Tigan 300mg Capsules

Trimethobenzamide is an antiemetic agent that primarily acts on the chemoreceptor trigger zone (CTZ) in the medulla oblongata. It blocks emetic impulses from reaching the vomiting center, thereby inhibiting nausea and vomiting. Its exact mechanism of action is not fully elucidated but is thought to involve antagonism of dopamine D2 receptors in the CTZ, although it is not a phenothiazine derivative.

Serious Side Effects: Seek Medical Attention Immediately

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of liver problems, including:
+ Dark urine
+ Tiredness
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Severe dizziness or fainting
Shakiness, difficulty moving, or stiffness
Trouble controlling body movements, twitching, changes in balance, or difficulty swallowing or speaking
Muscle spasms
Muscle cramps
Restlessness
Blurred vision
Depression
Seizures
Confusion
Fever, chills, or sore throat
Unexplained bruising or bleeding
Feeling extremely tired or weak

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:

Diarrhea
Dizziness or drowsiness
Headache

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances. Be sure to describe the allergic reaction and its symptoms.
If you have liver disease, as this may affect the medication's safety and efficacy.
If you are taking any medications that may increase the risk of involuntary body movements. There are numerous medications that can cause this side effect, so consult your doctor or pharmacist if you are unsure.

Please note that this is not an exhaustive list of all potential interactions between this medication and other substances. To ensure your safety, it is crucial to:

Inform your doctor and pharmacist about all medications you are taking, including prescription and over-the-counter medications, natural products, and vitamins.
Discuss all your health problems with your doctor and pharmacist to verify that it is safe to take this medication in conjunction with your other medications and health conditions.
Never start, stop, or change the dosage of any medication without first consulting your doctor to avoid potential interactions or adverse effects.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

To ensure your safety, avoid operating a vehicle or engaging in activities that require alertness until you understand how this medication affects you. Additionally, refrain from consuming alcohol while taking this drug, as it may exacerbate its effects.

Before using marijuana, other forms of cannabis, or any prescription or over-the-counter (OTC) medications that may cause drowsiness or impair your reactions, consult with your doctor to discuss potential interactions.

If you are 65 years or older, exercise caution when taking this medication, as you may be more susceptible to experiencing side effects.

If you are pregnant, planning to become pregnant, or are breast-feeding, notify your doctor. It is crucial to discuss the potential benefits and risks of this medication to both you and your baby.

This medication is not approved for use in children, as it may increase the risk of severe side effects. If your child has been prescribed this drug, consult with their doctor to understand the benefits and risks associated with its use. If you have any questions or concerns about administering this medication to your child, discuss them with their doctor.

• Phenothiazines (e.g., prochlorperazine, promethazine): Increased risk of extrapyramidal symptoms (EPS) and other CNS side effects.
• Other CNS depressants (e.g., opioids, benzodiazepines, sedatives, hypnotics, general anesthetics): Additive CNS depression, including drowsiness and respiratory depression.

• Alcohol: Additive CNS depression.
• Anticholinergic drugs: May potentiate anticholinergic effects.

• Dizziness
• Drowsiness
• Headache
• Diarrhea
• Constipation
• Muscle cramps
• Blurred vision
• Rash
• Uncontrolled muscle movements (e.g., tremor, rigidity, restlessness)

Category C. Trimethobenzamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans.

Trimethobenzamide is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Contraindicated in neonates. Not recommended for use in children and adolescents, especially those with viral illnesses (e.g., chickenpox, flu-like symptoms), due to the potential association with Reye's syndrome and increased risk of CNS side effects (e.g., seizures, extrapyramidal symptoms).

Elderly patients may be more susceptible to the CNS side effects (e.g., drowsiness, dizziness, confusion) and extrapyramidal symptoms. Use with caution and consider starting with lower doses.

• Trimethobenzamide is generally less effective for motion sickness compared to other antiemetics.
• It is often used when other antiemetics are contraindicated or have failed, particularly for postoperative nausea and vomiting or nausea associated with gastroenteritis.
• Patients should be advised to avoid activities requiring mental alertness until they know how the drug affects them.
• The risk of Reye's syndrome in children is a significant concern, making its use in this population generally contraindicated.

• Ondansetron (Zofran)
• Promethazine (Phenergan)
• Prochlorperazine (Compazine)
• Metoclopramide (Reglan)
• Dimenhydrinate (Dramamine)
• Meclizine (Antivert)

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide details about the medication taken, the amount, and the time it occurred.