Trijardy XR 25mg/5mg/1000mg Tabs
WARNING: Rarely, metformin may cause too much lactic acid in the blood (lactic acidosis). The risk is higher in people who have kidney problems, liver problems, heart failure, use alcohol, or take certain other drugs, including topiramate. The risk is also higher in people who are 65 or older and in people who are having surgery, an exam or test with contrast, or other procedures. If lactic acidosis happens, it can lead to other health problems and can be deadly. Kidney tests may be done while taking this drug.Do not take this drug if you have a very bad infection, low oxygen, or a lot of fluid loss (dehydration).Call your doctor right away if you have signs of too much lactic acid in the blood (lactic acidosis) like confusion; fast breathing; fast or slow heartbeat; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; feeling very tired or weak; very bad dizziness; feeling cold; or muscle pain or cramps. @ COMMON USES: It is used to help control blood sugar in people with type 2 diabetes.It is used to lower the chance of death from heart disease in certain people.
Drug Class
See FDA label
Overview
How to Use This Medicine
Taking Your Medication Correctly
To get the most benefit from your medication, follow your doctor's instructions carefully. Read all the information provided to you and follow the instructions closely.
Take your medication in the morning, with a meal.
Swallow the tablet whole; do not chew, break, crush, or dissolve it.
If you have trouble swallowing, consult your doctor.
Drink plenty of non-caffeinated liquids, unless your doctor advises you to limit your fluid intake.
Important Notes
You may notice what appears to be the tablet in your stool; this is normal and not a cause for concern.
If you have questions or concerns, discuss them with your doctor.
Continue taking your medication as directed by your doctor, even if you feel well.
Follow the diet and exercise plan recommended by your doctor.
If you are on a low-sodium or sodium-free diet, consult your doctor.
Monitoring Your Condition
Have your blood work checked as directed by your doctor.
Discuss with your doctor which glucose tests are best for you to use.
Be cautious in hot weather or during physical activity; drink plenty of fluids to avoid dehydration.
If you are unable to drink liquids or experience persistent stomach upset, vomiting, or diarrhea, contact your doctor to avoid dehydration, which can lead to low blood pressure or worsen kidney problems.
Potential Side Effects
Stomach problems, such as upset stomach, vomiting, or diarrhea, are common when starting this medication. If you experience these symptoms later in your treatment, contact your doctor immediately, as they may be a sign of lactic acidosis.
Stress, infection, injury, or surgery can affect your blood sugar control. Changes in physical activity, exercise, or diet can also impact your blood sugar levels.
Monitor your blood sugar levels as directed by your doctor.
Interactions with Lab Tests
Inform all your healthcare providers and lab workers that you are taking this medication, as it may affect certain lab tests.
Storing and Disposing of Your Medication
Store your medication at room temperature in a dry place, away from the bathroom.
Keep all medications in a safe place, out of the reach of children and pets.
Dispose of unused or expired medications properly; do not flush them down the toilet or pour them down the drain unless instructed to do so. Consult your pharmacist for guidance on disposal.
Missing a Dose
If you miss a dose, take it as soon as you remember.
If it is close to the time for your next dose and you have already eaten, skip the missed dose and resume your regular schedule.
* Do not take two doses at the same time or take extra doses.
To get the most benefit from your medication, follow your doctor's instructions carefully. Read all the information provided to you and follow the instructions closely.
Take your medication in the morning, with a meal.
Swallow the tablet whole; do not chew, break, crush, or dissolve it.
If you have trouble swallowing, consult your doctor.
Drink plenty of non-caffeinated liquids, unless your doctor advises you to limit your fluid intake.
Important Notes
You may notice what appears to be the tablet in your stool; this is normal and not a cause for concern.
If you have questions or concerns, discuss them with your doctor.
Continue taking your medication as directed by your doctor, even if you feel well.
Follow the diet and exercise plan recommended by your doctor.
If you are on a low-sodium or sodium-free diet, consult your doctor.
Monitoring Your Condition
Have your blood work checked as directed by your doctor.
