Lincocin 300mg/ml Inj, 10ml

Lincomycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide bond formation and translocation. It is primarily bacteriostatic but may be bactericidal against highly susceptible organisms at high concentrations.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Urination problems, such as inability to pass urine or changes in urine output
Yellowing of the skin or eyes (jaundice)
Mouth irritation or mouth sores
Ringing in the ears (tinnitus)
Pale skin
Fever, chills, or sore throat
Unexplained bruising or bleeding
Feeling extremely tired or weak
Vaginal itching or discharge
Chest pain or pressure
Severe dizziness or fainting
Severe skin reactions, including:
+ Stevens-Johnson syndrome (SJS)
+ Toxic epidermal necrolysis (TEN)
+ Other severe skin reactions, characterized by:
- Red, swollen, blistered, or peeling skin (with or without fever)
- Skin irritation
- Red or irritated eyes
- Sores in the mouth, throat, nose, or eyes

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms, contact your doctor for advice:

Diarrhea
Upset stomach or vomiting
Stomach pain
Dizziness or drowsiness
Headache
* Irritation at the injection site

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects. If you have questions or concerns, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you are currently using any products that contain erythromycin.

This list is not exhaustive, and it is crucial to discuss all your medications, health conditions, and potential interactions with your doctor. Please provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your existing health problems

Before starting, stopping, or changing the dose of any medication, including this one, you must consult with your doctor to ensure your safety. It is vital to verify that it is safe to take this medication in combination with all your other medications and health conditions.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

Do not use this medication for longer than prescribed, as this can increase the risk of a second infection. Older adults, particularly those 65 years or older, should use this medication with caution, as they may be more susceptible to side effects.

This medication contains benzyl alcohol, which can be harmful to newborns and infants. If possible, avoid using products containing benzyl alcohol in these age groups, as high doses or combination with other benzyl alcohol-containing products can cause serious side effects. If you have concerns, consult your doctor.

If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor. They will discuss the potential benefits and risks of this medication to you and your baby, helping you make an informed decision.

• Neuromuscular blocking agents (e.g., succinylcholine, rocuronium): Lincomycin may potentiate the neuromuscular blocking action, leading to respiratory depression or paralysis.
• Erythromycin: Antagonistic effect due to competition for the same ribosomal binding site.

• Kaolin-pectin (for oral lincomycin, not injectable): Decreases oral absorption of lincomycin.
• Oral typhoid vaccine: Antibiotics may reduce the therapeutic effect of the vaccine.

• Severe, persistent diarrhea (especially if bloody or watery)
• Abdominal pain or cramping
• Fever
• Skin rash, itching, hives (signs of allergic reaction)
• Swelling of face, lips, tongue, or throat (angioedema)
• Difficulty breathing or swallowing
• Yellowing of skin or eyes (jaundice)
• Unusual tiredness or weakness
• Sore throat, fever, or other signs of infection (may indicate blood dyscrasias or superinfection)

Lincomycin is classified as Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal studies have shown some adverse effects, but there are no adequate and well-controlled studies in pregnant women.

Lincomycin is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants (e.g., diarrhea, candidiasis, sensitization), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Lincomycin can be used in pediatric patients (infants and children) with appropriate dose adjustments based on weight. However, use in neonates is not well-established, and caution is advised due to immature renal and hepatic function. Monitor for adverse effects, especially gastrointestinal issues.

No specific dose adjustment is generally required based on age alone. However, elderly patients are more likely to have decreased renal or hepatic function, which may necessitate dose adjustments. Monitor renal and hepatic function closely in this population. Elderly patients may also be more susceptible to the development of C. difficile-associated diarrhea.

• Lincomycin is a less commonly used lincosamide compared to clindamycin, but it has a similar spectrum of activity, primarily against Gram-positive bacteria (e.g., Staphylococcus, Streptococcus) and anaerobes.
• It is NOT effective for infections of the central nervous system (e.g., meningitis) due to poor penetration into the CSF.
• The most significant adverse effect is the risk of Clostridium difficile-associated diarrhea (CDAD), which can range from mild to life-threatening. Patients should be educated on symptoms and advised to seek immediate medical attention if they occur.
• Rapid intravenous administration can lead to hypotension and cardiopulmonary arrest; infuse slowly over at least 1 hour per gram.
• Consider alternative antibiotics if a patient has a history of severe hypersensitivity to lincomycin or clindamycin.

• Clindamycin (another lincosamide, often preferred due to better oral absorption and similar spectrum)
• Macrolides (e.g., azithromycin, clarithromycin, erythromycin - for susceptible Gram-positive infections, but antagonism with lincomycin is possible)
• Beta-lactam antibiotics (e.g., penicillin, cephalosporins - depending on the specific bacterial pathogen and site of infection)
• Vancomycin (for severe Gram-positive infections, especially MRSA)
• Metronidazole (for anaerobic infections)

If your symptoms or health problems persist or worsen, it is essential to contact your doctor for further guidance. To ensure safe use, never share your medication with others, and do not take medication prescribed for someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Properly dispose of unused or expired medications by checking with your pharmacist for the recommended disposal method. Unless instructed to do so, avoid flushing medications down the toilet or pouring them down the drain, as this can harm the environment. Many communities offer drug take-back programs, which your pharmacist can help you locate. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist. If you have any questions or concerns about your medication, consult with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. Be prepared to provide information about the medication taken, the amount, and the time it was taken, as this will aid in providing appropriate care.