Heparin Lock Flush 10u/ml Inj, 1ml
It is used to thin the blood so that clots will not form.It is used to treat blood clots. It is used to keep blood from clotting in catheters. It may be given to you for other reasons. Talk with the doctor.
Drug Class
Anticoagulant, Catheter Patency Agent
Pharmacologic Class
Anticoagulant, Indirect Thrombin Inhibitor
Pregnancy Category
C
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Heparin lock flush is a very small amount of medicine used to keep your IV (intravenous) line or catheter from getting clogged. It helps prevent blood clots from forming inside the tube, so your IV can be used easily when needed.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication safely and effectively, follow your doctor's instructions carefully. Read all the information provided to you and adhere to the instructions precisely. This medication can be administered in various ways, including:
- through a catheter
- as an injection into a vein
- as an injection into the fatty part of the skin
- as an infusion into a vein over a period of time
If you have any questions or concerns, discuss them with your doctor.
Storing and Disposing of Your Medication
If you need to store this medication at home, consult with your doctor, nurse, or pharmacist to determine the proper storage method.
Missing a Dose
If you miss a dose, contact your doctor to receive guidance on the appropriate course of action.
To use this medication safely and effectively, follow your doctor's instructions carefully. Read all the information provided to you and adhere to the instructions precisely. This medication can be administered in various ways, including:
- through a catheter
- as an injection into a vein
- as an injection into the fatty part of the skin
- as an infusion into a vein over a period of time
If you have any questions or concerns, discuss them with your doctor.
Storing and Disposing of Your Medication
If you need to store this medication at home, consult with your doctor, nurse, or pharmacist to determine the proper storage method.
Missing a Dose
If you miss a dose, contact your doctor to receive guidance on the appropriate course of action.
Lifestyle & Tips
- Report any signs of redness, swelling, pain, or leakage around your IV site.
- Report any unusual bleeding or bruising, though this is very rare with this type of heparin.
Available Forms & Alternatives
Available Strengths:
- Heparin Lock Flush 100u/ml Inj, 1ml
- Heparin Lock Flush 100u/ml Inj, 5ml
- Heparin Sod 1000u/ml Inj, 2ml
- Heparin Sod 5,000u/ml Inj, 10ml
- Heparin Sod 5000u/0.5ml Inj, 0.5ml
- Heparin Sod 5,000u/ml Inj, 1ml
- Heparin Lock Flush 10u/ml Inj, 5ml
- Heparin Sod 1000u/ml Inj, 10ml
- Heparin Sod 1000u/ml Inj, 1ml
- Heparin Sod 10,000u/ml Inj, 4ml
- Heparin Sod 5000u/ml Carpuject, 1ml
- Heparin Lock Flush 100u/ml Inj, 3ml
- Heparin Sod 1000u/ml Inj, 30ml
- Heparin Sod 5000u/ml Prefilled Syr
- Heparin Sod 5000u/ml Inj, 1ml
- Heparin Lock Flush 10u/ml Inj, 1ml
- Heparin Sod 10,000u/ml Inj, 1ml
- Heparin Sod 20000u/ml Inj 1ml
- Heparin Sod 10,000u/ml Inj, 5ml
- Heparin Lock Flush 10u/ml Inj, 3ml
- Heparin Sod/nacl 25000u Inj, 500ml
- Heparin Sod/d5w 100u/ml Inj, 250ml
- Hep Sod/nacl 25000unt Inj, 250ml
- Heparin Na 50u/1ml/sod Cl 0.45% Inj
- Heparin Posiflush 100u/ml Inj, 3ml
- Heparin Sod 1000u/ml Inj,30ml
Dosing & Administration
Adult Dosing
Standard Dose:
10 units/mL solution, instill sufficient volume to fill the lumen of the catheter or extension set (typically 1-5 mL), flush after each use or every 8-24 hours for intermittent use.
Dose Range:
1 - 5 mg
Condition-Specific Dosing:
centralVenousCatheters:
2-5 mL of 10 units/mL solution
peripheralIVs:
1-2 mL of 10 units/mL solution
Pediatric Dosing
Neonatal:
0.5-1 mL of 10 units/mL solution, or volume sufficient to fill the lumen of the catheter.
