Trijardy XR 10mg/5mg/1000mg Tabs
WARNING: Rarely, metformin may cause too much lactic acid in the blood (lactic acidosis). The risk is higher in people who have kidney problems, liver problems, heart failure, use alcohol, or take certain other drugs, including topiramate. The risk is also higher in people who are 65 or older and in people who are having surgery, an exam or test with contrast, or other procedures. If lactic acidosis happens, it can lead to other health problems and can be deadly. Kidney tests may be done while taking this drug.Do not take this drug if you have a very bad infection, low oxygen, or a lot of fluid loss (dehydration).Call your doctor right away if you have signs of too much lactic acid in the blood (lactic acidosis) like confusion; fast breathing; fast or slow heartbeat; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; feeling very tired or weak; very bad dizziness; feeling cold; or muscle pain or cramps. @ COMMON USES: It is used to help control blood sugar in people with type 2 diabetes.It is used to lower the chance of death from heart disease in certain people.
Drug Class
See FDA label
Overview
How to Use This Medicine
Taking Your Medication Correctly
To get the most benefit from your medication, follow your doctor's instructions carefully. Read all the information provided to you and follow the instructions closely.
Take your medication in the morning, with a meal.
Swallow the tablet whole; do not chew, break, crush, or dissolve it.
If you have trouble swallowing, talk to your doctor.
Drink plenty of non-caffeinated liquids, unless your doctor advises you to limit your fluid intake.
What to Expect
You may notice what looks like a tablet in your stool; this is normal and not a cause for concern. If you have any questions or concerns, discuss them with your doctor.
Continuing Your Treatment
Continue taking your medication as directed by your doctor or healthcare provider, even if you feel well. Follow the diet and exercise plan recommended by your doctor. If you are on a low-sodium or sodium-free diet, consult with your doctor.
Monitoring Your Condition
Have your blood work checked as directed by your doctor. Discuss with your doctor which glucose tests are best for you to use.
Staying Safe in Hot Weather
Be careful in hot weather or when engaging in physical activity. Drink plenty of fluids to avoid dehydration. If you are unable to drink liquids by mouth or experience persistent stomach upset, vomiting, or diarrhea, contact your doctor to avoid dehydration, which can lead to low blood pressure or worsen kidney problems.
Managing Side Effects
It is common to experience stomach problems like upset stomach, vomiting, or diarrhea when starting this medication. If you experience stomach problems later in your treatment, call your doctor right away, as this may be a sign of a condition called lactic acidosis.
Controlling Blood Sugar
Your blood sugar levels may be harder to control during times of stress, such as fever, infection, injury, or surgery. Changes in physical activity, exercise, or diet can also affect your blood sugar levels. Check your blood sugar levels as directed by your doctor.
Interactions with Lab Tests
This medication may affect certain lab tests. Inform all your healthcare providers and lab workers that you are taking this medication.
Storing and Disposing of Your Medication
Store your medication at room temperature in a dry place, away from the bathroom. Keep all medications in a safe place, out of the reach of children and pets. Dispose of unused or expired medications according to the instructions of your pharmacist. Do not flush medications down the toilet or pour them down the drain unless advised to do so. Check with your pharmacist for information on drug take-back programs in your area.
Missing a Dose
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose and you have already eaten, skip the missed dose and return to your regular schedule. Do not take two doses at the same time or extra doses.
To get the most benefit from your medication, follow your doctor's instructions carefully. Read all the information provided to you and follow the instructions closely.
Take your medication in the morning, with a meal.
Swallow the tablet whole; do not chew, break, crush, or dissolve it.
If you have trouble swallowing, talk to your doctor.
Drink plenty of non-caffeinated liquids, unless your doctor advises you to limit your fluid intake.
What to Expect
You may notice what looks like a tablet in your stool; this is normal and not a cause for concern. If you have any questions or concerns, discuss them with your doctor.
Continuing Your Treatment
Continue taking your medication as directed by your doctor or healthcare provider, even if you feel well. Follow the diet and exercise plan recommended by your doctor. If you are on a low-sodium or sodium-free diet, consult with your doctor.
