Drysol Liquid 37.5ml
It is used to treat very bad sweating.
Drug Class
Antiperspirant
Pharmacologic Class
Astringent
Pregnancy Category
Not available
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Drysol is a strong antiperspirant liquid used to reduce excessive sweating (hyperhidrosis). It works by blocking your sweat glands, preventing sweat from reaching the skin surface.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. This medication is for topical use only, meaning it should be applied directly to the affected area of your skin. Avoid getting it in your mouth, nose, or eyes, as it may cause burning.
Application Instructions
1. Wash your hands before and after applying the medication, unless your hand is the treated area. In that case, do not wash your hand after application.
2. Clean the affected area before use and dry it thoroughly.
3. Apply a thin layer of the medication to the affected area at bedtime.
4. To apply, turn the bottle upside down and use light pressure to dispense the solution. Avoid using excessive pressure on the bottle.
5. Do not use this medication as a roll-on.
After Application
If directed by your doctor, you may cover the treated area with plastic wrap, followed by a T-shirt, mitten, shower cap, or sock.
In the morning, wash the affected skin and pat it dry.
Important Safety Precautions
This medication is flammable, so avoid using it near an open flame or while smoking.
Storage and Disposal
Store the medication at room temperature with the lid tightly closed.
Protect it from heat and open flames.
Keep all medications in a safe place, out of the reach of children and pets.
Missed Dose
If you miss a dose, skip it and resume your normal application schedule.
Do not apply extra doses or double doses.
* Since this medication is often used as needed, follow your doctor's instructions regarding frequency of use and do not use it more often than directed.
To use this medication correctly, follow your doctor's instructions and read all the information provided. This medication is for topical use only, meaning it should be applied directly to the affected area of your skin. Avoid getting it in your mouth, nose, or eyes, as it may cause burning.
Application Instructions
1. Wash your hands before and after applying the medication, unless your hand is the treated area. In that case, do not wash your hand after application.
2. Clean the affected area before use and dry it thoroughly.
3. Apply a thin layer of the medication to the affected area at bedtime.
4. To apply, turn the bottle upside down and use light pressure to dispense the solution. Avoid using excessive pressure on the bottle.
5. Do not use this medication as a roll-on.
After Application
If directed by your doctor, you may cover the treated area with plastic wrap, followed by a T-shirt, mitten, shower cap, or sock.
In the morning, wash the affected skin and pat it dry.
Important Safety Precautions
This medication is flammable, so avoid using it near an open flame or while smoking.
Storage and Disposal
Store the medication at room temperature with the lid tightly closed.
Protect it from heat and open flames.
Keep all medications in a safe place, out of the reach of children and pets.
Missed Dose
If you miss a dose, skip it and resume your normal application schedule.
Do not apply extra doses or double doses.
* Since this medication is often used as needed, follow your doctor's instructions regarding frequency of use and do not use it more often than directed.
Lifestyle & Tips
- Apply only to completely dry skin, preferably at bedtime. Moisture on the skin can react with the product and cause irritation.
- Do not apply to broken, irritated, or recently shaved skin.
- Wash the treated area with soap and water in the morning.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Avoid contact with clothing or jewelry as it can stain or damage them.
- If irritation occurs, reduce frequency of application or temporarily stop use. Consult a doctor if irritation persists or is severe.
Available Forms & Alternatives
Available Strengths:
Dosing & Administration
Adult Dosing
Standard Dose:
Apply to affected area at bedtime, usually 1-2 times per week, or as directed. Wash off in the morning.
Condition-Specific Dosing:
hyperhidrosis:
Apply to dry skin at bedtime. Initially, apply nightly until sweating is controlled (typically 3-4 nights), then reduce frequency to once or twice weekly or as needed to maintain control. Wash off in the morning with soap and water.
Pediatric Dosing
Neonatal:
Not established
Infant:
Not established
Child:
Use with caution and under medical supervision. Dosing typically similar to adults but adjusted based on tolerance and severity. Not recommended for routine use in young children.
