Viibryd 20mg Tablets

Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at serotonin 5-HT1A receptors. It is believed that the combination of these two activities contributes to its antidepressant effects.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash or hives
+ Itching or red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing or tightness in the chest or throat
+ Difficulty breathing, swallowing, or talking
+ Unusual hoarseness or swelling of the mouth, face, lips, tongue, or throat
Signs of low sodium levels, including:
+ Headache
+ Trouble focusing or memory problems
+ Feeling confused or weak
+ Seizures or changes in balance
Signs of bleeding, such as:
+ Vomiting or coughing up blood
+ Vomit that resembles coffee grounds
+ Blood in the urine
+ Black, red, or tarry stools
+ Bleeding from the gums
+ Abnormal vaginal bleeding
+ Unexplained bruises or bruises that get bigger
+ Uncontrollable bleeding
Seizures
Sex problems, including:
+ Decreased interest in sex
+ Difficulty having an orgasm
+ Ejaculation problems
+ Trouble getting or maintaining an erection
Serotonin syndrome, a potentially life-threatening condition that may occur, especially if you take certain other medications. Call your doctor right away if you experience:
+ Agitation
+ Changes in balance
+ Confusion
+ Hallucinations
+ Fever
+ Fast or abnormal heartbeat
+ Flushing
+ Muscle twitching or stiffness
+ Seizures
+ Shivering or shaking
+ Excessive sweating
+ Severe diarrhea, stomach upset, or vomiting
+ Severe headache

Other Possible Side Effects

Most people do not experience severe side effects, and some may have only minor side effects. However, if you notice any of the following symptoms, contact your doctor or seek medical attention if they bother you or do not go away:

Trouble sleeping
Diarrhea, stomach pain, upset stomach, or vomiting
Dry mouth
Dizziness or headache
* Feeling sleepy

Reporting Side Effects

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
If you have been diagnosed with glaucoma.
If you are currently taking or have recently taken certain medications, including:
+ Linezolid or methylene blue.
+ Certain antidepressants or Parkinson's disease medications within the last 14 days, such as isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline, as this may increase the risk of very high blood pressure.
Other medications, including prescription and over-the-counter drugs, natural products, and vitamins, as this is not an exhaustive list of potential interactions.

To ensure your safety, it is crucial to discuss all your medications and health conditions with your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before engaging in activities that require alertness, such as driving, wait until you understand how this drug affects you. Additionally, avoid consuming alcohol while taking this medication.

Before using marijuana, other forms of cannabis, or prescription or over-the-counter (OTC) drugs that may cause drowsiness, consult with your doctor. It may take several weeks to experience the full effects of this medication.

Do not abruptly stop taking this drug without consulting your doctor, as this may increase your risk of side effects. If you need to discontinue this medication, your doctor will instruct you on how to gradually stop taking it to minimize potential risks.

This medication may increase the risk of bleeding, which can be life-threatening in some cases. Discuss this risk with your doctor. Certain individuals may have a higher risk of developing eye problems while taking this drug. Your doctor may recommend an eye exam to assess your risk. If you experience eye pain, changes in vision, or swelling and redness in or around the eye, contact your doctor immediately.

Low blood sodium levels (hyponatremia) can occur with this medication, and in severe cases, this can be fatal. Discuss this risk with your doctor. If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects.

If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor. You will need to discuss the benefits and risks of taking this medication during pregnancy and breastfeeding. Taking this drug during the third trimester of pregnancy may increase your risk of bleeding after delivery and may lead to health problems in the newborn. Your doctor will help you weigh the benefits and risks of taking this medication while breastfeeding.

• Monoamine Oxidase Inhibitors (MAOIs) (e.g., phenelzine, tranylcypromine, selegiline, linezolid, methylene blue) - risk of serotonin syndrome. Allow at least 14 days between discontinuing an MAOI and starting vilazodone, and 14 days between discontinuing vilazodone and starting an MAOI.

• Strong CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin, ritonavir): Reduce vilazodone dose by half (e.g., from 40 mg to 20 mg, or from 20 mg to 10 mg).
• Strong CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin): Increase vilazodone dose (e.g., from 20 mg to 40 mg).
• Other Serotonergic Drugs (e.g., SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan, St. John's Wort): Increased risk of serotonin syndrome.
• Drugs that impair platelet aggregation (e.g., NSAIDs, aspirin, warfarin): Increased risk of bleeding.

• Moderate CYP3A4 Inhibitors (e.g., erythromycin, diltiazem, verapamil): Monitor for increased vilazodone effects.
• Moderate CYP3A4 Inducers (e.g., efavirenz, bosentan): Monitor for decreased vilazodone efficacy.

• Not specifically defined for minor interactions; generally, monitor for additive CNS effects with other CNS depressants.

• Worsening depression
• Suicidal thoughts or attempts
• Unusual changes in behavior or mood (e.g., agitation, irritability, anxiety, panic attacks, insomnia, aggression, impulsivity, akathisia, hypomania, mania)
• Serotonin syndrome symptoms (e.g., agitation, hallucinations, delirium, coma, tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia, tremor, rigidity, myoclonus, hyperreflexia, incoordination, GI symptoms)
• Hyponatremia symptoms (e.g., headache, difficulty concentrating, memory impairment, confusion, weakness, unsteadiness, hallucinations, syncope, seizures, coma)
• Abnormal bleeding or bruising
• Gastrointestinal upset (nausea, diarrhea, vomiting)
• Insomnia or somnolence
• Sexual dysfunction

Vilazodone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant women. Neonates exposed to SSRIs/SNRIs late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. These complications can arise immediately upon delivery.

Vilazodone is present in human milk. The effects on the breastfed infant and on milk production are unknown. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Safety and effectiveness in pediatric patients (under 18 years of age) have not been established. Antidepressants, including vilazodone, increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults.

No overall differences in safety or effectiveness were observed between elderly subjects and younger subjects, but greater sensitivity of some older individuals cannot be ruled out. Elderly patients may be at increased risk for hyponatremia (low sodium levels) when treated with vilazodone. A lower starting dose (10 mg) may be considered for some elderly patients.

• Vilazodone MUST be taken with food. Taking it without food significantly reduces its absorption and effectiveness.
• The initial 10 mg dose for 7 days is a titration step to improve tolerability; patients should then increase to 20 mg daily.
• Like other antidepressants, vilazodone should not be stopped abruptly due to the risk of discontinuation syndrome (e.g., dizziness, sensory disturbances, agitation, anxiety, nausea, sweating, tremor, confusion). Tapering is recommended.
• Monitor for symptoms of serotonin syndrome, especially when co-administered with other serotonergic agents.
• Be aware of the Black Box Warning regarding increased risk of suicidality in children, adolescents, and young adults.

• Other Selective Serotonin Reuptake Inhibitors (SSRIs) (e.g., fluoxetine, sertraline, escitalopram, citalopram, paroxetine)
• Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) (e.g., venlafaxine, duloxetine, desvenlafaxine)
• Atypical Antidepressants (e.g., bupropion, mirtazapine, vortioxetine)
• Tricyclic Antidepressants (TCAs)
• Monoamine Oxidase Inhibitors (MAOIs)
• Psychotherapy (e.g., Cognitive Behavioral Therapy - CBT)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others or take someone else's medication. This medication is accompanied by a Medication Guide, which provides crucial information for patients. Please read this guide carefully and review it again whenever you receive a refill of this medication. If you have any questions or concerns about this medication, consult your doctor, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the substance taken, the amount, and the time it occurred.