Monitoring Your Condition
Have your blood work checked as directed by your doctor. Discuss with your doctor which glucose tests are best for you to use.
Staying Safe in Hot Weather
Be careful in hot weather or when engaging in physical activity. Drink plenty of fluids to avoid dehydration. If you are unable to drink liquids by mouth or experience persistent stomach upset, vomiting, or diarrhea, contact your doctor to avoid dehydration, which can lead to low blood pressure or worsen kidney problems.
Managing Side Effects
It is common to experience stomach problems like upset stomach, vomiting, or diarrhea when starting this medication. If you experience stomach problems later in your treatment, call your doctor right away, as this may be a sign of a condition called lactic acidosis.
Controlling Blood Sugar
Your blood sugar levels may be harder to control during times of stress, such as fever, infection, injury, or surgery. Changes in physical activity, exercise, or diet can also affect your blood sugar levels. Check your blood sugar levels as directed by your doctor.
Interactions with Lab Tests
This medication may affect certain lab tests. Inform all your healthcare providers and lab workers that you are taking this medication.
Storing and Disposing of Your Medication
Store your medication at room temperature in a dry place, away from the bathroom. Keep all medications in a safe place, out of the reach of children and pets. Dispose of unused or expired medications according to the instructions of your pharmacist. Do not flush medications down the toilet or pour them down the drain unless advised to do so. Check with your pharmacist for information on drug take-back programs in your area.
Missing a Dose
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose and you have already eaten, skip the missed dose and return to your regular schedule. Do not take two doses at the same time or extra doses.
Available Forms & Alternatives
Dosing & Administration
Pharmacology
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Allergic Reaction: Rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Fluid and Electrolyte Imbalance: Mood changes, confusion, muscle pain or weakness, abnormal heartbeat, severe dizziness or fainting, increased thirst, seizures, extreme fatigue or weakness, decreased appetite, inability to urinate or changes in urine output, dry mouth, dry eyes, or severe nausea and vomiting.
Pancreatitis (Pancreas Problem): Severe stomach pain, severe back pain, or severe nausea and vomiting.
Kidney Problems: Inability to urinate, changes in urine output, blood in the urine, or sudden weight gain.
Urinary Tract Infection (UTI): Blood in the urine, burning or pain while urinating, frequent or urgent need to urinate, fever, lower abdominal pain, or pelvic pain.
Vaginal Yeast Infection: Itching, unpleasant odor, or discharge. Report these symptoms to your doctor.
Yeast Infection of the Penis: Pain, swelling, rash, or discharge. Report these symptoms to your doctor.
Severe Joint Pain: This medication may cause joint pain that can be severe and debilitating. Contact your doctor immediately if you experience severe joint pain or persistent joint pain.
Low Blood Sugar: This can occur, especially when used with other diabetes medications. Symptoms may include dizziness, headache, feeling sleepy or weak, shaking, rapid heartbeat, confusion, hunger, or sweating. If you experience any of these symptoms, contact your doctor right away. Follow your doctor's instructions for managing low blood sugar, which may include taking glucose tablets, liquid glucose, or certain fruit juices.
Other Possible Side Effects
Most people do not experience significant side effects, but some may occur. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical attention if they bother you or persist:
Common cold symptoms
Nose or throat irritation
Diarrhea or constipation
* Headache
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Allergic Reaction: Rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Fluid and Electrolyte Imbalance: Mood changes, confusion, muscle pain or weakness, abnormal heartbeat, severe dizziness or fainting, increased thirst, seizures, extreme fatigue or weakness, decreased appetite, inability to urinate or changes in urine output, dry mouth, dry eyes, or severe nausea and vomiting.
Pancreatitis (Pancreas Problem): Severe stomach pain, severe back pain, or severe nausea and vomiting.
Kidney Problems: Inability to urinate, changes in urine output, blood in the urine, or sudden weight gain.
