Rifampin 600mg Inj, 1 Vial

Rifampin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing RNA synthesis and protein synthesis. It is bactericidal against both intracellular and extracellular Mycobacterium tuberculosis organisms.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of liver problems, including:
+ Dark urine
+ Tiredness
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Signs of kidney problems, such as:
+ Inability to pass urine
+ Changes in urine output
+ Blood in the urine
+ Sudden weight gain
Dizziness or fainting
Flu-like symptoms
Fever, chills, or sore throat
Unexplained bruising or bleeding
Feeling extremely tired or weak
Joint pain or swelling
Muscle pain or weakness
Chest pain
Excessive sweating
Abnormal heartbeat
Swelling in the arms or legs
Purple spots or redness of the skin
Changes in balance
Confusion, difficulty focusing, or changes in behavior
Menstrual changes
Changes in vision, eye pain, or severe eye irritation
Changes in tooth color (which may be long-lasting)

If you experience any new or worsening symptoms, such as cough, fever, fatigue, shortness of breath, headache, pain, night sweats, swollen glands, decreased appetite, weight loss, or skin sores, contact your doctor right away.

Important Warnings

Diarrhea is a common side effect of antibiotics. However, a severe form called C. diff-associated diarrhea (CDAD) may occur, which can lead to life-threatening bowel problems. If you experience stomach pain, cramps, or very loose, watery, or bloody stools, contact your doctor immediately.
Severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions, may occur. These reactions can be life-threatening and may affect other organs. Seek medical help right away if you notice:
+ Red, swollen, blistered, or peeling skin
+ Red or irritated eyes
+ Sores in your mouth, throat, nose, eyes, genitals, or skin
+ Fever
+ Chills
+ Body aches
+ Shortness of breath
+ Swollen glands
Rare but potentially life-threatening blood problems, such as thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), may occur. Contact your doctor immediately if you experience:
+ Extreme tiredness or weakness
+ Bruising or bleeding
+ Dark urine or yellow skin or eyes
+ Pale skin
+ Changes in urine output
+ Changes in vision
+ Weakness on one side of the body
+ Trouble speaking or thinking
+ Changes in balance
+ Fever
This medication may cause vein irritation. If you notice redness, burning, pain, swelling, or fluid leakage at the injection site, inform your nurse.

Other Possible Side Effects

While many people may not experience any side effects or only minor ones, it's essential to be aware of the following:

Drowsiness
Gas
Diarrhea
Upset stomach or vomiting
Heartburn
Stomach cramps
* Changes in body fluid color to orange or red

If you experience any of these side effects or others that bother you or do not go away, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have previously experienced liver problems while taking this medication.
Any medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is crucial because certain medications, such as those used to treat HIV, infections, depression, and other conditions, should not be taken with this medication. Your doctor or pharmacist can advise you on potential interactions.
Please note that this is not an exhaustive list of all medications or health conditions that may interact with this medication.

To ensure your safety, it is vital to discuss all of your medications (prescription and OTC), natural products, vitamins, and health conditions with your doctor and pharmacist. This will help determine whether it is safe to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Regular blood work and laboratory tests, as directed by your doctor, are crucial to monitor your condition.

This medication may interfere with certain laboratory tests, so it is vital to notify all your healthcare providers and laboratory personnel that you are taking this drug.

To minimize potential risks, avoid consuming alcohol while taking this medication. If you have diabetes, closely monitor your blood sugar levels, as this medication can affect them. Be aware of signs of high blood sugar, such as confusion, drowsiness, increased thirst or hunger, frequent urination, flushing, rapid breathing, or fruity-smelling breath, and report them to your doctor promptly.

Additionally, this medication may cause discoloration of contact lenses. Do not use this medication for an extended period beyond the recommended duration, as this may increase the risk of a second infection.

Rifampin, the active ingredient in this medication, has been associated with liver problems, which can be severe and potentially life-threatening, especially in individuals with pre-existing liver disease or those taking other medications that may increase the risk of liver damage. If you have concerns, discuss them with your doctor.

This medication has also been linked to certain lung problems, which can be fatal. If you have questions or concerns, consult your doctor.

If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects.

It is essential to note that birth control pills and other hormone-based contraceptives may be less effective while taking this medication. To prevent pregnancy, use an additional form of birth control, such as a condom.

If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor to discuss the potential benefits and risks of this medication to you and your baby.

• Protease inhibitors (e.g., tipranavir/ritonavir, saquinavir/ritonavir, atazanavir, darunavir, fosamprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, telaprevir) due to significant reduction in PI concentrations and loss of antiviral effect.
• Delamanid (concurrent use not recommended due to potential for QT prolongation)

• Oral contraceptives (decreased efficacy, leading to contraceptive failure)
• Warfarin (decreased anticoagulant effect)
• Cyclosporine, Tacrolimus, Sirolimus (decreased immunosuppressant levels)
• Corticosteroids (decreased corticosteroid levels)
• Oral hypoglycemics (e.g., sulfonylureas, glinides - decreased efficacy)
• Phenytoin (decreased anticonvulsant levels)
• Digoxin (decreased digoxin levels)
• Antiarrhythmics (e.g., quinidine, disopyramide, mexiletine, propafenone - decreased levels)
• Azole antifungals (e.g., fluconazole, itraconazole, voriconazole - decreased antifungal levels)
• Non-nucleoside reverse transcriptase inhibitors (NNRTIs) (e.g., efavirenz, nevirapine - altered levels)
• Certain calcium channel blockers (e.g., verapamil, diltiazem, nifedipine - decreased levels)
• Methadone (decreased methadone levels, leading to withdrawal symptoms)
• Clopidogrel (decreased antiplatelet effect)
• Dapsone (altered dapsone levels)
• Theophylline (decreased theophylline levels)
• Statins (e.g., simvastatin, atorvastatin - decreased statin levels)

