Onyda XR 0.1mg/ml Oral Susp 60ml

Clonidine is a centrally acting alpha-2 adrenergic agonist. It stimulates alpha-2 adrenergic receptors in the brain, resulting in reduced sympathetic outflow from the central nervous system. This leads to a decrease in peripheral vascular resistance, heart rate, and blood pressure. In ADHD, its mechanism is thought to involve modulation of noradrenergic activity in the prefrontal cortex, improving attention and reducing impulsivity/hyperactivity.

Urgent Side Effects: Seek Medical Help Right Away
If your child experiences any of the following symptoms, contact their doctor or seek medical attention immediately, as they may be signs of a severe and potentially life-threatening reaction:
- Allergic reaction symptoms, such as rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat
- Severe dizziness or fainting
- Abnormal heart rhythms, including fast, slow, or irregular heartbeat

Other Possible Side Effects
Like all medications, this drug can cause side effects. While many children may not experience any side effects or only minor ones, it's essential to monitor your child's response to the medication. Contact your child's doctor if any of the following side effects bother your child or persist:
- Constipation
- Dry mouth
- Dizziness, sleepiness, tiredness, or weakness
- Headache
- Upset stomach
- Difficulty sleeping
- Bad dreams
- Decreased appetite
- Stomach pain
- Irritability

Remember: This list does not include all possible side effects. If you have concerns about side effects or any questions, consult your child's doctor for personalized advice and guidance.

Before Your Child Takes This Medication: Inform Your Doctor If:
- Your child has an allergy to this medication, any of its components, or any other medications, foods, or substances. Describe the allergy and the symptoms it caused.
- Your child is currently taking another medication that contains the same active ingredient as this drug.
- Your child is taking any of the following medications: digoxin, diltiazem, verapamil, or beta blockers such as metoprolol or propranolol.
Note: This list does not include all possible medications or health issues that may interact with this drug.

It is essential to inform your doctor and pharmacist about all medications your child is taking, including prescription and over-the-counter drugs, natural products, and vitamins, as well as any health problems they may have. This information is necessary to ensure the safe use of this medication with your child's other medications and health conditions. Never start, stop, or change the dosage of any medication your child is taking without first consulting with their doctor.

It is essential to inform all of your child's healthcare providers, including doctors, nurses, pharmacists, and dentists, that your child is taking this medication.

Until you understand how this medication affects your child, it is crucial to have them avoid activities that require alertness, such as riding a bike, playing sports, or using potentially hazardous items like scissors, lawnmowers, electric scooters, toy cars, or motorized vehicles.

As directed by the doctor, regularly monitor your child's blood pressure and heart rate to ensure their safety while taking this medication.

To minimize the risk of dizziness or fainting, instruct your child to rise slowly from a sitting or lying down position. Additionally, caution them when navigating stairs to prevent accidents.

Alcohol consumption may interact with this medication, so ensure your child does not drink alcohol while taking it.

If your child has high blood pressure, consult with the doctor before administering any over-the-counter (OTC) products that may increase blood pressure, such as cough or cold medications, diet pills, stimulants, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, and certain natural products or aids.

In hot weather or during physical activity, encourage your child to drink plenty of fluids to prevent dehydration and fluid loss. Also, advise them to exercise caution in these conditions to avoid heat-related complications.

This medication may cause dry eyes. If your child wears contact lenses and experiences dry eyes or a change in how their contact lenses feel, consult with the doctor for guidance.

Avoid giving your child marijuana or other forms of cannabis, as well as prescription or OTC medications that may slow their actions, as these can interact with this medication.

If your child vomits after taking a dose of this medication, consult with the doctor to determine the best course of action.

If your child has previously used a patch form of this medication and experienced skin irritation, inform the doctor, as they may be more likely to develop a rash on other parts of their body with any form of this medication.

For pregnant or breast-feeding mothers, it is crucial to discuss the benefits and risks of this medication with the doctor, especially if your child becomes pregnant or is breast-feeding a baby while taking this medication.

• CNS depressants (e.g., alcohol, barbiturates, benzodiazepines, opioids, sedating antihistamines): Increased sedation and CNS depression.
• Beta-blockers: Risk of rebound hypertension upon clonidine withdrawal; potential for additive bradycardia and AV block.
• Tricyclic antidepressants (TCAs): May antagonize the hypotensive effect of clonidine.

• Other antihypertensives: Additive hypotensive effects.
• Digoxin: Potential for additive bradycardia.
• Calcium channel blockers: Potential for additive bradycardia and AV block.
• Alpha-1 blockers (e.g., prazosin): May enhance hypotensive effects.
• Neuroleptics (e.g., haloperidol): May increase risk of orthostatic hypotension.

• Dizziness
• Sedation/drowsiness
• Dry mouth
• Fatigue
• Irritability
• Headache
• Nausea
• Constipation
• Orthostatic hypotension (lightheadedness upon standing)
• Symptoms of rebound hypertension upon abrupt discontinuation (e.g., nervousness, agitation, headache, tremor, rapid rise in BP)

Clonidine is classified as Pregnancy Category C. Studies in animals have shown adverse effects on the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Abrupt discontinuation in pregnant women can lead to rebound hypertension.

Clonidine is excreted into human breast milk. Due to the potential for serious adverse reactions in breastfed infants (e.g., sedation, bradycardia, hypotension), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Onyda XR is specifically indicated for the treatment of ADHD in pediatric patients 6 years of age and older. Safety and effectiveness in pediatric patients younger than 6 years of age have not been established. Closely monitor BP and HR.

Clonidine is generally not indicated for ADHD in the geriatric population. If used for other indications, use with caution in elderly patients due to increased sensitivity to hypotensive and sedative effects. Start with lower doses and titrate slowly. Monitor for orthostatic hypotension and cognitive impairment.

• Onyda XR is an extended-release oral suspension of clonidine, specifically formulated and approved for ADHD in children aged 6 and older, taken once daily at bedtime.
• Unlike immediate-release clonidine, Onyda XR is NOT indicated for hypertension.
• Always emphasize the importance of gradual tapering when discontinuing clonidine to avoid rebound hypertension.
• Educate patients/caregivers about common side effects like sedation and dry mouth, which often improve with continued use.
• Monitor blood pressure and heart rate regularly, especially during dose titration.
• The oral suspension formulation may be beneficial for patients who have difficulty swallowing tablets.

• Other non-stimulant medications for ADHD (e.g., atomoxetine, guanfacine extended-release (Intuniv))
• Stimulant medications for ADHD (e.g., methylphenidate, amphetamines)
• Behavioral therapy for ADHD

If your child's symptoms or health issues persist or worsen, it is essential to contact their doctor promptly. To ensure safe and effective treatment, never share your child's medication with others, and do not administer someone else's medication to your child. Some medications may include an additional patient information leaflet; if you have questions or concerns about this medication, consult with your child's doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide detailed information, including the substance taken, the quantity, and the time it occurred.