Terconazole 80mg Vaginal Supp 3's
It is used to treat vaginal infections. If this drug has been given for some other reason, talk with the doctor for more information.
Drug Class
Antifungal
Pharmacologic Class
Triazole Antifungal
Pregnancy Category
Category C
FDA Approved
Jan 1987
DEA Schedule
Not Controlled
Overview
What is this medicine?
Terconazole is an antifungal medicine used to treat vaginal yeast infections. It works by stopping the growth of the yeast that causes the infection. It comes as a suppository that you insert into your vagina.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication effectively, follow your doctor's instructions carefully. Read all the information provided and adhere to the instructions closely. Continue using the medication as directed, even if your symptoms improve.
Important Administration Guidelines
Do not take this medication by mouth. It is for vaginal use only.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning.
Wash your hands before and after using the medication.
For best results, use the medication at bedtime.
* Clean the applicator after each use.
Storing and Disposing of Your Medication
Store the medication at room temperature, keeping it in a safe location out of the reach of children and pets. Dispose of unused or expired medication properly. Do not flush it down the toilet or pour it down the drain unless instructed to do so. If you have questions about disposing of your medication, consult your pharmacist. You may also want to check if there are drug take-back programs available in your area.
Missing a Dose
If you miss a dose, use it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not use two doses at the same time or take extra doses.
To use this medication effectively, follow your doctor's instructions carefully. Read all the information provided and adhere to the instructions closely. Continue using the medication as directed, even if your symptoms improve.
Important Administration Guidelines
Do not take this medication by mouth. It is for vaginal use only.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning.
Wash your hands before and after using the medication.
For best results, use the medication at bedtime.
* Clean the applicator after each use.
Storing and Disposing of Your Medication
Store the medication at room temperature, keeping it in a safe location out of the reach of children and pets. Dispose of unused or expired medication properly. Do not flush it down the toilet or pour it down the drain unless instructed to do so. If you have questions about disposing of your medication, consult your pharmacist. You may also want to check if there are drug take-back programs available in your area.
Missing a Dose
If you miss a dose, use it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not use two doses at the same time or take extra doses.
Lifestyle & Tips
- Insert the suppository high into the vagina, preferably at bedtime.
- Complete the full 3-day course of treatment, even if symptoms improve.
- Avoid sexual intercourse during treatment to prevent reinfection or irritation.
- Wear cotton underwear and avoid tight-fitting clothing.
- Avoid douching or using tampons during treatment.
- Consult a healthcare provider if symptoms do not improve or worsen after treatment.
Available Forms & Alternatives
Dosing & Administration
Adult Dosing
Standard Dose:
One 80 mg vaginal suppository administered once daily at bedtime for 3 consecutive days.
Dose Range:
80 - 80 mg
Condition-Specific Dosing:
vulvovaginalCandidiasis:
One 80 mg vaginal suppository administered once daily at bedtime for 3 consecutive days.
Pediatric Dosing
Neonatal:
Not established
Infant:
Not established
Child:
Not established
Adolescent:
Not established (safety and efficacy not established in pediatric patients under 18 years of age)
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Dialysis:
No specific considerations due to minimal systemic absorption
Hepatic Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Pharmacology
Mechanism of Action
Terconazole is a triazole antifungal agent that exerts its fungicidal activity by altering the permeability of the fungal cell membrane. It inhibits the biosynthesis of ergosterol, a vital component of fungal cell membranes, by interfering with the activity of cytochrome P450-dependent enzymes involved in ergosterol synthesis. This leads to structural and functional impairment of the fungal cell membrane, resulting in leakage of essential intracellular components and ultimately cell death.
Pharmacokinetics
Absorption:
Bioavailability:
Approximately 5-8% (systemic absorption after vaginal administration)
Tmax:
Approximately 6.6 hours (for systemic absorption, but local action is immediate)
FoodEffect:
Not applicable (vaginal administration)
Distribution:
Vd:
Not available (primarily local action)
ProteinBinding:
94.9% (systemically absorbed portion)
CnssPenetration:
Limited (not clinically relevant for vaginal use)
Elimination:
HalfLife:
Approximately 6.9 hours (systemically absorbed portion)
Clearance:
Not available
ExcretionRoute:
Fecal (primarily), urinary (minor) for systemically absorbed drug
Unchanged:
Not available (minimal systemic excretion of unchanged drug)
Pharmacodynamics
OnsetOfAction:
Within 24-48 hours (symptomatic relief)
PeakEffect:
Within 3-7 days (completion of treatment course)
DurationOfAction:
Sustained local antifungal activity throughout the 3-day treatment course
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Irritation at the site where the medication was applied
Fever or chills
Flu-like symptoms
A severe skin reaction (toxic epidermal necrolysis) may occur, which can lead to serious health problems and even death. Seek medical help immediately if you experience:
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Red or irritated eyes
+ Sores in your mouth, throat, nose, or eyes
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:
Headache
Menstrual (period) pain
Burning
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Irritation at the site where the medication was applied
Fever or chills
Flu-like symptoms
A severe skin reaction (toxic epidermal necrolysis) may occur, which can lead to serious health problems and even death. Seek medical help immediately if you experience:
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Red or irritated eyes
+ Sores in your mouth, throat, nose, or eyes
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:
Headache
Menstrual (period) pain
Burning
This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Increased vaginal irritation, burning, or itching
- Hives or rash
- Swelling of the face, lips, tongue, or throat
- Severe abdominal pain
- Fever or chills
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
Potential interactions with other medications or health conditions. This medication may interact with other drugs or exacerbate certain health problems.
To ensure your safety, provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are currently taking
Any natural products or vitamins you are using
* Existing health problems
Carefully review your medications and health conditions to confirm that it is safe to take this medication in conjunction with them. Never start, stop, or adjust the dosage of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
Potential interactions with other medications or health conditions. This medication may interact with other drugs or exacerbate certain health problems.
