Tridesilon 0.05% Ointment 15gm
It is used to treat skin rashes and other skin irritation.
Drug Class
Topical Corticosteroid
Pharmacologic Class
Corticosteroid, Anti-inflammatory
Pregnancy Category
Category C
FDA Approved
Jun 1978
DEA Schedule
Not Controlled
Overview
What is this medicine?
Desonide ointment is a mild corticosteroid medication applied to the skin to reduce redness, swelling, and itching caused by various skin conditions like eczema or dermatitis. It helps calm down the skin's immune response.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning.
Wash your hands before and after applying the medication, unless your hand is the area being treated.
Clean the affected area before applying the medication and dry it thoroughly.
Apply a thin layer of the medication to the affected skin and gently rub it in.
Do not cover the treated area with bandages or dressings unless your doctor instructs you to do so.
Unless directed by your doctor, do not apply the medication to your face, underarms, or groin area.
Storage and Disposal
Store the medication at room temperature, avoiding freezing.
Keep all medications in a safe place, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your doctor or pharmacist.
Check with your pharmacist for guidance on the best way to dispose of medications, and consider participating in local drug take-back programs.
Missed Dose
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next dose, skip the missed dose and resume your regular schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning.
Wash your hands before and after applying the medication, unless your hand is the area being treated.
Clean the affected area before applying the medication and dry it thoroughly.
Apply a thin layer of the medication to the affected skin and gently rub it in.
Do not cover the treated area with bandages or dressings unless your doctor instructs you to do so.
Unless directed by your doctor, do not apply the medication to your face, underarms, or groin area.
Storage and Disposal
Store the medication at room temperature, avoiding freezing.
Keep all medications in a safe place, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your doctor or pharmacist.
Check with your pharmacist for guidance on the best way to dispose of medications, and consider participating in local drug take-back programs.
Missed Dose
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next dose, skip the missed dose and resume your regular schedule.
Do not apply two doses at the same time or use extra doses to make up for a missed dose.
Lifestyle & Tips
- Wash hands before and after applying the ointment.
- Apply a thin layer to the affected area and rub it in gently until it disappears.
- Do not cover the treated area with bandages or tight dressings unless specifically instructed by your doctor, as this can increase absorption and side effects.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Do not use on the face, groin, or armpits unless directed by your doctor.
- Do not use for longer than prescribed, especially in children, as prolonged use can lead to skin thinning or other side effects.
- Inform your doctor if your condition does not improve after 2-4 weeks of treatment.
Available Forms & Alternatives
Available Strengths:
Generic Alternatives:
Dosing & Administration
Adult Dosing
Standard Dose:
Apply a thin film to the affected skin areas two to three times daily.
Condition-Specific Dosing:
generalUse:
Apply sparingly to affected areas. Rub in gently and completely. Do not use occlusive dressings unless directed by a physician.
Pediatric Dosing
Neonatal:
Not established
Infant:
Apply a thin film to the affected skin areas two to three times daily. Use with caution; increased risk of systemic absorption and HPA axis suppression.
Child:
Apply a thin film to the affected skin areas two to three times daily. Use with caution; increased risk of systemic absorption and HPA axis suppression.
Adolescent:
Apply a thin film to the affected skin areas two to three times daily.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed for topical use.
Moderate:
No adjustment needed for topical use.
Severe:
No adjustment needed for topical use.
Dialysis:
No specific considerations for topical use.
Hepatic Impairment:
Mild:
No adjustment needed for topical use.
Moderate:
No adjustment needed for topical use.
Severe:
No adjustment needed for topical use.
Pharmacology
Mechanism of Action
Desonide is a low-potency corticosteroid. Corticosteroids exert their anti-inflammatory actions by inducing phospholipase A2 inhibitory proteins, lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Corticosteroids also suppress the migration of polymorphonuclear leukocytes and reverse increased capillary permeability.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption; varies with skin integrity, site, vehicle, and occlusive dressings.
Tmax:
Not applicable for topical use (systemic Tmax not clinically relevant for typical use).
FoodEffect:
Not applicable for topical use.
Distribution:
Vd:
Not applicable for topical use (minimal systemic distribution).
ProteinBinding:
Not applicable for topical use (minimal systemic protein binding).
CnssPenetration:
Limited
Elimination:
HalfLife:
Not applicable for topical use (systemic half-life not clinically relevant for typical use).
Clearance:
Not applicable for topical use.
ExcretionRoute:
Renal, if systemically absorbed.
Unchanged:
Not applicable for topical use.
Pharmacodynamics
OnsetOfAction:
Hours to days for symptomatic relief.
PeakEffect:
Days to weeks of consistent use.
