Insulin Glarg U300 Max Solstr Inj

Insulin glargine is a long-acting human insulin analog. It lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Signs of infection, such as:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or changed sputum production
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Signs of high blood pressure, including:
+ Severe headache or dizziness
+ Fainting
+ Changes in vision
Thick skin, pits, or lumps at the injection site
Swelling in the arms or legs
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Rapid heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures

If you experience any of these symptoms, contact your doctor right away. If you have low blood sugar, follow your doctor's instructions, which may include taking glucose tablets, liquid glucose, or consuming certain fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical attention if you experience any of the following side effects or if they persist or bother you:

Irritation at the injection site
Back pain
Diarrhea
Headache
Weight gain
Common cold symptoms
Nose or throat irritation
Flu-like symptoms
Joint pain
* Pain in the arms or legs

This is not an exhaustive list of possible side effects. If you have questions or concerns, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
Certain health conditions, including:
+ Acidic blood problems
+ Low blood sugar

This list is not exhaustive, and it is crucial to discuss all your health problems with your doctor.

Additionally, provide your doctor and pharmacist with a comprehensive list of all the medications you are taking, including:
Prescription medications
Over-the-counter (OTC) medications
Natural products
Vitamins

It is vital to verify that it is safe to take this medication with all your other medications and health conditions. Do not initiate, stop, or modify the dosage of any medication without first consulting your doctor.

Important Warnings and Cautions

It is crucial to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. This brand of insulin has a concentrated formula, containing 3 times as much insulin as other brands, and is designed to be used with a prefilled pen. Do not attempt to withdraw insulin from the pen using a syringe, as this can lead to severe side effects or life-threatening hypoglycemia (low blood sugar).

To ensure safe use, it is essential to use the correct dose of this medication. Consult your doctor to confirm the proper dosage. Be aware that hypoglycemia may occur with this medication, and severe cases can cause seizures, loss of consciousness, permanent brain damage, and even death. If you experience any symptoms of hypoglycemia, contact your doctor immediately.

Additionally, this medication may cause hypokalemia (low blood potassium), which can lead to abnormal heart rhythms, severe breathing difficulties, and potentially death if left untreated. If you have concerns, discuss them with your doctor.

Until you understand how this medication affects you, avoid driving and other activities that require alertness. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure when used with insulin. If you are taking one of these medications, consult your doctor to discuss potential risks.

Verify that you have the correct insulin product, as insulin is available in various containers, including vials, cartridges, and pens. Ensure you understand how to measure and prepare your dose correctly. If you have any questions, contact your doctor or pharmacist.

Be aware that stress, illness, injury, or surgery can affect blood sugar control, as can changes in physical activity, exercise, or diet. Wear a medical alert identification (ID) to inform others of your condition.

Do not drive if you have experienced hypoglycemia, as this can increase your risk of being involved in an accident. Monitor your blood sugar levels as directed by your doctor and undergo regular blood tests as scheduled.

Before consuming alcohol or using products containing alcohol, consult your doctor. Never share your insulin product or any associated devices, including pens, cartridges, needles, or syringes, as this can transmit infections between individuals.

When using this medication in children, be aware that they may be more susceptible to side effects. If you are 65 or older, use this medication with caution, as you may be more prone to side effects. If you are pregnant, plan to become pregnant, or are breastfeeding, discuss the potential benefits and risks with your doctor.

• Beta-blockers (may mask symptoms of hypoglycemia)
• Thiazolidinediones (TZDs) (increased risk of fluid retention and heart failure when used with insulin)
• Alcohol (may potentiate hypoglycemic effect)

• Oral antidiabetic agents (additive glucose-lowering effect)
• ACE inhibitors (may enhance insulin sensitivity and increase risk of hypoglycemia)
• Angiotensin receptor blockers (ARBs) (may enhance insulin sensitivity and increase risk of hypoglycemia)
• Salicylates (e.g., aspirin) (may enhance insulin sensitivity and increase risk of hypoglycemia)
• Sulfonamide antibiotics (may enhance insulin sensitivity and increase risk of hypoglycemia)
• Monoamine oxidase inhibitors (MAOIs) (may enhance insulin sensitivity and increase risk of hypoglycemia)
• Corticosteroids (may increase blood glucose, requiring higher insulin doses)
• Diuretics (e.g., thiazides, loop diuretics) (may increase blood glucose, requiring higher insulin doses)
• Sympathomimetics (e.g., decongestants, asthma medications) (may increase blood glucose, requiring higher insulin doses)
• Growth hormone (may increase blood glucose, requiring higher insulin doses)
• Danazol (may increase blood glucose, requiring higher insulin doses)
• Atypical antipsychotics (e.g., olanzapine, clozapine) (may cause hyperglycemia)
• Protease inhibitors (may cause hyperglycemia)

• Symptoms of hypoglycemia (e.g., sweating, shakiness, dizziness, confusion, hunger, irritability, blurred vision, headache, rapid heartbeat, anxiety, weakness)
• Symptoms of hyperglycemia (e.g., increased thirst, increased urination, fatigue, blurred vision, unexplained weight loss)
• Signs of allergic reaction (e.g., rash, itching, hives, swelling of face/lips/tongue/throat, difficulty breathing)
• Signs of fluid retention/heart failure (e.g., unusual weight gain, swelling in ankles/feet, shortness of breath) if used with TZDs

Insulin glargine U-300 is considered a Category B drug in pregnancy. Insulin is the preferred treatment for diabetes in pregnancy. Close monitoring of blood glucose is essential.

Insulin is compatible with breastfeeding. It is not excreted in human milk in clinically significant amounts and is not expected to harm the breastfed infant.

Approved for children 6 years and older with type 1 or type 2 diabetes. Dosing should be individualized based on metabolic needs and blood glucose monitoring. Younger children (under 6 years) have not been studied.

No overall differences in safety or effectiveness were observed between older and younger patients, but greater sensitivity to insulin and increased risk of hypoglycemia may occur in some older individuals. Careful glucose monitoring and dose titration are recommended.

• Insulin glargine U-300 (Toujeo) is a more concentrated formulation (300 units/mL) of insulin glargine compared to U-100 (Lantus, Basaglar). This allows for a smaller injection volume.
• Its duration of action is prolonged beyond 24 hours, often exceeding 36 hours, providing a flatter and more consistent basal insulin profile.
• Due to its prolonged action, it can be administered at any time of day, but should be given at the same time each day.
• When converting from U-100 glargine to U-300 glargine, a dose reduction of approximately 20% is often recommended to minimize the risk of hypoglycemia, followed by careful titration.
• Patients should be educated on the correct injection technique for the specific pen device (Solostar or Max Solostar) and the importance of not diluting or mixing this insulin.

• Other long-acting insulins (e.g., insulin glargine U-100 [Lantus, Basaglar], insulin detemir [Levemir], insulin degludec [Tresiba])
• Intermediate-acting insulins (e.g., NPH insulin)
• Oral antidiabetic agents (e.g., metformin, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists)
• Other injectable non-insulin antidiabetic agents (e.g., GLP-1 receptor agonists, amylin analogs)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the medication taken, the amount, and the time it occurred.