Mupirocin 2% Ointment 22gm
It is used to treat skin infections.It may be given to you for other reasons. Talk with the doctor.
Drug Class
Topical Antibiotic
Pharmacologic Class
Isoleucyl-tRNA Synthetase Inhibitor
Pregnancy Category
Category B
FDA Approved
Dec 1987
DEA Schedule
Not Controlled
Overview
What is this medicine?
Mupirocin ointment is an antibiotic medicine applied to the skin to treat certain bacterial skin infections like impetigo. It works by stopping the growth of bacteria.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, eyes, or other sensitive areas, as it may cause burning. If accidental contact occurs, rinse the area thoroughly with water.
Wash your hands before and after applying the medication, unless your hand is the treated area. In this case, do not wash your hand after application.
Clean and dry the affected area before applying the medication.
Use a gauze pad or cotton swab to apply a small amount of the medication to the affected skin.
If recommended by your doctor, you may cover the treated area with a dressing.
Storage and Disposal
Store this medication at room temperature, away from refrigeration and freezing.
Keep all medications in a safe location, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist. Check with your pharmacist for guidance on the best disposal method, and consider participating in local drug take-back programs.
Missed Dose Instructions
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, eyes, or other sensitive areas, as it may cause burning. If accidental contact occurs, rinse the area thoroughly with water.
Wash your hands before and after applying the medication, unless your hand is the treated area. In this case, do not wash your hand after application.
Clean and dry the affected area before applying the medication.
Use a gauze pad or cotton swab to apply a small amount of the medication to the affected skin.
If recommended by your doctor, you may cover the treated area with a dressing.
Storage and Disposal
Store this medication at room temperature, away from refrigeration and freezing.
Keep all medications in a safe location, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist. Check with your pharmacist for guidance on the best disposal method, and consider participating in local drug take-back programs.
Missed Dose Instructions
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
Lifestyle & Tips
- Wash hands thoroughly before and after applying the ointment.
- Clean the affected area gently before application, if advised by your doctor.
- Apply a thin layer of ointment to cover the entire affected area.
- You may cover the treated area with gauze if directed by your doctor.
- Avoid getting the ointment in your eyes, nose, or mouth. If it gets into your eyes, rinse thoroughly with water.
- Do not use this ointment for longer than prescribed, even if the infection seems to be gone, to prevent recurrence and antibiotic resistance.
- Do not share this medication with others.
Available Forms & Alternatives
Dosing & Administration
Adult Dosing
Standard Dose:
Apply a small amount to the affected area 3 times daily.
Condition-Specific Dosing:
impetigo:
Apply a small amount to the affected area 3 times daily for 5 to 10 days.
secondarySkinInfections:
Apply a small amount to the affected area 3 times daily for 5 to 10 days.
Pediatric Dosing
Neonatal:
Not established (use with caution, consult pediatrician)
Infant:
Apply a small amount to the affected area 3 times daily for 5 to 10 days (2 months and older).
Child:
Apply a small amount to the affected area 3 times daily for 5 to 10 days (2 months to 12 years).
Adolescent:
Apply a small amount to the affected area 3 times daily for 5 to 10 days (12 years and older).
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (minimal systemic absorption).
Moderate:
No adjustment needed (minimal systemic absorption).
Severe:
No adjustment needed (minimal systemic absorption).
Dialysis:
No specific considerations for topical use (minimal systemic absorption).
Hepatic Impairment:
Mild:
No adjustment needed (minimal systemic absorption).
Moderate:
No adjustment needed (minimal systemic absorption).
Severe:
No adjustment needed (minimal systemic absorption).
Confidence:
High
Pharmacology
Mechanism of Action
Mupirocin is an antibacterial agent that inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl-tRNA synthetase. This prevents the incorporation of isoleucine into bacterial proteins, leading to bacterial cell death.
Pharmacokinetics
Absorption:
Bioavailability:
Less than 0.2% (through intact skin); increased with damaged skin.
