Glyset 50mg Tablets

Miglitol is an oral alpha-glucosidase inhibitor that acts in the small intestine to delay the digestion of carbohydrates (e.g., starch, dextrin, maltose, sucrose) into monosaccharides (e.g., glucose). This delays glucose absorption, resulting in a lower and more prolonged postprandial blood glucose rise.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Low blood sugar (hypoglycemia), which can occur when this medication is used with other diabetes medications. Symptoms may include:
+ Dizziness
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Fast heartbeat
+ Confusion
+ Hunger
+ Sweating

If you experience any of these symptoms, call your doctor right away and follow their instructions for managing low blood sugar, which may include taking glucose tablets, liquid glucose, or some fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects, although many people may not experience any or may only have mild symptoms. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical help if they bother you or do not go away:

Stomach pain
Diarrhea
* Gas

This is not a comprehensive list of all possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
Certain health conditions, including:
+ Bowel obstruction or being at risk for bowel obstruction
+ Bowel problems, such as inflammatory bowel disease
+ Diabetic acidosis
+ Malabsorption syndrome
+ Difficulty breaking down food
+ Ulcers in the colon
Kidney disease
If you are breastfeeding, as you should not breastfeed while taking this medication

This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health problems with your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

If you experience low blood sugar, do not operate a vehicle, as this increases your risk of being involved in an accident.

To monitor your condition effectively, check your blood sugar levels as directed by your doctor. Additionally, have your blood work and other laboratory tests performed as scheduled by your doctor.

Adhere to the diet and exercise plan recommended by your doctor to maintain optimal control over your blood sugar levels. Be aware that stress, such as fever, infection, injury, or surgery, can make it more challenging to manage your blood sugar. Similarly, changes in physical activity, exercise, or diet can also impact your blood sugar control.

If you are pregnant or planning to become pregnant, notify your doctor. It is crucial to discuss the potential benefits and risks associated with using this medication during pregnancy to make an informed decision.

• Insulin and Sulfonylureas: Increased risk of hypoglycemia when used concomitantly. If hypoglycemia occurs, treat with glucose (dextrose), not sucrose (table sugar), as miglitol inhibits sucrose breakdown.

• Intestinal Adsorbents (e.g., charcoal): May reduce the effect of miglitol by adsorbing it.
• Digestive Enzyme Preparations (e.g., amylase, pancreatin): May reduce the effect of miglitol by counteracting its mechanism of action.

• Symptoms of hypoglycemia (e.g., sweating, tremor, confusion, hunger, dizziness) especially if used with insulin or sulfonylureas.
• Gastrointestinal side effects (e.g., flatulence, diarrhea, abdominal pain, bloating), especially during initiation and dose titration.

Miglitol is Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed.

Miglitol is excreted in human milk. Due to the potential for hypoglycemia in the nursing infant and the lack of long-term data, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Safety and effectiveness in pediatric patients (under 18 years of age) have not been established. Use is generally not recommended.

No specific dose adjustment is required based solely on age. However, due to the higher likelihood of decreased renal function in elderly patients, renal function should be assessed before initiating miglitol and monitored periodically. Contraindicated in severe renal impairment.

• Miglitol primarily targets postprandial hyperglycemia, making it particularly useful for patients with elevated post-meal glucose levels.
• The most common side effects are gastrointestinal (flatulence, diarrhea, abdominal pain), which tend to be dose-related and often diminish over time with continued use. Starting with a low dose and titrating slowly can help mitigate these effects.
• Unlike sulfonylureas or insulin, miglitol does not cause hypoglycemia when used as monotherapy. However, it can increase the risk of hypoglycemia when combined with these agents.
• If hypoglycemia occurs while on miglitol, it must be treated with glucose (dextrose) as miglitol inhibits the breakdown of sucrose (table sugar) and complex carbohydrates.
• Patients should be advised to take miglitol with the first bite of each main meal for optimal efficacy.

• Metformin (Biguanide)
• Acarbose (another Alpha-glucosidase inhibitor)
• Sulfonylureas (e.g., Glipizide, Glyburide)
• Thiazolidinediones (e.g., Pioglitazone, Rosiglitazone)
• DPP-4 Inhibitors (e.g., Sitagliptin, Saxagliptin)
• SGLT2 Inhibitors (e.g., Canagliflozin, Dapagliflozin)
• GLP-1 Receptor Agonists (e.g., Liraglutide, Semaglutide)
• Insulin

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, including the amount and time of ingestion.