Triamcinolone Topical Spray 100gm
It is used to treat skin rashes and other skin irritation.
Drug Class
Anti-inflammatory, Antipruritic
Pharmacologic Class
Corticosteroid (Topical)
Pregnancy Category
Category C
FDA Approved
Aug 1962
DEA Schedule
Not Controlled
Overview
What is this medicine?
Triamcinolone topical spray is a steroid medicine that you spray on your skin to help reduce redness, itching, and swelling caused by certain skin conditions like eczema or psoriasis. It works by calming down your body's natural response to inflammation.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. Use this medication only as directed, and continue to use it even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, avoiding the mouth, nose, and eyes, as it may cause burning.
Wash your hands before and after applying the medication, unless your hand is the treated area, in which case you should not wash it after application.
Clean the affected area before applying the medication, and make sure it is dry.
Apply a thin layer of the medication to the affected skin and gently rub it in.
Avoid applying the medication to the face, underarms, or groin area unless your doctor instructs you to do so.
Do not use bandages, dressings, or other coverings unless your doctor advises you to do so.
If the treated area is in the diaper region, avoid using tight-fitting diapers or plastic pants, as this may increase the amount of medication absorbed into the body.
Do not use this medication to treat diaper rash.
Avoid applying the medication to cuts, scrapes, or damaged skin.
Before use, shake the medication well.
Storage and Disposal
Store the medication at room temperature, avoiding freezing.
Protect the medication from heat and open flames.
Do not puncture or burn the medication, even if it appears to be empty.
Keep all medications in a safe location, out of the reach of children and pets.
Missed Dose
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next dose, skip the missed dose and resume your regular schedule.
* Do not apply two doses at the same time or use extra doses.
To use this medication correctly, follow your doctor's instructions and read all the information provided. Use this medication only as directed, and continue to use it even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, avoiding the mouth, nose, and eyes, as it may cause burning.
Wash your hands before and after applying the medication, unless your hand is the treated area, in which case you should not wash it after application.
Clean the affected area before applying the medication, and make sure it is dry.
Apply a thin layer of the medication to the affected skin and gently rub it in.
Avoid applying the medication to the face, underarms, or groin area unless your doctor instructs you to do so.
Do not use bandages, dressings, or other coverings unless your doctor advises you to do so.
If the treated area is in the diaper region, avoid using tight-fitting diapers or plastic pants, as this may increase the amount of medication absorbed into the body.
Do not use this medication to treat diaper rash.
Avoid applying the medication to cuts, scrapes, or damaged skin.
Before use, shake the medication well.
Storage and Disposal
Store the medication at room temperature, avoiding freezing.
Protect the medication from heat and open flames.
Do not puncture or burn the medication, even if it appears to be empty.
Keep all medications in a safe location, out of the reach of children and pets.
Missed Dose
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next dose, skip the missed dose and resume your regular schedule.
* Do not apply two doses at the same time or use extra doses.
Lifestyle & Tips
- Use exactly as directed by your doctor. Do not use more often or for longer than prescribed.
- Shake the spray well before each use.
- Hold the spray nozzle about 3 to 6 inches from the affected skin area and spray lightly. Do not spray directly into your face or eyes.
- Avoid contact with eyes, mouth, and nose. If contact occurs, rinse thoroughly with water.
- Do not use on the face, groin, or armpits unless specifically directed by your doctor.
- Do not cover the treated area with bandages or other dressings unless instructed by your doctor, as this can increase absorption and side effects.
- Wash your hands before and after applying the medication.
- Keep out of reach of children.