Tmax:
Not precisely quantified for topical application due to minimal systemic absorption.
FoodEffect:
Not applicable for topical formulation.
Distribution:
Vd:
Not precisely quantified for topical application.
ProteinBinding:
Not precisely quantified for topical application.
CnssPenetration:
Limited (minimal systemic absorption).
Elimination:
HalfLife:
20-40 minutes (systemic, for absorbed drug).
Clearance:
Not precisely quantified for topical application.
ExcretionRoute:
Renal (as monic acid).
Unchanged:
Negligible (systemically).
Pharmacodynamics
OnsetOfAction:
Clinical improvement typically seen within 3-5 days.
PeakEffect:
Not precisely quantified for topical application.
DurationOfAction:
Not precisely quantified for topical application; applied 3 times daily.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Attention Immediately
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe irritation at the site where the medication was applied
Dizziness
Fast or abnormal heartbeat
A severe form of diarrhea called C diff-associated diarrhea (CDAD), which can be life-threatening. This may occur while taking the medication or within a few months after stopping it. Watch for:
+ Stomach pain or cramps
+ Very loose or watery stools
+ Bloody stools
If you experience any of these symptoms, do not try to treat the diarrhea without first consulting your doctor.
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only have mild ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience any of the following side effects or if they bother you or do not go away:
Burning or stinging
Short-term pain after use
Itching
Headache
Upset stomach
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe irritation at the site where the medication was applied
Dizziness
Fast or abnormal heartbeat
A severe form of diarrhea called C diff-associated diarrhea (CDAD), which can be life-threatening. This may occur while taking the medication or within a few months after stopping it. Watch for:
+ Stomach pain or cramps
+ Very loose or watery stools
+ Bloody stools
If you experience any of these symptoms, do not try to treat the diarrhea without first consulting your doctor.
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only have mild ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience any of the following side effects or if they bother you or do not go away:
Burning or stinging
Short-term pain after use
Itching
Headache
Upset stomach
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Signs of an allergic reaction (e.g., severe rash, itching, swelling, severe dizziness, trouble breathing)
- Worsening of the infection or no improvement after 3-5 days of treatment
- New signs of infection (e.g., new redness, pus, pain) in the treated area or elsewhere
- Severe or persistent irritation, burning, stinging, or itching at the application site
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If a large skin area requires treatment.
If your skin is damaged or has open wounds, as this medication should not be applied to damaged skin or open wounds.
This medication may interact with other medications or health conditions. Therefore, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
Your health problems, including any medical conditions or concerns
Before starting, stopping, or changing the dose of any medication, including this one, consult with your doctor to ensure your safety. It is vital to verify that it is safe to take this medication with all your other medications and health conditions.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If a large skin area requires treatment.
If your skin is damaged or has open wounds, as this medication should not be applied to damaged skin or open wounds.
This medication may interact with other medications or health conditions. Therefore, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
Your health problems, including any medical conditions or concerns
Before starting, stopping, or changing the dose of any medication, including this one, consult with your doctor to ensure your safety. It is vital to verify that it is safe to take this medication with all your other medications and health conditions.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Adhere to the prescribed duration of use, as prolonged use may increase the risk of a second infection. Before using any other medications or products on your skin, including soaps, consult with your doctor to ensure safe use. Avoid applying this medication near areas where intravenous drugs are administered; if you have any concerns, discuss them with your doctor. If you are pregnant, planning to become pregnant, or are breastfeeding, notify your doctor to discuss the potential benefits and risks to you and your baby. If you are breastfeeding and apply this medication to your breast or nipple, be sure to wash the area thoroughly before nursing your child.
Overdose Information
Overdose Symptoms:
- Overdose with topical mupirocin is unlikely due to minimal systemic absorption. However, excessive application over large areas of broken skin could theoretically lead to increased systemic exposure, though specific symptoms are not well-defined.
