Ibuprofen 100mg/5ml Oral Susp

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that exerts its therapeutic effects primarily by inhibiting the cyclooxygenase (COX) enzymes, COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. Inhibition of COX-1 contributes to gastrointestinal and platelet-related side effects, while inhibition of COX-2 is primarily responsible for the anti-inflammatory, analgesic, and antipyretic effects.

Urgent Side Effects: Seek Medical Help Immediately

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention right away:

Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Signs of bleeding: vomiting or coughing up blood, vomit that resembles coffee grounds, blood in the urine, black, red, or tarry stools, bleeding from the gums, abnormal vaginal bleeding, unexplained bruises or bruises that enlarge, or uncontrollable bleeding.
Signs of kidney problems: inability to urinate, changes in urine output, blood in the urine, or sudden significant weight gain.
Signs of high potassium levels: irregular heartbeat, confusion, weakness, lightheadedness, dizziness, feeling faint, numbness or tingling, or shortness of breath.
Signs of high blood pressure: severe headache or dizziness, fainting, or changes in vision.
Shortness of breath, significant weight gain, or swelling in the arms or legs.
Chest pain or pressure, or rapid heartbeat.
Weakness on one side of the body, difficulty speaking or thinking, balance problems, drooping on one side of the face, or blurred vision.
Extreme fatigue or weakness.
Ringing in the ears.
Severe back pain.
Changes in vision.

Severe Skin Reactions

This medication can cause severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions. These reactions can affect other organs and be life-threatening. Seek medical help immediately if you experience:

Red, swollen, blistered, or peeling skin
Red or irritated eyes
Sores in the mouth, throat, nose, eyes, genitals, or skin
Fever
Chills
Body aches
Shortness of breath
Swollen glands

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or only minor ones. If you are bothered by any of the following side effects or if they persist, contact your doctor:

Constipation
Diarrhea
Stomach pain
Upset stomach
Vomiting
Heartburn
Gas
Dizziness

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction and its symptoms.
Allergies to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
A history of asthma triggered by salicylate medications, such as aspirin, or NSAIDs.
Certain health conditions, including:
+ Gastrointestinal (GI) bleeding
+ Kidney problems
+ Heart failure (a weakened heart)
+ Recent heart attack
Current use of other NSAIDs, salicylate drugs like aspirin, or pemetrexed.
Fertility issues or ongoing fertility evaluation, as this medication may affect fertility.
* Pregnancy, planned pregnancy, or suspected pregnancy. This medication can harm an unborn baby if taken after 20 weeks of pregnancy. If you are between 20 and 30 weeks pregnant, only take this medication under your doctor's guidance. Do not take this medication if you are more than 30 weeks pregnant.

This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. Verify that it is safe to take this medication with your existing treatments and health status. Never start, stop, or adjust the dosage of any medication without consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

You should also have your blood pressure checked regularly, as medications like this one can cause high blood pressure. Your doctor will advise you on how often to have your blood pressure checked.

Before consuming alcohol, discuss the potential risks with your doctor. If you smoke, talk to your doctor about the potential interactions with this medication. Additionally, if you have asthma, consult with your doctor, as you may be more sensitive to this drug.

It is crucial to follow your doctor's instructions regarding the dosage and duration of treatment. Taking more than the prescribed amount or using this medication for longer than recommended can increase your risk of severe side effects.

As this medication may affect your blood's ability to clot, you may be more prone to bleeding. To minimize this risk, be careful to avoid injuries, use a soft toothbrush, and consider using an electric razor.

The use of medications like this one can increase the risk of heart failure, heart attack, and death, particularly in people who have already experienced heart failure. If you have a history of heart failure, discuss the potential risks with your doctor. Furthermore, if you have recently had a heart attack, be aware that this medication may increase your risk of another heart attack or heart-related death.

There is also a risk of a severe brain condition called aseptic meningitis associated with this medication. If you experience symptoms such as headache, fever, chills, nausea, vomiting, stiff neck, rash, sensitivity to light, drowsiness, or confusion, contact your doctor immediately.

In rare cases, medications like this one can cause liver problems, which can be life-threatening. If you notice signs of liver problems, such as dark urine, fatigue, loss of appetite, stomach pain, pale stools, vomiting, or yellowing of the skin or eyes, seek medical attention promptly.

If you are 60 years or older, use this medication with caution, as you may be more susceptible to side effects.

Women of childbearing age should be aware that NSAIDs like this medication may affect ovulation, potentially impacting fertility. However, this effect is reversible when the medication is stopped. Discuss any concerns with your doctor.

If you are breastfeeding, consult with your doctor to discuss the potential risks to your baby.

