Prevident 5000 Bst Plus Paste/fruit
This supplement is used to prevent cavities.
Drug Class
Dental Caries Prophylactic
Pharmacologic Class
Fluoride Agent; Remineralizing Agent
Pregnancy Category
Category B
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Prevident 5000 Bst Plus is a prescription-strength toothpaste containing a high concentration of fluoride. It works by strengthening your tooth enamel, making it more resistant to acid attacks from bacteria and food, and helping to repair early signs of tooth decay. This helps prevent cavities, especially if you are at high risk for them.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication properly, follow your doctor's instructions and read all accompanying information carefully. Replace your regular toothpaste with this medication unless your doctor advises otherwise. Brush your teeth as directed, then spit out the medication. It is essential not to swallow this drug. After using the medication, wait at least 30 minutes before eating, drinking, or rinsing your mouth.
Storing and Disposing of Your Medication
Store this medication at room temperature, keeping it in a secure location that is out of reach of children and pets. When disposing of unused or expired medication, do not flush it down the toilet or pour it down the drain unless instructed to do so. If you are unsure about the proper disposal method, consult your pharmacist. You may also want to inquire about drug take-back programs available in your area.
Managing Missed Doses
If you miss a dose, use it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not use two doses at the same time or take extra doses to make up for the missed one.
To use this medication properly, follow your doctor's instructions and read all accompanying information carefully. Replace your regular toothpaste with this medication unless your doctor advises otherwise. Brush your teeth as directed, then spit out the medication. It is essential not to swallow this drug. After using the medication, wait at least 30 minutes before eating, drinking, or rinsing your mouth.
Storing and Disposing of Your Medication
Store this medication at room temperature, keeping it in a secure location that is out of reach of children and pets. When disposing of unused or expired medication, do not flush it down the toilet or pour it down the drain unless instructed to do so. If you are unsure about the proper disposal method, consult your pharmacist. You may also want to inquire about drug take-back programs available in your area.
Managing Missed Doses
If you miss a dose, use it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not use two doses at the same time or take extra doses to make up for the missed one.
Lifestyle & Tips
- Use as directed by your dentist or physician, typically once daily at bedtime.
- Brush thoroughly for at least one minute.
- Spit out the toothpaste completely after brushing. DO NOT SWALLOW.
- Do not rinse your mouth, eat, or drink for at least 30 minutes after brushing to allow the fluoride to work effectively.
- Keep out of reach of children, especially those under 6 years old, to prevent accidental ingestion.
- Maintain good oral hygiene practices, including regular brushing, flossing, and dental check-ups.
Available Forms & Alternatives
Available Strengths:
- Prevident Gel Mint 56.6gm
- Prevident 1.1% Gel Berry 56.6gm
- Prevident 5000plus Cream(spearmint)
- Prevident 5000 Plus Cream (fruit)
- Prevident 5000 Sensitive Paste Mint
- Prevident 5000 Dry Mouthmint Paste
- Prevident 5000 Enamel Mint Paste
- Prevident 5000 Bstr Plus Paste/mint
- Prevident 5000 Bst Plus Paste/fruit
- Prevident 0.2% Solution 473ml
Dosing & Administration
Adult Dosing
Standard Dose:
Apply a thin ribbon (pea-sized amount) to a toothbrush and brush thoroughly once daily for at least one minute, preferably at bedtime. Spit out after brushing. Do not rinse, eat, or drink for 30 minutes.
Condition-Specific Dosing:
dental_caries_prophylaxis:
Once daily, preferably at bedtime.
Pediatric Dosing
Neonatal:
Not established
Infant:
Not established
Child:
Children 6 years and older: Apply a thin ribbon (pea-sized amount) to a toothbrush and brush thoroughly once daily for at least one minute, preferably at bedtime. Spit out after brushing. Do not rinse, eat, or drink for 30 minutes. Supervise children to minimize swallowing.
Adolescent:
Same as adult dosing.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed for topical use.
Moderate:
No adjustment needed for topical use.
Severe:
No adjustment needed for topical use. Caution with significant ingestion due to renal excretion of absorbed fluoride.
Dialysis:
No adjustment needed for topical use. Caution with significant ingestion.
Hepatic Impairment:
Mild:
No adjustment needed.
Moderate:
No adjustment needed.
Severe:
No adjustment needed.