Available Forms & Alternatives
Available Strengths:
- Triamcinolone 0.5% Cream 15gm
- Triamcinolone 0.5% Oint 15gm
- Triamcinolone 0.025% Ointment 15gm
- Triamcinolone 0.025% Ointment 80gm
- Triamcinolone 0.025% Cream 15gm
- Triamcinolone 0.1% Cream 30gm
- Triamcinolone 0.1% Cream 15gm
- Triamcinolone 0.025% Cream 454gm
- Triamcinolone 0.1% Ointment 15gm
- Triamcinolone 0.1% Cream 80gm
- Triamcinolone 0.1% Ointment 80gm
- Triamcinolone 0.1% Ointment 454gm
- Triamcinolone 0.1% Cream 454gm
- Triamcinolone 0.025% Ointment 454gm
- Triamcinolone 0.1% Ointment 15gm
- Triamcinolone 0.025% Cream 80gm
- Triamcinolone 0.1% Ointment 80gm
- Triamcinolone Topical Spray 100gm
- Triamcinolone Topical Spray 63gm
- Triamcinolone 0.1% Lotion 60ml
- Triamcinolone 0.1% Ointment 15gm
- Triamcinolone 0.1% Ointment 30gm
- Triamcinolone 55mcg Nasalsp (120)
- Triamcinolone Ace 40mg/ml, 1ml
- Triamcinolone Topical Spray 63gm
- Triamcinolone Topical Spray 100gm
- Triamcinolone Ace 40mg/ml Inj, 10ml
- Triamcinolone Ace 0.05% Oint 430gm
- Triamcinolone Ace 40mg/ml, 5ml
- Triamcin Ace 40mg/ml Inj, 10ml
- Triamcinolone 0.1% Lotion 60ml
- Triamcinolone 0.025% Lotion 60ml
- Triamcinolone 400mg/10ml Inj, 10ml
- Triamcinolone 0.1% Ointment 454gm
Dosing & Administration
Adult Dosing
Standard Dose:
Apply sparingly to the affected area 2 to 4 times daily.
Condition-Specific Dosing:
general:
Apply a thin film to the affected skin area and rub in gently. Do not use occlusive dressings unless directed by a physician.
Pediatric Dosing
Neonatal:
Not established
Infant:
Apply sparingly to the affected area 2 to 4 times daily. Use with caution due to higher surface area to body weight ratio and increased risk of systemic absorption.
Child:
Apply sparingly to the affected area 2 to 4 times daily. Use with caution due to higher surface area to body weight ratio and increased risk of systemic absorption.
Adolescent:
Apply sparingly to the affected area 2 to 4 times daily.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed for topical use.
Moderate:
No adjustment needed for topical use.
Severe:
No adjustment needed for topical use.
Dialysis:
No specific considerations for topical use, as systemic absorption is minimal.
Hepatic Impairment:
Mild:
No adjustment needed for topical use.
Moderate:
No adjustment needed for topical use.
Severe:
No adjustment needed for topical use.
Pharmacology
Mechanism of Action
Triamcinolone acetonide is a synthetic corticosteroid that possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. It acts by inducing phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Pharmacokinetics
Absorption:
Bioavailability:
Not applicable (topical); systemic absorption is minimal but can occur, especially with inflamed skin, prolonged use, large surface areas, or occlusive dressings. Percutaneous absorption varies from <1% to 5%.
Tmax:
Not applicable (topical); if systemic absorption occurs, peak plasma levels are generally very low and variable.
FoodEffect:
Not applicable
Distribution:
Vd:
Not available (for topical absorption)
ProteinBinding:
Not available (for topical absorption); if absorbed systemically, corticosteroids are bound to plasma proteins to varying degrees.
CnssPenetration:
Limited (if systemic absorption occurs)
Elimination:
HalfLife:
Not available (for topical absorption); systemic half-life of absorbed triamcinolone is approximately 2-5 hours.
Clearance:
Not available (for topical absorption)
ExcretionRoute:
Renal (if absorbed systemically)
Unchanged:
Not available (for topical absorption)
Pharmacodynamics
OnsetOfAction:
Hours to days (for symptomatic relief)
PeakEffect:
Days to weeks (with consistent application)
DurationOfAction:
Varies with frequency of application and severity of condition
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Signs of high blood sugar: confusion, drowsiness, unusual thirst or hunger, frequent urination, flushing, rapid breathing, or fruity-smelling breath.