DurationOfAction:
Varies with individual and condition, typically requires continued application.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood sugar, including:
+ Confusion
+ Feeling sleepy
+ Unusual thirst or hunger
+ Passing urine more often
+ Flushing
+ Fast breathing
+ Breath that smells like fruit
Signs of a weak adrenal gland, such as:
+ Severe upset stomach or vomiting
+ Severe dizziness or passing out
+ Muscle weakness
+ Feeling very tired
+ Mood changes
+ Decreased appetite
+ Weight loss
Signs of Cushing's syndrome, including:
+ Weight gain in the upper back or belly
+ Moon face
+ Severe headache
+ Slow healing
Skin irritation
Skin changes (pimples, stretch marks, slow healing, hair growth)
Change in skin color
Changes in eyesight, eye pain, or severe eye irritation
Other Possible Side Effects
Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you notice any of the following side effects or any other symptoms that concern you, contact your doctor or seek medical help:
Burning or stinging
Dry skin
* Signs of a common cold
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood sugar, including:
+ Confusion
+ Feeling sleepy
+ Unusual thirst or hunger
+ Passing urine more often
+ Flushing
+ Fast breathing
+ Breath that smells like fruit
Signs of a weak adrenal gland, such as:
+ Severe upset stomach or vomiting
+ Severe dizziness or passing out
+ Muscle weakness
+ Feeling very tired
+ Mood changes
+ Decreased appetite
+ Weight loss
Signs of Cushing's syndrome, including:
+ Weight gain in the upper back or belly
+ Moon face
+ Severe headache
+ Slow healing
Skin irritation
Skin changes (pimples, stretch marks, slow healing, hair growth)
Change in skin color
Changes in eyesight, eye pain, or severe eye irritation
Other Possible Side Effects
Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you notice any of the following side effects or any other symptoms that concern you, contact your doctor or seek medical help:
Burning or stinging
Dry skin
* Signs of a common cold
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Increased redness, swelling, or pus at the application site (signs of infection)
- Severe burning, itching, or irritation that was not present before
- Thinning of the skin, easy bruising, or stretch marks (striae) in the treated area
- Changes in skin color (lightening or darkening)
- Acne-like breakouts or increased hair growth in the treated area
- Unusual fatigue, weakness, weight gain, or swelling in the ankles/feet (signs of systemic absorption, especially with prolonged or extensive use)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
The presence of an infection at the site where this medication will be applied.
* Any areas of thin skin where you plan to apply this medication.
This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. They will help you determine if it is safe to take this medication with your other medications and health conditions.
Remember, do not start, stop, or adjust the dosage of any medication without first consulting your doctor to ensure your safety.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
The presence of an infection at the site where this medication will be applied.
* Any areas of thin skin where you plan to apply this medication.
This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. They will help you determine if it is safe to take this medication with your other medications and health conditions.
Remember, do not start, stop, or adjust the dosage of any medication without first consulting your doctor to ensure your safety.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before using any other medications or skin products, such as soaps, consult with your doctor to ensure safe use.
When applying this medication, avoid using tight-fitting diapers or plastic pants if the treated area is in the diaper region, as this can increase the amount of medication absorbed into the body. Do not apply this medication to cuts, scrapes, or damaged skin. If you need to use this medication on a large area of skin, exercise caution and discuss this with your doctor.
Use this medication only for the duration prescribed by your doctor. Prolonged use can increase the risk of developing cataracts or glaucoma, so it is crucial to monitor your condition and discuss any concerns with your doctor.
When using this medication in children, it is essential to exercise caution, as the risk of certain side effects may be higher in this population. In some cases, this medication can affect growth in children and teenagers, and regular growth checks may be necessary. Your doctor will discuss the potential risks and benefits with you.
If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor, as they will need to weigh the benefits and risks of using this medication for both you and your baby. If you are breastfeeding and apply this medication to your breast or nipple, be sure to wash the area thoroughly before feeding your child.
When applying this medication, avoid using tight-fitting diapers or plastic pants if the treated area is in the diaper region, as this can increase the amount of medication absorbed into the body. Do not apply this medication to cuts, scrapes, or damaged skin. If you need to use this medication on a large area of skin, exercise caution and discuss this with your doctor.
Use this medication only for the duration prescribed by your doctor. Prolonged use can increase the risk of developing cataracts or glaucoma, so it is crucial to monitor your condition and discuss any concerns with your doctor.
When using this medication in children, it is essential to exercise caution, as the risk of certain side effects may be higher in this population. In some cases, this medication can affect growth in children and teenagers, and regular growth checks may be necessary. Your doctor will discuss the potential risks and benefits with you.
If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor, as they will need to weigh the benefits and risks of using this medication for both you and your baby. If you are breastfeeding and apply this medication to your breast or nipple, be sure to wash the area thoroughly before feeding your child.