Pharmacology
Mechanism of Action
Fluoride acts primarily topically to prevent dental caries. It incorporates into the enamel structure, forming fluorapatite, which is more resistant to acid demineralization than hydroxyapatite. It also inhibits bacterial enzymes involved in glycolysis, thereby reducing acid production by oral bacteria. Furthermore, fluoride promotes remineralization of early carious lesions by attracting calcium and phosphate ions to the tooth surface.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption from topical application to intact oral mucosa. If ingested, rapidly absorbed from the gastrointestinal tract (up to 90%).
Tmax:
30-60 minutes (if ingested)
FoodEffect:
Calcium, magnesium, and aluminum-containing products (e.g., dairy, antacids) can reduce absorption if ingested.
Distribution:
Vd:
Not applicable for topical use; if absorbed, rapidly distributed to extracellular fluid.
ProteinBinding:
Low (approximately 5-10%)
CnssPenetration:
Limited
Elimination:
HalfLife:
2-9 hours (plasma half-life; longer in bone)
Clearance:
Primarily renal clearance
ExcretionRoute:
Renal (urine)
Unchanged:
Nearly 100% of absorbed fluoride is excreted unchanged.
Pharmacodynamics
OnsetOfAction:
Immediate local effect on tooth surface upon application.
PeakEffect:
Continuous effect with regular use.
DurationOfAction:
Local effect persists on tooth surface until removed by brushing/saliva; systemic effect if ingested is transient.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
If you experience any of the following symptoms, call your doctor immediately or seek emergency medical attention, as they may be signs of a severe and potentially life-threatening reaction:
Allergic reaction symptoms, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Difficulty breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe stomach upset or vomiting
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or do not go away, contact your doctor for advice:
Note: This list is not exhaustive, and you may experience other side effects not mentioned here. If you have questions or concerns about side effects, consult your doctor.
Reporting Side Effects
To report side effects, you can:
Call your doctor for medical advice
Contact the FDA at 1-800-332-1088
* Submit a report online at https://www.fda.gov/medwatch
If you experience any of the following symptoms, call your doctor immediately or seek emergency medical attention, as they may be signs of a severe and potentially life-threatening reaction:
Allergic reaction symptoms, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Difficulty breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe stomach upset or vomiting
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or do not go away, contact your doctor for advice:
Note: This list is not exhaustive, and you may experience other side effects not mentioned here. If you have questions or concerns about side effects, consult your doctor.
Reporting Side Effects
To report side effects, you can:
Call your doctor for medical advice
Contact the FDA at 1-800-332-1088
* Submit a report online at https://www.fda.gov/medwatch
Seek Immediate Medical Attention If You Experience:
- Nausea, vomiting, or stomach upset (if swallowed)
- Diarrhea (if swallowed)
- Headache (rare)
- Skin rash (rare)
- White, yellow, or brown spots on teeth (signs of fluorosis, especially in children)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced.
Certain health conditions, including:
+ Bone problems
+ Joint problems
+ Kidney problems
+ Ulcers
The level of fluoride in your drinking water, particularly if it is greater than or equal to 0.6 parts per million.
Additionally, to ensure safe use, provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter medications you are taking
Natural products and vitamins you are using
Any existing health problems
This information will help your doctor determine if it is safe for you to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced.
Certain health conditions, including:
+ Bone problems
+ Joint problems
+ Kidney problems
+ Ulcers
The level of fluoride in your drinking water, particularly if it is greater than or equal to 0.6 parts per million.
Additionally, to ensure safe use, provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter medications you are taking
Natural products and vitamins you are using
Any existing health problems
This information will help your doctor determine if it is safe for you to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you notice any staining or spotting on your teeth, be sure to mention this to your dentist. Regular dental care is crucial, so schedule frequent dental check-ups to maintain good oral health.
In the event of accidental ingestion of a large amount of this medication, seek immediate medical attention by calling a doctor or a poison control center. Note that different brands of this medication may be suitable for children of various ages, so it is crucial to consult with your doctor before administering this drug to a child.
If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor. You and your doctor will need to discuss the potential benefits and risks of this medication to both you and your baby to make an informed decision.
In the event of accidental ingestion of a large amount of this medication, seek immediate medical attention by calling a doctor or a poison control center. Note that different brands of this medication may be suitable for children of various ages, so it is crucial to consult with your doctor before administering this drug to a child.