To ensure your safety, provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are currently taking
Any natural products or vitamins you are using
* Existing health problems
Carefully review your medications and health conditions to confirm that it is safe to take this medication in conjunction with them. Never start, stop, or adjust the dosage of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you have a known allergy to any type of nuts or seeds, discuss this with your doctor, as some products may contain nuts.
Do not use this medication if you experience abdominal pain, fever, or foul-smelling vaginal discharge. Instead, consult your doctor for guidance. This medication is specifically intended for the treatment of vaginal yeast infections and should not be used to address itching caused by other health issues. If you frequently experience vaginal yeast infections, consult your doctor to discuss the best course of action.
To minimize the risk of staining, take precautions to protect your clothing and fabrics. Avoid using tampons during treatment. After showering, bathing, or swimming, thoroughly dry the external vaginal area to prevent moisture buildup. Change into dry clothing as soon as possible, especially after wearing wet bathing suits or damp workout clothes.
Unless advised by your doctor, refrain from using douches, as this may disrupt the natural balance of the vagina. Avoid scratching the affected area, as this can lead to increased irritation and potentially spread the infection. It is recommended to abstain from vaginal sex while using this medication.
If you are pregnant, planning to become pregnant, or are breastfeeding, consult your doctor to discuss the potential benefits and risks to you and your baby. When using this medication, avoid contact between the drug and latex products, such as condoms or diaphragms, as it may damage the latex and compromise the effectiveness of these products.
Do not use this medication if you experience abdominal pain, fever, or foul-smelling vaginal discharge. Instead, consult your doctor for guidance. This medication is specifically intended for the treatment of vaginal yeast infections and should not be used to address itching caused by other health issues. If you frequently experience vaginal yeast infections, consult your doctor to discuss the best course of action.
To minimize the risk of staining, take precautions to protect your clothing and fabrics. Avoid using tampons during treatment. After showering, bathing, or swimming, thoroughly dry the external vaginal area to prevent moisture buildup. Change into dry clothing as soon as possible, especially after wearing wet bathing suits or damp workout clothes.
Unless advised by your doctor, refrain from using douches, as this may disrupt the natural balance of the vagina. Avoid scratching the affected area, as this can lead to increased irritation and potentially spread the infection. It is recommended to abstain from vaginal sex while using this medication.
If you are pregnant, planning to become pregnant, or are breastfeeding, consult your doctor to discuss the potential benefits and risks to you and your baby. When using this medication, avoid contact between the drug and latex products, such as condoms or diaphragms, as it may damage the latex and compromise the effectiveness of these products.
Overdose Information
Overdose Symptoms:
- Unlikely due to minimal systemic absorption with vaginal use. Local irritation may occur with excessive use.
What to Do:
Discontinue use. If accidentally ingested, contact a poison control center or seek medical attention. Call 1-800-222-1222 for Poison Control.
Drug Interactions
Monitoring
Baseline Monitoring
Diagnosis of Vulvovaginal Candidiasis
Rationale: To confirm fungal infection and rule out other causes of vaginitis.
Timing: Prior to initiation of therapy
Routine Monitoring
Resolution of symptoms (itching, burning, discharge)
Frequency: Daily during treatment, and at follow-up
Target: Complete resolution
Action Threshold: If symptoms persist or worsen after 3 days of treatment, re-evaluate diagnosis and consider alternative therapy.
Symptom Monitoring
- Vaginal itching
- Vaginal burning
- Vaginal discharge (change in consistency or odor)
- Vaginal irritation
- Headache
- Abdominal pain
Special Patient Groups
Pregnancy
Terconazole is Pregnancy Category C. Use during pregnancy should only be considered if the potential benefit justifies the potential risk to the fetus. Systemic absorption is minimal, but animal studies have shown some adverse effects at high doses.
Trimester-Specific Risks:
First Trimester:
Limited data. Use with caution, only if clearly needed.
Second Trimester:
Limited data. Use with caution, only if clearly needed.
Third Trimester:
Limited data. Use with caution, only if clearly needed.
Lactation
Terconazole is minimally absorbed systemically after vaginal administration, and it is unlikely to be excreted in breast milk in clinically significant amounts. Considered generally compatible with breastfeeding, but caution is advised.
Infant Risk:
Low risk of adverse effects to the breastfed infant.
Pediatric Use
Safety and efficacy have not been established in pediatric patients under 18 years of age. Not recommended for use in this population.
Geriatric Use
No specific dosage adjustments are necessary for geriatric patients. Systemic absorption is minimal, and adverse effects are similar to those in younger adults.
Clinical Information
Clinical Pearls
- Terconazole is a good option for patients who prefer a shorter course of treatment (3 days) compared to some other vaginal antifungals.
- Advise patients to insert the suppository as high as possible into the vagina, preferably at bedtime, to minimize leakage.
- Patients should be instructed to complete the entire course of therapy, even if symptoms improve, to prevent recurrence.
- If symptoms persist or recur frequently, consider re-evaluating the diagnosis or exploring underlying causes (e.g., diabetes, immunosuppression).
Alternative Therapies
- Clotrimazole vaginal cream/suppository (e.g., 1-day, 3-day, 7-day courses)
- Miconazole vaginal cream/suppository (e.g., 1-day, 3-day, 7-day courses)
- Tioconazole vaginal ointment (1-day course)
- Fluconazole oral tablet (single dose)
Cost & Coverage
Average Cost:
Varies, typically $30-$60 per 3 suppositories
Generic Available:
Yes
Insurance Coverage:
Tier 1 or 2 (generic), Tier 3 (brand)
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the medication taken, the amount, and the time it occurred.