this drug, you are at risk for low blood sugar (hypoglycemia), which can lead to severe complications, including seizures, loss of consciousness, permanent brain damage, and even death. It is crucial to discuss this risk with your doctor. Additionally, this medication may cause low blood potassium (hypokalemia), which, if left untreated, can result in abnormal heart rhythms, severe breathing difficulties, and potentially be fatal. If you experience any symptoms, consult your doctor promptly.

Until you understand how this medication affects you, avoid driving and other activities that require your full attention. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure or worsen existing heart failure, especially when combined with insulin. If you are taking one of these medications, consult your doctor to discuss the potential risks.

To ensure safe use, verify that you have the correct insulin product and are familiar with its administration. Insulin products are available in various containers, including vials, cartridges, and pens. If you have any questions or concerns about measuring or preparing your dose, contact your doctor or pharmacist.

During periods of stress, such as illness, infection, injury, or surgery, your blood sugar levels may be more challenging to control. Changes in physical activity, exercise, or diet can also impact your blood sugar levels.

For your safety, wear a medical alert identification (ID) that indicates your condition. If you have experienced low blood sugar, do not drive, as this increases your risk of being involved in an accident. Monitor your blood sugar levels as directed by your doctor and undergo regular blood tests as scheduled.

Before consuming alcohol or using products containing alcohol, consult your doctor to discuss potential risks. Never share your insulin product, including pens, cartridge devices, needles, or syringes, with another person, even if the needle has been changed, as this can transmit infections.

If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the benefits and risks of this medication for both you and your baby.

• Pramlintide (increased risk of severe hypoglycemia)
• Beta-blockers (may mask symptoms of hypoglycemia)
• Thiazolidinediones (TZDs) (increased risk of fluid retention and heart failure when co-administered with insulin)

• Oral antidiabetic agents (additive hypoglycemic effect)
• ACE inhibitors (may enhance insulin's glucose-lowering effect)
• Angiotensin Receptor Blockers (ARBs) (may enhance insulin's glucose-lowering effect)
• Salicylates (e.g., aspirin) (may enhance insulin's glucose-lowering effect)
• Sulfonamide antibiotics (may enhance insulin's glucose-lowering effect)
• Monoamine Oxidase Inhibitors (MAOIs) (may enhance insulin's glucose-lowering effect)
• Alcohol (may potentiate or diminish insulin's glucose-lowering effect)
• Corticosteroids (may decrease insulin's glucose-lowering effect)
• Diuretics (e.g., thiazides, loop diuretics) (may decrease insulin's glucose-lowering effect)
• Sympathomimetics (e.g., epinephrine, albuterol) (may decrease insulin's glucose-lowering effect)
• Growth hormone (may decrease insulin's glucose-lowering effect)
• Danazol (may decrease insulin's glucose-lowering effect)
• Oral contraceptives (may decrease insulin's glucose-lowering effect)
• Thyroid hormones (may decrease insulin's glucose-lowering effect)
• Atypical antipsychotics (e.g., olanzapine, clozapine) (may decrease insulin's glucose-lowering effect)

• Symptoms of hypoglycemia (e.g., sweating, tremor, palpitations, anxiety, hunger, confusion, dizziness, headache, blurred vision, slurred speech, irritability, mood changes, unsteadiness, seizures, unconsciousness)
• Symptoms of hyperglycemia (e.g., increased thirst, increased urination, fatigue, blurred vision, unexplained weight loss)
• Injection site reactions (e.g., redness, swelling, itching, pain, lipodystrophy)

Insulin is the preferred treatment for managing diabetes in pregnant women. Available data from published studies and postmarketing reports of insulin use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Tight glycemic control is crucial during pregnancy to reduce risks to both mother and fetus.

Insulin is considered compatible with breastfeeding. Insulin is a normal component of human milk and is not orally absorbed by the infant. No adverse effects on the breastfed infant are expected. Maternal insulin requirements may change during lactation.

Insulin Lispro is safe and effective for use in pediatric patients with diabetes mellitus. Dosing must be individualized based on age, weight, and metabolic needs, with careful monitoring to prevent hypoglycemia.

Use with caution in elderly patients due to increased susceptibility to hypoglycemia, potential for renal/hepatic impairment, and comorbidities. Start with lower doses and titrate carefully. Monitor blood glucose more frequently.

• Insulin Lispro is a rapid-acting insulin, meaning it starts working quickly and has a short duration. It's crucial to administer it close to mealtime (5-15 minutes before or immediately after) to match the glucose rise from food.
• Always verify the insulin type (rapid, short, intermediate, long-acting) before administration to avoid dosing errors.
• Educate patients on proper injection technique, site rotation, and safe disposal of needles/pens.
• Stress the importance of consistent carbohydrate intake and meal timing when using mealtime insulin to prevent hypoglycemia.
• Patients should be advised to carry a source of fast-acting carbohydrates for hypoglycemia treatment.
• Be aware of factors that can affect insulin absorption (e.g., injection site, temperature, exercise).

• Other rapid-acting insulins (e.g., Insulin Aspart, Insulin Glulisine, faster-acting Insulin Aspart, ultra-rapid Insulin Lispro)
• Short-acting insulins (e.g., Regular Human Insulin)
• Intermediate-acting insulins (e.g., NPH Human Insulin)
• Long-acting insulins (e.g., Insulin Glargine, Insulin Detemir, Insulin Degludec)
• Oral antidiabetic agents (e.g., Metformin, Sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists) for Type 2 Diabetes.

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it is a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, consult with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the medication taken, the amount, and the time it occurred.