Ibuprofen 100mg/5ml Oral Susp Berry

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that exerts its therapeutic effects primarily through the inhibition of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. By reducing prostaglandin levels, ibuprofen produces analgesic, anti-inflammatory, and antipyretic effects.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Allergic Reaction: Rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Bleeding: Vomiting or coughing up blood, vomit that resembles coffee grounds, blood in the urine, black, red, or tarry stools, bleeding from the gums, abnormal vaginal bleeding, unexplained bruises or bruises that enlarge, or uncontrollable bleeding.
Kidney Problems: Inability to urinate, changes in urine output, blood in the urine, or sudden significant weight gain.
High Potassium Levels: Abnormal heartbeat, confusion, weakness, lightheadedness, dizziness, feeling faint, numbness or tingling, or shortness of breath.
High Blood Pressure: Severe headache or dizziness, fainting, or changes in vision.
Respiratory Issues: Shortness of breath, significant weight gain, or swelling in the arms or legs.
Cardiovascular Concerns: Chest pain or pressure, rapid heartbeat, or weakness on one side of the body.
Neurological Symptoms: Difficulty speaking or thinking, balance changes, drooping on one side of the face, or blurred vision.
General Concerns: Extreme fatigue or weakness, ringing in the ears, severe back pain, or changes in vision.
Severe Skin Reactions: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or other serious reactions, which may be life-threatening. Seek immediate medical help if you experience red, swollen, blistered, or peeling skin; red or irritated eyes; sores in your mouth, throat, nose, eyes, genitals, or skin; fever; chills; body aches; shortness of breath; or swollen glands.

Other Possible Side Effects

Most medications can cause side effects, but many people experience none or only mild symptoms. If you encounter any of the following side effects or any other concerns, contact your doctor or seek medical attention:

Constipation, diarrhea, stomach pain, upset stomach, or vomiting.
Heartburn.
Gas.
Dizziness.

This is not an exhaustive list of potential side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions and situations to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction and its symptoms.
Allergies to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
A history of asthma triggered by salicylate medications, such as aspirin, or NSAIDs.
Presence of gastrointestinal (GI) bleeding or kidney problems.
Heart failure (weak heart) or a recent heart attack.
Current use of other NSAIDs, salicylate drugs like aspirin, or pemetrexed.
Difficulty conceiving or undergoing fertility evaluation.
Pregnancy, planned pregnancy, or pregnancy during treatment. This medication may harm an unborn baby if taken after 20 weeks of gestation. If you are between 20 and 30 weeks pregnant, only take this medication under your doctor's guidance. Do not take this medication if you are more than 30 weeks pregnant.

This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health issues with your doctor and pharmacist. Verify that it is safe to take this medication with your existing treatments and health conditions. Never start, stop, or adjust the dosage of any medication without consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

There is a risk of developing high blood pressure while taking this medication. Your doctor will likely advise you to have your blood pressure checked regularly. Additionally, discuss your alcohol consumption with your doctor before drinking. If you smoke, talk to your doctor about the potential risks. Individuals with asthma should also consult their doctor, as they may be more sensitive to this medication.

Adhere to the prescribed dosage and do not exceed the recommended amount, as this may increase the risk of severe side effects. Do not take this medication for longer than your doctor has instructed.

Be cautious, as this medication may affect your blood's ability to clot, making you more prone to bleeding. To minimize the risk of injury, use a soft toothbrush and an electric razor.

The use of this medication may increase the risk of heart failure, particularly in individuals who already have a history of heart failure. This may lead to a higher risk of heart attack, hospitalization, and death. Discuss these risks with your doctor. Furthermore, individuals who have recently experienced a heart attack may be at a higher risk of heart attack and heart-related death while taking this medication. Your doctor can provide more information on this potential risk.

There is a rare but serious risk of developing aseptic meningitis, a brain condition, while taking this medication. If you experience symptoms such as headache, fever, chills, nausea, vomiting, stiff neck, rash, sensitivity to light, drowsiness, or confusion, contact your doctor immediately.

Liver problems, including potentially life-threatening conditions, have been associated with this medication. If you notice signs of liver problems, such as dark urine, fatigue, decreased appetite, stomach pain, pale stools, vomiting, or yellowing of the skin and eyes, seek medical attention promptly.