If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor. You and your doctor will need to discuss the potential benefits and risks of this medication to both you and your baby to make an informed decision.
Overdose Information
Overdose Symptoms:
- Acute toxicity (if large amounts are ingested): Nausea, vomiting, abdominal pain, salivation, diarrhea, weakness, tremors, convulsions, cardiac arrhythmias, and potentially death.
- Chronic toxicity (fluorosis): Dental fluorosis (mottling, discoloration, or pitting of tooth enamel) from excessive fluoride intake during tooth development; skeletal fluorosis (bone pain, stiffness, joint calcification) from very high chronic intake.
What to Do:
For acute ingestion, immediately seek emergency medical attention or call a Poison Control Center (1-800-222-1222). Induce vomiting if advised by medical professional. Administer calcium (e.g., milk, calcium gluconate) to bind fluoride. For chronic fluorosis, discontinue fluoride source and consult a dentist/physician.
Drug Interactions
Monitoring
Baseline Monitoring
Dental examination
Rationale: To assess oral health, identify existing caries, and determine the need for high-concentration fluoride.
Timing: Prior to initiation of therapy.
Routine Monitoring
Oral hygiene practices
Frequency: At each dental visit (typically every 6-12 months)
Target: Effective brushing and spitting habits.
Action Threshold: Poor compliance or swallowing of toothpaste requires re-education.
Signs of dental fluorosis (especially in children)
Frequency: At each dental visit
Target: Absence of white/brown mottling or pitting of enamel.
Action Threshold: Presence of fluorosis may indicate excessive fluoride intake and require re-evaluation of fluoride regimen.
Symptom Monitoring
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Salivation
- Weakness
- Headache
- Skin rash (rare)
- Signs of dental fluorosis (white, yellow, or brown discoloration, or pitting of tooth enamel)
Special Patient Groups
Pregnancy
Generally considered safe for topical use during pregnancy. Systemic absorption is minimal. Consult with a healthcare provider.
Trimester-Specific Risks:
First Trimester:
Low risk with topical use.
Second Trimester:
Low risk with topical use.
Third Trimester:
Low risk with topical use.
Lactation
Generally considered safe for topical use during lactation. Minimal systemic absorption means negligible amounts are transferred into breast milk. Infant risk is low.
Infant Risk:
Low
Pediatric Use
Use in children under 6 years old is generally not recommended due to the risk of dental fluorosis from accidental ingestion. For children 6 years and older, use a pea-sized amount and supervise brushing to ensure the child spits out the toothpaste and does not swallow it. Excessive fluoride intake during tooth development can lead to dental fluorosis.
Geriatric Use
No specific dose adjustments are needed. Beneficial for older adults, especially those with root caries or xerostomia (dry mouth) which increases caries risk.
Clinical Information
Clinical Pearls
- Prevident 5000 Bst Plus is a prescription-strength fluoride toothpaste, not a regular over-the-counter product. It's intended for individuals at high risk of dental caries.
- Emphasize the importance of spitting out the toothpaste and not rinsing, eating, or drinking for 30 minutes after use to maximize fluoride's topical effect.
- Educate patients, especially parents, about the risk of dental fluorosis if children swallow excessive amounts of fluoride during tooth development.
- This product is a supplement to, not a replacement for, good oral hygiene practices like regular brushing, flossing, and dental check-ups.
Alternative Therapies
- Other high-concentration fluoride toothpastes (e.g., Clinpro 5000, Fluoridex Daily Defense)
- Fluoride varnishes (e.g., Duraphat, Vanish)
- Fluoride gels (e.g., Phos-Flur, Gel-Kam)
- Fluoride rinses (e.g., ACT Fluoride Rinse, Listerine Smart Rinse)
- Non-fluoride remineralizing agents (e.g., products containing amorphous calcium phosphate (ACP) or casein phosphopeptide-amorphous calcium phosphate (CPP-ACP))
- Silver diamine fluoride (SDF) for arresting caries
Cost & Coverage
Average Cost:
$15 - $30 per 112g tube
Generic Available:
Yes
Insurance Coverage:
Often covered by dental insurance plans or eligible for FSA/HSA. May require prescription.
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the medication taken, the amount, and the time it occurred.