Adolescent:
Dosing typically similar to adults, applied at bedtime to dry skin, washed off in the morning. Frequency adjusted based on response.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Dialysis:
No specific considerations; minimal systemic absorption.
Hepatic Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Pharmacology
Mechanism of Action
Aluminum chloride hexahydrate works as an antiperspirant by forming a physical plug within the sweat ducts. When applied to the skin, the aluminum salts react with electrolytes in the sweat to form a precipitate, which then blocks the sweat glands, preventing sweat from reaching the skin surface. The astringent properties also cause the sweat ducts to constrict.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption (<1%)
Tmax:
Not applicable (topical)
FoodEffect:
Not applicable
Distribution:
Vd:
Not applicable (minimal systemic absorption)
ProteinBinding:
Not applicable (minimal systemic absorption)
CnssPenetration:
No
Elimination:
HalfLife:
Not applicable (minimal systemic absorption)
Clearance:
Not applicable (minimal systemic absorption)
ExcretionRoute:
Not applicable (minimal systemic absorption)
Unchanged:
Not applicable (minimal systemic absorption)
Pharmacodynamics
OnsetOfAction:
Within a few applications (days)
PeakEffect:
Within 1-2 weeks of consistent use
DurationOfAction:
Maintained with regular, reduced frequency application (e.g., 1-2 times/week)
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Attention Immediately
If you experience any of the following severe side effects, contact your doctor or seek medical help right away, as they can be life-threatening:
- Signs of an allergic reaction, such as:
- Rash
- Hives
- Itching
- Red, swollen, blistered, or peeling skin, with or without fever
- Wheezing
- Tightness in the chest or throat
- Trouble breathing, swallowing, or talking
- Unusual hoarseness
- Swelling of the mouth, face, lips, tongue, or throat
- Irritation at the site where the drug was applied
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience any of the following side effects or if they persist or bother you:
- Itching
- Burning or stinging
- Prickling
Note: This list is not exhaustive, and you may experience other side effects not mentioned here. If you have questions or concerns about side effects, consult your doctor for advice. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
If you experience any of the following severe side effects, contact your doctor or seek medical help right away, as they can be life-threatening:
- Signs of an allergic reaction, such as:
- Rash
- Hives
- Itching
- Red, swollen, blistered, or peeling skin, with or without fever
- Wheezing
- Tightness in the chest or throat
- Trouble breathing, swallowing, or talking
- Unusual hoarseness
- Swelling of the mouth, face, lips, tongue, or throat
- Irritation at the site where the drug was applied
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience any of the following side effects or if they persist or bother you:
- Itching
- Burning or stinging
- Prickling
Note: This list is not exhaustive, and you may experience other side effects not mentioned here. If you have questions or concerns about side effects, consult your doctor for advice. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe itching
- Intense burning or stinging
- Significant redness or rash
- Swelling at the application site
- Signs of allergic reaction (e.g., hives, difficulty breathing, swelling of face/lips/tongue/throat - seek immediate medical attention)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor identify potential interactions between this medication and other substances.
* Any existing health problems you have. This information is crucial in determining the safety of taking this medication in conjunction with your other health conditions.
To ensure your safety, do not start, stop, or change the dosage of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to assess potential interactions and determine the best course of treatment for you.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor identify potential interactions between this medication and other substances.
* Any existing health problems you have. This information is crucial in determining the safety of taking this medication in conjunction with your other health conditions.
To ensure your safety, do not start, stop, or change the dosage of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions. Your doctor and pharmacist will work together to assess potential interactions and determine the best course of treatment for you.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.
To avoid staining, take precautions to protect your clothing and fabrics when using this drug, as it may cause discoloration. Additionally, be aware that this medication may react with certain metals, potentially causing harm.
