Insulin Glarg-Yfgn 100u/ml Pen Inj

Insulin glargine-yfgn is a long-acting human insulin analog. It lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis, and enhances protein synthesis.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Signs of infection, such as:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or changed sputum production
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Signs of high blood pressure, including:
+ Severe headache or dizziness
+ Fainting
+ Changes in vision
Thick skin, pits, or lumps at the injection site
Swelling in the arms or legs
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Fast heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures

If you experience low blood sugar, follow your doctor's instructions, which may include taking glucose tablets, liquid glucose, or some fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you notice any of the following side effects or any other symptoms that bother you or don't go away, contact your doctor:

Irritation at the injection site
Back pain
Diarrhea
Headache
Weight gain
Common cold symptoms
Nose or throat irritation
Flu-like symptoms
Joint pain
* Pain in the arms or legs

This is not a complete list of possible side effects. If you have questions or concerns, talk to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
Certain health conditions, including:
+ Acidic blood problems
+ Low blood sugar

This list is not exhaustive, and it is crucial to discuss all your health problems with your doctor.

Additionally, provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Any health problems you have

This information will help your doctor determine whether it is safe for you to take this medication in combination with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

When using this drug, you are at risk for low blood sugar (hypoglycemia), which can lead to severe complications, including seizures, loss of consciousness, permanent brain damage, and even death. It is crucial to discuss this risk with your doctor.

Additionally, this medication may cause low blood potassium levels (hypokalemia), which can result in abnormal heart rhythms, severe breathing difficulties, and potentially be fatal if left untreated. You should consult with your doctor if you experience any symptoms.

Until you understand how this medication affects you, avoid driving and other activities that require your full attention. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure, especially when combined with insulin. If you are taking one of these medications, consult with your doctor to discuss the potential risks.

To ensure safe use, verify that you have the correct insulin product and are familiar with its administration. Insulin products are available in various containers, including vials, cartridges, and pens. If you have any questions or concerns about measuring or preparing your dose, contact your doctor or pharmacist.

Your blood sugar levels may be more challenging to control during periods of stress, such as illness, infection, injury, or surgery. Changes in your physical activity, exercise routine, or diet can also impact your blood sugar levels.

For your safety, wear a medical alert identification (ID) that indicates your condition. Avoid driving if you have experienced low blood sugar, as it can increase your risk of being involved in an accident.

Monitor your blood sugar levels as directed by your doctor and undergo regular blood tests to ensure your safety while taking this medication. Consult with your doctor before consuming alcohol or using products that contain alcohol.

Do not share your insulin product, including pens, cartridge devices, needles, or syringes, with anyone else, even if the needle has been changed. Sharing can transmit infections, including those you may not be aware of having.

When using this medication in children, they may be more susceptible to side effects. Consult with your doctor to discuss the potential risks and benefits. If you are 65 or older, use this medication with caution, as you may be more prone to side effects.

If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor to discuss the potential benefits and risks to you and your baby.

• Thiazolidinediones (TZDs): Increased risk of fluid retention and heart failure when co-administered with insulin.
• Beta-blockers: May mask symptoms of hypoglycemia and delay recovery from hypoglycemia.
• Alcohol: May potentiate the blood glucose lowering effect of insulin, increasing risk of hypoglycemia.

• Oral antidiabetic agents (e.g., sulfonylureas, metformin, DPP-4 inhibitors, SGLT2 inhibitors): Increased risk of hypoglycemia.
• ACE inhibitors, Angiotensin Receptor Blockers (ARBs): May increase insulin sensitivity and risk of hypoglycemia.
• Salicylates (e.g., aspirin): May increase insulin sensitivity and risk of hypoglycemia.
• Somatostatin analogs (e.g., octreotide, lanreotide): May increase or decrease insulin requirements.
• Corticosteroids, Sympathomimetics (e.g., epinephrine, albuterol), Diuretics (e.g., thiazides, loop diuretics), Thyroid hormones, Atypical antipsychotics, Protease inhibitors: May decrease the blood glucose lowering effect of insulin, leading to hyperglycemia.

• Symptoms of hypoglycemia (e.g., sweating, dizziness, lightheadedness, tremor, hunger, confusion, irritability, headache, blurred vision, slurred speech, anxiety, rapid heartbeat)
• Symptoms of hyperglycemia (e.g., increased thirst, increased urination, fatigue, blurred vision, nausea, vomiting)
• Signs of allergic reactions (e.g., rash, itching, hives, swelling of face/lips/tongue/throat, difficulty breathing)
• Signs of fluid retention/heart failure (e.g., unusual weight gain, swelling in ankles/feet, shortness of breath) if co-administered with TZDs.

Insulin glargine-yfgn is generally considered safe and is often the preferred treatment for diabetes in pregnancy when insulin is required. Careful monitoring of blood glucose is essential. The benefits of strict glycemic control outweigh potential risks.

Insulin is compatible with breastfeeding. It is a large protein molecule and is not excreted into breast milk in clinically significant amounts. It is not expected to cause adverse effects in a breastfed infant.

Insulin glargine-yfgn is approved for use in pediatric patients 6 years and older with Type 1 diabetes and in pediatric patients 6 years and older with Type 2 diabetes. Dosing must be individualized and carefully titrated based on blood glucose monitoring.

No overall differences in safety or effectiveness have been observed between elderly and younger patients, but greater sensitivity to insulin's effects may occur. Dose selection should be cautious, starting at the low end of the dosing range, due to the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant disease or other drug therapy. Increased risk of hypoglycemia.

• Insulin glargine-yfgn is a biosimilar to Lantus and is interchangeable with Lantus.
• It is a basal insulin, providing a relatively constant glucose-lowering effect over 24 hours, typically administered once daily.
• Always check the insulin label carefully before administration to avoid medication errors (e.g., confusing U-100 with U-300 concentrations, or rapid-acting with long-acting insulin).
• Patients should be educated on proper injection technique, site rotation, and storage of insulin.
• Never share insulin pens or needles between patients due to the risk of blood-borne pathogen transmission.
• Patients should be aware of the signs and symptoms of hypoglycemia and how to treat it.
• Dose adjustments are often needed in patients with renal or hepatic impairment due to decreased insulin clearance and increased risk of hypoglycemia.

• Other long-acting insulins (e.g., insulin detemir, insulin degludec, other insulin glargine products like Lantus, Toujeo)
• Intermediate-acting insulins (e.g., NPH insulin)
• Rapid-acting insulins (e.g., insulin aspart, insulin lispro, insulin glulisine) for mealtime coverage
• Oral antidiabetic agents (e.g., metformin, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists) for Type 2 Diabetes

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.