Urinary Tract Infection (UTI): Blood in the urine, burning or pain while urinating, frequent or urgent need to urinate, fever, lower abdominal pain, or pelvic pain.
Vaginal Yeast Infection: Itching, unpleasant odor, or discharge. Report these symptoms to your doctor.
Yeast Infection of the Penis: Pain, swelling, rash, or discharge. Report these symptoms to your doctor.
Severe Joint Pain: This medication may cause joint pain that can be severe and debilitating. Contact your doctor immediately if you experience severe joint pain or persistent joint pain.
Low Blood Sugar: This can occur, especially when used with other diabetes medications. Symptoms may include dizziness, headache, feeling sleepy or weak, shaking, rapid heartbeat, confusion, hunger, or sweating. If you experience any of these symptoms, contact your doctor right away. Follow your doctor's instructions for managing low blood sugar, which may include taking glucose tablets, liquid glucose, or certain fruit juices.
Other Possible Side Effects
Most people do not experience significant side effects, but some may occur. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical attention if they bother you or persist:
Common cold symptoms
Nose or throat irritation
Diarrhea or constipation
* Headache
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following conditions to ensure safe treatment:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction you experienced, including the symptoms that occurred.
If you have type 1 diabetes, as this medication is not intended to treat this condition.
Presence of any of the following health issues:
+ Acidic blood problem (acidosis)
+ Kidney disease
+ Liver disease
Recent heart attack or stroke
Inability to eat or drink normally, including situations before undergoing certain procedures or surgery
Upcoming or recent exams or tests involving contrast media (within the past 48 hours)
Current use of rifampin
Pregnancy or potential pregnancy, as this medication should not be taken during the second or third trimester
* Breast-feeding, as you should not breast-feed while taking this medication
This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health problems with your doctor and pharmacist. They will help determine the safety of taking this medication with your other treatments and health conditions. Never start, stop, or adjust the dosage of any medication without consulting your doctor first.
It is essential to inform your doctor about the following conditions to ensure safe treatment:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction you experienced, including the symptoms that occurred.
If you have type 1 diabetes, as this medication is not intended to treat this condition.
Presence of any of the following health issues:
+ Acidic blood problem (acidosis)
+ Kidney disease
+ Liver disease
Recent heart attack or stroke
Inability to eat or drink normally, including situations before undergoing certain procedures or surgery
Upcoming or recent exams or tests involving contrast media (within the past 48 hours)
Current use of rifampin
Pregnancy or potential pregnancy, as this medication should not be taken during the second or third trimester
* Breast-feeding, as you should not breast-feed while taking this medication
This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health problems with your doctor and pharmacist. They will help determine the safety of taking this medication with your other treatments and health conditions. Never start, stop, or adjust the dosage of any medication without consulting your doctor first.
Precautions & Cautions
Important Warnings and Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.
To minimize the risk of dizziness or fainting, rise slowly from a sitting or lying position, and exercise caution when climbing stairs.
Do not operate a vehicle if your blood sugar levels are low, as this increases the risk of accidents.
Before consuming alcohol, consult with your doctor to discuss potential risks and interactions.
Long-term treatment with metformin may lead to decreased vitamin B-12 levels. If you have a history of low vitamin B-12 levels, discuss this with your doctor.
There is a risk of developing a severe and potentially life-threatening pancreas problem (pancreatitis) associated with this medication.
This drug may cause a condition known as ketoacidosis, characterized by excessive acid in the blood or urine. This can be a life-threatening condition requiring hospitalization, even if your blood sugar levels are below 250. Individuals with diabetes, pancreas problems, or those who are sick, dehydrated, or have poor eating habits are at higher risk. Additionally, people on a ketogenic diet, undergoing surgery, or taking insulin with reduced or missed doses are also at increased risk. Monitor your ketone levels as instructed by your doctor, and seek medical attention if you have questions or concerns.
Severe urinary tract infections (UTIs) have been reported with this medication, sometimes requiring hospitalization. Kidney problems may also occur, potentially necessitating hospitalization or dialysis. In rare cases, a life-threatening infection can develop. Seek immediate medical attention if you experience tenderness, redness, or swelling in the genital area, accompanied by fever or general malaise.
