Ed A-Hist DM 10mg-4mg-10mg Tablets

Chlorpheniramine is a first-generation antihistamine that competitively antagonizes H1 receptors, thereby preventing histamine-mediated effects such as sneezing, rhinorrhea, and itching. Phenylephrine is a direct-acting sympathomimetic amine that acts predominantly on alpha-adrenergic receptors, causing vasoconstriction in the nasal mucosa, leading to decongestion. Dextromethorphan is a non-opioid antitussive that acts centrally on the cough center in the medulla to elevate the cough threshold. It is also an NMDA receptor antagonist and sigma-1 receptor agonist.

Urgent Side Effects: Seek Medical Attention Immediately
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical help right away:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood pressure, including:
+ Severe headache
+ Dizziness
+ Fainting
+ Changes in eyesight
Chest pain or pressure
Rapid heartbeat
Shakiness

Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or do not go away, contact your doctor:

Dizziness
Drowsiness
Feeling nervous and excitable
* Trouble sleeping

Reporting Side Effects
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have a cough that produces a significant amount of mucus, a chronic cough caused by smoking or exposure to smoke, or lung conditions like asthma or emphysema.
If you have taken certain medications for depression or Parkinson's disease within the last 14 days, including isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline, as this may increase the risk of severely high blood pressure.
If you are currently taking linezolid or methylene blue, as these medications can interact with this drug.

To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of all your medications, including:

Prescription and over-the-counter (OTC) drugs
Natural products
* Vitamins

Additionally, inform them about any existing health problems. This information will help your doctor determine whether it is safe for you to take this medication with your other medications and health conditions. Never start, stop, or change the dosage of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before engaging in activities that require your full attention, such as driving, wait until you understand how this drug affects you.

To minimize the risk of severe side effects, adhere strictly to the dosage instructions provided by your doctor. Do not exceed the recommended dose, as this may increase your likelihood of experiencing adverse effects. Additionally, do not take this medication for a longer duration than prescribed by your doctor.

While taking this drug, it is recommended that you avoid consuming alcohol. Before using marijuana, other forms of cannabis, or any prescription or over-the-counter medications that may cause drowsiness, consult with your doctor to discuss potential interactions.

When administering this medication to a child, exercise caution, as children may be at a higher risk of experiencing excitability. It is crucial to note that different brands of this medication may be suitable for children of various ages. Therefore, consult with your doctor before giving this drug to a child. Furthermore, do not use this medication as a means to induce sleep in a child; instead, discuss alternative solutions with your doctor.

If you are pregnant, planning to become pregnant, or are breast-feeding, inform your doctor. It is necessary to have a discussion about the potential benefits and risks of this medication to both you and your baby.

• Monoamine Oxidase Inhibitors (MAOIs) (concurrent use or within 14 days of stopping MAOIs due to risk of hypertensive crisis with phenylephrine and serotonin syndrome with dextromethorphan)

• Other sympathomimetics (e.g., pseudoephedrine, ephedrine, stimulants) - increased cardiovascular effects
• Tricyclic antidepressants (TCAs) - potentiated pressor effects of phenylephrine
• Beta-blockers (non-selective) - increased risk of hypertension and bradycardia with phenylephrine
• CNS depressants (e.g., alcohol, sedatives, hypnotics, anxiolytics, opioids) - increased sedation and respiratory depression with chlorpheniramine and dextromethorphan
• Anticholinergic drugs (e.g., atropine, some antipsychotics, TCAs) - increased anticholinergic side effects with chlorpheniramine
• Serotonergic drugs (e.g., SSRIs, SNRIs, triptans, linezolid, St. John's Wort) - increased risk of serotonin syndrome with dextromethorphan
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine) - increased dextromethorphan and chlorpheniramine levels, potentially leading to toxicity

• Digoxin - potential for increased cardiac effects with phenylephrine
• Antihypertensives - phenylephrine may reduce the effect of antihypertensive medications
• Metoclopramide - may affect absorption of other drugs

• Food (see pharmacokinetics)

• Drowsiness or sedation
• Dizziness
• Nervousness or restlessness
• Insomnia
• Dry mouth, nose, or throat
• Blurred vision
• Urinary difficulty
• Constipation
• Signs of serotonin syndrome (agitation, hallucinations, rapid heart rate, fever, overactive reflexes, nausea, vomiting, diarrhea, incoordination)
• Signs of allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Generally not recommended during pregnancy due to the presence of phenylephrine (Category C) and dextromethorphan (Category C), and chlorpheniramine (Category B/C). Consult a healthcare provider before use.

Use is generally not recommended. All three components are excreted into breast milk. Chlorpheniramine can cause drowsiness in the infant and may decrease milk supply. Phenylephrine can cause irritability and may decrease milk supply. Dextromethorphan can cause drowsiness in the infant. Consult a healthcare provider.

Not recommended for children under 6 years of age due to potential for serious side effects, including overdose. For children 6-12 years, use only under the guidance of a healthcare professional and with specific pediatric formulations/dosing. Adolescents (12 years and older) can generally follow adult dosing.

Use with caution in elderly patients (65 years and older) due to increased susceptibility to anticholinergic effects (e.g., confusion, urinary retention, constipation, dry mouth) from chlorpheniramine and cardiovascular effects (e.g., increased blood pressure, heart rate) from phenylephrine. Start with lower doses and monitor closely.

• This combination product is designed for multi-symptom relief of cold, cough, and allergy symptoms. Ensure the patient's symptoms align with the active ingredients to avoid unnecessary drug exposure.
• Counsel patients on the potential for drowsiness and to avoid activities requiring mental alertness until they know how the medication affects them.
• Emphasize the critical interaction with MAOIs; patients must be explicitly warned about this.
• Advise patients with underlying conditions such as high blood pressure, heart disease, thyroid disease, diabetes, glaucoma, or prostate enlargement to consult a doctor before use.
• Over-the-counter cough and cold products should not be used in children under 6 years of age.
• Be aware of the risk of serotonin syndrome, especially if patients are taking other serotonergic medications.

• Single-ingredient antihistamines (e.g., loratadine, cetirizine for non-drowsy allergy relief)
• Single-ingredient decongestants (e.g., pseudoephedrine, oxymetazoline nasal spray)
• Single-ingredient antitussives (e.g., guaifenesin, benzonatate)
• Non-pharmacological remedies (e.g., saline nasal sprays, humidifiers, honey for cough, rest, fluids)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.