Tazicef 1gm Inj , 1vial

Ceftazidime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, leading to inhibition of cell wall biosynthesis and eventually bacterial cell lysis.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of a severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis), such as:
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Red or irritated eyes
+ Sores in the mouth, throat, nose, or eyes
Dark urine or yellow skin and eyes
Difficulty urinating or changes in urine output
Fever, chills, or sore throat
Unexplained bruising or bleeding
Feeling extremely tired or weak
Redness or white patches in the mouth or throat
Vaginal itching or discharge
Severe diarrhea, which can be a sign of a potentially life-threatening condition called C. diff-associated diarrhea (CDAD)
Stomach pain, cramps, or very loose, watery, or bloody stools (if you experience any of these symptoms, contact your doctor right away)
Seizures, confusion, shakiness, muscle twitching, or difficulty controlling body movements (if you have kidney problems, talk to your doctor, as your dose may need to be adjusted)

Other Possible Side Effects

Most people do not experience severe side effects, and some may not have any side effects at all. However, if you notice any of the following side effects, contact your doctor if they bother you or do not go away:

Diarrhea
Upset stomach or vomiting
Stomach pain
Irritation at the injection site

This is not a comprehensive list of all possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
If you are currently taking chloramphenicol.

This is not an exhaustive list of potential interactions. Therefore, it is crucial to discuss all of your medications (including prescription and over-the-counter drugs, natural products, and vitamins) and health conditions with your doctor and pharmacist. This will help ensure your safety while taking this medication.

To avoid potential interactions, do not start, stop, or modify the dosage of any medication without first consulting your doctor. Your doctor will help you determine whether it is safe to take this medication in conjunction with your other medications and health conditions.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

If you have diabetes and regularly test your urine for glucose, consult with your doctor to determine the most suitable testing method for you, as this medication may affect the accuracy of certain tests. Additionally, be sure to notify all your healthcare providers and laboratory personnel that you are taking this medication, as it may interfere with the results of some lab tests.

Do not take this medication for longer than prescribed, as this can increase the risk of developing a secondary infection. Older adults (65 years and older) should use this medication with caution, as they may be more susceptible to side effects.

If you are pregnant, planning to become pregnant, or breastfeeding, it is crucial to discuss the potential benefits and risks of this medication with your doctor to ensure the best possible outcome for you and your baby.

• Aminoglycosides (e.g., gentamicin, tobramycin): Increased risk of nephrotoxicity and ototoxicity. Monitor renal function closely.
• Loop Diuretics (e.g., furosemide): May increase the risk of nephrotoxicity when co-administered with cephalosporins, especially in patients with pre-existing renal impairment.

• Probenecid: Decreases renal tubular secretion of ceftazidime, leading to increased and prolonged plasma concentrations of ceftazidime. Generally not recommended for co-administration.
• Oral Contraceptives: Theoretical risk of reduced efficacy due to alteration of gut flora, though clinical significance is low. Advise backup contraception.
• Warfarin: Cephalosporins may alter vitamin K metabolism or gut flora, potentially enhancing the anticoagulant effect of warfarin. Monitor INR closely.

• Typhoid Vaccine (live, oral): Antibiotics may reduce the therapeutic effect of the live typhoid vaccine. Administer at least 24 hours apart.

• Signs of allergic reaction (rash, itching, hives, swelling, difficulty breathing)
• Gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal pain)
• Neurological symptoms (headache, dizziness, seizures, especially in patients with renal impairment or high doses)
• Signs of Clostridioides difficile-associated diarrhea (CDAD) (severe, persistent diarrhea, abdominal cramps, fever)
• Injection site reactions (pain, inflammation, phlebitis)

Ceftazidime is classified as Pregnancy Category B. Animal reproduction studies have not demonstrated a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed.

Ceftazidime is excreted in human milk in low concentrations. The amount ingested by the infant is small and generally considered compatible with breastfeeding. Monitor the infant for potential changes in bowel flora (e.g., diarrhea, candidiasis) or allergic reactions.

Ceftazidime has been used safely and effectively in pediatric patients, including neonates. Dosing must be carefully adjusted based on age, weight, and renal function. Neonates and infants may have immature renal function, requiring careful monitoring and dose adjustment.

Elderly patients are more likely to have decreased renal function, which necessitates careful dose adjustment based on creatinine clearance. They may also be more susceptible to adverse effects, particularly neurological effects (e.g., seizures) if doses are not appropriately adjusted for renal impairment.

• Ceftazidime has excellent activity against Pseudomonas aeruginosa, making it a crucial agent for treating infections caused by this challenging pathogen.
• It is often used empirically in febrile neutropenia due to its broad-spectrum gram-negative coverage, including Pseudomonas.
• Always adjust the dose in patients with renal impairment to prevent accumulation and potential neurotoxicity (e.g., seizures).
• While generally well-tolerated, monitor for C. difficile-associated diarrhea, which can occur during or after therapy.
• Ceftazidime does not have significant activity against MRSA or enterococci.

• Other third-generation cephalosporins (e.g., cefotaxime, ceftriaxone - but generally less active against Pseudomonas)
• Fourth-generation cephalosporins (e.g., cefepime - good anti-pseudomonal activity)
• Carbapenems (e.g., meropenem, imipenem/cilastatin, doripenem - broad-spectrum, including Pseudomonas)
• Aminoglycosides (e.g., tobramycin, amikacin - often used in combination with beta-lactams for severe Pseudomonas infections)
• Antipseudomonal penicillins (e.g., piperacillin/tazobactam)

If your symptoms or health problems persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others, and do not take medication prescribed for someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly. Unless instructed to do so by a healthcare professional, avoid flushing medications down the toilet or pouring them down the drain. If you are unsure about the correct disposal method, consult your pharmacist for guidance. Many communities offer drug take-back programs, which your pharmacist can help you locate. Some medications may come with an additional patient information leaflet; check with your pharmacist to see if this applies to your prescription. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide information about the medication taken, the amount, and the time it was taken to ensure prompt and effective treatment.