Overdose Information
Overdose Symptoms:
- Chronic overdose or misuse can lead to systemic effects of hypercorticism (Cushing's syndrome), including adrenal suppression, hyperglycemia, and glucosuria. Local symptoms include skin atrophy, striae, and telangiectasias.
What to Do:
Discontinue the medication gradually under medical supervision. Symptomatic and supportive treatment. Call 1-800-222-1222 (Poison Control Center) for advice.
Drug Interactions
Monitoring
Baseline Monitoring
Skin condition assessment
Rationale: To establish baseline severity of dermatosis and identify any contraindications (e.g., active infection).
Timing: Prior to initiation of therapy.
Routine Monitoring
Clinical response (reduction in inflammation, pruritus)
Frequency: Weekly to bi-weekly during initial treatment, then as needed.
Target: Improvement in symptoms and appearance of affected skin.
Action Threshold: Lack of improvement or worsening of symptoms after 2-4 weeks may indicate need for re-evaluation or alternative therapy.
Local adverse effects (e.g., skin atrophy, striae, telangiectasias, folliculitis, burning, itching)
Frequency: At each follow-up visit.
Target: Absence or minimal signs of adverse effects.
Action Threshold: Presence of significant or worsening local adverse effects warrants reduction in frequency, discontinuation, or change to a different therapy.
Signs of systemic absorption (e.g., Cushing's syndrome, hyperglycemia, HPA axis suppression)
Frequency: Periodically, especially with prolonged use, large surface area application, or in pediatric patients.
Target: Normal adrenal function and glucose levels.
Action Threshold: Symptoms of systemic absorption or abnormal laboratory tests (e.g., morning cortisol) require immediate medical attention and discontinuation of therapy.
Symptom Monitoring
- Burning
- Itching
- Irritation
- Dryness
- Folliculitis
- Hypertrichosis
- Acneiform eruptions
- Hypopigmentation
- Perioral dermatitis
- Allergic contact dermatitis
- Maceration of the skin
- Secondary infection
- Skin atrophy
- Striae
- Miliaria
- Signs of Cushing's syndrome (e.g., moon face, buffalo hump, central obesity)
- Unusual fatigue or weakness
Special Patient Groups
Pregnancy
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal studies have shown teratogenic effects with corticosteroids.
Trimester-Specific Risks:
First Trimester:
Potential for teratogenic effects, though systemic absorption from topical use is minimal.
Second Trimester:
Minimal risk with appropriate topical use.
Third Trimester:
Minimal risk with appropriate topical use.
Lactation
Caution should be exercised when desonide is administered to a nursing woman. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Avoid applying to the breast area to prevent infant ingestion.
Infant Risk:
Low risk with proper application, but monitor for potential adverse effects if significant systemic absorption occurs in the mother.
Pediatric Use
Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than mature adults because of a larger skin surface area to body weight ratio. Use the least potent corticosteroid for the shortest duration possible. Avoid prolonged use or occlusive dressings.
Geriatric Use
No overall differences in safety or effectiveness have been observed between elderly and younger patients. However, elderly patients may have thinner skin, making them potentially more susceptible to local adverse effects like skin atrophy.
Clinical Information
Clinical Pearls
- Desonide is a low-potency topical corticosteroid, making it suitable for sensitive areas like the face, intertriginous areas, and for pediatric use, but still requires careful monitoring.
- Ointment formulations are generally more potent and occlusive than creams or gels, providing better penetration for dry, scaly lesions.
- Educate patients on the 'less is more' principle: a thin layer is sufficient. Overuse does not improve efficacy and increases risk of side effects.
- Avoid abrupt discontinuation after prolonged use on large areas, especially if HPA axis suppression is suspected, to prevent adrenal insufficiency.
- Always rule out fungal or bacterial infections before initiating corticosteroid therapy, as steroids can worsen these conditions.
Alternative Therapies
- Hydrocortisone (lower potency topical corticosteroid)
- Triamcinolone acetonide (medium potency topical corticosteroid)
- Fluocinolone acetonide (medium potency topical corticosteroid)
- Pimecrolimus cream (Elidel) - topical calcineurin inhibitor
- Tacrolimus ointment (Protopic) - topical calcineurin inhibitor
- Crisaborole ointment (Eucrisa) - topical phosphodiesterase-4 (PDE4) inhibitor
- Emollients/moisturizers for dry skin conditions
Cost & Coverage
Average Cost:
$20 - $50 per 15gm tube
Generic Available:
Yes
Insurance Coverage:
Tier 1 or Tier 2 (Generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication, including the amount taken and the time it happened, to facilitate prompt and effective treatment.