Mupirocin 2% Cream 30gm
It is used to treat skin infections.It may be given to you for other reasons. Talk with the doctor.
Drug Class
Topical antibacterial
Pharmacologic Class
Isoleucyl-tRNA synthetase inhibitor
Pregnancy Category
Category B
FDA Approved
Dec 1997
DEA Schedule
Not Controlled
Overview
What is this medicine?
Mupirocin cream is an antibiotic medicine applied to the skin to treat certain bacterial skin infections, such as impetigo. It works by stopping the growth of bacteria.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, eyes, or other sensitive areas, as it may cause burning. If accidental contact occurs, rinse the area thoroughly with water.
Wash your hands before and after applying the medication, unless your hand is the treated area. In this case, do not wash your hand after application.
Clean and dry the affected area before applying the medication.
Use a gauze pad or cotton swab to apply a small amount of the medication to the affected skin.
If recommended by your doctor, you may cover the treated area with a dressing.
Storage and Disposal
Store this medication at room temperature, away from refrigeration and freezing.
Keep all medications in a safe and secure location, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist. Check with your pharmacist for guidance on the best disposal method, and consider participating in local drug take-back programs.
Missed Dose Instructions
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, eyes, or other sensitive areas, as it may cause burning. If accidental contact occurs, rinse the area thoroughly with water.
Wash your hands before and after applying the medication, unless your hand is the treated area. In this case, do not wash your hand after application.
Clean and dry the affected area before applying the medication.
Use a gauze pad or cotton swab to apply a small amount of the medication to the affected skin.
If recommended by your doctor, you may cover the treated area with a dressing.
Storage and Disposal
Store this medication at room temperature, away from refrigeration and freezing.
Keep all medications in a safe and secure location, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist. Check with your pharmacist for guidance on the best disposal method, and consider participating in local drug take-back programs.
Missed Dose Instructions
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
Lifestyle & Tips
- Wash your hands thoroughly before and after applying the cream.
- Apply only a small amount of cream to cover the affected area.
- Do not use on large areas of skin or for longer than prescribed.
- Avoid contact with eyes, nose, mouth, and mucous membranes. If contact occurs, rinse thoroughly with water.
- Do not use this cream in your nose (a different formulation is available for nasal use).
- Cover the treated area with gauze if directed by your doctor.
Available Forms & Alternatives
Dosing & Administration
Adult Dosing
Standard Dose:
Apply a small amount to the affected area 3 times daily.
Condition-Specific Dosing:
impetigo:
Apply a small amount to the affected area 3 times daily for 10 days.
secondary_infected_traumatic_skin_lesions:
Apply a small amount to the affected area 3 times daily for 10 days.
Pediatric Dosing
Neonatal:
Not established (safety and efficacy not established in neonates <2 months of age)
Infant:
Apply a small amount to the affected area 3 times daily for 10 days (for infants 2 months and older)
Child:
Apply a small amount to the affected area 3 times daily for 10 days
Adolescent:
Apply a small amount to the affected area 3 times daily for 10 days
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Dialysis:
No adjustment needed (minimal systemic absorption)
Hepatic Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Pharmacology
Mechanism of Action
Mupirocin inhibits bacterial protein synthesis by reversibly binding to bacterial isoleucyl-tRNA synthetase. This prevents the incorporation of isoleucine into bacterial proteins, leading to bacterial cell death.
Pharmacokinetics
Absorption:
Bioavailability:
Very low (<0.2% systemically through intact skin; increased through abraded skin)
Tmax:
Not well-defined for topical application
FoodEffect:
Not applicable (topical administration)
Distribution:
Vd:
Not applicable (primarily local action)
ProteinBinding:
Approximately 95% (systemic)
CnssPenetration:
No
Elimination:
HalfLife:
20-40 minutes (systemic, but minimal absorption)
Clearance:
Rapid (systemic)
ExcretionRoute:
Renal (as monic acid)
Unchanged:
Minimal
Pharmacodynamics
OnsetOfAction:
Clinical improvement typically seen within 3-5 days
PeakEffect:
Not well-defined for topical application
DurationOfAction:
Not well-defined for topical application
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe irritation at the site where the medication was applied
Dizziness
Fast or abnormal heartbeat
A severe form of diarrhea called C diff-associated diarrhea (CDAD), which can be life-threatening. This may occur during or after treatment with the antibiotic. If you experience:
+ Stomach pain or cramps
+ Very loose or watery stools
+ Bloody stools
seek medical help right away. Do not attempt to treat diarrhea without consulting your doctor first.
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or persist, contact your doctor:
Burning or stinging
Short-term pain after use
Itching
Headache
Upset stomach
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe irritation at the site where the medication was applied
Dizziness
Fast or abnormal heartbeat
A severe form of diarrhea called C diff-associated diarrhea (CDAD), which can be life-threatening. This may occur during or after treatment with the antibiotic. If you experience:
+ Stomach pain or cramps
+ Very loose or watery stools
+ Bloody stools
seek medical help right away. Do not attempt to treat diarrhea without consulting your doctor first.