Discuss with your doctor which glucose tests are best for you to use.
Be cautious in hot weather or during physical activity; drink plenty of fluids to avoid dehydration.
If you are unable to drink liquids or experience persistent stomach upset, vomiting, or diarrhea, contact your doctor to avoid dehydration, which can lead to low blood pressure or worsen kidney problems.
Potential Side Effects
Stomach problems, such as upset stomach, vomiting, or diarrhea, are common when starting this medication. If you experience these symptoms later in your treatment, contact your doctor immediately, as they may be a sign of lactic acidosis.
Stress, infection, injury, or surgery can affect your blood sugar control. Changes in physical activity, exercise, or diet can also impact your blood sugar levels.
Monitor your blood sugar levels as directed by your doctor.
Interactions with Lab Tests
Inform all your healthcare providers and lab workers that you are taking this medication, as it may affect certain lab tests.
Storing and Disposing of Your Medication
Store your medication at room temperature in a dry place, away from the bathroom.
Keep all medications in a safe place, out of the reach of children and pets.
Dispose of unused or expired medications properly; do not flush them down the toilet or pour them down the drain unless instructed to do so. Consult your pharmacist for guidance on disposal.
Missing a Dose
If you miss a dose, take it as soon as you remember.
If it is close to the time for your next dose and you have already eaten, skip the missed dose and resume your regular schedule.
* Do not take two doses at the same time or take extra doses.
Available Forms & Alternatives
Dosing & Administration
Pharmacology
Safety & Warnings
Side Effects
Serious Side Effects: Seek Medical Help Right Away
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek medical attention:
Allergic Reaction: Rash, hives, itching, red, swollen, blistered, or peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Fluid and Electrolyte Problems: Mood changes, confusion, muscle pain or weakness, fast or abnormal heartbeat, severe dizziness or fainting, increased thirst, seizures, feeling extremely tired or weak, decreased appetite, inability to pass urine or changes in urine output, dry mouth, dry eyes, or severe stomach upset or vomiting.
Pancreas Problems (Pancreatitis): Severe stomach pain, severe back pain, or severe stomach upset or vomiting.
Kidney Problems: Inability to pass urine, changes in urine output, blood in the urine, or sudden weight gain.
Urinary Tract Infection (UTI): Blood in the urine, burning or pain while urinating, frequent or urgent need to urinate, fever, lower stomach pain, or pelvic pain.
Vaginal Yeast Infection: Itching, bad odor, or discharge. Report these symptoms to your doctor.
Yeast Infection of the Penis: Pain, swelling, rash, or discharge. Report these symptoms to your doctor.
Severe Joint Pain: This medication may cause joint pain that can be severe and disabling. Contact your doctor immediately if you experience severe joint pain or persistent joint pain.
Low Blood Sugar: This can occur, especially when used with other diabetes medications. Signs may include dizziness, headache, feeling sleepy or weak, shaking, fast heartbeat, confusion, hunger, or sweating. If you experience any of these symptoms, contact your doctor right away and follow your instructions for managing low blood sugar, which may include taking glucose tablets, liquid glucose, or some fruit juices.
Other Possible Side Effects
Most people do not experience serious side effects, but some may occur. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical attention if they bother you or do not go away:
Common cold symptoms
Nose or throat irritation
Diarrhea or constipation
* Headache
Reporting Side Effects
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek medical attention:
Allergic Reaction: Rash, hives, itching, red, swollen, blistered, or peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Fluid and Electrolyte Problems: Mood changes, confusion, muscle pain or weakness, fast or abnormal heartbeat, severe dizziness or fainting, increased thirst, seizures, feeling extremely tired or weak, decreased appetite, inability to pass urine or changes in urine output, dry mouth, dry eyes, or severe stomach upset or vomiting.
Pancreas Problems (Pancreatitis): Severe stomach pain, severe back pain, or severe stomach upset or vomiting.
Kidney Problems: Inability to pass urine, changes in urine output, blood in the urine, or sudden weight gain.