What to Do:
If accidental ingestion occurs, contact a poison control center immediately (e.g., 1-800-222-1222 in the US). For excessive topical application, wipe off excess and monitor for irritation. Treatment is generally supportive.
Drug Interactions
Monitoring
Baseline Monitoring
Assessment of infection (type, extent, severity)
Rationale: To confirm diagnosis and guide treatment duration.
Timing: Prior to initiation of therapy.
Skin integrity at application site
Rationale: To assess potential for increased systemic absorption and local irritation.
Timing: Prior to initiation of therapy.
Routine Monitoring
Resolution of infection symptoms (e.g., reduced redness, swelling, pus, pain)
Frequency: Daily by patient, periodically by clinician.
Target: Progressive improvement.
Action Threshold: Lack of improvement or worsening after 3-5 days; consider alternative therapy or re-evaluation.
Signs of local irritation or sensitization (e.g., itching, burning, stinging, rash)
Frequency: Daily by patient.
Target: Absence of significant irritation.
Action Threshold: Significant or persistent irritation; discontinue use and consult clinician.
Signs of superinfection (e.g., fungal infection, non-susceptible bacterial overgrowth)
Frequency: Daily by patient, periodically by clinician.
Target: Absence of new or worsening infection signs.
Action Threshold: New or worsening signs; discontinue use and consult clinician.
Symptom Monitoring
- Redness
- Swelling
- Pain
- Pus or discharge
- Itching
- Burning
- Stinging
- Rash
- Lack of healing
Special Patient Groups
Pregnancy
Mupirocin is classified as Pregnancy Category B. Animal reproduction studies have not demonstrated a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed, considering minimal systemic absorption.
Trimester-Specific Risks:
First Trimester:
Low risk based on animal data and minimal systemic absorption.
Second Trimester:
Low risk based on animal data and minimal systemic absorption.
Third Trimester:
Low risk based on animal data and minimal systemic absorption.
Lactation
Mupirocin is considered to have a low risk during breastfeeding (Lactation Risk Category L2). Systemic absorption is minimal, making infant exposure unlikely. If applied to the breast, ensure the area is thoroughly cleaned before nursing to prevent infant ingestion.
Infant Risk:
Low risk of adverse effects to the infant due to minimal systemic absorption and rapid metabolism of any absorbed drug.
Pediatric Use
Mupirocin ointment is safe and effective for pediatric patients 2 months of age and older. Safety and effectiveness in neonates (less than 2 months of age) have not been established. Use with caution in infants due to potentially larger surface area to body weight ratio and immature skin barrier, which could theoretically increase systemic absorption.
Geriatric Use
No specific dosage adjustments are necessary for geriatric patients. Clinical studies did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, due to minimal systemic absorption, no age-related differences in safety or efficacy are expected.
Clinical Information
Clinical Pearls
- Mupirocin is effective against Gram-positive bacteria, including MRSA (Methicillin-resistant Staphylococcus aureus), making it a valuable topical option for skin infections.
- It is important to complete the full course of treatment, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Avoid using mupirocin ointment in the eyes or nose (unless specifically formulated for nasal use, which is a different product).
- Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Monitor for signs of superinfection.
- If no improvement is seen after 3 to 5 days of treatment, the diagnosis should be re-evaluated.
Alternative Therapies
- Topical retapamulin (Altabax)
- Topical fusidic acid (not widely available in US)
- Topical bacitracin
- Topical neomycin/polymyxin B (Neosporin)
- Oral antibiotics (e.g., cephalexin, clindamycin, doxycycline) for more severe or widespread infections.
Cost & Coverage
Average Cost:
Varies widely, typically $10-$50 per 22gm tube
Generic Available:
Yes
Insurance Coverage:
Tier 1 or 2 (Generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it is a good idea to consult with your pharmacist. If you have any questions or concerns about this medication, do not hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the medication taken, the amount, and the time it occurred.