If you are 60 years or older, use this medication with caution, as you may be more susceptible to side effects. Women of childbearing age should be aware that this medication may affect ovulation, potentially impacting fertility. However, this effect is typically reversible when the medication is discontinued. Discuss any concerns with your doctor.

If you are breastfeeding, consult your doctor to discuss the potential risks to your baby.

• Other NSAIDs (increased risk of GI adverse events)
• Aspirin (regular use, high dose, due to interference with antiplatelet effect)
• Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)

• Anticoagulants (e.g., Warfarin, Dabigatran, Rivaroxaban) - increased risk of bleeding
• Antiplatelet agents (e.g., Clopidogrel, Ticagrelor) - increased risk of bleeding
• Corticosteroids (e.g., Prednisone) - increased risk of GI ulceration/bleeding
• SSRIs/SNRIs (e.g., Fluoxetine, Sertraline) - increased risk of GI bleeding
• Lithium - increased lithium levels and toxicity
• Methotrexate - increased methotrexate levels and toxicity
• Diuretics (e.g., Furosemide, Hydrochlorothiazide) - reduced diuretic and antihypertensive effects, increased risk of renal impairment
• ACE inhibitors (e.g., Lisinopril) - reduced antihypertensive effect, increased risk of renal impairment
• Angiotensin Receptor Blockers (ARBs) (e.g., Valsartan) - reduced antihypertensive effect, increased risk of renal impairment
• Cyclosporine - increased risk of nephrotoxicity
• Tacrolimus - increased risk of nephrotoxicity
• Digoxin - increased digoxin levels

• Sulfonylureas (e.g., Glipizide) - enhanced hypoglycemic effect
• Phenytoin - increased phenytoin levels
• Cholestyramine - reduced ibuprofen absorption (administer ibuprofen 1 hour before or 4-6 hours after cholestyramine)
• Alcohol - increased risk of GI irritation/bleeding

• Ginkgo Biloba - theoretical increased bleeding risk

• Abdominal pain
• Indigestion (dyspepsia)
• Nausea
• Vomiting
• Black, tarry stools (melena)
• Vomiting blood or coffee-ground like material (hematemesis)
• Unusual bruising or bleeding
• Swelling of ankles, feet, or hands (edema)
• Unexplained weight gain
• Shortness of breath or chest pain
• Skin rash or blistering
• Yellowing of skin or eyes (jaundice)
• Dark urine
• Unusual fatigue or weakness
• Flu-like symptoms (fever, body aches, chills)

Use of NSAIDs, including ibuprofen, should be avoided in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and fetal renal dysfunction. Use in the first and second trimesters should be with caution and only if the potential benefit justifies the potential risk to the fetus.

Ibuprofen is considered compatible with breastfeeding. It is excreted into breast milk in very small amounts, and adverse effects on breastfed infants are unlikely.

Ibuprofen 100mg/5ml oral suspension is specifically formulated and commonly used for pediatric patients (6 months and older) for fever and pain relief. Dosing is weight-based. Contraindicated in infants younger than 6 months without specific medical advice. Close monitoring for adverse effects, especially GI and renal, is important.

Elderly patients are at increased risk for serious adverse reactions to NSAIDs, particularly gastrointestinal bleeding and perforation, and renal impairment. Use the lowest effective dose for the shortest possible duration. Monitor renal function and for signs of GI bleeding closely.

• Always use the provided measuring device (syringe or cup) for accurate dosing, especially in children.
• Administer with food or milk to minimize gastrointestinal upset.
• Educate parents/caregivers on weight-based dosing for children and the maximum daily dose.
• Remind patients that ibuprofen is an NSAID and carries risks of GI bleeding and cardiovascular events, even at OTC doses.
• Advise against concomitant use with other NSAIDs (including aspirin for pain/fever) to avoid additive toxicity.
• Ensure adequate hydration, particularly in febrile children, to reduce the risk of renal complications.

• Acetaminophen (Paracetamol) - for fever and pain relief (different mechanism, no anti-inflammatory effect)
• Naproxen - another NSAID (longer half-life, less frequent dosing)
• Celecoxib - selective COX-2 inhibitor (prescription, lower GI risk but similar cardiovascular risk)
• Topical analgesics (e.g., lidocaine patches, capsaicin cream) - for localized pain
• Non-pharmacological interventions (e.g., rest, ice, heat, massage, hydration)

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.