Signs of a weak adrenal gland: severe nausea or vomiting, severe dizziness or fainting, muscle weakness, extreme fatigue, mood changes, decreased appetite, or weight loss.
Signs of Cushing's syndrome: weight gain in the upper back or abdomen, moon face, severe headache, or slow wound healing.
Irritation at the site of application.
Skin changes, such as acne, stretch marks, slow healing, or excessive hair growth.
Changes in skin color.
Thinning of the skin.
Other Possible Side Effects
Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you experience any of the following side effects or any other symptoms that concern you or do not go away, contact your doctor:
Burning sensation.
Itching.
* Dry skin.
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Signs of high blood sugar: confusion, drowsiness, unusual thirst or hunger, frequent urination, flushing, rapid breathing, or fruity-smelling breath.
Signs of a weak adrenal gland: severe nausea or vomiting, severe dizziness or fainting, muscle weakness, extreme fatigue, mood changes, decreased appetite, or weight loss.
Signs of Cushing's syndrome: weight gain in the upper back or abdomen, moon face, severe headache, or slow wound healing.
Irritation at the site of application.
Skin changes, such as acne, stretch marks, slow healing, or excessive hair growth.
Changes in skin color.
Thinning of the skin.
Other Possible Side Effects
Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you experience any of the following side effects or any other symptoms that concern you or do not go away, contact your doctor:
Burning sensation.
Itching.
* Dry skin.
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Worsening of your skin condition or no improvement after 2 weeks.
- Signs of a skin infection (e.g., increased redness, swelling, pain, pus).
- Severe burning, itching, or irritation at the application site.
- Unusual weight gain, swelling in your face or ankles, increased thirst or urination (signs of possible systemic absorption).
- Blurred vision or other vision problems.
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as they may affect the safety and efficacy of this medication.
To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to determine the best course of treatment for you.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor assess potential interactions between this medication and other substances you are taking.
* Any health problems you have, as they may affect the safety and efficacy of this medication.
To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to determine the best course of treatment for you.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Adhere to the prescribed duration of use, as specified by your doctor, and avoid using it for an extended period.
Before using any other medications or products on your skin, including soaps, consult with your doctor to ensure safe use. Exercise caution when applying this medication to a large area of skin, and discuss any concerns with your doctor.
Using this medication too frequently can exacerbate your skin condition. Be aware that this medication is flammable, so avoid using it near open flames or while smoking. Inhaling the vapors is also not recommended.
When using this medication in children, exercise caution, as the risk of certain side effects may be higher in this population. In some cases, this medication may affect growth in children and teenagers, and regular growth checks may be necessary. Consult with your doctor to discuss this potential risk.
If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor, as they will need to weigh the benefits and risks of using this medication to ensure the well-being of both you and your baby.
Before using any other medications or products on your skin, including soaps, consult with your doctor to ensure safe use. Exercise caution when applying this medication to a large area of skin, and discuss any concerns with your doctor.
Using this medication too frequently can exacerbate your skin condition. Be aware that this medication is flammable, so avoid using it near open flames or while smoking. Inhaling the vapors is also not recommended.
When using this medication in children, exercise caution, as the risk of certain side effects may be higher in this population. In some cases, this medication may affect growth in children and teenagers, and regular growth checks may be necessary. Consult with your doctor to discuss this potential risk.
If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor, as they will need to weigh the benefits and risks of using this medication to ensure the well-being of both you and your baby.
Overdose Information
Overdose Symptoms:
- Prolonged or excessive use can lead to systemic side effects, including Cushing's syndrome (e.g., moon face, central obesity, thinning skin, easy bruising), adrenal suppression, hyperglycemia, and growth retardation in children.
What to Do:
If you suspect an overdose or significant systemic absorption, contact your doctor or a poison control center immediately. Call 1-800-222-1222. Treatment is supportive and may involve gradual withdrawal of the medication.
