Stahist Ad 25-60mg Tablets

Chlorcyclizine is a first-generation antihistamine that acts as an H1-receptor antagonist, competing with histamine for H1-receptor sites on effector cells, thereby preventing histamine-mediated responses such as vasodilation, increased capillary permeability, and pruritus. It also possesses anticholinergic and sedative properties. Pseudoephedrine is a sympathomimetic amine that acts directly and indirectly on adrenergic receptors. It primarily causes vasoconstriction of respiratory tract mucosa by stimulating alpha-adrenergic receptors, leading to reduced swelling and nasal congestion. It also has some beta-adrenergic activity.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek emergency medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood pressure, including:
+ Severe headache
+ Dizziness
+ Passing out
+ Changes in eyesight
Chest pain or pressure
Fast heartbeat
Shakiness

Other Possible Side Effects

Like all medications, this drug can cause side effects. Although many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or persist, contact your doctor for guidance:

Dizziness
Drowsiness
Feeling nervous and excitable
* Trouble sleeping

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects not mentioned here. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have taken certain medications for depression or Parkinson's disease within the last 14 days, including isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline, as this may increase the risk of very high blood pressure.
If you are currently taking linezolid or methylene blue, as these medications can interact with this drug.

Additionally, it is crucial to provide your doctor and pharmacist with a comprehensive list of all your medications, including:

Prescription and over-the-counter (OTC) medications
Natural products
Vitamins

You should also inform them about any existing health problems. This information will help your doctor determine whether it is safe for you to take this medication with your other medications and health conditions. Do not start, stop, or change the dose of any medication without first consulting your doctor to ensure your safety.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Adhere strictly to the dosage instructions provided by your doctor, as taking more than prescribed may increase your risk of experiencing severe side effects. Do not exceed the recommended treatment duration, and only take this medication for the length of time specified by your doctor.

Until you are aware of how this medication affects you, exercise caution when engaging in activities that require alertness, such as driving, to ensure your safety. Additionally, refrain from consuming alcohol while taking this drug, as it may interact with the medication.

Before using marijuana, other cannabis products, or any prescription or over-the-counter (OTC) medications that may cause drowsiness or impair your reactions, consult with your doctor to discuss potential risks and interactions.

When administering this medication to children, use caution, as they may be at a higher risk of experiencing excitability. If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor, as they will need to discuss the potential benefits and risks of this medication to both you and your baby.

• Monoamine Oxidase Inhibitors (MAOIs) (concurrent use or within 14 days of MAOI discontinuation) - risk of hypertensive crisis.
• Other sympathomimetics (e.g., other decongestants, appetite suppressants, amphetamines) - risk of additive cardiovascular and CNS stimulant effects.

• CNS Depressants (e.g., alcohol, sedatives, hypnotics, opioids, anxiolytics) - increased sedation and CNS depression.
• Antihypertensives (e.g., beta-blockers, methyldopa, reserpine, guanethidine) - pseudoephedrine may reduce their hypotensive effects.
• Tricyclic Antidepressants (TCAs) - may potentiate cardiovascular effects of pseudoephedrine.
• Digitalis glycosides - increased risk of ectopic pacemaker activity.
• Ergot alkaloids (e.g., ergotamine, dihydroergotamine) - increased risk of vasoconstriction.

• Anticholinergics (e.g., atropine, certain antipsychotics, TCAs) - additive anticholinergic effects (e.g., dry mouth, urinary retention, blurred vision).
• Urinary acidifiers (e.g., ammonium chloride, ascorbic acid) - may increase pseudoephedrine excretion, reducing its efficacy.
• Urinary alkalinizers (e.g., sodium bicarbonate, acetazolamide) - may decrease pseudoephedrine excretion, increasing its effects.

• None commonly cited as minor for this combination.

• Drowsiness
• Dizziness
• Nervousness
• Insomnia
• Dry mouth
• Blurred vision
• Urinary retention
• Palpitations
• Increased blood pressure
• Headache

Category C. Use only if the potential benefit justifies the potential risk to the fetus. Pseudoephedrine has been associated with gastroschisis in some studies, particularly in the first trimester, though data are conflicting. Chlorcyclizine data in pregnancy are limited.

Not recommended. Both chlorcyclizine and pseudoephedrine are excreted into breast milk. Chlorcyclizine, a first-generation antihistamine, can cause drowsiness, irritability, or other adverse effects in the infant and may decrease milk supply. Pseudoephedrine can also decrease milk supply, especially in mothers with established lactation.

Generally not recommended for children under 12 years of age due to the risk of serious adverse effects, including CNS stimulation, seizures, and cardiovascular events, particularly with pseudoephedrine. First-generation antihistamines like chlorcyclizine can cause paradoxical excitation or profound sedation in young children. Always consult a pediatrician for appropriate dosing and alternatives for children.

Use with extreme caution. Elderly patients are more susceptible to the anticholinergic effects (e.g., urinary retention, constipation, confusion, dry mouth, blurred vision) and sympathomimetic effects (e.g., hypertension, tachycardia, nervousness, insomnia) of this combination. Start with the lowest effective dose and monitor closely for adverse effects. Avoid in patients with prostatic hypertrophy, glaucoma, or significant cardiovascular disease.

• This combination is effective for allergic rhinitis with significant nasal congestion.
• Warn patients about potential for drowsiness and advise against driving or operating machinery.
• Counsel patients to avoid alcohol and other CNS depressants.
• Carefully screen for contraindications, especially MAOI use, severe hypertension, and narrow-angle glaucoma.
• Advise patients with prostatic hypertrophy about the risk of urinary retention.
• Pseudoephedrine is a List I chemical and is subject to federal and state regulations regarding sales limits and record-keeping.
• Consider single-agent therapy (e.g., non-sedating antihistamine or nasal steroid) if only one symptom predominates or if side effects are intolerable.

• Nasal corticosteroids (e.g., fluticasone, mometasone) for allergic rhinitis
• Second-generation antihistamines (e.g., loratadine, cetirizine, fexofenadine) for allergy symptoms without sedation
• Topical decongestants (e.g., oxymetazoline, phenylephrine nasal spray) for nasal congestion (short-term use only)
• Oral phenylephrine (less effective than pseudoephedrine)
• Saline nasal sprays/washes

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.