Amoxicillin 125mg Chewable Tablets

Amoxicillin is a bactericidal beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs). This inhibits the transpeptidation step of peptidoglycan synthesis, leading to bacterial cell lysis and death.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Rarely, some allergic reactions can be fatal.
Signs of drug-induced enterocolitis syndrome, a type of allergic reaction, such as:
+ Vomiting within 1 to 4 hours after taking this medication
+ Diarrhea within 24 hours after taking this medication
+ Pale or gray skin
+ Feeling tired or unwell
+ Signs of low blood pressure, including severe dizziness or passing out
Unexplained bruising or bleeding
Fever or chills
Vaginal itching or discharge
Diarrhea is a common side effect of antibiotics, but rarely, a severe form called C. diff-associated diarrhea (CDAD) may occur. If you experience:
+ Stomach pain
+ Cramps
+ Very loose, watery, or bloody stools
+ Contact your doctor right away. Do not treat diarrhea without consulting your doctor first.
Severe skin reactions, including:
+ Stevens-Johnson syndrome (SJS)
+ Toxic epidermal necrolysis (TEN)
+ Other serious reactions, which can affect body organs and be life-threatening. Seek medical help immediately if you notice:
- Red, swollen, blistered, or peeling skin
- Red or irritated eyes
- Sores in your mouth, throat, nose, eyes, genitals, or any areas of skin
- Fever
- Chills
- Body aches
- Shortness of breath
- Swollen glands

Other Possible Side Effects

Most people do not experience severe side effects, and some may not have any side effects at all. However, if you notice any of the following side effects, contact your doctor or seek medical attention if they bother you or do not go away:

Diarrhea
Upset stomach
Vomiting
Headache

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
If you are allergic to penicillin, as this may impact your ability to take this medication safely.
If you have been diagnosed with mononucleosis (mono), as this condition may affect how you respond to this medication.

Please note that this is not an exhaustive list of potential interactions. To ensure your safety, it is crucial to discuss all of your:

Prescription and over-the-counter (OTC) medications
Natural products
Vitamins
* Health problems

with your doctor and pharmacist. They will help you determine whether it is safe to take this medication in conjunction with your other medications and health conditions. Never start, stop, or adjust the dosage of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug long-term, your doctor may recommend regular blood tests to monitor your condition.

This medication may interfere with certain laboratory tests, so it is crucial to notify all your healthcare providers and lab personnel that you are taking this drug. If you have diabetes and test your urine glucose levels, consult with your doctor to determine the most suitable tests to use.

Individuals with phenylketonuria (PKU) should discuss this condition with their doctor, as some products may contain phenylalanine.

Do not take this medication for longer than prescribed, as this may increase the risk of a second infection. A common side effect, particularly in children, is a change in tooth color to yellow-gray-brown. In most cases, this discoloration can be reduced or eliminated with regular brushing or dental cleaning. If you notice any changes in tooth color, consult with your doctor.

Women taking birth control pills or other hormone-based contraceptives should be aware that this medication may reduce their effectiveness. To prevent pregnancy, use an additional form of birth control, such as a condom, while taking this drug.

If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor. You will need to discuss the potential benefits and risks of taking this medication to both you and your baby.

• Methotrexate (increased methotrexate levels and toxicity)
• Warfarin (increased INR/bleeding risk, monitor INR)

• Allopurinol (increased risk of amoxicillin-induced rash)
• Oral contraceptives (potential decrease in efficacy, though clinical significance debated)
• Tetracyclines (may antagonize amoxicillin's bactericidal effect)
• Probenecid (increases amoxicillin plasma levels and prolongs half-life)

• Skin rash or hives (signs of allergic reaction)
• Difficulty breathing or swallowing (signs of severe allergic reaction)
• Severe or persistent diarrhea (may indicate C. difficile infection)
• Nausea, vomiting, abdominal pain
• Unusual bruising or bleeding (if on warfarin)
• Oral thrush or vaginal yeast infection (signs of superinfection)

Considered generally safe for use during pregnancy. Amoxicillin is a Category B drug, meaning animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women, or animal studies have shown an adverse effect but human studies have not.

Considered safe for use during breastfeeding (L1 - Safest). Amoxicillin is excreted in breast milk in small amounts. Monitor infant for potential diarrhea, candidiasis (thrush, diaper rash), or allergic reactions.

Amoxicillin chewable tablets are commonly used and well-tolerated in pediatric patients. Dosing is weight-based and adjusted for age and infection type. Close monitoring for allergic reactions is important.

No specific dose adjustment is needed based solely on age. However, geriatric patients are more likely to have decreased renal function, which may necessitate dose adjustment based on creatinine clearance. Monitor for adverse effects, especially gastrointestinal disturbances and potential for C. difficile infection.

• Amoxicillin chewable tablets are ideal for pediatric patients who have difficulty swallowing pills.
• Ensure the patient chews the tablet completely to ensure proper absorption and avoid choking hazards.
• Counsel patients on the importance of completing the full course of antibiotics, even if symptoms improve, to prevent resistance.
• Amoxicillin is a common cause of non-allergic rash, especially in patients with mononucleosis. Differentiate this from a true allergic reaction.
• While food does not significantly affect absorption, taking it with food may help reduce gastrointestinal upset.

• Cephalexin (Keflex) - another beta-lactam antibiotic
• Azithromycin (Zithromax) - macrolide antibiotic
• Clindamycin (Cleocin) - lincosamide antibiotic
• Cefdinir (Omnicef) - third-generation cephalosporin

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the medication taken, the amount, and the time it occurred.