Minolira 105mg Tablets

Minocycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit, thereby preventing the binding of aminoacyl tRNA to the mRNA-ribosome complex. This action is primarily bacteriostatic. It also exhibits anti-inflammatory properties relevant to its use in acne.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Pancreatitis (pancreas problem): severe stomach pain, severe back pain, or severe upset stomach or vomiting.
Kidney problems: inability to pass urine, changes in urine output, blood in the urine, or significant weight gain.
Lupus-like symptoms: rash on the cheeks or other body parts, easy sunburn, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs.
Fever, chills, or sore throat.
Unexplained bruising or bleeding, or feeling extremely tired or weak.
Changes in hearing.
Joint pain or swelling.
Muscle pain or weakness.
Ringing in the ears.
Seizures.
Shortness of breath.
Chest pain.
Abnormal heartbeat.
Swelling.
Darkening of nail, skin, eye, scar, tooth, or gum color.
Mouth irritation or mouth sores.
Burning, numbness, or tingling sensations.
Redness or white patches in the mouth or throat.
Rectal or genital irritation.
Vaginal itching or discharge.

Antibiotic-Related Diarrhea

Diarrhea is a common side effect of antibiotics. However, a severe form called C. diff-associated diarrhea (CDAD) can occur, which may lead to life-threatening bowel problems. If you experience stomach pain, cramps, or loose, watery, or bloody stools, contact your doctor immediately. Do not treat diarrhea without consulting your doctor.

Liver Problems

Liver problems, including life-threatening cases, have been reported with this medication. If you notice any of the following symptoms, contact your doctor right away: dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, vomiting, or yellow skin or eyes.

Raised Brain Pressure

Raised pressure in the brain has been reported with this medication, which may lead to loss of eyesight. If you experience headaches or eyesight problems, such as blurred vision, double vision, or loss of eyesight, contact your doctor immediately.

Thyroid Cancer

Cases of thyroid cancer have been reported with long-term use of this medication. If you notice lasting hoarseness, a neck mass, or trouble breathing or swallowing, contact your doctor right away.

Severe Skin Reactions

Severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions, can occur with this medication. These reactions can be life-threatening and may affect other organs. If you experience any of the following symptoms, seek medical help immediately: red, swollen, blistered, or peeling skin; red or irritated eyes; sores in the mouth, throat, nose, eyes, genitals, or skin; fever; chills; body aches; shortness of breath; or swollen glands.

Other Side Effects

Most people do not experience severe side effects, and many have only minor or no side effects at all. However, if you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical attention:

Diarrhea, upset stomach, or vomiting.
Decreased appetite.
Dizziness, drowsiness, tiredness, or weakness.

Reporting Side Effects

If you have questions about side effects or want to report any side effects, contact your doctor or the FDA at 1-800-332-1088 or https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction you experienced, including the symptoms that occurred.
If you are currently taking any of the following medications: Acitretin, Isotretinoin, or a Penicillin.
If you are pregnant or think you might be pregnant. Do not take this medication if you are pregnant.
If you are trying to conceive or father a child.
* If you are breastfeeding or plan to breastfeed. You may need to avoid breastfeeding while taking this medication.

This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before engaging in activities that require alertness, such as driving, wait until you understand how this drug affects you.

Regular blood tests will be necessary, as directed by your doctor. Be sure to discuss any concerns or questions with your doctor. Additionally, this medication may interfere with certain laboratory tests, so it is crucial to notify all healthcare providers and laboratory personnel that you are taking this drug.

Do not exceed the prescribed duration of treatment, as this may increase the risk of a secondary infection. When taking this medication, be cautious when exposed to sunlight, as it may increase your susceptibility to sunburn. If you experience unusual sunburn, inform your doctor promptly.

In children under 8 years old, this medication may cause permanent tooth discoloration, resulting in a yellow-gray-brown color. If this occurs, the discoloration will be irreversible. Discuss this risk with your doctor. This medication is not approved for use in children under 12 years old, so consult with your doctor to determine the best course of treatment.

