Augmentin ES-600mg Susp 200ml

Amoxicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial lysis. Clavulanate potassium is a beta-lactamase inhibitor that protects amoxicillin from degradation by beta-lactamase enzymes produced by many resistant bacteria, thereby extending amoxicillin's antibacterial spectrum.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you or your child experience any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Rarely, allergic reactions can be fatal.
Signs of drug-induced enterocolitis syndrome, a type of allergic reaction, such as:
+ Vomiting within 1 to 4 hours after taking this medication
+ Diarrhea within 24 hours after taking this medication
+ Pale or gray skin
+ Feeling tired or unwell
+ Signs of low blood pressure, such as severe dizziness or passing out
Vaginal irritation or discharge
Fever or chills
Unexplained bruising or bleeding
Diarrhea is a common side effect of antibiotics. However, in rare cases, a severe form called C. diff-associated diarrhea (CDAD) may occur, which can lead to a life-threatening bowel problem. If your child experiences:
+ Stomach pain
+ Cramps
+ Very loose, watery, or bloody stools
contact your child's doctor right away. Before treating diarrhea, consult with your child's doctor.
Liver problems, which can be fatal, have been associated with this medication. If your child exhibits signs of liver problems, such as:
+ Dark urine
+ Tiredness
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
contact the doctor immediately.
Severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions, can occur with this medication. These reactions can affect body organs and be fatal. Seek medical help right away if your child experiences:
+ Red, swollen, blistered, or peeling skin
+ Red or irritated eyes
+ Sores in the mouth, throat, nose, eyes, genitals, or any areas of skin
+ Fever
+ Chills
+ Body aches
+ Shortness of breath
+ Swollen glands

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people experience no side effects or only minor ones. If your child experiences any of the following side effects or any other side effects that bother them or do not go away, contact your child's doctor or seek medical help:

Diarrhea
Upset stomach
Vomiting
* Diaper rash

This is not an exhaustive list of all possible side effects. If you have questions or concerns about side effects, contact your child's doctor for medical advice.

Before Your Child Takes This Medication: Inform Your Doctor If:
- Your child has an allergy to this medication, any of its components, or other drugs, foods, or substances, and describe the allergic reaction they experienced.
- Your child is allergic to penicillin.
- Your child has kidney disease.
- Your child has previously experienced jaundice (turned yellow) or liver-related side effects while taking this medication.
- Your child has mononucleosis (mono).
- Your child is currently taking probenecid.

Important: This list does not encompass all possible drug interactions or health issues that may affect the use of this medication. It is crucial to inform your doctor and pharmacist about all prescription and over-the-counter medications, natural products, and vitamins your child is taking, as well as any health problems they may have. Always verify with your doctor that it is safe to take this medication in conjunction with other drugs and health conditions. Never initiate, cease, or adjust the dosage of any medication without first consulting your doctor.

It is essential to inform all of your child's healthcare providers, including doctors, nurses, pharmacists, and dentists, that your child is taking this medication.

If your child is taking this medication long-term, regular blood tests will be necessary to monitor their condition. Consult with your child's doctor to discuss the details.

This medication may interfere with certain laboratory tests. Be sure to notify all of your child's healthcare providers and laboratory personnel that your child is taking this medication.

For children with diabetes who undergo urine glucose testing, consult with your child's doctor to determine the most suitable testing methods.

If your child has phenylketonuria (PKU), consult with their doctor, as some products contain phenylalanine.

Do not administer this medication to your child for an extended period beyond the recommended duration, as this may increase the risk of a secondary infection.

A change in tooth color to yellow-gray-brown has been reported in some cases, primarily in children. In most instances, the discoloration lessened or resolved with regular brushing or dental cleaning. If you notice any changes in your child's tooth color, consult with their doctor.

For sexually active children:
Be aware that birth control pills and other hormone-based contraceptives may be less effective while taking this medication. It is recommended that your child uses an additional form of birth control, such as condoms, to prevent pregnancy.

For pregnant or breastfeeding children:
If your child is pregnant, becomes pregnant, or is breastfeeding, consult with their doctor to discuss the potential benefits and risks to both your child and the baby.

• Warfarin (increased INR, bleeding risk)
• Methotrexate (increased methotrexate levels, toxicity, especially with high-dose methotrexate)
• Oral Contraceptives (potential for reduced efficacy, though evidence is mixed)

• Probenecid (increases and prolongs amoxicillin blood levels)
• Allopurinol (increased incidence of skin rash, particularly in hyperuricemic patients)

• Allergic reactions (rash, itching, hives, swelling of face/lips/tongue, difficulty breathing)
• Gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal pain)
• Signs of C. difficile-associated diarrhea (severe, watery diarrhea, fever, abdominal cramps)
• Signs of cholestatic jaundice or hepatitis (yellowing of skin/eyes, dark urine, pale stools, persistent nausea/vomiting)
• Signs of superinfection (new or worsening symptoms of infection)

Category B. Animal reproduction studies have shown no evidence of harm to the fetus. Human studies are limited but generally reassuring. Use only if clearly needed.

Amoxicillin and clavulanate are excreted in breast milk in small amounts. Generally considered compatible with breastfeeding, but monitor infant for potential adverse effects.

Augmentin ES-600 is specifically formulated and dosed for pediatric patients, particularly for acute otitis media caused by penicillin-resistant S. pneumoniae. Dosing is weight-based (90 mg/kg/day of amoxicillin component). Not recommended for infants younger than 3 months.

No overall differences in safety or effectiveness have been observed between elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Dose adjustment is necessary for elderly patients with renal impairment.

• Augmentin ES-600 is specifically designed for pediatric acute otitis media (AOM) where high-dose amoxicillin is needed, particularly for suspected penicillin-resistant Streptococcus pneumoniae.
• Always ensure the correct formulation (ES-600 vs. other Augmentin strengths) is dispensed, as the clavulanate ratio differs significantly.
• Instruct patients to take the medication at the start of a meal to minimize gastrointestinal side effects and enhance absorption.
• Emphasize the importance of completing the full course of therapy, even if symptoms improve, to prevent the development of antibiotic resistance.
• Counsel on the risk of C. difficile-associated diarrhea, which can occur during or even several weeks after antibiotic therapy.
• Reconstituted suspension must be refrigerated and discarded after 10 days.

• Ceftriaxone (for AOM, especially in severe cases or non-compliance)
• Cefdinir (for AOM, but less effective against resistant S. pneumoniae)
• Levofloxacin (for resistant infections, but generally avoided in pediatrics unless no other options)
• Clindamycin (for penicillin-allergic patients, but limited spectrum)

If your child's symptoms or health issues persist or worsen, it is essential to contact their doctor promptly. To ensure safe and effective treatment, never share your child's medication with others, and do not administer someone else's medication to your child. Some medications may come with an additional patient information leaflet; if you have any questions or concerns about this medication, consult with your child's doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call the poison control center or seek medical attention. When reporting the incident, be prepared to provide detailed information, including the substance taken, the quantity, and the time it occurred.