Mupirocin 2% Cream 15gm
It is used to treat skin infections.It may be given to you for other reasons. Talk with the doctor.
Drug Class
Topical Antibiotic
Pharmacologic Class
Topical antibacterial; Isoleucyl-tRNA synthetase inhibitor
Pregnancy Category
Category B
FDA Approved
Dec 1987
DEA Schedule
Not Controlled
Overview
What is this medicine?
Mupirocin cream is an antibiotic medicine applied to the skin to treat certain bacterial skin infections, such as impetigo. It works by stopping the growth of bacteria.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, eyes, or other sensitive areas, as it may cause burning. If accidental contact occurs, rinse the area thoroughly with water.
Wash your hands before and after applying the medication, unless your hand is the treated area. In this case, do not wash your hand after application.
Clean and dry the affected area before applying the medication.
Use a gauze pad or cotton swab to apply a small amount of the medication to the affected skin.
If recommended by your doctor, you may cover the treated area with a dressing.
Storage and Disposal
Store this medication at room temperature, avoiding refrigeration or freezing.
Keep all medications in a safe location, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist. Check with your pharmacist for guidance on the best disposal method, and consider participating in local drug take-back programs.
Missed Dose
If you miss a dose, apply it as soon as you remember.
If the missed dose is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, eyes, or other sensitive areas, as it may cause burning. If accidental contact occurs, rinse the area thoroughly with water.
Wash your hands before and after applying the medication, unless your hand is the treated area. In this case, do not wash your hand after application.
Clean and dry the affected area before applying the medication.
Use a gauze pad or cotton swab to apply a small amount of the medication to the affected skin.
If recommended by your doctor, you may cover the treated area with a dressing.
Storage and Disposal
Store this medication at room temperature, avoiding refrigeration or freezing.
Keep all medications in a safe location, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist. Check with your pharmacist for guidance on the best disposal method, and consider participating in local drug take-back programs.
Missed Dose
If you miss a dose, apply it as soon as you remember.
If the missed dose is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
Lifestyle & Tips
- Wash hands before and after applying the cream.
- Clean the affected area gently before application.
- Apply a thin layer of cream to cover the entire affected area.
- Do not cover the treated area with bandages unless directed by your doctor.
- Complete the full course of treatment, even if symptoms improve, to prevent recurrence and resistance.
- Avoid contact with eyes, nose, mouth, and mucous membranes. If contact occurs, rinse thoroughly with water.
- Do not use on large areas of skin or on broken skin for prolonged periods due to potential for systemic absorption.
Available Forms & Alternatives
Dosing & Administration
Adult Dosing
Standard Dose:
Apply a small amount to the affected area three times daily
Dose Range:
5 - 10 mg
Condition-Specific Dosing:
impetigo:
Apply a small amount to the affected area three times daily for 5 to 10 days.
Pediatric Dosing
Neonatal:
Not established
Infant:
Apply a small amount to the affected area three times daily for 5 to 10 days (2 months and older)
Child:
Apply a small amount to the affected area three times daily for 5 to 10 days
Adolescent:
Apply a small amount to the affected area three times daily for 5 to 10 days
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Dialysis:
No adjustment needed (minimal systemic absorption)
Hepatic Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Pharmacology
Mechanism of Action
Mupirocin is an antibacterial agent that inhibits bacterial protein synthesis by reversibly binding to bacterial isoleucyl-tRNA synthetase. This prevents the incorporation of isoleucine into bacterial proteins, leading to the cessation of protein synthesis and bacterial death.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption (<0.2% after topical application to intact skin)
Tmax:
Not applicable (minimal systemic absorption)
FoodEffect:
Not applicable (topical administration)
Distribution:
Vd:
Not applicable (minimal systemic absorption)
ProteinBinding:
Not applicable (minimal systemic absorption)
CnssPenetration:
No
Elimination:
HalfLife:
20-40 minutes (for systemic absorption, but minimal)
Clearance:
Not applicable (minimal systemic absorption)
ExcretionRoute:
Renal (as monic acid)
Unchanged:
Not applicable (minimal systemic absorption)
Pharmacodynamics
OnsetOfAction:
Within days (clinical improvement)
PeakEffect:
Within 3-5 days of treatment
DurationOfAction:
Maintained as long as applied
Safety & Warnings
Side Effects
Important Side Effects to Report to Your Doctor Immediately
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you experience any of the following symptoms, seek medical attention right away:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe irritation at the site where the medication was applied
Dizziness
Fast or abnormal heartbeat
A severe form of diarrhea called C diff-associated diarrhea (CDAD), which can be life-threatening. This may occur during or after treatment with the antibiotic. If you experience:
+ Stomach pain or cramps
+ Very loose or watery stools
+ Bloody stools
seek medical attention immediately. Do not attempt to treat diarrhea without consulting your doctor first.
Other Possible Side Effects
Most people do not experience significant side effects, but some may occur. If you experience any of the following side effects or any other unusual symptoms, contact your doctor for advice:
Burning or stinging
Short-term pain after application
Itching
Headache
Upset stomach
This is not an exhaustive list of possible side effects. If you have concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you experience any of the following symptoms, seek medical attention right away:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe irritation at the site where the medication was applied
Dizziness
Fast or abnormal heartbeat
A severe form of diarrhea called C diff-associated diarrhea (CDAD), which can be life-threatening. This may occur during or after treatment with the antibiotic. If you experience:
+ Stomach pain or cramps
+ Very loose or watery stools
+ Bloody stools
seek medical attention immediately. Do not attempt to treat diarrhea without consulting your doctor first.
