Trimethobenzamide 300mg Capsules

Trimethobenzamide is an antiemetic agent that acts primarily on the chemoreceptor trigger zone (CTZ) in the medulla oblongata. It is thought to block emetic impulses by inhibiting dopamine receptors in the CTZ, thereby reducing the sensitivity of the CTZ to emetogenic stimuli. It has weak antihistaminic and anticholinergic properties.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. Immediately contact your doctor or seek medical attention if you experience any of the following symptoms:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of liver problems, including:
+ Dark urine
+ Tiredness
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Severe dizziness or fainting
Shakiness, difficulty moving, or stiffness
Trouble controlling body movements, twitching, balance problems, or difficulty swallowing or speaking
Muscle spasms
Muscle cramps
Restlessness
Blurred vision
Depression
Seizures
Confusion
Fever, chills, or sore throat
Unexplained bruising or bleeding
Feeling extremely tired or weak

Other Possible Side Effects

Like all medications, this drug can cause side effects. Although many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience any of the following side effects or if they persist or bother you:

Diarrhea
Dizziness or drowsiness
Headache

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
If you have liver disease, as this may affect how your body processes the medication.
If you are taking any medications that may increase the risk of involuntary body movements. There are numerous drugs that can cause this side effect, so it is crucial to ask your doctor or pharmacist if you are unsure.

Please note that this is not an exhaustive list of all potential interactions between this medication and other substances. To ensure your safety, it is vital to:

Inform your doctor and pharmacist about all the medications you are taking, including prescription and over-the-counter drugs, natural products, and vitamins.
Share any health problems you have, as these may interact with the medication.
Verify that it is safe to take this medication with all your other medications and health conditions before starting, stopping, or changing the dose of any drug. Always consult your doctor before making any changes to your medication regimen.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Until you understand how this drug affects you, avoid operating a vehicle and engaging in other activities that require alertness. Additionally, refrain from consuming alcohol while taking this medication.

Before using marijuana, other forms of cannabis, or prescription or over-the-counter (OTC) drugs that may cause drowsiness or slow your reactions, consult with your doctor. If you are 65 years or older, exercise caution when using this medication, as you may be more susceptible to side effects.

If you are pregnant, planning to become pregnant, or are breast-feeding, discuss the potential benefits and risks to you and your baby with your doctor. This medication is not approved for use in children, as it may increase the risk of severe side effects. If your child has been prescribed this drug, consult with their doctor to understand the benefits and risks associated with its use. If you have any questions or concerns about giving this medication to your child, be sure to discuss them with their doctor.

• CNS depressants (e.g., alcohol, opioids, sedatives, hypnotics, tranquilizers)
• Phenothiazines (e.g., prochlorperazine, promethazine)

• Anticholinergic drugs (e.g., tricyclic antidepressants, antihistamines with anticholinergic effects)

• Drowsiness
• Dizziness
• Headache
• Diarrhea
• Constipation
• Blurred vision
• Muscle cramps/spasms
• Tremors
• Rash
• Hives
• Difficulty breathing or swallowing (signs of allergic reaction)

Trimethobenzamide is Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans.

It is not known whether trimethobenzamide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when trimethobenzamide is administered to a nursing woman.

Contraindicated in neonates and premature infants due to potential for respiratory depression and CNS effects. Use with caution in children, especially those with acute illnesses (e.g., viral infections, dehydration) due to increased risk of extrapyramidal symptoms and CNS effects. Dosing is weight-based for children.

Elderly patients may be more susceptible to the adverse effects of trimethobenzamide, particularly CNS effects (drowsiness, dizziness, confusion) and anticholinergic effects (e.g., urinary retention, constipation). Use with caution, and consider lower starting doses.

• Trimethobenzamide is generally considered a weaker antiemetic compared to some newer agents, but can be useful for mild to moderate nausea and vomiting.
• It is primarily effective for nausea and vomiting due to its action on the CTZ, rather than direct action on the GI tract.
• Avoid use in patients with known hypersensitivity to trimethobenzamide or any of its components.
• Caution should be exercised in patients with acute febrile illness, encephalitis, gastroenteritis, or dehydration, especially in children, as these conditions may increase the risk of extrapyramidal symptoms.
• Patients should be advised to avoid activities requiring mental alertness until the drug's effects are known.

• Ondansetron (5-HT3 receptor antagonist)
• Promethazine (Phenothiazine, H1-antihistamine)
• Prochlorperazine (Phenothiazine, dopamine receptor antagonist)
• Metoclopramide (Dopamine receptor antagonist, prokinetic)
• Dimenhydrinate (Antihistamine)
• Meclizine (Antihistamine)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it is a good idea to check with your pharmacist for more information. If you have any questions or concerns about your medication, do not hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.