A rare skin reaction called bullous pemphigoid has been associated with this medication, sometimes requiring hospitalization. If you develop blisters or notice skin breakdown, contact your doctor promptly.
Heart failure has been reported in individuals taking this medication. If you have a history of heart failure or kidney problems, inform your doctor. Seek medical attention immediately if you experience extreme fatigue, shortness of breath, significant weight gain, or swelling in the arms or legs.
This medication may increase the risk of lower limb amputations, particularly toe and foot amputations. To minimize this risk, discuss foot care with your doctor. If you have a history of amputations, blood vessel disease, nerve disease, or foot ulcers related to diabetes, inform your doctor. Seek medical attention promptly if you experience new pain, tenderness, sores, ulcers, or infections in your legs or feet.
If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects.
Women of childbearing age who have not been ovulating may be at risk of pregnancy. To avoid pregnancy, use birth control while taking this medication.
This medication may harm the unborn baby if taken during pregnancy. If you become pregnant or suspect you may be pregnant while taking this medication, contact your doctor immediately.
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.
To minimize the risk of dizziness or fainting, rise slowly from a sitting or lying position, and exercise caution when climbing stairs.
Do not operate a vehicle if your blood sugar levels are low, as this increases the risk of accidents.
Before consuming alcohol, consult with your doctor to discuss potential risks and interactions.
Long-term treatment with metformin may lead to decreased vitamin B-12 levels. If you have a history of low vitamin B-12 levels, discuss this with your doctor.
There is a risk of developing a severe and potentially life-threatening pancreas problem (pancreatitis) associated with this medication.
This drug may cause a condition known as ketoacidosis, characterized by excessive acid in the blood or urine. This can be a life-threatening condition requiring hospitalization, even if your blood sugar levels are below 250. Individuals with diabetes, pancreas problems, or those who are sick, dehydrated, or have poor eating habits are at higher risk. Additionally, people on a ketogenic diet, undergoing surgery, or taking insulin with reduced or missed doses are also at increased risk. Monitor your ketone levels as instructed by your doctor, and seek medical attention if you have questions or concerns.
Severe urinary tract infections (UTIs) have been reported with this medication, sometimes requiring hospitalization. Kidney problems may also occur, potentially necessitating hospitalization or dialysis. In rare cases, a life-threatening infection can develop. Seek immediate medical attention if you experience tenderness, redness, or swelling in the genital area, accompanied by fever or general malaise.
A rare skin reaction called bullous pemphigoid has been associated with this medication, sometimes requiring hospitalization. If you develop blisters or notice skin breakdown, contact your doctor promptly.
Heart failure has been reported in individuals taking this medication. If you have a history of heart failure or kidney problems, inform your doctor. Seek medical attention immediately if you experience extreme fatigue, shortness of breath, significant weight gain, or swelling in the arms or legs.
This medication may increase the risk of lower limb amputations, particularly toe and foot amputations. To minimize this risk, discuss foot care with your doctor. If you have a history of amputations, blood vessel disease, nerve disease, or foot ulcers related to diabetes, inform your doctor. Seek medical attention promptly if you experience new pain, tenderness, sores, ulcers, or infections in your legs or feet.
If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects.
Women of childbearing age who have not been ovulating may be at risk of pregnancy. To avoid pregnancy, use birth control while taking this medication.
This medication may harm the unborn baby if taken during pregnancy. If you become pregnant or suspect you may be pregnant while taking this medication, contact your doctor immediately.
Drug Interactions
Monitoring
Special Patient Groups
Clinical Information
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure your safety, never share your medication with others or take someone else's medication. This medication is accompanied by a Medication Guide, which provides crucial information. Please read this guide carefully and review it again whenever you receive a refill. If you have any questions or concerns about this medication, we encourage you to discuss them with your doctor, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the substance taken, the amount, and the time it occurred.