Infant:
0.5-1 mL of 10 units/mL solution, or volume sufficient to fill the lumen of the catheter.
Child:
1-3 mL of 10 units/mL solution, or volume sufficient to fill the lumen of the catheter.
Adolescent:
1-5 mL of 10 units/mL solution, or volume sufficient to fill the lumen of the catheter.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (minimal systemic absorption).
Moderate:
No adjustment needed (minimal systemic absorption).
Severe:
No adjustment needed (minimal systemic absorption).
Dialysis:
No adjustment needed (minimal systemic absorption).
Hepatic Impairment:
Mild:
No adjustment needed (minimal systemic absorption).
Moderate:
No adjustment needed (minimal systemic absorption).
Severe:
No adjustment needed (minimal systemic absorption).
Confidence:
High
Pharmacology
Mechanism of Action
Heparin binds to antithrombin III (a plasma protein), which causes a conformational change in antithrombin III, greatly accelerating its inhibitory action on various coagulation factors, particularly thrombin (Factor IIa) and Factor Xa. In the context of a lock flush, this action prevents the formation of fibrin clots within the lumen of an intravenous catheter, maintaining its patency.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption (primarily local effect within the catheter).
Tmax:
Not applicable for systemic effect; immediate local effect.
FoodEffect:
Not applicable.
Distribution:
Vd:
Not applicable for lock flush (minimal systemic absorption).
ProteinBinding:
Not applicable for lock flush (minimal systemic absorption).
CnssPenetration:
No
Elimination:
HalfLife:
Not applicable for lock flush (minimal systemic absorption). Systemic heparin has a dose-dependent half-life of 1-2.5 hours.
Clearance:
Not applicable for lock flush (minimal systemic absorption).
ExcretionRoute:
Not applicable for lock flush (minimal systemic absorption). Systemic heparin is primarily excreted renally.
Unchanged:
Not applicable for lock flush (minimal systemic absorption).
Pharmacodynamics
OnsetOfAction:
Immediate (local effect within catheter).
PeakEffect:
Immediate (local effect within catheter).
DurationOfAction:
Maintains catheter patency until next flush or for up to 8-24 hours depending on protocol.
Confidence:
High
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of bleeding, including:
+ Vomiting or coughing up blood
+ Vomit that resembles coffee grounds
+ Blood in the urine
+ Black, red, or tarry stools
+ Bleeding from the gums
+ Abnormal vaginal bleeding
+ Unexplained bruises or bruises that increase in size
+ Uncontrollable bleeding
Neurological symptoms, such as:
+ Weakness on one side of the body
+ Difficulty speaking or thinking
+ Changes in balance
+ Drooping on one side of the face
+ Blurred vision
Confusion
Severe headache
Dizziness or fainting
Upset stomach or vomiting
Unusual burning sensations, particularly on the soles of the feet
Swelling, warmth, numbness, color changes, or pain in a leg or arm
Chest pain or pressure
Shortness of breath
Back pain
Groin or pelvic pain or swelling
Changes in skin color at the injection site
Skin breakdown at the site of administration
Fever or chills
Other Possible Side Effects
As with any medication, you may experience side effects. While many people do not have any side effects or only minor ones, it is essential to discuss any concerns with your doctor. If you experience any side effects that bother you or persist, contact your doctor for guidance.
Please note that this list is not exhaustive, and you should consult your doctor if you have any questions or concerns about side effects. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of bleeding, including:
+ Vomiting or coughing up blood
+ Vomit that resembles coffee grounds
+ Blood in the urine
+ Black, red, or tarry stools
+ Bleeding from the gums
+ Abnormal vaginal bleeding
+ Unexplained bruises or bruises that increase in size
+ Uncontrollable bleeding
Neurological symptoms, such as:
+ Weakness on one side of the body
+ Difficulty speaking or thinking
+ Changes in balance
+ Drooping on one side of the face
+ Blurred vision
Confusion
Severe headache
Dizziness or fainting
Upset stomach or vomiting
Unusual burning sensations, particularly on the soles of the feet
Swelling, warmth, numbness, color changes, or pain in a leg or arm
Chest pain or pressure
Shortness of breath
Back pain
Groin or pelvic pain or swelling
Changes in skin color at the injection site
Skin breakdown at the site of administration
Fever or chills
Other Possible Side Effects
As with any medication, you may experience side effects. While many people do not have any side effects or only minor ones, it is essential to discuss any concerns with your doctor. If you experience any side effects that bother you or persist, contact your doctor for guidance.
