Amoxicillin 125mg/5ml Susp 80ml

Amoxicillin is a bactericidal beta-lactam antibiotic. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which are located on the bacterial cell wall. This binding inhibits the transpeptidation step of peptidoglycan synthesis, leading to the disruption of the cell wall and ultimately bacterial cell lysis and death.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash or hives
+ Itching or red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing or tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Rarely, allergic reactions can be fatal.
Signs of drug-induced enterocolitis syndrome, a type of allergic reaction, such as:
+ Vomiting within 1 to 4 hours after taking this medication
+ Diarrhea within 24 hours after taking this medication
+ Pale or gray skin
+ Feeling tired or unwell
+ Signs of low blood pressure, including severe dizziness or passing out
Unexplained bruising or bleeding
Fever or chills
Vaginal itching or discharge
Diarrhea is a common side effect of antibiotics, but rarely, a severe form called C. diff-associated diarrhea (CDAD) may occur. If you experience:
+ Stomach pain or cramps
+ Very loose, watery, or bloody stools
+ CDAD may occur during or a few months after taking antibiotics; contact your doctor immediately
Severe skin reactions, including:
+ Stevens-Johnson syndrome (SJS)
+ Toxic epidermal necrolysis (TEN)
+ Other serious reactions, which can affect body organs and be life-threatening
+ Signs of severe skin reactions include:
- Red, swollen, blistered, or peeling skin
- Red or irritated eyes
- Sores in the mouth, throat, nose, eyes, genitals, or skin
- Fever or chills
- Body aches or shortness of breath
- Swollen glands

Other Possible Side Effects

Most people experience no side effects or only minor ones while taking this medication. However, if you notice any of the following side effects or if they bother you or persist, contact your doctor:

Diarrhea
Upset stomach or vomiting
* Headache

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you are allergic to penicillin, as this may impact your ability to take this medication safely.
* If you have been diagnosed with mononucleosis (mono), as this condition may affect how you respond to this medication.

This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. They will help you determine if it is safe to take this medication in combination with your other medications and health conditions.

Remember, do not start, stop, or change the dosage of any medication without first consulting your doctor to ensure your safety.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

This medication may interfere with certain laboratory tests, so it is crucial to notify all your healthcare providers and lab personnel that you are taking this drug. If you have diabetes and test your urine glucose levels, consult with your doctor to determine the most suitable tests to use.

Do not take this medication for longer than prescribed, as this may increase the risk of a second infection.

A possible side effect of this medication is a change in tooth color, which may appear as yellow, gray, or brown. This has been reported primarily in children, but in most cases, the discoloration lessens or disappears with regular brushing or dental cleaning. If you notice any change in tooth color, consult with your doctor.

When taking this medication, birth control pills and other hormone-based birth control methods may be less effective in preventing pregnancy. To minimize the risk of unplanned pregnancy, use an additional form of birth control, such as a condom, while taking this drug.

If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor. You will need to discuss the potential benefits and risks of this medication to both you and your baby.

• Methotrexate (increased methotrexate levels and toxicity due to reduced renal clearance)
• Live Typhoid Vaccine (oral) (amoxicillin may reduce the immunologic response to the vaccine)

• Allopurinol (increased risk of rash, particularly in patients with hyperuricemia)
• Oral Contraceptives (may reduce efficacy, though clinical significance is debated; advise backup contraception)
• Probenecid (increases and prolongs amoxicillin plasma levels by inhibiting renal tubular secretion)
• Warfarin (may enhance anticoagulant effect; monitor INR)

• Rash or itching (signs of allergic reaction)
• Diarrhea (common side effect, but severe or persistent diarrhea may indicate C. difficile infection)
• Nausea/vomiting
• Unusual bruising or bleeding (rare, but possible hematologic effects)
• Signs of new infection (e.g., fever, sore throat, vaginal discharge)

Amoxicillin is generally considered safe for use during pregnancy (Pregnancy Category B). Studies in animals have not shown harm to the fetus, and there is no evidence of harm in well-controlled studies in pregnant women.

Amoxicillin is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding (Lactation Risk L1).

Amoxicillin is widely used and well-tolerated in pediatric patients. Dosing is weight-based. Care should be taken to ensure accurate measurement of the suspension dose. Higher doses (e.g., 80-90 mg/kg/day) are often used for resistant S. pneumoniae in otitis media.

No specific dose adjustment is needed based on age alone. However, geriatric patients are more likely to have decreased renal function, which may necessitate dose adjustment based on creatinine clearance. Monitor for signs of superinfection and C. difficile-associated diarrhea.

• Amoxicillin is a common cause of non-allergic rash, especially in patients with viral infections (e.g., infectious mononucleosis). This rash is typically maculopapular, non-pruritic, and does not preclude future use of penicillins.
• It is not effective against beta-lactamase producing bacteria (e.g., many strains of H. influenzae, M. catarrhalis, S. aureus). For these, amoxicillin/clavulanate (Augmentin) is often used.
• Ensure patients complete the full course of therapy to prevent resistance and recurrence of infection.
• Oral suspension must be shaken well before each use and refrigerated after reconstitution. Discard after 14 days.
• Amoxicillin is a first-line agent for many common bacterial infections, including acute otitis media, streptococcal pharyngitis, and community-acquired pneumonia (in certain cases).

• Penicillin V (for susceptible streptococcal infections)
• Cephalexin (a first-generation cephalosporin)
• Cefdinir (a third-generation cephalosporin)
• Azithromycin (a macrolide, for penicillin-allergic patients or atypical pathogens)
• Clindamycin (for certain anaerobic or skin/soft tissue infections)
• Doxycycline (for certain respiratory or skin infections)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.