Other Possible Side Effects
Most people do not experience significant side effects, but some may occur. If you experience any of the following side effects or any other unusual symptoms, contact your doctor for advice:
Burning or stinging
Short-term pain after application
Itching
Headache
Upset stomach
This is not an exhaustive list of possible side effects. If you have concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe burning, stinging, or itching at the application site
- Rash or other signs of allergic reaction (e.g., swelling, difficulty breathing)
- Worsening of the infection or development of new symptoms
- Diarrhea (rare, but can indicate C. difficile associated diarrhea if systemic absorption occurs)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If a large area of your skin needs to be treated with this medication.
If your skin is damaged or has open wounds, as this medication should not be applied to damaged skin or open wounds.
This medication may interact with other medications or health conditions. Therefore, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
Your existing health problems
Your doctor will help you determine whether it is safe to take this medication with your other medications and health conditions. Do not start, stop, or change the dose of any medication without first consulting your doctor to ensure your safety.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If a large area of your skin needs to be treated with this medication.
If your skin is damaged or has open wounds, as this medication should not be applied to damaged skin or open wounds.
This medication may interact with other medications or health conditions. Therefore, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
Your existing health problems
Your doctor will help you determine whether it is safe to take this medication with your other medications and health conditions. Do not start, stop, or change the dose of any medication without first consulting your doctor to ensure your safety.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Use this drug only for the duration prescribed by your healthcare provider, as prolonged use may increase the risk of a second infection. Before using any other medications or products on your skin, including soaps, consult with your doctor to ensure safe use. Avoid applying this drug near areas where intravenous medications are administered; if you have any questions or concerns, discuss them with your doctor. If you are pregnant, planning to become pregnant, or are breastfeeding, consult your doctor to discuss the potential benefits and risks to you and your baby. If you are breastfeeding and apply this drug to your breast or nipple, be sure to wash the area thoroughly before nursing your child.
Overdose Information
Overdose Symptoms:
- Unlikely with topical application due to minimal systemic absorption. Ingestion may cause gastrointestinal upset.
What to Do:
If accidentally ingested, contact a poison control center or seek medical attention. For topical overdose, wipe off excess cream. Call 1-800-222-1222
Drug Interactions
Monitoring
Routine Monitoring
Clinical improvement of infection
Frequency: Daily
Target: Reduction in redness, swelling, pus, pain
Action Threshold: No improvement or worsening after 3-5 days; consider alternative therapy or re-evaluation
Local adverse reactions (e.g., burning, stinging, itching)
Frequency: Daily
Target: Absence or mild, tolerable reactions
Action Threshold: Severe or persistent irritation; discontinue use
Symptom Monitoring
- Resolution of skin lesions (e.g., crusts, blisters, redness)
- Decrease in pain or tenderness at the site of infection
- Absence of fever or systemic signs of infection
- Monitoring for signs of superinfection (e.g., fungal infection, non-susceptible bacterial growth)
Special Patient Groups
Pregnancy
Mupirocin is classified as Pregnancy Category B. Animal studies have not shown harm to the fetus. It is generally considered safe for use during pregnancy, but should be used only if clearly needed.
Trimester-Specific Risks:
First Trimester:
Low risk, minimal systemic absorption.
Second Trimester:
Low risk, minimal systemic absorption.
Third Trimester:
Low risk, minimal systemic absorption.
Lactation
Mupirocin is considered to have a low risk during breastfeeding (Lactation Risk Category L2). Systemic absorption is minimal, making infant exposure unlikely. If applied to the breast, ensure the area is thoroughly cleaned before nursing to prevent infant ingestion.
Infant Risk:
Low risk
Pediatric Use
Mupirocin cream is safe and effective for use in pediatric patients 2 months of age and older for the treatment of impetigo. Dosing is similar to adults. Safety and effectiveness in neonates (under 2 months) have not been established.
Geriatric Use
No specific dosage adjustments are necessary for geriatric patients. The minimal systemic absorption means that age-related changes in renal or hepatic function are unlikely to significantly impact drug exposure.
Clinical Information
Clinical Pearls
- Mupirocin is highly effective against Gram-positive bacteria, especially Staphylococcus aureus (including MRSA) and Streptococcus pyogenes, which are common causes of impetigo.
- It is important to complete the full course of treatment to prevent the development of antibiotic resistance and ensure complete eradication of the infection.
- Mupirocin cream is for external use only. Avoid use in the eyes, nose, or mouth.
- Prolonged use of topical antibiotics can lead to the overgrowth of non-susceptible organisms, including fungi. Monitor for signs of superinfection.
- The cream formulation is generally preferred for dry, scaly lesions, while the ointment may be better for moist, weeping lesions or nasal colonization.
Alternative Therapies
- Topical retapamulin
- Topical fusidic acid (not available in all regions)
- Oral antibiotics (e.g., cephalexin, dicloxacillin, clindamycin) for more severe or widespread infections
Cost & Coverage
Average Cost:
$15 - $40 per 15gm tube
Generic Available:
Yes
Insurance Coverage:
Tier 1/2 (Generic)
General Drug Facts
If your symptoms or health condition do not improve or worsen over time, it is essential to contact your doctor for further evaluation and guidance. To ensure your safety and the effectiveness of your treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it is a good idea to check with your pharmacist for more information. If you have any questions or concerns about your medication, do not hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the name of the medication taken, the amount, and the time it occurred.