Augmentin 400mg/5ml Susp100ml

Amoxicillin, a beta-lactam antibiotic, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. Clavulanate potassium is a beta-lactamase inhibitor that irreversibly binds to and inactivates a wide range of bacterial beta-lactamase enzymes, preventing the degradation of amoxicillin and extending its antibacterial spectrum.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek emergency medical attention:

Signs of an allergic reaction, such as:
+ Rash or hives
+ Itching or red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing or tightness in the chest or throat
+ Difficulty breathing, swallowing, or talking
+ Unusual hoarseness or swelling of the mouth, face, lips, tongue, or throat
Rarely, allergic reactions can be fatal.
Signs of drug-induced enterocolitis syndrome, a type of allergic reaction, such as:
+ Vomiting within 1 to 4 hours after taking this medication
+ Diarrhea within 24 hours after taking this medication
+ Pale or gray skin
+ Feeling tired or unwell
+ Signs of low blood pressure, including severe dizziness or fainting
Vaginal irritation or discharge
Fever or chills
Unexplained bruising or bleeding
Diarrhea is a common side effect of antibiotics. However, in rare cases, a severe form called C. diff-associated diarrhea (CDAD) may occur, which can lead to life-threatening bowel problems. If you experience:
+ Stomach pain or cramps
+ Very loose, watery, or bloody stools
+ Contact your doctor immediately. Do not treat diarrhea without consulting your doctor first.
Liver problems, which can be fatal, may occur with this medication. Seek medical help right away if you experience:
+ Dark urine
+ Tiredness
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions, may occur. These reactions can affect body organs and be life-threatening. Seek medical help immediately if you experience:
+ Red, swollen, blistered, or peeling skin
+ Red or irritated eyes
+ Sores in your mouth, throat, nose, eyes, genitals, or skin
+ Fever
+ Chills
+ Body aches
+ Shortness of breath
+ Swollen glands

Other Side Effects

Most people do not experience significant side effects, but some may occur. If you are concerned about any side effects or if they persist, contact your doctor:

Common side effects for all patients taking this medication:
+ Diarrhea
+ Upset stomach
+ Vomiting
* Common side effects in children:
+ Diaper rash

Reporting Side Effects

This list is not exhaustive. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
If you are allergic to penicillin, as this may affect your ability to take this medication.
Existing kidney disease, as this may impact the medication's effectiveness or increase the risk of side effects.
Previous experiences with liver problems or jaundice (turning yellow) while taking this medication.
If you have been diagnosed with mononucleosis (mono).
If you are currently taking probenecid, as this may interact with the medication.

This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. They will help you determine if it is safe to take this medication with your existing treatments and health conditions. Never start, stop, or adjust the dosage of any medication without consulting your doctor first.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

This medication may interfere with certain laboratory tests, so it is crucial to notify all your healthcare providers and lab personnel that you are taking this drug. If you have diabetes and test your urine glucose levels, consult with your doctor to determine the most suitable tests to use.

Individuals with phenylketonuria (PKU) should discuss this condition with their doctor, as some products may contain phenylalanine.

Do not take this medication for longer than prescribed, as this may increase the risk of a second infection. A common side effect of this drug, particularly in children, is a change in tooth color to a yellow-gray-brown hue. In most cases, this discoloration can be reduced or eliminated with regular brushing or dental cleaning. If you notice any changes in tooth color, consult with your doctor.

Women taking birth control pills or other hormone-based contraceptives should be aware that this medication may reduce their effectiveness. To prevent pregnancy, consider using an additional form of birth control, such as a condom, while taking this drug.

If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor. You will need to discuss the potential benefits and risks of taking this medication to both you and your baby.

• Warfarin (increased INR, bleeding risk)
• Methotrexate (increased methotrexate levels, toxicity)
• Allopurinol (increased incidence of rash)

• Oral Contraceptives (potential for reduced efficacy)
• Probenecid (increased and prolonged amoxicillin blood levels)
• Mycophenolate Mofetil (reduced mycophenolic acid (MPA) concentrations)

• Skin rash or itching (signs of allergic reaction)
• Severe or persistent diarrhea (may indicate C. difficile infection)
• Nausea, vomiting, abdominal pain
• Yellowing of skin or eyes (jaundice), dark urine, pale stools (signs of liver problems)
• Difficulty breathing or swallowing, swelling of face/lips/tongue (signs of severe allergic reaction)
• Unusual bruising or bleeding

Augmentin is classified as Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed and the potential benefits outweigh the potential risks.

Amoxicillin and clavulanate are excreted into breast milk. While generally considered compatible with breastfeeding (Lactation Risk L2), caution is advised. Monitor breastfed infants for potential adverse effects.

Dosing is weight-based and specific formulations (e.g., 400mg/57mg per 5ml, 600mg/42.9mg per 5ml) are designed to provide appropriate amoxicillin doses while minimizing clavulanate exposure. Not recommended for neonates (<12 weeks of age) due to immature renal function.

No overall differences in safety or effectiveness have been observed between elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Dose adjustment is necessary for elderly patients with renal impairment. Increased risk of gastrointestinal side effects and C. difficile infection.

• Always ensure the correct formulation (e.g., 400mg/57mg per 5ml vs. 600mg/42.9mg per 5ml) is prescribed and dispensed, as the clavulanate ratio differs and affects dosing, especially in pediatrics.
• Instruct patients to take Augmentin at the start of a meal to minimize gastrointestinal upset, which is a common side effect.
• Emphasize the importance of completing the full course of therapy, even if symptoms improve, to prevent bacterial resistance and relapse.
• Reconstituted suspension must be refrigerated and discarded after 10 days.
• Augmentin is not effective against viral infections; avoid inappropriate prescribing to reduce antibiotic resistance.
• High incidence of diarrhea is common; advise patients on managing this side effect and to report severe or persistent diarrhea.

• Cephalosporins (e.g., Cefdinir, Cefpodoxime, Cefuroxime)
• Macrolides (e.g., Azithromycin, Clarithromycin) - for atypical pathogens or penicillin allergy
• Fluoroquinolones (e.g., Levofloxacin, Moxifloxacin) - for specific indications and older patients
• Tetracyclines (e.g., Doxycycline) - for specific indications and older children/adults

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it occurred.