Risamine Ointment
It is used to protect skin from wetness, urine, or stools.It is used to treat diaper rash.It is used to treat minor cuts, scrapes, or burns.It is used at wound or fistula sites.It is used to treat signs of hemorrhoids or rectal irritation.
Drug Class
Topical Analgesic; Skin Protectant
Pharmacologic Class
Counterirritant (Menthol); Astringent/Skin Protectant (Zinc Oxide)
Pregnancy Category
Category C
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Risamine Ointment is a skin cream that contains menthol and zinc oxide. Menthol provides a cooling sensation to help relieve minor pain and itching. Zinc oxide forms a protective barrier on your skin to help heal and prevent irritation, like diaper rash or chafing. It's used for temporary relief of muscle/joint pain, itching, and to protect irritated skin.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. For all uses of this medication:
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning.
Wash your hands before and after applying the medication, unless your hand is the area being treated.
Clean the affected area before applying the medication and dry it thoroughly.
Apply a thin layer of the medication to the affected skin and gently rub it in.
Do not use the medication for longer than your doctor has prescribed.
Rectal Use
If you are using this medication rectally, do not insert it into the rectum using your fingers or an applicator. Instead, follow your doctor's specific instructions.
Storage and Disposal
Store this medication at room temperature, away from heat and moisture. Do not freeze the medication. Keep it in a dry place, such as a closet or drawer, and avoid storing it in a bathroom. Keep all medications out of the reach of children and pets.
Missed Dose
If you use this medication regularly and miss a dose, apply it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply two doses at the same time or use extra doses. If you are using this medication on an as-needed basis, do not use it more frequently than your doctor has recommended.
To use this medication correctly, follow your doctor's instructions and read all the information provided. For all uses of this medication:
Apply this medication only to your skin, as directed by your doctor. Do not take it by mouth.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning.
Wash your hands before and after applying the medication, unless your hand is the area being treated.
Clean the affected area before applying the medication and dry it thoroughly.
Apply a thin layer of the medication to the affected skin and gently rub it in.
Do not use the medication for longer than your doctor has prescribed.
Rectal Use
If you are using this medication rectally, do not insert it into the rectum using your fingers or an applicator. Instead, follow your doctor's specific instructions.
Storage and Disposal
Store this medication at room temperature, away from heat and moisture. Do not freeze the medication. Keep it in a dry place, such as a closet or drawer, and avoid storing it in a bathroom. Keep all medications out of the reach of children and pets.
Missed Dose
If you use this medication regularly and miss a dose, apply it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply two doses at the same time or use extra doses. If you are using this medication on an as-needed basis, do not use it more frequently than your doctor has recommended.
Lifestyle & Tips
- Clean and dry the affected skin area before applying the ointment.
- Wash hands thoroughly before and after application.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Do not apply to large areas of the body or to broken, irritated, or blistered skin.
- Do not bandage tightly or use with a heating pad.
Available Forms & Alternatives
Available Strengths:
Dosing & Administration
Adult Dosing
Standard Dose:
Apply a thin layer to the affected area 3 to 4 times daily as needed.
Condition-Specific Dosing:
skinIrritation:
Apply to clean, dry skin.
painRelief:
Apply to affected area for temporary relief of minor aches and pains of muscles and joints.
Pediatric Dosing
Neonatal:
Not established (consult pediatrician)
Infant:
Not established (consult pediatrician)
Child:
Apply a thin layer to the affected area 3 to 4 times daily as needed (for children 2 years and older, consult physician for younger children).
Adolescent:
Apply a thin layer to the affected area 3 to 4 times daily as needed.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Dialysis:
No specific considerations (minimal systemic absorption)
Hepatic Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Pharmacology
Mechanism of Action
Menthol acts as a counterirritant by stimulating cold receptors (TRPM8 channels) in the skin, producing a cooling sensation that distracts from pain and itch. It also has mild local anesthetic properties. Zinc Oxide acts as a skin protectant by forming a physical barrier on the skin, preventing irritation from moisture and friction. It also has mild astringent and antiseptic properties, and reflects UV radiation.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption from topical application to intact skin.
Tmax:
Not applicable (minimal systemic absorption); local effect onset is rapid.
FoodEffect:
Not applicable (topical administration).
Distribution:
Vd:
Not applicable (minimal systemic absorption).
ProteinBinding:
Not applicable (minimal systemic absorption).
CnssPenetration:
No (minimal systemic absorption).
Elimination:
HalfLife:
Not applicable (minimal systemic absorption).
Clearance:
Not applicable (minimal systemic absorption).
ExcretionRoute:
Not applicable (minimal systemic absorption).
Unchanged:
Not applicable (minimal systemic absorption).
Pharmacodynamics
OnsetOfAction:
Within minutes (for cooling/soothing effect).
PeakEffect:
Within 15-30 minutes.