• Other NSAIDs (increased risk of GI adverse events)
• Aspirin (high-dose, for anti-inflammatory effect - may reduce cardioprotective effect of low-dose aspirin)
• Ketorolac
• Celecoxib (if used with other NSAIDs)

• Anticoagulants (e.g., Warfarin, Heparin, DOACs - increased risk of bleeding)
• Antiplatelet agents (e.g., Clopidogrel, Ticagrelor - increased risk of bleeding)
• Corticosteroids (increased risk of GI ulceration/bleeding)
• Diuretics (e.g., Furosemide, Hydrochlorothiazide - reduced diuretic and antihypertensive effect, increased risk of renal impairment)
• ACE inhibitors (e.g., Lisinopril, Enalapril - reduced antihypertensive effect, increased risk of renal impairment)
• Angiotensin Receptor Blockers (ARBs) (e.g., Valsartan, Losartan - reduced antihypertensive effect, increased risk of renal impairment)
• Lithium (increased lithium levels and toxicity)
• Methotrexate (increased methotrexate levels and toxicity)
• Cyclosporine (increased risk of nephrotoxicity)
• Tacrolimus (increased risk of nephrotoxicity)
• SSRIs/SNRIs (increased risk of GI bleeding)

• Beta-blockers (reduced antihypertensive effect)
• Digoxin (may increase digoxin levels)
• Phenytoin (may increase phenytoin levels)
• Sulfonylureas (may enhance hypoglycemic effect)
• Quinolone antibiotics (increased risk of seizures)
• Aminoglycosides (may increase aminoglycoside levels)
• Pemetrexed (increased risk of myelosuppression, renal, and GI toxicity)

• Alcohol (increased risk of GI irritation/bleeding)
• Ginkgo biloba (theoretical increased bleeding risk)

• Signs of gastrointestinal bleeding (black, tarry stools; coffee-ground vomit; severe abdominal pain)
• Signs of renal dysfunction (decreased urine output, swelling in ankles/feet, unusual fatigue)
• Signs of allergic reaction (rash, itching, hives, swelling of face/lips/tongue, difficulty breathing)
• Signs of cardiovascular events (chest pain, shortness of breath, weakness on one side of the body, slurred speech)
• Unexplained weight gain or edema
• Persistent headache or vision changes

Avoid use in the third trimester due to the risk of premature closure of the fetal ductus arteriosus and persistent pulmonary hypertension in the newborn. Use in the first and second trimesters should only be if the potential benefit justifies the potential risk to the fetus, and at the lowest effective dose for the shortest duration possible.

Considered compatible with breastfeeding. Ibuprofen is excreted into breast milk in very small amounts, and adverse effects on breastfed infants are unlikely.

Ibuprofen oral suspension is specifically formulated for pediatric use. Dosing must be carefully calculated based on the child's weight or age to avoid overdose. Not recommended for infants under 6 months of age without consulting a healthcare professional. Use with caution in dehydrated children due to increased risk of renal adverse effects.

Elderly patients are at increased risk for serious adverse effects, particularly gastrointestinal bleeding, ulceration, and perforation, as well as renal impairment and cardiovascular events. Use the lowest effective dose for the shortest duration possible. Monitor renal function and signs of GI bleeding closely.

• Always use the provided dosing device (syringe or cup) for accurate measurement of oral suspension, especially in children.
• Advise patients to take ibuprofen with food or milk to minimize gastrointestinal upset.
• Educate patients about the signs and symptoms of GI bleeding and renal dysfunction, and when to seek immediate medical attention.
• Remind patients that ibuprofen is an NSAID and should not be taken with other NSAIDs (including other OTC products like naproxen or aspirin for pain) to avoid additive toxicity.
• For fever, if the child is not drinking fluids well or has signs of dehydration, consider acetaminophen as an alternative or consult a physician before administering ibuprofen.
• Counsel patients on the black box warnings regarding cardiovascular and gastrointestinal risks, especially for long-term use or in high-risk individuals.

• Acetaminophen (Tylenol, Paracetamol) - for pain and fever, generally safer for GI and renal systems, especially in children and high-risk patients.
• Naproxen (Aleve) - another NSAID, longer half-life, less frequent dosing.
• Aspirin (low-dose for antiplatelet effect, high-dose for pain/inflammation - generally avoided in children due to Reye's Syndrome risk).
• Topical analgesics (e.g., lidocaine patches, diclofenac gel) for localized pain.
• Non-pharmacological interventions (e.g., rest, ice/heat, hydration).

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it is a good idea to check with your pharmacist. If you have any questions or concerns about this medication, consult with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the medication taken, the amount, and the time it occurred.