Lincocin Vial 300mg/ml, 2ml

Lincomycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide bond formation and inhibiting the translocation of peptidyl tRNA. This action is primarily bacteriostatic, but may be bactericidal at higher concentrations against highly susceptible organisms.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Urination problems, such as inability to pass urine or changes in urine output
Yellowing of the skin or eyes (jaundice)
Mouth irritation or mouth sores
Ringing in the ears (tinnitus)
Pale skin
Fever, chills, or sore throat
Unexplained bruising or bleeding
Feeling extremely tired or weak
Vaginal itching or discharge
Chest pain or pressure
Severe dizziness or fainting

Severe Skin Reactions

This medication can cause severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other severe skin reactions. Seek medical help immediately if you experience:

Red, swollen, blistered, or peeling skin
Skin irritation (with or without fever)
Red or irritated eyes
Sores in your mouth, throat, nose, or eyes

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:

Diarrhea
Upset stomach or vomiting
Stomach pain
Dizziness or drowsiness
Headache
Irritation at the injection site

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you are currently using any products that contain erythromycin.

This is not an exhaustive list of all potential interactions with this medication. Therefore, it is crucial to discuss all of your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. Additionally, share any existing health problems with your doctor to ensure safe use.

To guarantee your safety, do not start, stop, or modify the dosage of any medication without first consulting your doctor. It is vital to verify that it is safe to take this medication in conjunction with all of your other medications and health conditions.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

Do not take this medication for longer than prescribed, as this can increase the risk of a second infection. Older adults, particularly those 65 years or older, should use this medication with caution, as they may be more susceptible to side effects.

This medication contains benzyl alcohol, which can be harmful to newborns and infants. If possible, avoid using products that contain benzyl alcohol in these age groups, as high doses or combination with other benzyl alcohol-containing products can cause serious side effects. If you have any concerns, consult your doctor.

If you are pregnant, planning to become pregnant, or are breast-feeding, inform your doctor. You and your doctor will need to discuss the potential benefits and risks of this medication to both you and your baby.

• Neuromuscular blocking agents (e.g., succinylcholine, rocuronium): May enhance neuromuscular blockade, leading to respiratory depression or paralysis.
• Kaolin-pectin: May significantly reduce oral absorption of lincomycin (not relevant for injectable, but important for patient education if switching).

• Erythromycin: May antagonize the antibacterial effect of lincomycin due to competitive binding at the 50S ribosomal subunit.
• Opioid analgesics: Increased risk of respiratory depression when used concurrently with neuromuscular blocking agents potentiated by lincomycin.

• Severe, persistent diarrhea (especially if bloody or mucoid)
• Abdominal pain or cramping
• Fever
• Skin rash, itching, hives
• Swelling of face, lips, tongue, or throat (signs of allergic reaction)
• Difficulty breathing or swallowing
• Yellowing of skin or eyes (jaundice)
• Unusual bleeding or bruising
• Sore throat, fever, chills (signs of blood dyscrasias)

Lincomycin is classified as Pregnancy Category C. Animal studies have shown adverse effects on the fetus, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lincomycin is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants (e.g., diarrhea, candidiasis, sensitization), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Use with caution in infants less than one month of age due to immature renal and hepatic function. Monitor closely for adverse effects. Dosage adjustments are based on weight and severity of infection.

No specific dose adjustment is generally needed based on age alone, but elderly patients are more likely to have decreased renal or hepatic function, which may require dose adjustment. They may also be more susceptible to C. difficile-associated diarrhea.

• Lincomycin is a lincosamide, chemically related to clindamycin, but generally considered less potent and with a narrower spectrum of activity. Clindamycin has largely replaced lincomycin in clinical practice due to better oral absorption and broader spectrum.
• Primarily used for serious infections caused by susceptible Gram-positive bacteria (e.g., streptococci, staphylococci, pneumococci) in patients allergic to penicillin or where other antibiotics are ineffective.
• Not effective against Gram-negative bacteria or enterococci.
• Administer IV infusions slowly over at least 1 hour per gram to avoid hypotension and cardiopulmonary arrest.
• Always warn patients about the risk of severe diarrhea (CDAD) and instruct them to seek immediate medical attention if it occurs.

• Clindamycin (another lincosamide, often preferred due to better pharmacokinetics and spectrum)
• Macrolides (e.g., azithromycin, erythromycin, clarithromycin) for Gram-positive infections in penicillin-allergic patients
• Vancomycin (for severe Gram-positive infections, especially MRSA)
• Linezolid (for resistant Gram-positive infections)

If your symptoms or health problems persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others, and do not take medication prescribed for someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly. Unless instructed otherwise, avoid flushing medications down the toilet or pouring them down the drain. If you are unsure about the correct disposal method, consult your pharmacist for guidance. Many communities offer drug take-back programs, which your pharmacist can help you locate. Some medications may come with an additional patient information leaflet; check with your pharmacist for more information. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide details about the medication taken, the amount, and the time it occurred.