Urinary Tract Infection (UTI): Blood in the urine, burning or pain while urinating, frequent or urgent need to urinate, fever, lower stomach pain, or pelvic pain.
Vaginal Yeast Infection: Itching, bad odor, or discharge. Report these symptoms to your doctor.
Yeast Infection of the Penis: Pain, swelling, rash, or discharge. Report these symptoms to your doctor.
Severe Joint Pain: This medication may cause joint pain that can be severe and disabling. Contact your doctor immediately if you experience severe joint pain or persistent joint pain.
Low Blood Sugar: This can occur, especially when used with other diabetes medications. Signs may include dizziness, headache, feeling sleepy or weak, shaking, fast heartbeat, confusion, hunger, or sweating. If you experience any of these symptoms, contact your doctor right away and follow your instructions for managing low blood sugar, which may include taking glucose tablets, liquid glucose, or some fruit juices.
Other Possible Side Effects
Most people do not experience serious side effects, but some may occur. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical attention if they bother you or do not go away:
Common cold symptoms
Nose or throat irritation
Diarrhea or constipation
* Headache
Reporting Side Effects
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following conditions to ensure safe treatment:
Any allergies you have, including allergies to this medication, its components, or other substances. Describe the allergic reaction and its symptoms.
If you have type 1 diabetes, as this medication is not intended to treat this condition.
Presence of certain health issues, such as:
+ Acidic blood problems
+ Kidney disease
+ Liver disease
Recent heart attack or stroke
Inability to eat or drink normally, including situations before procedures or surgery
Upcoming or recent exams or tests using contrast agents (within the past 48 hours)
Current use of rifampin
Pregnancy or potential pregnancy. Do not take this medication during the second or third trimester of pregnancy.
* Breast-feeding. Avoid breast-feeding while taking this medication.
This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. Verify that it is safe to take this medication with your existing treatments and health issues. Never start, stop, or adjust the dose of any medication without consulting your doctor.
It is essential to inform your doctor about the following conditions to ensure safe treatment:
Any allergies you have, including allergies to this medication, its components, or other substances. Describe the allergic reaction and its symptoms.
If you have type 1 diabetes, as this medication is not intended to treat this condition.
Presence of certain health issues, such as:
+ Acidic blood problems
+ Kidney disease
+ Liver disease
Recent heart attack or stroke
Inability to eat or drink normally, including situations before procedures or surgery
Upcoming or recent exams or tests using contrast agents (within the past 48 hours)
Current use of rifampin
Pregnancy or potential pregnancy. Do not take this medication during the second or third trimester of pregnancy.
* Breast-feeding. Avoid breast-feeding while taking this medication.
This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. Verify that it is safe to take this medication with your existing treatments and health issues. Never start, stop, or adjust the dose of any medication without consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. To minimize the risk of dizziness or fainting, get up slowly from a sitting or lying position, and be cautious when climbing stairs.
If your blood sugar levels are low, avoid driving, as this can increase your risk of being involved in an accident. Additionally, consult your doctor before consuming alcohol.
Long-term use of metformin may lead to a decrease in vitamin B-12 levels. If you have a history of low vitamin B-12 levels, discuss this with your doctor.
There is a risk of developing a severe and potentially life-threatening pancreas problem (pancreatitis) associated with this type of medication. Furthermore, this drug can cause a condition called ketoacidosis, which is characterized by an excess of acid in the blood or urine. This condition may require hospitalization and can be fatal, even if your blood sugar levels are below 250. Certain individuals are at a higher risk of developing ketoacidosis, including those with diabetes, pancreas problems, or people who are ill, dehydrated, or have difficulty eating or drinking. The risk is also increased in individuals who follow a ketogenic diet, have undergone surgery, or take insulin and miss doses or take less than the prescribed amount. It is crucial to monitor your ketone levels as advised by your doctor, and if you have any questions or concerns, discuss them with your doctor.
Severe urinary tract infections (UTIs) have been reported with this medication, and in some cases, hospitalization was necessary. Kidney problems have also occurred, which may require hospitalization or dialysis. A rare but potentially life-threatening infection can occur with this type of medication. Seek immediate medical attention if you experience tenderness, redness, or swelling in the genital area or the area between your genitals and rectum, accompanied by a fever or feeling unwell.
