Atropine Sulfate 0.1mg/ml Inj, 10ml

Atropine is a competitive antagonist of acetylcholine at muscarinic receptors. It blocks the effects of parasympathetic stimulation, leading to increased heart rate, decreased glandular secretions (salivary, bronchial, sweat), relaxation of smooth muscle (bronchi, GI tract, urinary bladder), and mydriasis.

Serious Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you experience any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Urination problems
Chest pain or pressure, rapid heartbeat, or irregular heartbeat
Severe dizziness or fainting
Breathing difficulties, slow breathing, or shallow breathing
Confusion
Balance problems
Hallucinations (seeing or hearing things that are not there)
Extreme fatigue or weakness
Restlessness
Shakiness
Abdominal swelling
Severe constipation or stomach pain, which may be signs of a serious bowel problem
Erectile dysfunction or decreased libido
Depression
Changes in vision, eye pain, or severe eye irritation
Inability to sweat during physical activity or in warm temperatures

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only mild ones, it's essential to contact your doctor if you're bothered by any of the following:

Blurred vision
Sensitivity to bright lights
Constipation
Stomach pain
Nausea or vomiting
Reduced sweating
Dizziness or headache
Dry mouth
Dry eyes
Dry nose
Dilated pupils
Flushing
Pain at the injection site

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor and pharmacist assess potential interactions between this medication and other substances you are taking.
* Any existing health problems, as this medication may interact with certain conditions or exacerbate underlying health issues.

To ensure your safety, it is crucial to verify that it is safe to take this medication in conjunction with all your other medications and health conditions. Never start, stop, or adjust the dosage of any medication without first consulting your doctor.

Important Warnings and Precautions

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

To minimize the risk of dehydration, be cautious in hot weather or when engaging in physical activity, and drink plenty of fluids to prevent fluid loss.

Accidental Ingestion Warning
If this medication is swallowed, seek immediate medical attention by calling a doctor or poison control center.

Special Considerations

If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects.
When administering this medication to children, use caution, as the risk of certain side effects may be higher in this population.

Pregnancy and Breastfeeding
If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor to discuss the potential benefits and risks to you and your baby.

Multi-Dose Container Warning
Some products contain benzyl alcohol. To minimize the risk of serious side effects, avoid using products with benzyl alcohol in newborns and infants whenever possible. Benzyl alcohol can cause severe adverse effects in these children, particularly when combined with other medications containing benzyl alcohol. Consult your doctor to determine if this product contains benzyl alcohol and to discuss alternative options.

• Other anticholinergic drugs (e.g., tricyclic antidepressants, phenothiazines, antihistamines, disopyramide): May lead to additive anticholinergic effects (e.g., severe constipation, urinary retention, blurred vision, CNS effects).
• Cholinesterase inhibitors (e.g., donepezil, rivastigmine, neostigmine, pyridostigmine): Atropine antagonizes their effects, reducing efficacy of cholinesterase inhibitors.

• Drugs that slow gastric emptying (e.g., opioids): May further delay absorption of other oral medications.
• Potassium chloride (oral forms): Increased risk of GI lesions due to delayed gastric emptying.

• Dry mouth
• Blurred vision
• Photophobia
• Urinary retention
• Constipation
• Tachycardia
• Palpitations
• Flushing
• Hot, dry skin
• Fever
• Agitation
• Delirium
• Hallucinations
• Coma

Atropine is classified as Pregnancy Category C. Animal studies have shown adverse effects, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Atropine is excreted in breast milk in small amounts. It may decrease milk production due to its anticholinergic effects. The infant risk is generally low with single or intermittent doses, but monitor for anticholinergic effects in the infant (e.g., dry mouth, constipation, urinary retention, drowsiness). L3 (Moderately safe).

Children, especially infants and young children, are more susceptible to the toxic effects of atropine, particularly hyperthermia and CNS effects. Dosing is weight-based and requires careful calculation and monitoring. Paradoxical bradycardia may occur with very low doses.

Elderly patients are more sensitive to the anticholinergic effects of atropine, including CNS effects (confusion, delirium), urinary retention, and constipation. Use with caution and consider lower initial doses.

• Atropine is the first-line drug for symptomatic bradycardia in ACLS algorithms.
• In organophosphate poisoning, atropine is given until 'atropinization' is achieved (e.g., dry secretions, clear lungs, heart rate >80 bpm), which may require very large doses.
• Paradoxical bradycardia can occur if very low doses (e.g., <0.5 mg in adults) are given, as it may block presynaptic M1 receptors, leading to increased acetylcholine release.
• Monitor for signs of anticholinergic toxicity: 'Hot as a hare, blind as a bat, dry as a bone, red as a beet, and mad as a hatter.'
• Atropine does not reverse the neuromuscular blockade of organophosphates; pralidoxime is needed for that.

• For symptomatic bradycardia: Transcutaneous pacing, dopamine, epinephrine.
• For organophosphate poisoning: Pralidoxime (2-PAM) in conjunction with atropine.
• For pre-anesthetic drying of secretions: Glycopyrrolate (less CNS effects).

If your symptoms or health problems do not improve or worsen over time, it is essential to contact your doctor for further evaluation and guidance. To ensure safe and effective treatment, never share your medication with others or take someone else's medication.

Store all medications in a secure location, out of the reach of children and pets, to prevent accidental ingestion or exposure. Properly dispose of unused or expired medications by checking with your pharmacist for guidance on the best disposal method. Unless instructed to do so by a healthcare professional or pharmacist, avoid flushing medications down the toilet or pouring them down the drain. Many communities have drug take-back programs, which your pharmacist can help you locate.

Some medications may come with an additional patient information leaflet, so it is a good idea to check with your pharmacist for more information. If you have any questions or concerns about your medication, consult with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide information about the medication taken, the amount, and the time it was taken to ensure prompt and effective treatment.