Please note that this list is not exhaustive, and you should consult your doctor if you have any questions or concerns about side effects. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Redness, swelling, pain, or pus at the IV site (signs of infection).
- Inability to flush the IV line or draw blood from it (signs of occlusion).
- Unusual bleeding or bruising (extremely rare with lock flush).
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
If you are allergic to pork products, discuss this with your doctor.
* Certain health conditions, including:
+ Bleeding problems
+ Low platelet count
+ A history of low platelet count caused by heparin or pentosan polysulfate
This list is not exhaustive, and it is crucial to disclose all your medications (prescription, over-the-counter, natural products, and vitamins) and health issues to your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health conditions.
Remember, do not start, stop, or change the dose of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
If you are allergic to pork products, discuss this with your doctor.
* Certain health conditions, including:
+ Bleeding problems
+ Low platelet count
+ A history of low platelet count caused by heparin or pentosan polysulfate
This list is not exhaustive, and it is crucial to disclose all your medications (prescription, over-the-counter, natural products, and vitamins) and health issues to your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health conditions.
Remember, do not start, stop, or change the dose of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.
While taking this drug, you may experience easier bleeding. To minimize the risk of injury, be cautious and take preventive measures such as using a soft toothbrush and an electric razor.
There is a risk of severe and potentially life-threatening bleeding problems associated with this medication. Additionally, this drug can cause a condition known as heparin-induced thrombocytopenia (HIT), which may lead to the formation of blood clots, also referred to as heparin-induced thrombocytopenia and thrombosis (HITTS). Both HIT and HITTS can be fatal or cause other complications, and they may occur up to several weeks after discontinuing the medication. If you have any questions or concerns, discuss them with your doctor. It is crucial to undergo blood tests as directed by your doctor and to consult with them regarding any concerns.
This medication may interfere with certain laboratory tests. Therefore, it is vital to inform all your healthcare providers and laboratory personnel that you are taking this drug.
If you experience a fall, injury, or head trauma, contact your doctor immediately, even if you feel fine.
Ensure that you have the correct product, as this medication is available in various containers and strengths. If you have any doubts, consult your doctor or pharmacist.
If you are allergic to sulfites, inform your doctor, as some products contain sulfites.
Individuals over 60 years old should exercise caution when using this medication, as they may be more susceptible to side effects.
Some products contain benzyl alcohol, which can cause serious side effects in newborns and infants, particularly when combined with other medications containing benzyl alcohol. Consult your doctor to determine if the product contains benzyl alcohol and to discuss potential risks.
If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor to discuss the benefits and risks of this medication to both you and your baby.
While taking this drug, you may experience easier bleeding. To minimize the risk of injury, be cautious and take preventive measures such as using a soft toothbrush and an electric razor.
There is a risk of severe and potentially life-threatening bleeding problems associated with this medication. Additionally, this drug can cause a condition known as heparin-induced thrombocytopenia (HIT), which may lead to the formation of blood clots, also referred to as heparin-induced thrombocytopenia and thrombosis (HITTS). Both HIT and HITTS can be fatal or cause other complications, and they may occur up to several weeks after discontinuing the medication. If you have any questions or concerns, discuss them with your doctor. It is crucial to undergo blood tests as directed by your doctor and to consult with them regarding any concerns.
This medication may interfere with certain laboratory tests. Therefore, it is vital to inform all your healthcare providers and laboratory personnel that you are taking this drug.
If you experience a fall, injury, or head trauma, contact your doctor immediately, even if you feel fine.
Ensure that you have the correct product, as this medication is available in various containers and strengths. If you have any doubts, consult your doctor or pharmacist.
If you are allergic to sulfites, inform your doctor, as some products contain sulfites.
Individuals over 60 years old should exercise caution when using this medication, as they may be more susceptible to side effects.