• Beta-blockers (decreased beta-blocker levels)
• Clozapine (decreased clozapine levels)
• Tricyclic antidepressants (decreased antidepressant levels)
• Selective serotonin reuptake inhibitors (SSRIs) (altered SSRI levels)
• Benzodiazepines (e.g., midazolam, triazolam - decreased levels)
• Buspirone (decreased buspirone levels)
• Chloramphenicol (decreased chloramphenicol levels)
• Cimetidine (decreased cimetidine levels)
• Erythromycin (decreased erythromycin levels)
• Haloperidol (decreased haloperidol levels)
• Ketoconazole (decreased ketoconazole levels)
• Levothyroxine (decreased thyroid hormone levels)
• Losartan (decreased losartan levels)
• Metoprolol (decreased metoprolol levels)
• Nortriptyline (decreased nortriptyline levels)
• Ondansetron (decreased ondansetron levels)
• Propranolol (decreased propranolol levels)
• Quinine (decreased quinine levels)
• Sildenafil (decreased sildenafil levels)
• Tramadol (decreased tramadol levels)
• Zolpidem (decreased zolpidem levels)

• Not typically categorized as minor due to potent enzyme induction effects on most interacting drugs.

• Jaundice (yellowing of skin or eyes)
• Dark urine
• Pale stools
• Persistent nausea or vomiting
• Unusual fatigue or weakness
• Abdominal pain (especially right upper quadrant)
• Fever
• Rash or itching
• Flu-like symptoms (fever, chills, headache, muscle aches)
• Easy bruising or bleeding
• Changes in vision

Category C. Rifampin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is a risk of postnatal hemorrhage in the mother and infant when rifampin is given during the last few weeks of pregnancy, possibly due to vitamin K deficiency. Vitamin K supplementation may be considered for the mother during the last month of pregnancy and for the neonate.

Rifampin is excreted into breast milk. The American Academy of Pediatrics considers rifampin compatible with breastfeeding. However, due to the potential for adverse effects in the infant (e.g., jaundice, poor feeding, theoretical risk of liver toxicity), caution is advised. The benefits of breastfeeding for the infant and the mother's need for treatment should be weighed against the potential risks.

Rifampin is generally safe and effective for pediatric patients for appropriate indications (e.g., tuberculosis). Dosing is weight-based (10-20 mg/kg/day, max 600 mg/day). Close monitoring for adverse effects, particularly hepatotoxicity, is important.

No specific dose adjustment is generally needed for elderly patients based on age alone. However, geriatric patients may have age-related decreases in hepatic and/or renal function, and may be more susceptible to adverse effects. Close monitoring of liver function and overall tolerance is recommended.

• Rifampin is a potent inducer of numerous CYP450 enzymes (e.g., CYP3A4, CYP2C9, CYP2C19) and P-glycoprotein, leading to a high potential for significant drug-drug interactions. Always review concomitant medications carefully.
• Causes a harmless reddish-orange discoloration of body fluids (urine, sweat, tears, saliva), which can permanently stain soft contact lenses and clothing.
• Resistance to rifampin can develop rapidly if used as monotherapy; it should always be used in combination with other antitubercular drugs for the treatment of tuberculosis.
• Administer intravenous infusion over 3 hours. Rapid infusion can lead to 'red man syndrome' (flushing, rash, itching).
• Monitor liver function tests (AST, ALT, bilirubin) closely, especially in patients with pre-existing liver disease, alcoholism, or those receiving other hepatotoxic medications (e.g., isoniazid, pyrazinamide).
• For meningococcal prophylaxis, rifampin is effective but should be reserved for situations where other agents are contraindicated or not feasible, due to its broad-spectrum activity and potential for resistance development.

• Other antitubercular drugs (e.g., Isoniazid, Pyrazinamide, Ethambutol, Streptomycin, Bedaquiline, Linezolid, Moxifloxacin, Pretomanid)
• For meningococcal prophylaxis: Ceftriaxone, Ciprofloxacin

If your symptoms or health problems do not improve or worsen over time, it is essential to contact your doctor for further guidance. To ensure your safety and the safety of others, never share your prescription medications with anyone, and do not take medications that have been prescribed to someone else.

All medications should be stored in a secure location, out of the reach of children and pets, to prevent accidental ingestion. When disposing of unused or expired medications, do not flush them down the toilet or pour them down the drain unless specifically instructed to do so by a healthcare professional or pharmacist. Instead, consult with your pharmacist to determine the best method for disposal, as some communities have drug take-back programs in place.

Additionally, some medications may have a separate patient information leaflet; check with your pharmacist for more information. If you have any questions or concerns about your medication, it is crucial to discuss them with your doctor, nurse, pharmacist, or other healthcare provider.

In the event of a suspected overdose, immediately contact your local poison control center or seek emergency medical attention. Be prepared to provide detailed information about the medication, including the amount taken and the time it was ingested, to ensure prompt and effective treatment.