Drug Interactions
Monitoring
Baseline Monitoring
Skin assessment
Rationale: To evaluate the severity and extent of the dermatological condition and identify any pre-existing skin damage or infection.
Timing: Prior to initiation of therapy
Routine Monitoring
Local skin reactions (e.g., atrophy, striae, telangiectasias, burning, itching, irritation)
Frequency: Regularly during treatment, especially with prolonged use
Target: Absence of severe reactions
Action Threshold: If severe reactions occur, discontinue use and reassess treatment.
Signs of infection (e.g., redness, pus, warmth, fever)
Frequency: Regularly during treatment
Target: Absence of infection
Action Threshold: If infection develops, discontinue triamcinolone and initiate appropriate antimicrobial therapy.
Signs of systemic corticosteroid effects (e.g., Cushing's syndrome, adrenal suppression, hyperglycemia, growth retardation in children)
Frequency: Periodically, especially with prolonged use, large surface areas, or occlusive dressings
Target: Absence of systemic effects
Action Threshold: If systemic effects are suspected, evaluate HPA axis suppression and consider gradual withdrawal or reduction of dose.
Symptom Monitoring
- Worsening of skin condition
- Increased redness, swelling, or pain at application site
- Pus or discharge from skin lesions
- Unusual weight gain or swelling (especially in face/neck)
- Increased thirst or urination
- Fatigue or weakness
- Slowed growth in children
Special Patient Groups
Pregnancy
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Systemic absorption is minimal, but animal studies have shown corticosteroids to be teratogenic.
Trimester-Specific Risks:
First Trimester:
Potential for teratogenicity, though risk with topical use is low.
Second Trimester:
Generally considered safer than first trimester, but still use with caution.
Third Trimester:
Risk of adrenal suppression in the neonate if used extensively or for prolonged periods near term.
Lactation
Use with caution. It is not known whether topical triamcinolone is excreted in human milk. Systemic absorption is minimal, so infant exposure is likely low. Avoid applying to the breast area to prevent direct infant ingestion.
Infant Risk:
Low risk with proper use, but monitor infant for any unusual effects.
Pediatric Use
Pediatric patients may be more susceptible to systemic toxicity from topical corticosteroids due to their larger skin surface area to body weight ratio. Adrenal suppression, Cushing's syndrome, and intracranial hypertension have been reported. Use the lowest effective dose for the shortest duration possible. Monitor growth and development.
Geriatric Use
No specific dosage adjustments are typically needed. However, geriatric patients may have thinner skin, which could potentially increase the risk of local side effects like skin atrophy or purpura. Monitor for these effects.
Clinical Information
Clinical Pearls
- Topical triamcinolone is a medium-potency corticosteroid. Its potency can be increased by occlusive dressings, which should only be used under medical supervision.
- Advise patients to apply a thin layer and rub it in gently. Excessive application does not improve efficacy but increases the risk of side effects.
- Educate patients on the signs of local side effects (e.g., skin thinning, stretch marks, easy bruising) and systemic absorption (e.g., weight gain, swelling).
- Not intended for long-term continuous use, especially on sensitive areas like the face, groin, or axillae, due to risk of skin atrophy and other side effects.
- If no improvement is seen after 2 weeks, the diagnosis should be re-evaluated.
Alternative Therapies
- Topical calcineurin inhibitors (e.g., tacrolimus, pimecrolimus) for steroid-sparing therapy
- Emollients and moisturizers for dry skin conditions
- Antihistamines for pruritus
- Phototherapy for certain chronic skin conditions (e.g., psoriasis)
- Systemic immunomodulators for severe conditions
Cost & Coverage
Average Cost:
Varies, typically $20-$100+ per 100gm spray
Generic Available:
Yes
Insurance Coverage:
Tier 1 or Tier 2 (Generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide details about the medication taken, the amount, and the time it occurred.