Some products contain benzyl alcohol, which can cause serious side effects in newborns and infants, particularly when combined with other medications containing benzyl alcohol. Consult your doctor to determine if the product contains benzyl alcohol and to discuss potential risks.
If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor to discuss the benefits and risks of this medication to both you and your baby.
Overdose Information
Overdose Symptoms:
- Excessive bleeding (e.g., nosebleeds, bleeding gums, blood in urine/stools, unusual bruising)
- Hypotension (low blood pressure)
- Tachycardia (rapid heart rate)
What to Do:
Overdose with heparin lock flush is highly unlikely due to the very low concentration and volume. If accidental systemic administration of a large dose occurs, protamine sulfate can be used as an antidote. Call 911 or Poison Control at 1-800-222-1222 immediately.
Drug Interactions
Monitoring
Routine Monitoring
Catheter patency
Frequency: Before and after each use, or per institutional protocol (e.g., every 8-24 hours for intermittent use).
Target: Free flow of IV fluids and blood return.
Action Threshold: Resistance to flush, inability to aspirate blood, or signs of occlusion.
Symptom Monitoring
- Signs of bleeding (e.g., bruising, petechiae, epistaxis, hematuria) - rare with lock flush due to minimal systemic absorption.
- Signs of catheter-related infection (e.g., redness, swelling, pain at insertion site, fever).
Special Patient Groups
Pregnancy
Heparin is generally considered safe for use during pregnancy when systemically administered, as it does not cross the placenta. For lock flush, systemic absorption is minimal, posing negligible risk to the fetus. Use only when clearly indicated.
Trimester-Specific Risks:
First Trimester:
Minimal risk due to negligible systemic absorption.
Second Trimester:
Minimal risk due to negligible systemic absorption.
Third Trimester:
Minimal risk due to negligible systemic absorption.
Lactation
Heparin is not excreted into breast milk in significant amounts when systemically administered and is poorly absorbed orally by the infant. For lock flush, systemic absorption is minimal, posing negligible risk to the nursing infant. Considered compatible with breastfeeding.
Infant Risk:
Low (L1)
Pediatric Use
Heparin lock flush is commonly used in pediatric patients, including neonates, to maintain catheter patency. Dosing is adjusted based on catheter volume and patient size, typically using the 10 units/mL concentration. Careful attention to volume is crucial to prevent accidental systemic overdose, especially in very small infants.
Geriatric Use
No specific dose adjustments are typically required for geriatric patients for heparin lock flush due to minimal systemic absorption. Use with caution in patients with increased bleeding risk, although this risk is very low with lock flush concentrations.
Clinical Information
Clinical Pearls
- Heparin lock flush is NOT for systemic anticoagulation. It is specifically formulated in low concentrations (e.g., 10 units/mL or 100 units/mL) to maintain patency of intravenous catheters.
- Always verify the concentration of heparin before use to prevent medication errors. High concentrations (e.g., 1000 units/mL or 5000 units/mL) are for systemic anticoagulation and can be fatal if used as a lock flush.
- Saline flush (0.9% Sodium Chloride) is often preferred over heparin flush for maintaining patency of peripheral IVs and some central lines, as it avoids heparin exposure and the associated, albeit rare, risk of HIT.
- Follow institutional protocols for flush volume and frequency. Over-flushing can lead to systemic absorption, especially in pediatric patients.
- Ensure proper aseptic technique during flushing to prevent catheter-related bloodstream infections.
Alternative Therapies
- 0.9% Sodium Chloride (Saline) flush (most common alternative for catheter patency)
- Citrate solutions (e.g., 4% trisodium citrate) for some central venous catheters (less common, specific indications)
Cost & Coverage
Average Cost:
Low cost (e.g., $1-$5) per 1 mL vial
Generic Available:
Yes
Insurance Coverage:
Tier 1 (Generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others, and do not take medication prescribed for someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly; do not flush them down the toilet or pour them down the drain unless instructed to do so by a healthcare professional. If you are unsure about the correct disposal method, consult your pharmacist, who can also inform you about potential drug take-back programs in your area. Some medications may come with an additional patient information leaflet, which your pharmacist can provide. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide information about the medication taken, the amount, and the time it was taken to ensure prompt and effective treatment.