While using this drug, refrain from using other deodorants or antiperspirants to minimize potential interactions. In the event of accidental ingestion, seek immediate medical attention by calling a doctor or poison control center right away, as this medication can be harmful if swallowed.
If you are pregnant, planning to become pregnant, or are breast-feeding, it is crucial to discuss the benefits and risks of this medication with your doctor to ensure the best possible outcome for you and your baby.
To avoid staining, take precautions to protect your clothing and fabrics when using this drug, as it may cause discoloration. Additionally, be aware that this medication may react with certain metals, potentially causing harm.
While using this drug, refrain from using other deodorants or antiperspirants to minimize potential interactions. In the event of accidental ingestion, seek immediate medical attention by calling a doctor or poison control center right away, as this medication can be harmful if swallowed.
If you are pregnant, planning to become pregnant, or are breast-feeding, it is crucial to discuss the benefits and risks of this medication with your doctor to ensure the best possible outcome for you and your baby.
Overdose Information
Overdose Symptoms:
- Severe local skin irritation (burning, itching, redness, blistering)
- Systemic toxicity is highly unlikely due to minimal absorption.
What to Do:
Discontinue use, wash affected area thoroughly with soap and water. Apply soothing creams (e.g., hydrocortisone cream) if irritation is severe. For accidental ingestion, seek medical attention. Call 1-800-222-1222 (Poison Control).
Drug Interactions
Monitoring
Baseline Monitoring
Skin integrity
Rationale: To assess for pre-existing irritation or open wounds that could worsen with application.
Timing: Prior to first application
Routine Monitoring
Local skin irritation (e.g., itching, burning, redness)
Frequency: Daily during initial treatment phase, then as needed
Target: Absence of significant irritation
Action Threshold: If severe irritation occurs, discontinue use and consult a healthcare professional.
Symptom Monitoring
- Excessive itching
- Burning sensation
- Redness
- Rash
- Swelling at application site
Special Patient Groups
Pregnancy
Generally considered low risk due to minimal systemic absorption. However, formal studies are limited. Use only if clearly needed and potential benefits outweigh risks.
Trimester-Specific Risks:
First Trimester:
Low risk due to minimal systemic absorption.
Second Trimester:
Low risk due to minimal systemic absorption.
Third Trimester:
Low risk due to minimal systemic absorption.
Lactation
Considered low risk for nursing infants due to minimal systemic absorption by the mother. Apply to areas not likely to come into direct contact with the infant's skin or mouth.
Infant Risk:
Low
Pediatric Use
Use in children should be under medical supervision, especially in younger children, due to potential for increased skin sensitivity and absorption. Dosing and frequency may need to be adjusted.
Geriatric Use
No specific dose adjustments are typically needed. Elderly patients may have more fragile or sensitive skin, so monitor closely for irritation.
Clinical Information
Clinical Pearls
- Ensure skin is completely dry before application to minimize irritation. Using a hairdryer on a cool setting can help.
- Apply sparingly, a thin layer is sufficient.
- Applying at night allows the product to work effectively while sweat glands are less active.
- Washing off in the morning helps prevent irritation and staining of clothes.
- If irritation occurs, try applying less frequently (e.g., every other night, or 2-3 times a week).
- Can be used on various body areas prone to excessive sweating, including armpits, hands, and feet.
Alternative Therapies
- Other aluminum-based antiperspirants (lower concentrations)
- Botulinum toxin injections (Botox) for hyperhidrosis
- Iontophoresis
- Oral anticholinergics (e.g., glycopyrrolate, oxybutynin) for generalized hyperhidrosis
- Surgical sympathectomy (for severe cases)
Cost & Coverage
Average Cost:
Varies, typically $20-$50 per 37.5ml bottle
Generic Available:
Yes
Insurance Coverage:
Often OTC; may be covered by prescription plans if prescribed by a physician.
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication, including the amount taken and the time it happened, to ensure you receive the best possible care.