Ed A-Hist DM Liquid

Chlorpheniramine is an alkylamine antihistamine that competitively blocks H1-receptors, reducing histamine-mediated symptoms like sneezing and rhinorrhea. Phenylephrine is a direct-acting sympathomimetic amine that acts primarily on alpha-1 adrenergic receptors in the respiratory tract mucosa, causing vasoconstriction and reducing nasal congestion. Dextromethorphan is a non-opioid antitussive that acts centrally on the cough center in the medulla to elevate the cough threshold.

Urgent Side Effects: Seek Medical Attention Immediately

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood pressure, including:
+ Severe headache
+ Dizziness
+ Passing out
+ Changes in eyesight
Chest pain or pressure
Fast heartbeat
Shakiness

Other Possible Side Effects

Like all medications, this drug can cause side effects. Although many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor or seek medical help:

Dizziness
Drowsiness
Feeling nervous and excitable
* Trouble sleeping

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
Respiratory conditions, such as a cough that produces a significant amount of mucus, a persistent cough caused by smoking or exposure to smoke, or lung diseases like asthma or emphysema.
If you have taken certain medications for depression or Parkinson's disease within the last 14 days, including isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline, as this may increase the risk of severely high blood pressure.
If you are currently taking linezolid or methylene blue, as these medications can interact with this drug.

To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter medications you are taking
Any natural products or vitamins you are using
* Your medical history, including any health problems you have

This information will help your doctor determine whether it is safe for you to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before engaging in activities that require your full attention, such as driving, wait until you understand how this drug affects you.

To minimize the risk of severe side effects, adhere strictly to the dosage instructions provided by your doctor. Do not exceed the recommended dose, and do not take this medication for a longer period than prescribed.

While using this drug, avoid consuming alcohol, as it may interact with the medication. Additionally, consult your doctor before using marijuana, cannabis products, or any prescription or over-the-counter medications that may cause drowsiness or slow your reactions.

When administering this medication to a child, exercise caution, as children may have a higher risk of experiencing excitability. Note that different brands of this drug may be suitable for different age groups of children, so it is crucial to consult with your doctor before giving this medication to a child. Furthermore, do not use this drug as a means to induce sleep in a child; instead, discuss alternative solutions with your doctor.

If you are pregnant, planning to become pregnant, or are breast-feeding, inform your doctor, as they will need to discuss the potential benefits and risks of this medication to both you and your baby.

• Monoamine Oxidase Inhibitors (MAOIs) (concurrent use or within 14 days of stopping MAOIs) - risk of hypertensive crisis, hyperpyrexia, severe CNS depression or excitation.

• CNS Depressants (e.g., alcohol, sedatives, tranquilizers, opioids, anxiolytics) - increased sedation, respiratory depression, and CNS effects.
• Anticholinergic drugs (e.g., tricyclic antidepressants, atropine, some antipsychotics) - increased anticholinergic effects (dry mouth, urinary retention, blurred vision, constipation).
• Sympathomimetics (e.g., other decongestants, appetite suppressants, stimulants) - increased cardiovascular effects (hypertension, tachycardia).
• Serotonergic drugs (e.g., SSRIs, SNRIs, triptans, tricyclic antidepressants) - risk of serotonin syndrome with dextromethorphan.

• Antihypertensives (e.g., beta-blockers, ACE inhibitors) - phenylephrine may reduce their hypotensive effect.
• Digoxin - phenylephrine may increase risk of arrhythmias.
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine) - may increase dextromethorphan and chlorpheniramine levels, leading to increased side effects.

• Not available

• Effectiveness of cough suppression
• Degree of nasal decongestion
• Reduction in sneezing and rhinorrhea
• Sedation/drowsiness
• Dizziness
• Nervousness/restlessness
• Insomnia
• Dry mouth/throat
• Blurred vision
• Urinary difficulty
• Palpitations/tachycardia
• Increased blood pressure
• Nausea/vomiting

Generally not recommended during pregnancy, especially in the first trimester and near term. Phenylephrine (Category C) and Chlorpheniramine (Category C) have potential risks. Dextromethorphan (Category C) is generally considered safer than other antitussives but still requires caution. Use only if the potential benefit outweighs the potential risk to the fetus, and under medical supervision.

Use with caution or avoid. Chlorpheniramine is generally not recommended due to potential for sedation in the infant and reduction in milk supply. Phenylephrine is generally considered low risk but can reduce milk supply. Dextromethorphan is generally considered compatible with breastfeeding, but caution is advised with combination products. Monitor infant for drowsiness or irritability.

Not recommended for children under 6 years of age without consulting a doctor due to potential for serious side effects, including overdose. Dosing for children 6-12 years must be carefully followed. Always use a measuring device provided with the product to ensure accurate dosing.

Use with caution in elderly patients due to increased sensitivity to anticholinergic effects (e.g., sedation, confusion, urinary retention, constipation) and sympathomimetic effects (e.g., hypertension, tachycardia, insomnia). Start with lower doses and monitor closely.

• This is an OTC product; emphasize the importance of reading the Drug Facts label carefully and not exceeding recommended doses.
• Advise patients to check other medications (prescription and OTC) for similar ingredients to avoid accidental overdose.
• Warn patients about potential for drowsiness and impaired ability to drive or operate machinery.
• Educate on signs of serotonin syndrome, especially if patients are on other serotonergic drugs.
• For patients with underlying conditions (e.g., hypertension, diabetes, glaucoma), advise consultation with a healthcare provider before use.

• Single-ingredient antihistamines (e.g., loratadine, cetirizine for allergies)
• Single-ingredient decongestants (e.g., pseudoephedrine, oxymetazoline nasal spray for congestion)
• Single-ingredient cough suppressants (e.g., guaifenesin, plain dextromethorphan for cough)
• Non-pharmacological treatments (e.g., saline nasal sprays, humidifiers, warm fluids, rest)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the medication taken, the amount, and the time it occurred.