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or persist, contact your doctor:
Burning or stinging
Short-term pain after use
Itching
Headache
Upset stomach
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Worsening of the skin infection
- New or increased redness, swelling, itching, or rash at the application site
- Severe burning or stinging
- Signs of a new infection (e.g., fungal infection, different type of bacterial infection)
- Diarrhea (rare, but possible with any antibiotic, seek medical attention if severe)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If a large area of your skin needs to be treated with this medication.
If you have damaged skin or open wounds. Do not apply this medication to damaged skin or open wounds, as it may exacerbate the condition.
This medication may interact with other drugs or health conditions. Therefore, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
Your existing health problems
Your doctor will help you determine whether it is safe to take this medication with your other drugs and health conditions. Do not start, stop, or change the dose of any medication without first consulting your doctor to ensure your safety.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If a large area of your skin needs to be treated with this medication.
If you have damaged skin or open wounds. Do not apply this medication to damaged skin or open wounds, as it may exacerbate the condition.
This medication may interact with other drugs or health conditions. Therefore, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
Your existing health problems
Your doctor will help you determine whether it is safe to take this medication with your other drugs and health conditions. Do not start, stop, or change the dose of any medication without first consulting your doctor to ensure your safety.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Adhere to the prescribed duration of use, as prolonged use may increase the risk of a second infection. Before using any other medications or products on your skin, including soaps, consult with your doctor to ensure safe use. Avoid applying this medication near areas where intravenous drugs are administered; if you have any concerns, discuss them with your doctor. If you are pregnant, planning to become pregnant, or are breastfeeding, notify your doctor to discuss the potential benefits and risks to you and your baby. If you are breastfeeding and apply this medication to your breast or nipple, be sure to wash the area thoroughly before nursing your child.
Overdose Information
Overdose Symptoms:
- Unlikely with topical application due to minimal systemic absorption. Excessive application may lead to local irritation.
What to Do:
If accidentally ingested, seek medical advice. For excessive topical application, wipe off excess and monitor for local irritation. Call 1-800-222-1222 for poison control advice.
Drug Interactions
Monitoring
Baseline Monitoring
Clinical assessment of infection (e.g., lesion size, erythema, exudate)
Rationale: To establish baseline severity and guide treatment.
Timing: Prior to initiation of therapy
Routine Monitoring
Clinical assessment of infection resolution
Frequency: Daily or as clinically indicated
Target: Reduction in signs and symptoms of infection
Action Threshold: If no improvement after 3-5 days, or worsening of infection, re-evaluate diagnosis and treatment.
Local skin reactions (e.g., irritation, itching, burning)
Frequency: Daily
Target: Absence or minimal reactions
Action Threshold: Discontinue if severe local irritation, sensitization, or generalized rash occurs.
Symptom Monitoring
- Resolution of redness
- Reduction in swelling
- Decrease in pain or tenderness
- Absence of pus or discharge
- Healing of skin lesions
- New or worsening itching
- Burning sensation
- Stinging sensation
- Rash
- Signs of superinfection (e.g., fungal infection, non-susceptible bacterial growth)
Special Patient Groups
Pregnancy
Mupirocin is classified as Pregnancy Category B. Animal studies have not shown harm to the fetus. Systemic absorption following topical application is minimal, suggesting low risk.
Trimester-Specific Risks:
First Trimester:
Low risk due to minimal systemic absorption.
Second Trimester:
Low risk due to minimal systemic absorption.
Third Trimester:
Low risk due to minimal systemic absorption.
Lactation
Lactation Risk Category L3 (Limited data â probably compatible). It is unknown whether mupirocin is excreted in human milk. However, systemic absorption is minimal, so infant exposure is likely low. Use with caution; avoid applying to the breast area to prevent direct infant ingestion.
Infant Risk:
Low risk
Pediatric Use
Safe and effective for use in pediatric patients 2 months of age and older. Dosing is similar to adults. Safety and efficacy have not been established in neonates younger than 2 months of age.
Geriatric Use
No specific dose adjustments are necessary for geriatric patients. Clinical studies did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, minimal systemic absorption suggests no age-related concerns.
Clinical Information
Clinical Pearls
- Mupirocin cream is for external use only. It is not for ophthalmic (eye) or intranasal (nose) use.
- Discontinue use and consult a healthcare professional if irritation, sensitization, or a generalized rash occurs.
- Prolonged use of any antibiotic, including mupirocin, may result in the overgrowth of non-susceptible organisms, including fungi. Monitor for signs of superinfection.
- Avoid using mupirocin cream with other topical products on the same affected area unless specifically directed by a healthcare professional.
- Ensure patients understand the importance of completing the full course of therapy, even if symptoms improve, to prevent recurrence and resistance.
Alternative Therapies
- Retapamulin topical
- Fusidic acid topical (availability varies by region)
- Topical erythromycin
- Topical clindamycin
- Oral antibiotics (e.g., cephalexin, dicloxacillin) for more severe or widespread infections
Cost & Coverage
Average Cost:
Varies widely by pharmacy and generic manufacturer per 30gm tube
Generic Available:
Yes
Insurance Coverage:
Tier 1 or 2 (preferred generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet; consult your pharmacist for more information. If you have any questions or concerns about this medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the overdose, be prepared to provide details about the medication taken, the amount, and the time it occurred.