DurationOfAction:
Varies, typically 1-3 hours for cooling/analgesic effect; protective barrier lasts until removed.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical attention immediately:
* Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have any side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek medical attention immediately:
* Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have any side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, discuss them with your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe burning, stinging, or irritation where the ointment was applied.
- Rash or hives.
- Swelling.
- Symptoms worsen or do not improve within 7 days.
- Symptoms clear up and then return within a few days.
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have a deep wound or a puncture wound, as this may affect your treatment.
This medication can interact with other drugs and health conditions. To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your existing health problems
Carefully review your medications and health conditions with your doctor to confirm that it is safe to take this medication. Never start, stop, or change the dose of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have a deep wound or a puncture wound, as this may affect your treatment.
This medication can interact with other drugs and health conditions. To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your existing health problems
Carefully review your medications and health conditions with your doctor to confirm that it is safe to take this medication. Never start, stop, or change the dose of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.
When using this drug, avoid applying it to open wounds, deep wounds, animal bites, infected areas, or severe burns and cuts, as this may interfere with the healing process or lead to further complications.
In the event that this medication is accidentally ingested, it can be harmful. If you or someone else swallows this drug, immediately contact a doctor or a poison control center for assistance.
If you are pregnant, planning to become pregnant, or are currently breast-feeding, it is crucial to discuss this with your doctor. Your doctor will help you weigh the benefits and risks of using this medication during this time, considering both your health and the health of your baby.
When using this drug, avoid applying it to open wounds, deep wounds, animal bites, infected areas, or severe burns and cuts, as this may interfere with the healing process or lead to further complications.
In the event that this medication is accidentally ingested, it can be harmful. If you or someone else swallows this drug, immediately contact a doctor or a poison control center for assistance.
If you are pregnant, planning to become pregnant, or are currently breast-feeding, it is crucial to discuss this with your doctor. Your doctor will help you weigh the benefits and risks of using this medication during this time, considering both your health and the health of your baby.
Overdose Information
Overdose Symptoms:
- If ingested: Nausea, vomiting, abdominal pain, dizziness, confusion, seizures (especially with menthol).
- Excessive topical application: Severe skin irritation, blistering.
What to Do:
If ingested, seek immediate medical attention or call a Poison Control Center (1-800-222-1222). For severe topical reactions, wash off the product and seek medical advice.
Drug Interactions
Monitoring
Routine Monitoring
Skin condition (redness, irritation, rash)
Frequency: Daily, with each application
Target: Absence of irritation
Action Threshold: Discontinue use if irritation worsens or persists.
Symptom relief (pain, itch, discomfort)
Frequency: Daily, with each application
Target: Improvement in symptoms
Action Threshold: Consult healthcare provider if symptoms do not improve within 7 days or worsen.
Symptom Monitoring
- Skin redness
- Itching
- Burning sensation
- Rash
- Worsening pain or discomfort
Special Patient Groups
Pregnancy
Generally considered safe for topical use during pregnancy due to minimal systemic absorption, but use with caution and consult a healthcare provider, especially if applying to large areas or broken skin.
Trimester-Specific Risks:
First Trimester:
Low risk with topical use.
Second Trimester:
Low risk with topical use.
Third Trimester:
Low risk with topical use.
Lactation
Generally considered safe for topical use during lactation. Avoid applying to areas where the infant might ingest the product (e.g., breast area). Menthol can be irritating if ingested by infant.
Infant Risk:
Low risk with proper application; potential for irritation if ingested by infant.
Pediatric Use
Safe for children 2 years and older for most indications. For children under 2 years, consult a healthcare provider. Use with caution in infants, especially for menthol, due to potential for respiratory irritation if applied near the nose/face.
Geriatric Use
Generally safe for geriatric patients. No specific dose adjustments needed. Monitor for skin sensitivity or irritation, as older skin may be more fragile.
Clinical Information
Clinical Pearls
- This product is for external use only. Do not ingest.
- The cooling sensation from menthol can be intense; start with a small amount to test sensitivity.
- Zinc oxide can leave a white residue on the skin and clothing; apply thinly and rub in well if possible.
- Effective for minor skin irritations, chafing, diaper rash, and temporary relief of muscle/joint aches.
- Always read the specific product label for additional warnings and directions.
Alternative Therapies
- Topical NSAIDs (e.g., diclofenac gel) for localized pain.
- Topical corticosteroids for inflammatory skin conditions (prescription).
- Other skin protectants (e.g., petrolatum, lanolin).
- Oral analgesics (e.g., acetaminophen, ibuprofen) for systemic pain relief.
Cost & Coverage
Average Cost:
Price varies widely per tube/jar
Generic Available:
Yes
Insurance Coverage:
Not typically covered by prescription insurance (OTC product)
General Drug Facts
If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication, including the amount taken and the time it happened, to facilitate prompt and effective treatment.