A skin reaction called bullous pemphigoid has been associated with this type of medication, and in some cases, hospitalization was necessary. If you develop blisters or notice your skin breaking down, contact your doctor immediately.
Heart failure has been reported in individuals taking this type of medication. If you have a history of heart failure or kidney problems, inform your doctor. If you experience extreme fatigue, shortness of breath, significant weight gain, or swelling in your arms or legs, contact your doctor promptly.
This medication may increase the risk of lower limb amputations, with toe and foot amputations being the most common. Discuss foot care with your doctor, and if you have a history of amputation, blood vessel disease, nerve disease, or foot ulcers due to diabetes, inform your doctor. If you experience new pain or tenderness, sores or ulcers, or infections in your legs or feet, contact your doctor immediately.
If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects.
Women of childbearing age who have not been ovulating may be at risk of pregnancy. If you wish to avoid pregnancy, use birth control while taking this medication. Additionally, this medication may harm an unborn baby if taken during pregnancy. If you become pregnant or suspect you are pregnant while taking this medication, contact your doctor immediately.
If your blood sugar levels are low, avoid driving, as this can increase your risk of being involved in an accident. Additionally, consult your doctor before consuming alcohol.
Long-term use of metformin may lead to a decrease in vitamin B-12 levels. If you have a history of low vitamin B-12 levels, discuss this with your doctor.
There is a risk of developing a severe and potentially life-threatening pancreas problem (pancreatitis) associated with this type of medication. Furthermore, this drug can cause a condition called ketoacidosis, which is characterized by an excess of acid in the blood or urine. This condition may require hospitalization and can be fatal, even if your blood sugar levels are below 250. Certain individuals are at a higher risk of developing ketoacidosis, including those with diabetes, pancreas problems, or people who are ill, dehydrated, or have difficulty eating or drinking. The risk is also increased in individuals who follow a ketogenic diet, have undergone surgery, or take insulin and miss doses or take less than the prescribed amount. It is crucial to monitor your ketone levels as advised by your doctor, and if you have any questions or concerns, discuss them with your doctor.
Severe urinary tract infections (UTIs) have been reported with this medication, and in some cases, hospitalization was necessary. Kidney problems have also occurred, which may require hospitalization or dialysis. A rare but potentially life-threatening infection can occur with this type of medication. Seek immediate medical attention if you experience tenderness, redness, or swelling in the genital area or the area between your genitals and rectum, accompanied by a fever or feeling unwell.
A skin reaction called bullous pemphigoid has been associated with this type of medication, and in some cases, hospitalization was necessary. If you develop blisters or notice your skin breaking down, contact your doctor immediately.
Heart failure has been reported in individuals taking this type of medication. If you have a history of heart failure or kidney problems, inform your doctor. If you experience extreme fatigue, shortness of breath, significant weight gain, or swelling in your arms or legs, contact your doctor promptly.
This medication may increase the risk of lower limb amputations, with toe and foot amputations being the most common. Discuss foot care with your doctor, and if you have a history of amputation, blood vessel disease, nerve disease, or foot ulcers due to diabetes, inform your doctor. If you experience new pain or tenderness, sores or ulcers, or infections in your legs or feet, contact your doctor immediately.
If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects.
Women of childbearing age who have not been ovulating may be at risk of pregnancy. If you wish to avoid pregnancy, use birth control while taking this medication. Additionally, this medication may harm an unborn baby if taken during pregnancy. If you become pregnant or suspect you are pregnant while taking this medication, contact your doctor immediately.
Drug Interactions
Monitoring
Special Patient Groups
Clinical Information
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others or take someone else's medication. This medication is accompanied by a Medication Guide, which provides important information for patients. Please read this guide carefully and review it again whenever you receive a refill of this medication. If you have any questions or concerns about this medication, consult your doctor, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the overdose, be prepared to provide details about the medication taken, the amount, and the time it occurred.