Children under 8 years old should not be given this medication. Although rare, tooth discoloration has also been reported in adults, which typically resolves after discontinuing the medication and undergoing dental cleaning. Consult your doctor if you have concerns.

When taking this medication, the effectiveness of birth control pills and other hormone-based contraceptives may be reduced. To prevent pregnancy, use an additional form of birth control, such as a condom, in conjunction with your regular birth control method.

If you are pregnant or become pregnant while taking this medication, immediately contact your doctor, as it may pose a risk to the unborn baby.

• Isotretinoin (increased risk of pseudotumor cerebri)

• Oral Anticoagulants (e.g., Warfarin - may potentiate anticoagulant effect)
• Penicillins (may interfere with bactericidal action of penicillin)
• Oral Contraceptives (may reduce efficacy of oral contraceptives, leading to breakthrough bleeding or pregnancy)
• Ergot Alkaloids (theoretical increased risk of ergotism, though less documented for minocycline)
• Methotrexate (may increase methotrexate toxicity)

• Antacids containing aluminum, calcium, or magnesium (decreased minocycline absorption)
• Iron preparations (decreased minocycline absorption)
• Bismuth subsalicylate (decreased minocycline absorption)
• Cholestyramine (decreased minocycline absorption)
• Digoxin (may increase digoxin levels in some patients)

• Zinc supplements (potential for reduced minocycline absorption)

• Headache (especially severe or persistent)
• Blurred vision or other visual disturbances (e.g., diplopia, vision loss)
• Dizziness or lightheadedness
• Nausea, vomiting, diarrhea
• Skin rash, hives, or itching
• Photosensitivity (severe sunburn with minimal sun exposure)
• Joint pain or swelling
• Yellowing of skin or eyes (jaundice)
• Dark urine, pale stools
• Unusual fatigue or weakness
• Sore throat, fever, or unusual bleeding/bruising (signs of blood dyscrasias)

Minocycline is Pregnancy Category D. It can cause permanent tooth discoloration (yellow-gray-brown) and inhibition of bone growth in the fetus if used during pregnancy. Avoid use during pregnancy unless the potential benefit justifies the potential risk to the fetus.

Minocycline is excreted into breast milk. Due to the potential for serious adverse reactions in the nursing infant (e.g., tooth discoloration, inhibition of bone growth), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Minocycline is contraindicated in children under 8 years of age due to the risk of permanent tooth discoloration (yellow-gray-brown) and inhibition of bone growth. Minolira 105mg is indicated for patients 12 years and older.

No specific dose adjustment is generally required based on age alone. However, elderly patients may have reduced renal or hepatic function, which should be considered. Monitor for adverse effects, especially dizziness and gastrointestinal upset.

• Minolira 105mg is an extended-release formulation, designed for once-daily dosing, which may improve adherence compared to immediate-release minocycline.
• Counsel patients extensively on photosensitivity and the importance of sun protection.
• Warn patients about potential for dizziness, especially at the start of therapy, and advise caution with driving or operating machinery.
• Emphasize taking the medication with a full glass of water and remaining upright for at least 30 minutes to prevent esophageal irritation/ulceration.
• Educate patients about the risk of permanent tooth discoloration, particularly in children under 8 years, and the importance of avoiding the drug in this age group and during pregnancy.
• Be aware of the rare but serious adverse effects like pseudotumor cerebri (idiopathic intracranial hypertension) and drug-induced lupus-like syndrome; counsel patients on warning signs.

• Other oral tetracyclines (e.g., Doxycycline, Tetracycline)
• Other oral antibiotics for acne (e.g., Erythromycin, Azithromycin, Trimethoprim/Sulfamethoxazole)
• Topical antibiotics (e.g., Clindamycin, Erythromycin)
• Topical retinoids (e.g., Tretinoin, Adapalene, Tazarotene)
• Oral retinoids (e.g., Isotretinoin - for severe, recalcitrant acne)
• Benzoyl peroxide
• Hormonal therapies (e.g., Oral contraceptives for female patients)

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it occurred.